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Ralbp1
Gene Detail
Symbol

Name
ID
Ralbp1
ralA binding protein 1
MGI:108466
Synonyms
Rip1, RLIP76
Feature Type
protein coding gene
Genetic Map
Chromosome 17
35.26 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr17:65848433-65885755 bp, - strand
From Ensembl annotation of GRCm38

  37323 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4940  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: RALBP1
Gene Tree: Ralbp1

Human
homologs
RALBP1, ralA binding protein 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 10928
neXtProt AC: NX_Q15311

Human Synonyms: RIP1, RLIP1, RLIP76

Human Chr (Location): 18p11.3; chr18:9475532-9538108 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(164) : Gene trapped(161) Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous and heterozygous null mice display increased sensitivity to X-ray irradiation, increased oxidative stress, and impaired glutathione homeostasis. Mice homozygous for a gene trap insertion exhibit decreases in exploratory and locomotor activity and a decreased sensitivity to pain.
 
Interactions
Ralbp1 interacts with 220 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (26 annotations)
Process endocytosis, mitotic spindle organization, ...
Component intracellular, membrane, ...
Function ATPase activity, GTPase activator activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
cDNA source data(17)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase ralbp1 ; ZFIN ralbp1    NEW 
Molecular
reagents
All nucleic(18) cDNA(17) Primer pair(1)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000024096 (Evidence)
Entrez Gene 19765 (Evidence)
DFCI TC1572525, TC1631393
DoTS DT.102557404, DT.110555716, DT.533726
NIA Mouse Gene Index U038008
Consensus CDS Project CCDS37678.1
International Mouse Phenotyping Consortium Status Ralbp1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024096 Ensembl Gene Model | MGI Sequence Detail 37323 C57BL/6J ±  kb
transcript ENSMUST00000166543 Ensembl | MGI Sequence Detail 4089 Not Applicable 
polypeptide ENSMUSP00000129448 Ensembl | MGI Sequence Detail 648 Not Applicable 

For the selected sequences
All sequences(53) RefSeq(8) UniProt(10)
Polymorphisms
SNPs within 2kb(138 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000198 Rho GTPase-activating protein domain
InterPro IPR008936 Rho GTPase activation protein
Protein Ontology PR:000013697 RalA-binding protein 1
References
(Earliest) J:45479 Park SH, et al., A putative effector of Ral has homology to Rho/Rac GTPase activating proteins. Oncogene. 1995 Dec 7;11(11):2349-55
(Latest) J:202710 Singhal SS, et al., RLIP76 protein knockdown attenuates obesity due to a high-fat diet. J Biol Chem. 2013 Aug 9;288(32):23394-406
All references(55)
Other
accession IDs
MGD-MRK-37510

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory