Fzd7 MGI Mouse Gene Detail - MGI:108570 - frizzled class receptor 7

Symbol

Fzd7
Name

frizzled class receptor 7
Synonyms

Fz7

Feature Type

protein coding gene
IDs

MGI:108570
NCBI Gene: 14369
Alliance

genome feature page
Transcription Start Sites

7 TSS

Sequence Map

Chr1:59521583-59526114 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 30.08 cM
Mapping Data

2 experiments

SNPs within 2kb

132 from dbSNP Build 142
Strain Annotations

19
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_108570	protein coding gene	Chr1:59521306-59526114 (+)
129S1/SvImJ	ENSMUSG00200018207	protein coding gene	Chr1:57020546-57025077 (+)
A/J	ENSMUSG00195027151	protein coding gene	Chr1:56559723-56564254 (+)
AKR/J	ENSMUSG00220035901	protein coding gene	Chr1:56645259-56649788 (+)
BALB/cJ	ENSMUSG00180013120	protein coding gene	Chr1:56795301-56799830 (+)
C3H/HeJ	ENSMUSG00175000809	protein coding gene	Chr1:56937162-56941693 (+)
C57BL/6NJ	ENSMUSG00215022105	protein coding gene	Chr1:56869034-56873565 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014178	protein coding gene	Chr1:53204332-53208852 (+)
CAST/EiJ	ENSTCUG00005012827	protein coding gene	Chr1:56712404-56716930 (+)
CBA/J	ENSMUSG00210035151	protein coding gene	Chr1:56622203-56626734 (+)
DBA/2J	ENSMUSG00185037361	protein coding gene	Chr1:57741893-57746424 (+)
FVB/NJ	ENSMUSG00205016865	protein coding gene	Chr1:56582988-56587519 (+)
JF1/MsJ	ENSUMUG00000038851	protein coding gene	Chr1:56707714-56712207 (+)
LP/J	ENSMUSG00230025100	protein coding gene	Chr1:57742468-57746999 (+)
NOD/ShiLtJ	ENSMUSG00190036024	protein coding gene	Chr1:56776372-56780901 (+)
NZO/HlLtJ	ENSMUSG00225007634	protein coding gene	Chr1:60949847-60954378 (+)
PWK/PhJ	ENSLUMG00010022523	protein coding gene	Chr1:56217650-56222169 (+)
SPRET/EiJ	ENSMSPG00010025717	protein coding gene	Chr1:58157324-58161845 (+)
WSB/EiJ	ENSIUOG00005019809	protein coding gene	Chr1:56406450-56410980 (+)

Human Ortholog

FZD7, frizzled class receptor 7

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FZD7, frizzled class receptor 7
Synonyms

FzE3
Links

HGNC:4045

NCBI Gene ID: 8324

UniProt: O75084
Chr Location

2q33.1; chr2:202033855-202038441 (+) GRCh38

MGI Vertebrate Homology

Fzd7 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: FZD7
Gene Tree

Fzd7

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
18 phenotypes from multigenic genotypes
22 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

21
Chemically induced (other)

1
Endonuclease-mediated

6
Gene trapped

6
Radiation induced

1
Targeted

7
Genomic Mutations

2 involving Fzd7
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

38 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit a shorter tail with a distal kink with full penetrance as well as cardiac defects with low penetrance.

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All GO Annotations

49
GO References

14

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1168
Tissues

419
cDNA Data

74
Literature Summary

64

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA FZD7

Xenbase fzd7

ZFIN fzd7a, fzd7b

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All Sequences

37
RefSeq

2
UniProt

4
CCDS

CCDS14985.1

Ensembl

ENSMUSG00000041075 (Evidence)
NCBI Gene

14369

			Length	Strain/Species	Flank
genomic	ENSMUSG00000041075	Ensembl Gene Model \| MGI Sequence Detail	4532	C57BL/6J	± kb
transcript	ENSMUST00000114246	Ensembl \| MGI Sequence Detail	4532	Not Applicable
polypeptide	ENSMUSP00000109884	Ensembl \| MGI Sequence Detail	572	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000007723 frizzled-7

(term hierarchy)
InterPro Domains

IPR042742 Frizzled-7, cysteine-rich Wnt-binding domain

IPR036790 Frizzled cysteine-rich domain superfamily

IPR020067 Frizzled domain

IPR015526 Frizzled/secreted frizzled-related protein

IPR000539 Frizzled/Smoothened, 7TM

IPR017981 GPCR, family 2-like, 7TM
GlyGen

Q61090 2 sites

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All nucleic 103

Genomic 1

cDNA 75

Primer pair 23

Other 4

Antibodies 1

Microarray probesets 5

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MGD-MRK-37614

Summaries

All 128

Developmental Gene Expression 64

Gene Ontology 14

Phenotypes 22
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:375438 Wu CCN, et al., FZD7 expression marks mammary tumor-initiating cells. Proc Natl Acad Sci U S A. 2025 Nov 18;122(46):e2522465122

TSS for Fzd7:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr6869	Chr1:59521250-59521261 (+)	-327 bp
Tssr6870	Chr1:59521279-59521290 (+)	-298 bp
Tssr6871	Chr1:59521292-59521325 (+)	-274 bp
Tssr6872	Chr1:59521823-59521861 (+)	259 bp
Tssr6873	Chr1:59522030-59522053 (+)	459 bp
Tssr6874	Chr1:59522054-59522095 (+)	492 bp
Tssr6875	Chr1:59522099-59522111 (+)	522 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24