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Stc1 Gene Detail
Summary
  • Symbol
    Stc1
  • Name
    stanniocalcin 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:109131
    NCBI Gene: 20855
  • Gene Overview
    MyGene.info: STC1
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:69029289-69041401 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 35.98 cM
Strain
Comparison
more
  • SNPs within 2kb
    81 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109131
protein coding gene Chr14:69029238-69041804 (.)
129S1/SvImJ MGP_129S1SvImJ_G0021513
protein coding gene Chr14:63796666-63808899 (+)
A/J MGP_AJ_G0021472
protein coding gene Chr14:62281205-62293826 (+)
AKR/J MGP_AKRJ_G0021448
protein coding gene Chr14:64375111-64387203 (+)
BALB/cJ MGP_BALBcJ_G0021478
protein coding gene Chr14:62261680-62273777 (+)
C3H/HeJ MGP_C3HHeJ_G0021255
protein coding gene Chr14:64105613-64117776 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021917
protein coding gene Chr14:66703364-66715673 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019457
protein coding gene Chr14:60127916-60139920 (+)
CAST/EiJ MGP_CASTEiJ_G0020772
protein coding gene Chr14:60636551-60648649 (+)
CBA/J MGP_CBAJ_G0021222
protein coding gene Chr14:68771462-68788341 (+)
DBA/2J MGP_DBA2J_G0021345
protein coding gene Chr14:61884882-61896994 (+)
FVB/NJ MGP_FVBNJ_G0021324
protein coding gene Chr14:61303304-61315371 (+)
LP/J MGP_LPJ_G0021420
protein coding gene Chr14:64862878-64875200 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021353
protein coding gene Chr14:67745793-67757946 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021940
protein coding gene Chr14:63628182-63640256 (+)
PWK/PhJ MGP_PWKPhJ_G0020516
protein coding gene Chr14:58638042-58650697 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020349
protein coding gene Chr14:59553780-59565817 (+)
WSB/EiJ MGP_WSBEiJ_G0020825
protein coding gene Chr14:63931219-63943340 (+)



Homology
more
  • Human Ortholog
    STC1, stanniocalcin 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    STC1, stanniocalcin 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    STC
  • Links
    NCBI Gene ID: 6781
    neXtProt AC: NX_P52823
    UniProt: P52823

  • Chr Location
    8p21.2; chr8:23841921-23854807 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 2374
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: STC1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    3 phenotypes from multigenic genotypes
    12 phenotype references
Mice homozygous for disruptions in this gene display a normal phenotype.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 20855 NCBI Gene Model | MGI Sequence Detail 12113 C57BL/6J ±  kb
transcript NM_009285 RefSeq | MGI Sequence Detail 3743 C57BL/6  
polypeptide O55183 UniProt | EBI | MGI Sequence Detail 247 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 22
    cDNA 19
    Primer pair 2
    Other 1

    Microarray probesets 2
Other
Accession IDs
less
MGD-MRK-38175
References
more
  • Summaries
    All 52
    Developmental Gene Expression 15
    Gene Ontology 6
    Phenotypes 12
  • Earliest
    J:37688 Chang AC, et al., Molecular cloning and characterization of mouse stanniocalcin cDNA. Mol Cell Endocrinol. 1996 Nov 29;124(1-2):185-7
  • Latest
    J:254649 Roddy GW, et al., Stanniocalcin-1 Is an Ocular Hypotensive Agent and a Downstream Effector Molecule That Is Necessary for the Intraocular Pressure-Lowering Effects of Latanoprost. Invest Ophthalmol Vis Sci. 2017 May 1;58(5):2715-2724

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory