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Fzd7 Gene Detail
Summary
  • Symbol
    Fzd7
  • Name
    frizzled class receptor 7
  • Synonyms
    Fz7
  • Feature Type
    protein coding gene
  • IDs
    MGI:108570
    NCBI Gene: 14369
  • Gene Overview
    MyGene.info: FZD7
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr1:59482424-59486955 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      4532 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 30.08 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    FZD7, frizzled class receptor 7
  • Vertebrate Orthologs
    9
  • Human Ortholog
    FZD7, frizzled class receptor 7
    Orthology source: HGNC, HomoloGene
  • Synonyms
    FzE3
  • Links
    NCBI Gene ID: 8324
    neXtProt AC: NX_O75084
    UniProt: O75084

  • Chr Location
    2q33.1; chr2:202034587-202038437 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    18 phenotypes from multigenic genotypes
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit a shorter tail with a distal kink with full penetrance as well as cardiac defects with low penetrance.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000020777 VEGA Gene Model | MGI Sequence Detail 4532 C57BL/6J ±  kb
    transcript OTTMUST00000049127 VEGA | MGI Sequence Detail 4532 Not Applicable  
    polypeptide OTTMUSP00000022716 VEGA | MGI Sequence Detail 572 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      31 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 88
      Genomic 1
      cDNA 72
      Primer pair 12
      Other 3

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-37614
    References
    more
    • Summaries
      All 98
      Developmental Gene Expression 50
      Gene Ontology 10
      Phenotypes 13
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:262102 Guan S, et al., Frizzled-7 mediates TGF-beta-induced pulmonary fibrosis by transmitting non-canonical Wnt signaling. Exp Cell Res. 2017 Oct 1;359(1):226-234

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    09/11/2018
    MGI 6.12
    The Jackson Laboratory