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Fzd7
Gene Detail
Symbol

Name
ID
Fzd7
frizzled homolog 7 (Drosophila)
MGI:108570
Synonyms
Fz7
Feature Type
protein coding gene
Genetic Map
Chromosome 1
30.08 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr1:59482424-59486955 bp, + strand
From VEGA annotation of GRCm38

  4532 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20751  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: FZD7
Protein SuperFamily: G protein-coupled receptor frizzled
Gene Tree: Fzd7

Human
homologs
FZD7, frizzled class receptor 7
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 8324
neXtProt AC: NX_O75084

Human Synonyms: FzE3

Human Chr (Location): 2q33; chr2:202034587-202038437 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Gene trapped(7) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit a shorter tail with a distal kink with full penetrance as well as cardiac defects with low penetrance.
 
Interactions
Fzd7 interacts with 348 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (40 records)
Data Summary: Results (392)    Tissues (309)    Images (46)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 327
RT-PCR 65
cDNA source data(68)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA FZD7 ; Xenbase fzd7 ; ZFIN fzd7a, fzd7b    NEW 
Molecular
reagents
All nucleic(79) Genomic(1) cDNA(69) Primer pair(8) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000020777 (Evidence)
Ensembl Gene Model ENSMUSG00000041075 (Evidence)
Entrez Gene 14369 (Evidence)
UniGene 297906
DFCI TC1577715
DoTS DT.523781, DT.101212726
NIA Mouse Gene Index U000317
Consensus CDS Project CCDS14985.1
International Mouse Phenotyping Consortium Status Fzd7
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020777 VEGA Gene Model | MGI Sequence Detail 4532 C57BL/6J ±  kb
transcript OTTMUST00000049127 VEGA | MGI Sequence Detail 4532 Not Applicable 
polypeptide OTTMUSP00000022716 VEGA | MGI Sequence Detail 572 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(2) UniProt(4)
Polymorphisms
RFLP(1) : SNPs within 2kb(31 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR026552 Frizzled-7
InterPro IPR020067 Frizzled domain
InterPro IPR000539 Frizzled protein
InterPro IPR015526 Frizzled/secreted frizzled-related protein
InterPro IPR017981 GPCR, family 2-like
Protein Ontology PR:000007723 frizzled-7
References
(Earliest) J:37068 Wang Y, et al., A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled. J Biol Chem. 1996 Feb 23;271(8):4468-76
(Latest) J:215806 Bentzinger CF, et al., Wnt7a stimulates myogenic stem cell motility and engraftment resulting in improved muscle strength. J Cell Biol. 2014 Apr 14;205(1):97-111
All references(79)
Other
accession IDs
MGD-MRK-37614

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory