Kcnj12
Gene Detail

Symbol Name ID

Kcnj12 potassium inwardly-rectifying channel, subfamily J, member 12 MGI:108495

Synonyms

IRK2, Kir2.2, MB-IRK2

Feature Type

protein coding gene

Genetic Map

Chromosome 11

37.96 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr11:61022564-61071131 bp, + strand From VEGA annotation of GRCm38   48568 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:7793  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: G protein-activated inward rectifier potassium channel
Gene Tree: Kcnj12

Human homologs

Human Homolog		KCNJ12, potassium inwardly-rectifying channel, subfamily J, member 12
NCBI Gene ID		3768
neXtProt AC		NX_Q14500
Human Synonyms		hIRK, hIRK1, hkir2.2x, IRK2, IRK-2, kcnj12x, KCNJN1, Kir2.2, Kir2.2v
Human Chr (Location)		17p11.2; chr17:21279699-21323179 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(7) : Targeted(6) Gene trapped(1)
 

Homozygotes for a targeted null mutation are viable and fertile with no detected abnormalities.

 

Gene Ontology (GO) classifications

All GO classifications: (20 annotations)

Process	ion transport, potassium ion transport, ...
Component	dendrite, integral to membrane, ...
Function	inward rectifier potassium channel activity, ion channel activity, ...

External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (122)    Tissues (55)    Images (22)
Theiler Stages: 23, 28

Assay Type	Results
RNA in situ	76
RT-PCR	46

cDNA source data(12)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(13) cDNA(12) Primer pair(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000005827 (Evidence)
Ensembl Gene Model	ENSMUSG00000042529 (Evidence)
Entrez Gene	16515 (Evidence)
UniGene	4970
DFCI	TC1587288
DoTS	DT.101724298, DT.87072205
NIA Mouse Gene Index	U012712
Consensus CDS Project	CCDS24805.1
International Mouse Knockout Project Status	Kcnj12

Sequences

Length	Strain/Species
genomic	OTTMUSG00000005827	VEGA Gene Model | MGI Sequence Detail	48568	C57BL/6J
transcript	OTTMUST00000012930	VEGA | MGI Sequence Detail	2459	Not Applicable
polypeptide	OTTMUSP00000006016	VEGA | MGI Sequence Detail	529	Not Applicable

All sequences(31) RefSeq(4) UniProt(3)

Polymorphisms

RFLP(1) : SNPs(58 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR014756	Immunoglobulin E-set
InterPro	IPR016449	Potassium channel, inwardly rectifying, Kir
InterPro	IPR003272	Potassium channel, inwardly rectifying, Kir2.2
InterPro	IPR013518	Potassium channel, inwardly rectifying, Kir, cytoplasmic
InterPro	IPR013673	Potassium channel, inwardly rectifying, Kir, N-terminal
Protein Ontology	PR:000001981	ATP-sensitive inward rectifier potassium channel 12

References

(Earliest) J:20168 Takahashi N, et al., Molecular cloning and functional expression of cDNA encoding a second class of inward rectifier potassium channels in the mouse brain. J Biol Chem. 1994 Sep 16;269(37):23274-9
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(44)

Other accession IDs

MGD-MRK-37539