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Kcnj12
Gene Detail
 Symbol
Name
ID
Kcnj12
potassium inwardly-rectifying channel, subfamily J, member 12
MGI:108495
Synonyms IRK2, Kir2.2, MB-IRK2
Feature Type protein coding gene
Genetic Map
Chromosome 11
37.96 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr11:61022564-61071131 bp, + strand
From VEGA annotation of GRCm38

  48568 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7793  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: G protein-activated inward rectifier potassium channel
Gene Tree: Kcnj12

Human
homologs
Human Homolog KCNJ12, potassium inwardly-rectifying channel, subfamily J, member 12
NCBI Gene ID 3768
neXtProt AC  NX_Q14500
Human Synonyms  hIRK, hIRK1, hkir2.2x, IRK2, IRK-2, kcnj12x, KCNJN1, Kir2.2, Kir2.2v
Human Chr (Location)  17p11.2; chr17:21376387-21419872 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Gene trapped(1) Targeted(8)
Genomic Mutations involving Kcnj12 (2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted null mutation are viable and fertile with no detected abnormalities.
 
Alleles Annotated to Human Diseases(2)   
Interactions
Kcnj12 interacts with 93 markers (Mir22, Mir30a, Mir30b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process ion transport, potassium ion transmembrane transport, ...
Component dendrite, integral component of membrane, ...
Function inward rectifier potassium channel activity, PDZ domain binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (122)    Tissues (55)    Images (22)
Theiler Stages: 23, 28
Assay TypeResults
RNA in situ 76
RT-PCR 46
cDNA source data(13)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(14) cDNA(13) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000005827 (Evidence)
Ensembl Gene ModelENSMUSG00000042529 (Evidence)
Entrez Gene16515 (Evidence)
UniGene4970
DFCITC1587288
DoTSDT.101724298, DT.87072205
NIA Mouse Gene IndexU012712
Consensus CDS ProjectCCDS24805.1, CCDS59563.1
International Mouse Knockout Project StatusKcnj12
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005827 VEGA Gene Model | MGI Sequence Detail 48568 C57BL/6J ±  kb
transcript OTTMUST00000012930 VEGA | MGI Sequence Detail 2459 Not Applicable 
polypeptide OTTMUSP00000006016 VEGA | MGI Sequence Detail 529 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(6) UniProt(3)
Polymorphisms RFLP(1) : SNPs within 2kb(414 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR014756 Immunoglobulin E-set
InterPro IPR016449 Potassium channel, inwardly rectifying, Kir
InterPro IPR003272 Potassium channel, inwardly rectifying, Kir2.2
InterPro IPR013518 Potassium channel, inwardly rectifying, Kir, cytoplasmic
InterPro IPR013673 Potassium channel, inwardly rectifying, Kir, N-terminal
Protein Ontology PR:000001981 ATP-sensitive inward rectifier potassium channel 12
References (Earliest) J:20168 Takahashi N, et al., Molecular cloning and functional expression of cDNA encoding a second class of inward rectifier potassium channels in the mouse brain. J Biol Chem. 1994 Sep 16;269(37):23274-9
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(44)
Other
accession IDs
MGD-MRK-37539

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory