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Ralbp1 Gene Detail
Summary
  • Symbol
    Ralbp1
  • Name
    ralA binding protein 1
  • Synonyms
    Rip1, RLIP76
  • Feature Type
    protein coding gene
  • IDs
    MGI:108466
    NCBI Gene: 19765
  • Gene Overview
    MyGene.info: RALBP1
Location & Maps
more
  • Sequence Map
    Chr17:65848433-65885755 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      37323 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 35.26 cM
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    RALBP1, ralA binding protein 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RALBP1, ralA binding protein 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    RIP1, RLIP1, RLIP76
  • Links
    NCBI Gene ID: 10928
    neXtProt AC: NX_Q15311
    UniProt: Q15311

  • Chr Location
    18p11.22; chr18:9475532-9538108 (+)  GRCh38.p7
  • HomoloGene
    Vertebrate Homology Class 4940
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: RALBP1
  • Gene Tree
    Ralbp1
Human Diseases
more
  • Diseases
    1 with Ralbp1 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 3 alleles in 4 genetic backgrounds
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous and heterozygous null mice display increased sensitivity to X-ray irradiation, increased oxidative stress, and impaired glutathione homeostasis. Mice homozygous for a gene trap insertion exhibit decreases in exploratory and locomotor activity and a decreased sensitivity to pain.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
    17
  • Literature Summary
    1
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024096 Ensembl Gene Model | MGI Sequence Detail 37323 C57BL/6J ±  kb
transcript ENSMUST00000166543 Ensembl | MGI Sequence Detail 4089 Not Applicable  
polypeptide ENSMUSP00000129448 Ensembl | MGI Sequence Detail 648 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    137 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 18
    cDNA 17
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-37510
References
more
  • Summaries
    All 53
    Developmental Gene Expression 1
    Diseases 1
    Gene Ontology 6
    Phenotypes 20
  • Earliest
    J:45479 Park SH, et al., A putative effector of Ral has homology to Rho/Rac GTPase activating proteins. Oncogene. 1995 Dec 7;11(11):2349-55
  • Latest
    J:210388 Sahu M, et al., Lens specific RLIP76 transgenic mice show a phenotype similar to microphthalmia. Exp Eye Res. 2014 Jan;118:125-34
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/12/2017
MGI 6.10 		The Jackson Laboratory