Fzd8
Gene Detail

Symbol Name ID

Fzd8 frizzled homolog 8 (Drosophila) MGI:108460

Synonyms

Fz8, mFZ8

Feature Type

protein coding gene

Genetic Map

Chromosome 18

4.91 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr18:9212856-9216201 bp, + strand From NCBI annotation of GRCm38   3346 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; chimpanzee    (Mammalian Orthology)
Comparative Map (Mouse/Human Fzd8 ± 2 cM)

Protein SuperFamily: G protein-coupled receptor frizzled
Gene Tree: Fzd8

Human ortholog

FZD8 frizzled family receptor 8 NCBI Gene ID 8325
Human Synonyms: FZ-8, hFZ8
Human Chr10:35927177-35930362 bp, - strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Homozygous mutation of this gene does not appear to result in a phenotype.

 

Gene Ontology (GO) classifications

All GO classifications: (40 annotations)

Process	axonogenesis, brain development, ...
Component	cell projection, cytoplasm, ...
Function	G-protein coupled receptor activity, PDZ domain binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (51 records)
Data Summary: Results (483)    Tissues (279)    Images (112)
Theiler Stages: 1, 2, 3, 4, 5, 13, 14, 15, 16, 17, 19, 20, 22, 23, 24, 25, 28

Assay Type	Results
RNA in situ	300
In situ reporter (knock in)	83
RT-PCR	100

cDNA source data(25)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(36) Genomic(1) cDNA(27) Primer pair(7) Other(1)
Microarray probesets(2)

Other database links

Ensembl Gene Model	ENSMUSG00000036904 (Evidence)
Entrez Gene	14370 (Evidence)
UniGene	184289
DFCI	TC1608824
DoTS	DT.101364531
NIA Mouse Gene Index	U018390
PDB	1IJY, 4F0A
Consensus CDS Project	CCDS29048.1
International Mouse Knockout Project Status	Fzd8

Sequences

Length	Strain/Species
genomic	14370	NCBI Gene Model | MGI Sequence Detail	3346	C57BL/6J
transcript	NM_008058	RefSeq | MGI Sequence Detail	3346	Not Specified
polypeptide	Q61091	UniProt | EBI | MGI Sequence Detail	685	Not Applicable

All sequences(15) RefSeq(2) UniProt(1)

Polymorphisms

RFLP(1) : SNPs(7 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR026545	Frizzled-8
InterPro	IPR020067	Frizzled domain
InterPro	IPR000539	Frizzled protein
InterPro	IPR015526	Frizzled/secreted frizzled-related protein
InterPro	IPR017981	GPCR, family 2-like
Protein Ontology	PR:000007724	frizzled-8

Graphical View of Protein Domain Structure

References

(Earliest) J:37068 Wang Y, et al., A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled. J Biol Chem. 1996 Feb 23;271(8):4468-76
(Latest) J:186312 Sugimura R, et al., Noncanonical wnt signaling maintains hematopoietic stem cells in the niche. Cell. 2012 Jul 20;150(2):351-65
All references(88)

Other accession IDs

MGD-MRK-37504