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St6gal1 Gene Detail
Summary
  • Symbol
    St6gal1
  • Name
    beta galactoside alpha 2,6 sialyltransferase 1
  • Synonyms
    Siat1, St6Gal-I, ST6Gal I
  • Feature Type
    protein coding gene
  • IDs
    MGI:108470
    NCBI Gene: 20440
  • Gene Overview
    MyGene.info: ST6GAL1
  • Alliance
  • Transcription Start Sites
    21 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:23224740-23360350 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 14.03 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    767 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108470
protein coding gene Chr16:23224740-23360350 (.)
129S1/SvImJ MGP_129S1SvImJ_G0022682
protein coding gene Chr16:20798074-20942133 (+)
A/J MGP_AJ_G0022644
protein coding gene Chr16:19797426-19935655 (+)
AKR/J MGP_AKRJ_G0022618
protein coding gene Chr16:20644116-20787911 (+)
BALB/cJ MGP_BALBcJ_G0022649
protein coding gene Chr16:19999417-20135485 (+)
C3H/HeJ MGP_C3HHeJ_G0022413
protein coding gene Chr16:20761127-20903989 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023098
protein coding gene Chr16:21307293-21476995 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020616
protein coding gene Chr16:20435050-20574996 (+)
CAST/EiJ MGP_CASTEiJ_G0021942
protein coding gene Chr16:20739874-20891747 (+)
CBA/J MGP_CBAJ_G0022384
protein coding gene Chr16:22161978-22321533 (+)
DBA/2J MGP_DBA2J_G0022516
protein coding gene Chr16:19754697-19895388 (+)
FVB/NJ MGP_FVBNJ_G0022492
protein coding gene Chr16:19752176-19894052 (+)
LP/J MGP_LPJ_G0022584
protein coding gene Chr16:20589161-20728037 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022511
protein coding gene Chr16:21696007-21845109 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023110
protein coding gene Chr16:20594787-20737035 (+)
PWK/PhJ MGP_PWKPhJ_G0021681
protein coding gene Chr16:20027566-20165905 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021512
protein coding gene Chr16:20323619-20461888 (+)
WSB/EiJ MGP_WSBEiJ_G0021986
protein coding gene Chr16:20545010-20693548 (+)



Homology
more
  • Human Ortholog
    ST6GAL1, ST6 beta-galactoside alpha-2,6-sialyltransferase 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ST6GAL1, ST6 beta-galactoside alpha-2,6-sialyltransferase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    SIAT1, ST6GalI, ST6N
  • Links
    NCBI Gene ID: 6480
    neXtProt AC: NX_P15907
    UniProt: P15907

  • Chr Location
    3q27.3; chr3:186930343-187078553 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 3 alleles in 4 genetic backgrounds
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in altered terminal glycosylation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 20440 NCBI Gene Model | MGI Sequence Detail 135611 C57BL/6J ±  kb
transcript NM_145933 RefSeq | MGI Sequence Detail 4508 C57BL/6  
polypeptide Q64685 UniProt | EBI | MGI Sequence Detail 403 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 19
    Genomic 2
    cDNA 16
    Primer pair 1

    Microarray probesets 6
Other
Accession IDs
less
MGD-MRK-37514, MGI:2146670
References
more
  • Summaries
    All 66
    Developmental Gene Expression 5
    Gene Ontology 8
    Phenotypes 28
  • Earliest
    J:43576 Hamamoto T, et al., Two step single primer mediated polymerase chain reaction. Application to cloning of putative mouse, beta-galactoside alpha 2,6-sialyltransferase cDNA. Bioorg Med Chem. 1993 Aug;1(2):141-5
  • Latest
    J:247685 Dougher CWL, et al., The blood-borne sialyltransferase ST6Gal-1 is a negative systemic regulator of granulopoiesis. J Leukoc Biol. 2017 Aug;102(2):507-516

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory