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Kcnj12 Gene Detail
Summary
  • Symbol
    Kcnj12
  • Name
    potassium inwardly-rectifying channel, subfamily J, member 12
  • Synonyms
    IRK2, Kir2.2, MB-IRK2
  • Feature Type
    protein coding gene
  • IDs
    MGI:108495
    NCBI Gene: 16515
  • Gene Overview
    MyGene.info: KCNJ12
Location & Maps
more
  • Sequence Map
    Chr11:61022564-61071131 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      48568 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 37.96 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    KCNJ12, potassium voltage-gated channel subfamily J member 12
  • Vertebrate Orthologs
    10
  • Human Ortholog
    KCNJ12, potassium voltage-gated channel subfamily J member 12
    Orthology source: HomoloGene, HGNC
  • Synonyms
    hIRK, hIRK1, hkir2.2x, IRK2, IRK-2, kcnj12x, KCNJN1, Kir2.2, Kir2.2v
  • Links
    NCBI Gene ID: 3768
    neXtProt AC: NX_Q14500

  • Chr Location
    17p11.2; chr17:21376387-21419872 (+)  GRCh38.p2

Human Diseases
less
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    22 phenotype references
  • All Mutations and Alleles
    10
  • Chemically induced (other)
    1
  • Gene trapped
    1
  • Targeted
    8
  • Genomic Mutations
    3 involving Kcnj12
  • Incidental Mutations
Homozygotes for a targeted null mutation are viable and fertile with no detected abnormalities.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005827 VEGA Gene Model | MGI Sequence Detail 48568 C57BL/6J ±  kb
transcript OTTMUST00000012930 VEGA | MGI Sequence Detail 2459 Not Applicable  
polypeptide OTTMUSP00000006016 VEGA | MGI Sequence Detail 529 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    414 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000001981 ATP-sensitive inward rectifier potassium channel 12
  • InterPro Domains
    IPR014756 Immunoglobulin E-set
    IPR016449 Potassium channel, inwardly rectifying, Kir
    IPR003272 Potassium channel, inwardly rectifying, Kir2.2
    IPR013518 Potassium channel, inwardly rectifying, Kir, cytoplasmic
    IPR013673 Potassium channel, inwardly rectifying, Kir, N-terminal
Molecular
Reagents
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  • All nucleic 14
    cDNA 13
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-37539
References
more
  • Summaries
    All 40
    Developmental Gene Expression 5
    Diseases 2
    Gene Ontology 5
    Phenotypes 22
  • Earliest
    J:20168 Takahashi N, et al., Molecular cloning and functional expression of cDNA encoding a second class of inward rectifier potassium channels in the mouse brain. J Biol Chem. 1994 Sep 16;269(37):23274-9
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory