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Fzd7
Gene Detail
 Symbol
Name
ID
Fzd7
frizzled homolog 7 (Drosophila)
MGI:108570
Synonyms Fz7
Feature Type protein coding gene
Genetic Map
Chromosome 1
30.08 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr1:59482424-59486959 bp, + strand
From VEGA annotation of GRCm38

  4536 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20751  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: G protein-coupled receptor frizzled
Gene Tree: Fzd7

Human
homologs
Human Homolog FZD7, frizzled class receptor 7
NCBI Gene ID 8324
neXtProt AC  NX_O75084
Human Synonyms  FzE3
Human Chr (Location)  2q33; chr2:202034587-202038437 (+)  GRCh38
Alleles
and
phenotypes
All alleles(9) : Gene trapped(7) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit a shorter tail with a distal kink with full penetrance as well as cardiac defects with low penetrance.
 
Gene Ontology
(GO)
classifications
All GO classifications: (54 annotations)
Process axonogenesis, brain development, ...
Component apical part of cell, cytoplasm, ...
Function frizzled binding, G-protein coupled receptor activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (39 records)
Data Summary: Results (396)    Tissues (311)    Images (46)
Theiler Stages: 1, 2, 3, 4, 5, 7, 9, 10, 11, 13, 14, 15, 17, 18, 19, 20, 22, 23, 24, 25, 28
Assay TypeResults
RNA in situ 327
RT-PCR 69
cDNA source data(68)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(79) Genomic(1) cDNA(69) Primer pair(8) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000020777 (Evidence)
Ensembl Gene ModelENSMUSG00000041075 (Evidence)
Entrez Gene14369 (Evidence)
UniGene297906
DFCITC1577715
DoTSDT.101212726, DT.523781
NIA Mouse Gene IndexU000317
Consensus CDS ProjectCCDS14985.1
International Mouse Knockout Project StatusFzd7
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020777 VEGA Gene Model | MGI Sequence Detail 4536 C57BL/6J ±  kb
transcript OTTMUST00000049127 VEGA | MGI Sequence Detail 4536 Not Applicable 
polypeptide OTTMUSP00000022716 VEGA | MGI Sequence Detail 572 Not Applicable 

For the selected sequences
All sequences(26) RefSeq(2) UniProt(4)
Polymorphisms RFLP(1) : SNPs within 2kb(31 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR026552 Frizzled-7
InterPro IPR020067 Frizzled domain
InterPro IPR000539 Frizzled protein
InterPro IPR015526 Frizzled/secreted frizzled-related protein
InterPro IPR017981 GPCR, family 2-like
Protein Ontology PR:000007723 frizzled-7
References (Earliest) J:37068 Wang Y, et al., A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled. J Biol Chem. 1996 Feb 23;271(8):4468-76
(Latest) J:202907 Grigoryan T, et al., Wnt/Rspondin/beta-catenin signals control axonal sorting and lineage progression in Schwann cell development. Proc Natl Acad Sci U S A. 2013 Nov 5;110(45):18174-9
All references(79)
Other
accession IDs
MGD-MRK-37614

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory