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Dab1
Gene Detail
Symbol

Name
ID
Dab1
disabled 1
MGI:108554
Synonyms
C630028C02Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 4
47.79 cM
Detailed Genetic Map ± 1 cM


Mapping data(15)
Sequence Map
Chr4:103619359-104744844 bp, + strand
From VEGA annotation of GRCm38

  1125486 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:32084  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: DAB1
Gene Tree: Dab1

Human
homologs
DAB1, Dab, reelin signal transducer, homolog 1 (Drosophila)
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 1600
neXtProt AC: NX_O75553

Human Chr (Location): 1p32-p31; chr1:56997906-58250539 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(25) : Gene trapped(3) Spontaneous(7) Targeted(15)
Genomic Mutations involving Dab1 (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous null display unstable gait and whole-body tremor with a hypoplastic cerebellum devoid of folia, a probable consequence of defective neuronal migration.
 
Phenotype Images(5)
Interactions
Dab1 interacts with 414 markers (Mir1b, Mir7-1, Mir9-1, ...)
Expression
Literature Summary: (88 records)
Data Summary: Results (600)    Tissues (206)    Images (92)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 5
RNA in situ 490
Northern blot 27
Western blot 74
RT-PCR 4
cDNA source data(43)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase dab1 ; ZFIN dab1a, dab1b    NEW 
Molecular
reagents
All nucleic(57) Genomic(6) cDNA(45) Primer pair(3) Other(3)
Microarray probesets(10)
Other database
links
VEGA Gene Model OTTMUSG00000008111 (Evidence)
Ensembl Gene Model ENSMUSG00000028519 (Evidence)
Entrez Gene 13131 (Evidence)
UniGene 289682
DFCI TC1581923, TC1696753, TC1590877, TC1589457
DoTS DT.55182533, DT.50315002, DT.110834704, DT.103563936, DT.101367961, DT.101367960, DT.94184778, DT.99851763, DT.94353200
NIA Mouse Gene Index U004573
PDB 1OQN, 1NTV, 1NU2
Consensus CDS Project CCDS18413.1
International Mouse Phenotyping Consortium Status Dab1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000008111 VEGA Gene Model | MGI Sequence Detail 1125486 C57BL/6J ±  kb
transcript OTTMUST00000018430 VEGA | MGI Sequence Detail 5278 Not Applicable 
polypeptide OTTMUSP00000008462 VEGA | MGI Sequence Detail 555 Not Applicable 

For the selected sequences
All sequences(110) RefSeq(35) UniProt(6)
Polymorphisms
PCR(2) : SNPs within 2kb(9456 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006020 Phosphotyrosine interaction domain
InterPro IPR011993 Pleckstrin homology-like domain
Protein Ontology PR:000006258 disabled homolog 1
References
(Earliest) J:37166 Sweet HO, et al., Scrambler, a new neurological mutation of the mouse with abnormalities of neuronal migration. Mamm Genome. 1996 Nov;7(11):798-802
(Latest) J:217514 Onoue A, et al., Aberrant fragment of Dab1 protein is present in yotari mouse. Neurosci Res. 2014 Nov;88:23-7
All references(205)
Other
accession IDs
MGD-MRK-14318, MGD-MRK-14330, MGD-MRK-37598, MGI:1196335, MGI:2140405, MGI:2444714, MGI:98245

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory