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Hrh2
Gene Detail
Symbol

Name
ID
Hrh2
histamine receptor H2
MGI:108482
Synonyms
H2r
Feature Type
protein coding gene
Genetic Map
Chromosome 13
28.40 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr13:54192129-54222432 bp, + strand
From VEGA annotation of GRCm38

  30304 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:40613  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: H2 histamine receptor
Gene Tree: Hrh2

Human
homologs
Human Homolog HRH2, histamine receptor H2
NCBI Gene ID 3274
neXtProt AC  NX_P25021
Human Synonyms  H2R
Human Chr (Location)  5q35.2; chr5:175657844-175709236 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(14) : Gene trapped(12) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted null mutation exhibit enlarged folds in gastric mucosa, elevated serum gastrin levels, increased numbers of parietal and enterochromaffin-like cells, and lack of secretion of gastric acid in response to histamine or gastrin.
 
Interactions
Hrh2 interacts with 180 markers (Mir7-1, Mir10a, Mir10b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (25 annotations)
Process digestive tract development, epithelial cell morphogenesis, ...
Component integral component of membrane, membrane, ...
Function G-protein coupled receptor activity, histamine receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (13)    Tissues (8)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 1
Northern blot 1
RT-PCR 11
cDNA source data(7)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(11) Genomic(2) cDNA(7) Primer pair(1) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000034187 (Evidence)
Ensembl Gene ModelENSMUSG00000034987 (Evidence)
Entrez Gene15466 (Evidence)
UniGene57243
DFCITC1587668
DoTSDT.55227986
NIA Mouse Gene IndexU014858
Consensus CDS ProjectCCDS26526.1
International Mouse Knockout Project StatusHrh2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034187 VEGA Gene Model | MGI Sequence Detail 30304 C57BL/6J ±  kb
transcript OTTMUST00000086702 VEGA | MGI Sequence Detail 2789 Not Applicable 
polypeptide OTTMUSP00000046959 VEGA | MGI Sequence Detail 397 Not Applicable 

For the selected sequences
All sequences(43) RefSeq(10) UniProt(9)
Polymorphisms
RFLP(1) : SNPs within 2kb(302 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
InterPro IPR000503 Histamine H2 receptor
Protein Ontology PR:000001423 histamine H2 receptor
References
(Earliest) J:36739 Kobayashi T, et al., Cloning, RNA expression, and chromosomal location of a mouse histamine H2 receptor gene. Genomics. 1996 Nov 1;37(3):390-4
(Latest) J:204956 Saligrama N, et al., Systemic lack of canonical histamine receptor signaling results in increased resistance to autoimmune encephalomyelitis. J Immunol. 2013 Jul 15;191(2):614-22
All references(54)
Other
accession IDs
MGD-MRK-37526

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory