Ralbp1
Gene Detail

Symbol Name ID

Ralbp1 ralA binding protein 1 MGI:108466

Synonyms

Rip1, RLIP76

Feature Type

protein coding gene

Genetic Map

Chromosome 17

35.26 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr17:65848433-65885755 bp, - strand From Ensembl annotation of GRCm38   37323 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:4940  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Ralbp1

Human homologs

Human Homolog		RALBP1, ralA binding protein 1
NCBI Gene ID		10928
neXtProt AC		NX_Q15311
Human Synonyms		RIP1, RLIP1, RLIP76
Human Chr (Location)		18p11.3; chr18:9473436-9538108 (+)  GRCh38

Mutations, alleles, and phenotypes

All mutations/alleles(164) : Gene trapped(161) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 

Homozygous and heterozygous null mice display increased sensitivity to X-ray irradiation, increased oxidative stress, and impaired glutathione homeostasis. Mice homozygous for a gene trap insertion exhibit decreases in exploratory and locomotor activity and a decreased sensitivity to pain.

 

Interactions

Ralbp1 interacts with 221 markers (Mir7-1, Mir7-2, Mir7b, ...)

View All

Gene Ontology (GO) classifications

All GO classifications: (26 annotations)

Process	ATP catabolic process, endocytosis, ...
Component	intracellular, membrane, ...
Function	ATPase activity, ATPase activity, coupled to movement of substances, ...

External Resources: FuncBase

Expression

Literature Summary: (1 records)

cDNA source data(17)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular reagents

All nucleic(18) cDNA(17) Primer pair(1)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000024096 (Evidence)
Entrez Gene	19765 (Evidence)
DFCI	TC1572525, TC1631393
DoTS	DT.102557404, DT.110555716, DT.533726
NIA Mouse Gene Index	U038008
Consensus CDS Project	CCDS37678.1
International Mouse Knockout Project Status	Ralbp1

Sequences

Length	Strain/Species
genomic	ENSMUSG00000024096	Ensembl Gene Model | MGI Sequence Detail	37323	C57BL/6J
transcript	ENSMUST00000166543	Ensembl | MGI Sequence Detail	4089	Not Applicable
polypeptide	ENSMUSP00000129448	Ensembl | MGI Sequence Detail	648	Not Applicable

All sequences(55) RefSeq(10) UniProt(10)

Polymorphisms

SNPs within 2kb(138 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR000198	Rho GTPase-activating protein domain
InterPro	IPR008936	Rho GTPase activation protein
Protein Ontology	PR:000013697	RalA-binding protein 1

References

(Earliest) J:45479 Park SH, et al., A putative effector of Ral has homology to Rho/Rac GTPase activating proteins. Oncogene. 1995 Dec 7;11(11):2349-55
(Latest) J:202710 Singhal SS, et al., RLIP76 protein knockdown attenuates obesity due to a high-fat diet. J Biol Chem. 2013 Aug 9;288(32):23394-406
All references(55)

Other accession IDs

MGD-MRK-37510