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St5
Gene Detail
 Symbol
Name
ID
St5
suppression of tumorigenicity 5
MGI:108517
Synonyms 2010004M01Rik, 2610305K15Rik
Feature Type protein coding gene
Genetic Map
Chromosome 7
57.27 cM, cytoband F2
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr7:109523911-109617147 bp, - strand
From NCBI annotation of GRCm38

  93237 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3951  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: St5

Human
homologs
Human Homolog ST5, suppression of tumorigenicity 5
NCBI Gene ID 6764
neXtProt AC  NX_P78524
Human Synonyms  DENND2B, HTS1, p126
Human Chr (Location)  11p15; chr11:8693352-8910951 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(167) : Gene trapped(167)
Incidental mutations (data from Mutagenetix , APF )
Interactions
St5 interacts with 234 markers (Mir7-1, Mir10b, Mir15a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (5 annotations)
Process positive regulation of ERK1 and ERK2 cascade, positive regulation of Rab GTPase activity
Component cellular_component
Function guanyl-nucleotide exchange factor activity, Rab guanyl-nucleotide exchange factor activity
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (44)    Tissues (22)   
Theiler Stages: 15, 19, 21, 23, 28
Assay TypeResults
RNA in situ 44
cDNA source data(10)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(18) Genomic(6) cDNA(10) Primer pair(2)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000031024 (Evidence)
Entrez Gene76954 (Evidence)
DFCITC1577706, TC1603460, TC1603566
DoTSDT.101299003, DT.101407493, DT.101714725, DT.489943, DT.55231879
NIA Mouse Gene IndexU029106
Consensus CDS ProjectCCDS21734.1, CCDS21735.1
International Mouse Knockout Project StatusSt5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 76954 NCBI Gene Model | MGI Sequence Detail 93237 C57BL/6J ±  kb
transcript NR_037617 RefSeq | MGI Sequence Detail 4436 C57BL/6 
polypeptide Q924W7 UniProt | EBI | MGI Sequence Detail 1134 Not Applicable 

For the selected sequences
All sequences(57) RefSeq(22) UniProt(3)
Polymorphisms SNPs within 2kb(761 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005112 dDENN domain
InterPro IPR001194 DENN domain
InterPro IPR005113 uDENN domain
Protein Ontology PR:000015684 suppression of tumorigenicity 5 protein
Graphical View of Protein Domain Structure
References (Earliest) J:32718 Kleyn PW, et al., Identification and characterization of the mouse obesity gene tubby: a member of a novel gene family. Cell. 1996 Apr 19;85(2):281-90
(Latest) J:157306 Gohring I, et al., Disruption of ST5 is associated with mental retardation and multiple congenital anomalies. J Med Genet. 2010 Feb;47(2):91-8
All references(33)
Other
accession IDs
MGD-MRK-37561, MGI:1919751, MGI:1924204

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory