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Ralbp1
Gene Detail
 Symbol
Name
ID
Ralbp1
ralA binding protein 1
MGI:108466
Synonyms Rip1, RLIP76
Feature Type protein coding gene
Genetic Map
Chromosome 17
35.26 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr17:65848433-65885755 bp, - strand
From Ensembl annotation of GRCm38

  37323 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4940  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Ralbp1

Human
homologs
Human Homolog RALBP1, ralA binding protein 1
NCBI Gene ID 10928
neXtProt AC  NX_Q15311
Human Synonyms  RIP1, RLIP1, RLIP76
Human Chr (Location)  18p11.3; chr18:9473436-9538108 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(164) : Gene trapped(161) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous and heterozygous null mice display increased sensitivity to X-ray irradiation, increased oxidative stress, and impaired glutathione homeostasis. Mice homozygous for a gene trap insertion exhibit decreases in exploratory and locomotor activity and a decreased sensitivity to pain.
 
Interactions
Ralbp1 interacts with 221 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (25 annotations)
Process ATP catabolic process, endocytosis, ...
Component intracellular, membrane, ...
Function ATPase activity, ATPase activity, coupled to movement of substances, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
cDNA source data(17)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(18) cDNA(17) Primer pair(1)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000024096 (Evidence)
Entrez Gene19765 (Evidence)
DFCITC1572525, TC1631393
DoTSDT.533726, DT.102557404, DT.110555716
NIA Mouse Gene IndexU038008
Consensus CDS ProjectCCDS37678.1
International Mouse Knockout Project StatusRalbp1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024096 Ensembl Gene Model | MGI Sequence Detail 37323 C57BL/6J ±  kb
transcript ENSMUST00000166543 Ensembl | MGI Sequence Detail 4089 Not Applicable 
polypeptide ENSMUSP00000129448 Ensembl | MGI Sequence Detail 648 Not Applicable 

For the selected sequences
All sequences(55) RefSeq(10) UniProt(10)
Polymorphisms SNPs within 2kb(138 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000198 Rho GTPase-activating protein domain
InterPro IPR008936 Rho GTPase activation protein
Protein Ontology PR:000013697 RalA-binding protein 1
References (Earliest) J:45479 Park SH, et al., A putative effector of Ral has homology to Rho/Rac GTPase activating proteins. Oncogene. 1995 Dec 7;11(11):2349-55
(Latest) J:202710 Singhal SS, et al., RLIP76 protein knockdown attenuates obesity due to a high-fat diet. J Biol Chem. 2013 Aug 9;288(32):23394-406
All references(55)
Other
accession IDs
MGD-MRK-37510

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory