Fzd7
Gene Detail

Symbol Name ID

Fzd7 frizzled homolog 7 (Drosophila) MGI:108570

Synonyms

Fz7

Feature Type

protein coding gene

Genetic Map

Chromosome 1

30.08 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr1:59482424-59486959 bp, + strand From VEGA annotation of GRCm38   4536 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20751  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: G protein-coupled receptor frizzled
Gene Tree: Fzd7

Human homologs

Human Homolog		FZD7, frizzled family receptor 7
NCBI Gene ID		8324
neXtProt AC		NX_O75084
Human Synonyms		FzE3
Human Chr (Location)		2q33; chr2:202899310-202903160 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(9) : Targeted(2) Gene trapped(7)

Gene Ontology (GO) classifications

All GO classifications: (52 annotations)

Process	axonogenesis, brain development, ...
Component	apical part of cell, cytoplasm, ...
Function	G-protein coupled receptor activity, PDZ domain binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (37 records)
Data Summary: Results (291)    Tissues (217)    Images (36)
Theiler Stages: 1, 2, 3, 4, 5, 13, 14, 15, 17, 18, 19, 20, 22, 23, 24, 28

Assay Type	Results
RNA in situ	227
RT-PCR	64

cDNA source data(66)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(76) Genomic(1) cDNA(67) Primer pair(7) Other(1)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000020777 (Evidence)
Ensembl Gene Model	ENSMUSG00000041075 (Evidence)
Entrez Gene	14369 (Evidence)
UniGene	297906
DFCI	TC1577715
DoTS	DT.101212726, DT.523781
NIA Mouse Gene Index	U000317
Consensus CDS Project	CCDS14985.1
International Mouse Knockout Project Status	Fzd7

Sequences

Length	Strain/Species
genomic	OTTMUSG00000020777	VEGA Gene Model | MGI Sequence Detail	4536	C57BL/6J
transcript	OTTMUST00000049127	VEGA | MGI Sequence Detail	4536	Not Applicable
polypeptide	OTTMUSP00000022716	VEGA | MGI Sequence Detail	572	Not Applicable

All sequences(26) RefSeq(2) UniProt(4)

Polymorphisms

RFLP(1) : SNPs(11 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR026552	Frizzled-7
InterPro	IPR020067	Frizzled domain
InterPro	IPR000539	Frizzled protein
InterPro	IPR015526	Frizzled/secreted frizzled-related protein
InterPro	IPR017981	GPCR, family 2-like
Protein Ontology	PR:000007723	frizzled-7

References

(Earliest) J:37068 Wang Y, et al., A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled. J Biol Chem. 1996 Feb 23;271(8):4468-76
(Latest) J:189062 Yu H, et al., Frizzled 2 and frizzled 7 function redundantly in convergent extension and closure of the ventricular septum and palate: evidence for a network of interacting genes. Development. 2012 Dec;139(23):4383-94
All references(76)

Other accession IDs

MGD-MRK-37614