Dab1
Gene Detail

Symbol Name ID

Dab1 disabled 1 MGI:108554

Synonyms

C630028C02Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 4

47.79 cM
Detailed Genetic Map ± 1 cM


Mapping data(15)

Sequence Map

Chr4:103619359-104744844 bp, + strand From VEGA annotation of GRCm38   1125486 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:32084  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Dab1

Human homologs

Human Homolog		DAB1, Dab, reelin signal transducer, homolog 1 (Drosophila)
NCBI Gene ID		1600
neXtProt AC		NX_O75553
Human Chr (Location)		1p32-p31; chr1:56997906-58250539 (-)  GRCh38

Alleles and phenotypes

All alleles(23) : Gene trapped(3) Spontaneous(6) Targeted(14)
Incidental mutations (data from Mutagenetix , APF )
 

Homozygous null display unstable gait and whole-body tremor with a hypoplastic cerebellum devoid of folia, a probable consequence of defective neuronal migration.

 
Phenotype Images(5)

Gene Ontology (GO) classifications

All GO classifications: (50 annotations)

Process	adult walking behavior, cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex radial glia guided migration, ...
Component	apical part of cell, brush border, ...
Function	phosphatidylinositol 3-kinase binding, phospholipid binding, ...

External Resources: FuncBase

Expression

Literature Summary: (82 records)

Data Summary: Results (600)    Tissues (205)    Images (92)
Theiler Stages: 10, 14, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	5
RNA in situ	490
Northern blot	27
Western blot	74
RT-PCR	4

cDNA source data(43)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(57) Genomic(6) cDNA(45) Primer pair(3) Other(3)
Microarray probesets(10)

Other database links

VEGA Gene Model	OTTMUSG00000008111 (Evidence)
Ensembl Gene Model	ENSMUSG00000028519 (Evidence)
Entrez Gene	13131 (Evidence)
UniGene	289682
DFCI	TC1581923, TC1589457, TC1590877, TC1696753
DoTS	DT.101367960, DT.101367961, DT.103563936, DT.110834704, DT.50315002, DT.55182533, DT.94184778, DT.94353200, DT.99851763
NIA Mouse Gene Index	U004573
PDB	1NTV, 1OQN, 1NU2
Consensus CDS Project	CCDS18413.1
International Mouse Knockout Project Status	Dab1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000008111	VEGA Gene Model | MGI Sequence Detail	1125486	C57BL/6J
transcript	OTTMUST00000018430	VEGA | MGI Sequence Detail	5278	Not Applicable
polypeptide	OTTMUSP00000008462	VEGA | MGI Sequence Detail	555	Not Applicable

All sequences(105) RefSeq(31) UniProt(5)

Polymorphisms

PCR(2) : SNPs within 2kb(9456 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR006020	Phosphotyrosine interaction domain
InterPro	IPR011993	Pleckstrin homology-like domain
Protein Ontology	PR:000006258	disabled homolog 1

References

(Earliest) J:37166 Sweet HO, et al., Scrambler, a new neurological mutation of the mouse with abnormalities of neuronal migration. Mamm Genome. 1996 Nov;7(11):798-802
(Latest) J:209566 Tomassy GS, et al., Distinct profiles of myelin distribution along single axons of pyramidal neurons in the neocortex. Science. 2014 Apr 18;344(6181):319-24
All references(200)

Other accession IDs

MGD-MRK-14318, MGD-MRK-14330, MGD-MRK-37598, MGI:1196335, MGI:2140405, MGI:2444714, MGI:98245