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Dab1 Gene Detail
Summary
  • Symbol
    Dab1
  • Name
    disabled 1
  • Synonyms
    C630028C02Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:108554
    NCBI Gene: 13131
  • Gene Overview
    MyGene.info: DAB1
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:103619500-104744844 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 47.79 cM
  • Mapping Data
    15 experiments
Strain
Comparison
more
  • SNPs within 2kb
    9389 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108554
 protein coding gene Chr4:103619359-104744844 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028509
 protein coding gene Chr4:104077789-105264699 (+)
A/J MGP_AJ_G0028472
 protein coding gene Chr4:100418504-101549098 (+)
AKR/J MGP_AKRJ_G0028419
 protein coding gene Chr4:102862760-104009929 (+)
BALB/cJ MGP_BALBcJ_G0028491
 protein coding gene Chr4:100617149-101744979 (+)
C3H/HeJ MGP_C3HHeJ_G0028205
 protein coding gene Chr4:103621903-104780833 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028931
 protein coding gene Chr4:107964105-109141339 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026222
 protein coding gene Chr4:95750004-96858750 (+)
CAST/EiJ MGP_CASTEiJ_G0027641
 protein coding gene Chr4:101387182-102550640 (+)
CBA/J MGP_CBAJ_G0028174
 protein coding gene Chr4:111411672-112637814 (+)
DBA/2J MGP_DBA2J_G0028322
 protein coding gene Chr4:100068451-101197396 (+)
FVB/NJ MGP_FVBNJ_G0028289
 protein coding gene Chr4:98914471-100040718 (+)
LP/J MGP_LPJ_G0028423
 protein coding gene Chr4:104307484-105466515 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028316
 protein coding gene Chr4:116826562-118011353 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028966
 protein coding gene Chr4:103078593-104250716 (+)
PWK/PhJ MGP_PWKPhJ_G0027367
 protein coding gene Chr4:98264551-99403475 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027191
 protein coding gene Chr4:100471422-101633562 (+)
WSB/EiJ MGP_WSBEiJ_G0027721
 protein coding gene Chr4:103249420-104417113 (+)



Homology
more
  • Human Ortholog
    DAB1, DAB adaptor protein 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DAB1, DAB adaptor protein 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    SCA37
  • Links
    NCBI Gene ID: 1600
    neXtProt AC: NX_O75553
    UniProt: O75553

  • Chr Location
    1p32.2-p32.1; chr1:56997906-58250539 (-)  GRCh38.p7
  • HomoloGene
    Vertebrate Homology Class 32084
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: DAB1
  • Gene Tree
    Dab1
Human Diseases
more
  • Diseases
    1 with human DAB1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    58 phenotypes from 16 alleles in 15 genetic backgrounds
    8 phenotypes from multigenic genotypes
    5 images
    114 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null display unstable gait and whole-body tremor with a hypoplastic cerebellum devoid of folia, a probable consequence of defective neuronal migration.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    56
  • GO References
    27
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1437
  • Tissues
    249
  • cDNA Data
    47
  • Literature Summary
    107
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 13131 NCBI Gene Model | MGI Sequence Detail 1125345 C57BL/6J ±  kb
    transcript NM_001369049 RefSeq | MGI Sequence Detail 5837 C57BL/6  
    polypeptide P97318 UniProt | EBI | MGI Sequence Detail 588 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 70
      Genomic 6
      cDNA 49
      Primer pair 12
      Other 3

      Microarray probesets 10
    Other
    Accession IDs
    less
    MGD-MRK-14318, MGD-MRK-14330, MGD-MRK-37598, MGI:1196335, MGI:2140405, MGI:2444714, MGI:98245
    References
    more
    • Summaries
      All 256
      Developmental Gene Expression 107
      Gene Ontology 27
      Phenotypes 114
    • Earliest
      J:37166 Sweet HO, et al., Scrambler, a new neurological mutation of the mouse with abnormalities of neuronal migration. Mamm Genome. 1996 Nov;7(11):798-802
    • Latest
      J:296266 Ogino H, et al., The Secreted Glycoprotein Reelin Suppresses the Proliferation and Regulates the Distribution of Oligodendrocyte Progenitor Cells in the Embryonic Neocortex. J Neurosci. 2020 Sep 30;40(40):7625-7636
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    01/19/2021
    MGI 6.16     		The Jackson Laboratory