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St6gal1
Gene Detail
 Symbol
Name
ID
St6gal1
beta galactoside alpha 2,6 sialyltransferase 1
MGI:108470
Synonyms Siat1, St6Gal-I, ST6Gal I
Feature Type protein coding gene
Genetic Map
Chromosome 16
14.03 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr16:23224740-23360348 bp, + strand
From VEGA annotation of GRCm38

  135609 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2281  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: sialyltransferase
Gene Tree: St6gal1

Human
homologs
Human Homolog ST6GAL1, ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
NCBI Gene ID 6480
neXtProt AC  NX_P15907
Human Synonyms  SIAT1, ST6GalI, ST6N
Human Chr (Location)  3q27-q28; chr3:186930526-187078553 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(36) : Gene trapped(30) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in altered terminal glycosylation.
 
Interactions
St6gal1 interacts with 261 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process N-acetylneuraminate metabolic process, protein glycosylation, ...
Component extracellular region, extracellular vesicular exosome, ...
Function beta-galactoside alpha-2,6-sialyltransferase activity, sialyltransferase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (119)    Tissues (112)    Images (16)
Theiler Stages: 10, 12, 18, 22, 23, 25, 28
Assay TypeResults
RNA in situ 94
RT-PCR 25
cDNA source data(15)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(18) Genomic(2) cDNA(15) Primer pair(1)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000025920 (Evidence)
Ensembl Gene ModelENSMUSG00000022885 (Evidence)
Entrez Gene20440 (Evidence)
DFCITC1575344, TC1658602, TC1692349
DoTSDT.101247898, DT.101385066, DT.102541339, DT.488235
EC2.4.99.1
Consensus CDS ProjectCCDS28077.1
International Mouse Knockout Project StatusSt6gal1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025920 VEGA Gene Model | MGI Sequence Detail 135609 C57BL/6J ±  kb
transcript OTTMUST00000063898 VEGA | MGI Sequence Detail 4506 Not Applicable 
polypeptide OTTMUSP00000031674 VEGA | MGI Sequence Detail 403 Not Applicable 

For the selected sequences
All sequences(67) RefSeq(14) UniProt(4)
Polymorphisms RFLP(2) : SNPs within 2kb(774 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001675 Glycosyl transferase, family 29
InterPro IPR012163 Sialyltransferase
Protein Ontology PR:000015685 beta-galactoside alpha-2,6-sialyltransferase 1
References (Earliest) J:43576 Hamamoto T, et al., Two step single primer mediated polymerase chain reaction. Application to cloning of putative mouse, beta-galactoside alpha 2,6-sialyltransferase cDNA. Bioorg Med Chem. 1993 Aug;1(2):141-5
(Latest) J:212037 Croci DO, et al., Glycosylation-dependent lectin-receptor interactions preserve angiogenesis in anti-VEGF refractory tumors. Cell. 2014 Feb 13;156(4):744-58
All references(57)
Other
accession IDs
MGD-MRK-37514, MGI:2146670

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory