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Ralbp1 Gene Detail
Summary
  • Symbol
    Ralbp1
  • Name
    ralA binding protein 1
  • Synonyms
    Rip1, RLIP76
  • Feature Type
    protein coding gene
  • IDs
    MGI:108466
    NCBI Gene: 19765
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:66155410-66192750 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 35.26 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    131 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108466
 protein coding gene Chr17:66155410-66192793 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023981
 protein coding gene Chr17:68003923-68042935 (-)
A/J MGP_AJ_G0023939
 protein coding gene Chr17:65964797-66002603 (-)
AKR/J MGP_AKRJ_G0023908
 protein coding gene Chr17:66895141-66932422 (-)
BALB/cJ MGP_BALBcJ_G0023940
 protein coding gene Chr17:65919361-65956888 (-)
C3H/HeJ MGP_C3HHeJ_G0023704
 protein coding gene Chr17:67779273-67817439 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024386
 protein coding gene Chr17:70627407-70664681 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021832
 protein coding gene Chr17:61996471-62034920 (-)
CAST/EiJ MGP_CASTEiJ_G0023186
 protein coding gene Chr17:68117238-68154667 (-)
CBA/J MGP_CBAJ_G0023680
 protein coding gene Chr17:73389769-73430412 (-)
DBA/2J MGP_DBA2J_G0023808
 protein coding gene Chr17:64715168-64752928 (-)
FVB/NJ MGP_FVBNJ_G0023774
 protein coding gene Chr17:64200485-64238109 (-)
LP/J MGP_LPJ_G0023890
 protein coding gene Chr17:68719336-68756636 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023802
 protein coding gene Chr17:73487623-73529523 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024430
 protein coding gene Chr17:67347615-67384757 (-)
PWK/PhJ MGP_PWKPhJ_G0022932
 protein coding gene Chr17:63983753-64022231 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022743
 protein coding gene Chr17:64031256-64065045 (-)
WSB/EiJ MGP_WSBEiJ_G0023252
 protein coding gene Chr17:68055659-68094347 (-)



Homology
more
  • Human Ortholog
    RALBP1, ralA binding protein 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RALBP1, ralA binding protein 1
  • Synonyms
    RIP1, RLIP1, RLIP76
  • Links
    NCBI Gene ID: 10928
    neXtProt AC: NX_Q15311
    UniProt: Q15311

  • Chr Location
    18p11.22; chr18:9475532-9538108 (+)  GRCh38.p7
Human Diseases
more
  • Diseases
    1 with Ralbp1 mouse models; 1 with human RALBP1 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 3 alleles in 4 genetic backgrounds
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous and heterozygous null mice display increased sensitivity to X-ray irradiation, increased oxidative stress, and impaired glutathione homeostasis. Mice homozygous for a gene trap insertion exhibit decreases in exploratory and locomotor activity and a decreased sensitivity to pain.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    37
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    18
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 19765 NCBI Gene Model | MGI Sequence Detail 37341 C57BL/6J ±  kb
    transcript NM_009067 RefSeq | MGI Sequence Detail 4112 C57BL/6  
    polypeptide Q62172 UniProt | EBI | MGI Sequence Detail 648 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 18
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-37510
    References
    more
    • Summaries
      All 64
      Developmental Gene Expression 1
      Diseases 1
      Gene Ontology 9
      Phenotypes 23
    • Earliest
      J:45479 Park SH, et al., A putative effector of Ral has homology to Rho/Rac GTPase activating proteins. Oncogene. 1995 Dec 7;11(11):2349-55
    • Latest
      J:315726 Awasthi S, et al., RALBP1 in Oxidative Stress and Mitochondrial Dysfunction in Alzheimer's Disease. Cells. 2021 Nov 10;10(11)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/27/2022
    MGI 6.21     		The Jackson Laboratory