Hrh2 MGI Mouse Gene Detail - MGI:108482

Symbol

Hrh2
Name

histamine receptor H2
Synonyms

H2r

Feature Type

protein coding gene
IDs

MGI:108482
NCBI Gene: 15466
Alliance

genome feature page
Transcription Start Sites

2 TSS

Sequence Map

Chr13:54346148-54390199 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 28.40 cM
Mapping Data

5 experiments

SNPs within 2kb

1348 from dbSNP Build 142
Strain Annotations

19
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_108482	protein coding gene	Chr13:54345990-54390201 (+)
129S1/SvImJ	ENSMUSG00200015561	protein coding gene	Chr13:51218220-51262239 (+)
A/J	ENSMUSG00195038856	protein coding gene	Chr13:50683083-50727072 (+)
AKR/J	ENSMUSG00220034481	protein coding gene	Chr13:50226136-50270199 (+)
BALB/cJ	ENSMUSG00180014067	protein coding gene	Chr13:50934367-50978355 (+)
C3H/HeJ	ENSMUSG00175033647	protein coding gene	Chr13:50720900-50764891 (+)
C57BL/6NJ	ENSMUSG00215027794	protein coding gene	Chr13:50747262-50791316 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018532	protein coding gene	Chr13:49617363-49645613 (+)
CAST/EiJ	ENSTCUG00005038624	protein coding gene	Chr13:51143758-51187737 (+)
CBA/J	ENSMUSG00210035701	protein coding gene	Chr13:50925733-50969717 (+)
DBA/2J	ENSMUSG00185016461	protein coding gene	Chr13:51769541-51813594 (+)
FVB/NJ	ENSMUSG00205024573	protein coding gene	Chr13:50576332-50620375 (+)
JF1/MsJ	ENSUMUG00000013427	protein coding gene	Chr13:51164796-51215736 (+)
LP/J	ENSMUSG00230030605	protein coding gene	Chr13:61100872-61144891 (+)
NOD/ShiLtJ	ENSMUSG00190023382	protein coding gene	Chr13:50813178-50857221 (+)
NZO/HlLtJ	ENSMUSG00225034396	protein coding gene	Chr13:54841388-54885439 (+)
PWK/PhJ	ENSLUMG00010020137	protein coding gene	Chr13:50030924-50074820 (+)
SPRET/EiJ	ENSMSPG00010036740	protein coding gene	Chr13:50478559-50501188 (+)
WSB/EiJ	ENSIUOG00005022712	protein coding gene	Chr13:50236208-50280154 (+)

Human Ortholog

HRH2, histamine receptor H2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

HRH2, histamine receptor H2
Synonyms

H2R, HH2R
Links

HGNC:5183

NCBI Gene ID: 3274

UniProt: P25021
Chr Location

5q35.2; chr5:175657797-175710756 (+) GRCh38

MGI Vertebrate Homology

Hrh2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: HRH2
Gene Tree

Hrh2

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Phenotype Summary

15 phenotypes from 2 alleles in 2 genetic backgrounds
33 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Chemically induced (other)

1
Endonuclease-mediated

4
Gene trapped

5
Targeted

3
Genomic Mutations

1 involving Hrh2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

30 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygotes for a targeted null mutation exhibit enlarged folds in gastric mucosa, elevated serum gastrin levels, increased numbers of parietal and enterochromaffin-like cells, and lack of secretion of gastric acid in response to histamine or gastrin.

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All GO Annotations

30
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

610
Tissues

8
cDNA Data

8
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

ZFIN hrh2a, hrh2b

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All Sequences

56
RefSeq

9
UniProt

7
CCDS

CCDS26526.1

Ensembl

ENSMUSG00000034987 (Evidence)
NCBI Gene

15466

			Length	Strain/Species	Flank
genomic	ENSMUSG00000034987	Ensembl Gene Model \| MGI Sequence Detail	44052	C57BL/6J	± kb
transcript	ENSMUST00000209846	Ensembl \| MGI Sequence Detail	4074	Not Applicable
polypeptide	ENSMUSP00000148117	Ensembl \| MGI Sequence Detail	421	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000001423 histamine H2 receptor

(term hierarchy)
InterPro Domains

IPR017452 GPCR, rhodopsin-like, 7TM

IPR000276 G protein-coupled receptor, rhodopsin-like

IPR000503 Histamine H2 receptor
GlyGen

P97292 2 sites, 1 O-linked glycan (1 site)

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All nucleic 12

Genomic 2

cDNA 8

Primer pair 1

Other 1

Microarray probesets 3

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MGD-MRK-37526

Summaries

All 70

Developmental Gene Expression 2

Gene Ontology 9

Phenotypes 33
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:365124 An D, et al., Deficiency of histamine H(2) receptors in parvalbumin-positive neurons leads to hyperactivity, impulsivity, and impaired attention. Neuron. 2025 Jan 6;

TSS for Hrh2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr119841	Chr13:54346125-54346170 (+)	0 bp
Tssr119842	Chr13:54363649-54363669 (+)	17,511 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24