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Kcnj12 Gene Detail
Summary
  • Symbol
    Kcnj12
  • Name
    potassium inwardly-rectifying channel, subfamily J, member 12
  • Synonyms
    IRK2, Kir2.2, MB-IRK2
  • Feature Type
    protein coding gene
  • IDs
    MGI:108495
    NCBI Gene: 16515
  • Gene Overview
    MyGene.info: KCNJ12
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:61022564-61071131 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 37.96 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    414 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108495
protein coding gene Chr11:61022564-61073269 (.)
129S1/SvImJ MGP_129S1SvImJ_G0018431
protein coding gene Chr11:60957797-61007656 (+)
A/J MGP_AJ_G0018400
protein coding gene Chr11:58710065-58757221 (+)
AKR/J MGP_AKRJ_G0018370
protein coding gene Chr11:60555197-60602332 (+)
BALB/cJ MGP_BALBcJ_G0018371
protein coding gene Chr11:59015333-59065226 (+)
C3H/HeJ MGP_C3HHeJ_G0018184
protein coding gene Chr11:60518572-60567515 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018823
protein coding gene Chr11:62887522-62939117 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016469
protein coding gene Chr11:55850096-55896848 (+)
CAST/EiJ MGP_CASTEiJ_G0017741
protein coding gene Chr11:60624474-60672336 (+)
CBA/J MGP_CBAJ_G0018158
protein coding gene Chr11:65618936-65678146 (+)
DBA/2J MGP_DBA2J_G0018267
protein coding gene Chr11:58296009-58343972 (+)
FVB/NJ MGP_FVBNJ_G0018258
protein coding gene Chr11:57966830-58014608 (+)
LP/J MGP_LPJ_G0018340
protein coding gene Chr11:61529103-61583201 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018282
protein coding gene Chr11:66662638-66717419 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018864
protein coding gene Chr11:60675633-60728185 (+)
PWK/PhJ MGP_PWKPhJ_G0017514
protein coding gene Chr11:58883081-58931606 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017304
protein coding gene Chr11:60486779-60536846 (+)
WSB/EiJ MGP_WSBEiJ_G0017793
protein coding gene Chr11:60287438-60339629 (+)



Homology
more
  • Human Ortholog
    KCNJ12, potassium voltage-gated channel subfamily J member 12
  • Vertebrate Orthologs
    10
  • Human Ortholog
    KCNJ12, potassium voltage-gated channel subfamily J member 12
    Orthology source: HomoloGene, HGNC
  • Synonyms
    hIRK, hIRK1, hkir2.2x, IRK2, IRK-2, kcnj12x, KCNJN1, Kir2.2, Kir2.2v
  • Links
    NCBI Gene ID: 3768
    neXtProt AC: NX_Q14500
    UniProt: Q14500

  • Chr Location
    17p11.2; chr17:21376387-21419870 (+)  GRCh38.p7

Human Diseases
less
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    22 phenotype references
Homozygotes for a targeted null mutation are viable and fertile with no detected abnormalities.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000042529 Ensembl Gene Model | MGI Sequence Detail 48568 C57BL/6J ±  kb
transcript ENSMUST00000041944 Ensembl | MGI Sequence Detail 2459 Not Applicable  
polypeptide ENSMUSP00000041696 Ensembl | MGI Sequence Detail 529 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    3 Sequences
  • InterPro Domains
    IPR014756 Immunoglobulin E-set
    IPR016449 Potassium channel, inwardly rectifying, Kir
    IPR003272 Potassium channel, inwardly rectifying, Kir2.2
    IPR013518 Potassium channel, inwardly rectifying, Kir, cytoplasmic
    IPR013673 Potassium channel, inwardly rectifying, Kir, N-terminal
Molecular
Reagents
less
  • All nucleic 15
    cDNA 14
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-37539
References
more
  • Summaries
    All 55
    Developmental Gene Expression 6
    Diseases 2
    Gene Ontology 6
    Phenotypes 22
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:215487 Thompson CL, et al., A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory