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Cbx3 Gene Detail
Summary
  • Symbol
    Cbx3
  • Name
    chromobox 3
  • Synonyms
    heterochromatin protein 1 gamma, HP1g, M32
  • Feature Type
    protein coding gene
  • IDs
    MGI:108515
    NCBI Gene: 12417
  • Gene Overview
    MyGene.info: CBX3
  • Alliance
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:51470447-51483704 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 24.89 cM, cytoband B-C
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    31 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108515
protein coding gene Chr6:51470360-51483704 (.)
129S1/SvImJ MGP_129S1SvImJ_G0030735
protein coding gene Chr6:50658761-50671328 (+)
A/J MGP_AJ_G0030705
protein coding gene Chr6:48294982-48306972 (+)
AKR/J MGP_AKRJ_G0030631
protein coding gene Chr6:49977573-49990824 (+)
BALB/cJ MGP_BALBcJ_G0030716
protein coding gene Chr6:48651997-48662667 (+)
C3H/HeJ MGP_C3HHeJ_G0030430
protein coding gene Chr6:49995148-50005990 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031171
protein coding gene Chr6:51781129-51795069 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028378
protein coding gene Chr6:45965627-45978860 (+)
CAST/EiJ MGP_CASTEiJ_G0029832
protein coding gene Chr6:49762646-49781030 (+)
CBA/J MGP_CBAJ_G0030403
protein coding gene Chr6:53950906-53962790 (+)
DBA/2J MGP_DBA2J_G0030553
protein coding gene Chr6:48217844-48230128 (+)
FVB/NJ MGP_FVBNJ_G0030505
protein coding gene Chr6:47836350-47849268 (+)
LP/J MGP_LPJ_G0030638
protein coding gene Chr6:50628011-50642079 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030539
protein coding gene Chr6:56609405-56623394 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031201
protein coding gene Chr6:49895952-49909624 (+)
PWK/PhJ MGP_PWKPhJ_G0029545
protein coding gene Chr6:47820754-47833089 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029380
protein coding gene Chr6:49238200-49251324 (+)
WSB/EiJ MGP_WSBEiJ_G0029909
protein coding gene Chr6:49884224-49909107 (+)



Homology
more
  • Human Ortholog
    CBX3, chromobox 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CBX3, chromobox 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HECH, HP1-GAMMA, HP1Hs-gamma
  • Links
    NCBI Gene ID: 11335
    neXtProt AC: NX_Q13185
    UniProt: Q13185

  • Chr Location
    7p15.2; chr7:26201211-26213607 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 3 alleles in 3 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele are infertile. Mice homozygous for a hypomorphic targeted allele exhibit partial postnatal lethality and male infertility.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12417 NCBI Gene Model | MGI Sequence Detail 13258 C57BL/6J ±  kb
    transcript NM_001355002 RefSeq | MGI Sequence Detail 1938 C57BL/6  
    polypeptide P23198 UniProt | EBI | MGI Sequence Detail 183 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 17
      Primer pair 2

      Microarray probesets 13
    Other
    Accession IDs
    less
    MGD-MRK-37559
    References
    more
    • Summaries
      All 76
      Developmental Gene Expression 18
      Gene Ontology 14
      Phenotypes 10
    • Earliest
      J:32398 Singh PB, et al., A sequence motif found in a Drosophila heterochromatin protein is conserved in animals and plants. Nucleic Acids Res. 1991 Feb 25;19(4):789-94
    • Latest
      J:257469 Charo NL, et al., Heterochromatin protein (HP)1gamma is not only in the nucleus but also in the cytoplasm interacting with actin in both cell compartments. Biochim Biophys Acta. 2018 Feb;1865(2):432-443

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory