Kcnj12 MGI Mouse Gene Detail - MGI:108495 - potassium inwardly-rectifying channel, subfamily J, member 12

Symbol

Kcnj12
Name

potassium inwardly-rectifying channel, subfamily J, member 12
Synonyms

IRK2, Kir2.2, MB-IRK2

Feature Type

protein coding gene
IDs

MGI:108495
NCBI Gene: 16515
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr11:60913390-60961957 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 37.96 cM
Mapping Data

4 experiments

SNPs within 2kb

412 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_108495	protein coding gene	Chr11:60912970-60964095 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018431	protein coding gene	Chr11:60957797-61007656 (+)
A/J	MGP_AJ_G0018400	protein coding gene	Chr11:58710065-58757221 (+)
AKR/J	MGP_AKRJ_G0018370	protein coding gene	Chr11:60555197-60602332 (+)
BALB/cJ	MGP_BALBcJ_G0018371	protein coding gene	Chr11:59015333-59065226 (+)
C3H/HeJ	MGP_C3HHeJ_G0018184	protein coding gene	Chr11:60518572-60567515 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018823	protein coding gene	Chr11:62887522-62939117 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016469	protein coding gene	Chr11:55850096-55896848 (+)
CAST/EiJ	MGP_CASTEiJ_G0017741	protein coding gene	Chr11:60624474-60672336 (+)
CBA/J	MGP_CBAJ_G0018158	protein coding gene	Chr11:65618936-65678146 (+)
DBA/2J	MGP_DBA2J_G0018267	protein coding gene	Chr11:58296009-58343972 (+)
FVB/NJ	MGP_FVBNJ_G0018258	protein coding gene	Chr11:57966830-58014608 (+)
LP/J	MGP_LPJ_G0018340	protein coding gene	Chr11:61529103-61583201 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018282	protein coding gene	Chr11:66662638-66717419 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018864	protein coding gene	Chr11:60675633-60728185 (+)
PWK/PhJ	MGP_PWKPhJ_G0017514	protein coding gene	Chr11:58883081-58931606 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017304	protein coding gene	Chr11:60486779-60536846 (+)
WSB/EiJ	MGP_WSBEiJ_G0017793	protein coding gene	Chr11:60287438-60339629 (+)

Human Ortholog

KCNJ12, potassium inwardly rectifying channel subfamily J member 12

Vertebrate Orthologs

5

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

KCNJ12, potassium inwardly rectifying channel subfamily J member 12
Synonyms

hIRK, hIRK1, hkir2.2x, IRK2, IRK-2, kcnj12x, KCNJN1, Kir2.2
Links

HGNC:6258

NCBI Gene ID: 3768

neXtProt AC: NX_Q14500

UniProt: Q14500
Chr Location

17p11.2; chr17:21376357-21419870 (+) GRCh38

Human Ortholog

KCNJ18, potassium inwardly rectifying channel subfamily J member 18
Synonyms

KIR2.6, TTPP2
Links

HGNC:39080

NCBI Gene ID: 100134444

neXtProt AC: NX_B7U540

UniProt: B7U540
Chr Location

chr17:21692523-21704612 (+) GRCh38

MGI Vertebrate Homology

Kcnj12 stringent orthology
2 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: KCNJ12, KCNJ18
Gene Tree

Kcnj12

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References

2 with disease annotations

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
24 phenotype references

All Mutations and Alleles

12
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

1
Targeted

8
Genomic Mutations

3 involving Kcnj12
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

26 strains or lines available

Homozygotes for a targeted null mutation are viable and fertile with no detected abnormalities.

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All GO Annotations

17
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

839
Tissues

62
cDNA Data

14
Literature Summary

6

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase kcnj12

ZFIN kcnj12a, kcnj12b

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All Sequences

44
RefSeq

8
UniProt

3
CCDS

CCDS24805.1, CCDS59563.1

Ensembl

ENSMUSG00000042529 (Evidence)
NCBI Gene

16515

			Length	Strain/Species	Flank
genomic	ENSMUSG00000042529	Ensembl Gene Model \| MGI Sequence Detail	48568	C57BL/6J	± kb
transcript	ENSMUST00000041944	Ensembl \| MGI Sequence Detail	2459	Not Applicable
polypeptide	ENSMUSP00000041696	Ensembl \| MGI Sequence Detail	529	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000001981 ATP-sensitive inward rectifier potassium channel 12

(term hierarchy)
InterPro Domains

IPR014756 Immunoglobulin E-set

IPR041647 Inward rectifier potassium channel, C-terminal

IPR016449 Potassium channel, inwardly rectifying, Kir

IPR003272 Potassium channel, inwardly rectifying, Kir2.2

IPR013518 Potassium channel, inwardly rectifying, Kir, cytoplasmic

IPR013673 Potassium channel, inwardly rectifying, Kir, N-terminal

IPR040445 Potassium channel, inwardly rectifying, transmembrane domain

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All nucleic 16

cDNA 14

Primer pair 2

Microarray probesets 3

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MGD-MRK-37539

Summaries

All 57

Developmental Gene Expression 6

Diseases 2

Gene Ontology 5

Phenotypes 24
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:215487 Thompson CL, et al., A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23

TSS for Kcnj12:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr101936	Chr11:60912949-60912987 (+)	-422 bp
Tssr101937	Chr11:60913094-60913138 (+)	-274 bp
Tssr101938	Chr11:60913158-60913169 (+)	-226 bp
Tssr101939	Chr11:60913386-60913396 (+)	1 bp
Tssr101940	Chr11:60913406-60913435 (+)	31 bp
Tssr101941	Chr11:60956624-60956642 (+)	43,243 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23