About   Help   FAQ
Dab1 Gene Detail
Summary
  • Symbol
    Dab1
  • Name
    disabled 1
  • Synonyms
    C630028C02Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:108554
    NCBI Gene: 13131
  • Gene Overview
    MyGene.info: DAB1
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr4:103619359-104744844 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      1125486 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 47.79 cM
  • Mapping Data
    15 experiments
Homology
more
  • Human Ortholog
    DAB1, DAB1, reelin adaptor protein
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DAB1, DAB1, reelin adaptor protein
    Orthology source: HomoloGene, HGNC
  • Synonyms
    SCA37
  • Links
    NCBI Gene ID: 1600
    neXtProt AC: NX_O75553
    UniProt: O75553

  • Chr Location
    1p32.2; chr1:56997906-58250539 (-)  GRCh38.p7
  • HomoloGene
    Vertebrate Homology Class 32084
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: DAB1
  • Gene Tree
    Dab1
Human Diseases
more
  • Diseases
    1 with human DAB1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    57 phenotypes from 16 alleles in 15 genetic backgrounds
    8 phenotypes from multigenic genotypes
    5 images
    100 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null display unstable gait and whole-body tremor with a hypoplastic cerebellum devoid of folia, a probable consequence of defective neuronal migration.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    53
  • GO References
    25
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    648
  • Tissues
    215
  • cDNA Data
    43
  • Literature Summary
    98
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000008111 VEGA Gene Model | MGI Sequence Detail 1125486 C57BL/6J ±  kb
    transcript OTTMUST00000018430 VEGA | MGI Sequence Detail 5278 Not Applicable  
    polypeptide OTTMUSP00000008462 VEGA | MGI Sequence Detail 555 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      9389 from dbSNP Build 142
    • PCR
      2
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 66
      Genomic 6
      cDNA 45
      Primer pair 9
      Other 6

      Microarray probesets 10
    Other
    Accession IDs
    less
    MGD-MRK-14318, MGD-MRK-14330, MGD-MRK-37598, MGI:1196335, MGI:2140405, MGI:2444714, MGI:98245
    References
    more
    • Summaries
      All 234
      Developmental Gene Expression 98
      Gene Ontology 25
      Phenotypes 100
    • Earliest
      J:37166 Sweet HO, et al., Scrambler, a new neurological mutation of the mouse with abnormalities of neuronal migration. Mamm Genome. 1996 Nov;7(11):798-802
    • Latest
      J:261809 Mayer C, et al., Developmental diversification of cortical inhibitory interneurons. Nature. 2018 Mar 22;555(7697):457-462
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.     		last database update
    06/12/2018
    MGI 6.12     		The Jackson Laboratory