St6gal1
Gene Detail

Symbol Name ID

St6gal1 beta galactoside alpha 2,6 sialyltransferase 1 MGI:108470

Synonyms

Siat1, St6Gal-I, ST6Gal I

Feature Type

protein coding gene

Genetic Map

Chromosome 16

14.03 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr16:23224740-23360348 bp, + strand From VEGA annotation of GRCm38   135609 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:2281  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: sialyltransferase
Gene Tree: St6gal1

Human homologs

Human Homolog		ST6GAL1, ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
NCBI Gene ID		6480
neXtProt AC		NX_P15907
Human Synonyms		SIAT1, ST6GalI, ST6N
Human Chr (Location)		3q27-q28; chr3:186648315-186796341 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(36) : Targeted(6) Gene trapped(30)
 

Homozygous mutation of this gene results in altered terminal glycosylation.

 

Gene Ontology (GO) classifications

All GO classifications: (12 annotations)

Process	metabolic process, protein glycosylation
Component	extracellular region, Golgi apparatus, ...
Function	beta-galactoside alpha-2,6-sialyltransferase activity, sialyltransferase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (119)    Tissues (112)    Images (16)
Theiler Stages: 10, 12, 18, 22, 23, 25, 28

Assay Type	Results
RNA in situ	94
RT-PCR	25

cDNA source data(137)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(140) Genomic(2) cDNA(137) Primer pair(1)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000025920 (Evidence)
Ensembl Gene Model	ENSMUSG00000022885 (Evidence)
Entrez Gene	20440 (Evidence)
UniGene	149029
DFCI	TC1575344, TC1658602, TC1692349
DoTS	DT.101247898, DT.101385066, DT.102541339, DT.488235
EC	2.4.99.1
Consensus CDS Project	CCDS28077.1
International Mouse Knockout Project Status	St6gal1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000025920	VEGA Gene Model | MGI Sequence Detail	135609	C57BL/6J
transcript	OTTMUST00000063898	VEGA | MGI Sequence Detail	4506	Not Applicable
polypeptide	OTTMUSP00000031674	VEGA | MGI Sequence Detail	403	Not Applicable

All sequences(59) RefSeq(6) UniProt(4)

Polymorphisms

RFLP(2) : SNPs(512 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001675	Glycosyl transferase, family 29
InterPro	IPR012163	Sialyltransferase
Protein Ontology	PR:000015685	beta-galactoside alpha-2,6-sialyltransferase 1

References

(Earliest) J:43576 Hamamoto T, et al., Two step single primer mediated polymerase chain reaction. Application to cloning of putative mouse, beta-galactoside alpha 2,6-sialyltransferase cDNA. Bioorg Med Chem. 1993 Aug;1(2):141-5
(Latest) J:190554 Sindhava VJ, et al., Bone marrow dendritic cell-mediated regulation of TLR and B cell receptor signaling in B cells. J Immunol. 2012 Oct 1;189(7):3355-67
All references(55)

Other accession IDs

MGD-MRK-37514, MGI:2146670