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Mobp Gene Detail
Summary
  • Symbol
    Mobp
  • Name
    myelin-associated oligodendrocytic basic protein
  • Synonyms
    MOBP155
  • Feature Type
    protein coding gene
  • IDs
    MGI:108511
    NCBI Gene: 17433
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:120149690-120181329 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 71.41 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    461 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108511
protein coding gene Chr9:120149690-120181484 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035433
protein coding gene Chr9:122977142-123008750 (+)
A/J MGP_AJ_G0035414
protein coding gene Chr9:118366858-118398443 (+)
AKR/J MGP_AKRJ_G0035347
protein coding gene Chr9:121478903-121510443 (+)
BALB/cJ MGP_BALBcJ_G0035410
protein coding gene Chr9:118264067-118295674 (+)
C3H/HeJ MGP_C3HHeJ_G0035118
protein coding gene Chr9:121948092-121979679 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035933
protein coding gene Chr9:126339997-126371565 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032815
protein coding gene Chr9:115568652-115598472 (+)
CAST/EiJ MGP_CASTEiJ_G0034422
protein coding gene Chr9:121955452-121988032 (+)
CBA/J MGP_CBAJ_G0035085
protein coding gene Chr9:131054340-131086174 (+)
DBA/2J MGP_DBA2J_G0035244
protein coding gene Chr9:117819135-117850663 (+)
FVB/NJ MGP_FVBNJ_G0035191
protein coding gene Chr9:116707618-116738961 (+)
LP/J MGP_LPJ_G0035323
protein coding gene Chr9:123311191-123342795 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035232
protein coding gene Chr9:132001366-132032933 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035952
protein coding gene Chr9:121873047-121905192 (+)
PWK/PhJ MGP_PWKPhJ_G0034127
protein coding gene Chr9:118262966-118294749 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033963
protein coding gene Chr9:121962876-121994916 (+)
WSB/EiJ MGP_WSBEiJ_G0034542
protein coding gene Chr9:121754510-121786106 (+)



Homology
more
  • Human Ortholog
    MOBP, myelin associated oligodendrocyte basic protein
  • Vertebrate Orthologs
    7
  • Human Ortholog
    MOBP, myelin associated oligodendrocyte basic protein
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 4336
    neXtProt AC: NX_Q13875
    UniProt: Q13875

  • Chr Location
    3p22.1; chr3:39467573-39529497 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for one null allele show abnormal myelin arrangements but do not exhibit an overt behavorial phenotype. Mice homozygous for another allele have normal myelin.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 17433 NCBI Gene Model | MGI Sequence Detail 31640 C57BL/6J ±  kb
transcript NM_008614 RefSeq | MGI Sequence Detail 3292 C57BL/6  
polypeptide Q9D2P8 UniProt | EBI | MGI Sequence Detail 170 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 27
    cDNA 18
    Primer pair 9

    Microarray probesets 13
Other
Accession IDs
less
MGD-MRK-37555, MGI:2143124, MGI:2143130, MGI:2143445
References
more
  • Summaries
    All 50
    Developmental Gene Expression 11
    Gene Ontology 6
    Phenotypes 7
  • Earliest
    J:31411 Holz A, et al., Molecular and developmental characterization of novel cDNAs of the myelin-associated/oligodendrocytic basic protein. J Neurosci. 1996 Jan 15;16(2):467-77
  • Latest
    J:265733 Maloney SE, et al., The RNA-binding protein Celf6 is highly expressed in diencephalic nuclei and neuromodulatory cell populations of the mouse brain. Brain Struct Funct. 2016 May;221(4):1809-31

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory