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Fzd8 Gene Detail
Summary
  • Symbol
    Fzd8
  • Name
    frizzled class receptor 8
  • Synonyms
    Fz8, mFZ8
  • Feature Type
    protein coding gene
  • IDs
    MGI:108460
    NCBI Gene: 14370
  • Gene Overview
    MyGene.info: FZD8
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr18:9212856-9216201 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 4.91 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    9 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108460
protein coding gene Chr18:9212163-9218136 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024138
protein coding gene Chr18:6174385-6177730 (+)
A/J MGP_AJ_G0024100
protein coding gene Chr18:6123663-6127010 (+)
AKR/J MGP_AKRJ_G0024067
protein coding gene Chr18:6244873-6248220 (+)
BALB/cJ MGP_BALBcJ_G0024099
protein coding gene Chr18:6069721-6073067 (+)
C3H/HeJ MGP_C3HHeJ_G0023866
protein coding gene Chr18:6140813-6144159 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024544
protein coding gene Chr18:6510879-6514224 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021983
protein coding gene Chr18:5679968-5683312 (+)
CAST/EiJ MGP_CASTEiJ_G0023343
protein coding gene Chr18:6126405-6129748 (+)
CBA/J MGP_CBAJ_G0023838
protein coding gene Chr18:6478408-6481754 (+)
DBA/2J MGP_DBA2J_G0023967
protein coding gene Chr18:5949055-5952400 (+)
FVB/NJ MGP_FVBNJ_G0023932
protein coding gene Chr18:5939491-5942836 (+)
LP/J MGP_LPJ_G0024050
protein coding gene Chr18:6195352-6198697 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023961
protein coding gene Chr18:6677478-6680823 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024590
protein coding gene Chr18:6125547-6128892 (+)
PWK/PhJ MGP_PWKPhJ_G0023088
protein coding gene Chr18:6004289-6007632 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022899
protein coding gene Chr18:6384167-6387510 (+)
WSB/EiJ MGP_WSBEiJ_G0023409
protein coding gene Chr18:6083201-6086546 (+)



Homology
more
  • Human Ortholog
    FZD8, frizzled class receptor 8
  • Vertebrate Orthologs
    10
  • Human Ortholog
    FZD8, frizzled class receptor 8
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FZ-8, hFZ8
  • Links
    NCBI Gene ID: 8325
    neXtProt AC: NX_Q9H461
    UniProt: Q9H461

  • Chr Location
    10p11.21; chr10:35638249-35641434 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 3 alleles in 3 genetic backgrounds
    4 phenotypes from multigenic genotypes
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene does not appear to result in a phenotype.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14370 NCBI Gene Model | MGI Sequence Detail 3346 C57BL/6J ±  kb
    transcript NM_008058 RefSeq | MGI Sequence Detail 3346 Not Specified  
    polypeptide Q61091 UniProt | EBI | MGI Sequence Detail 685 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 38
      Genomic 1
      cDNA 26
      Primer pair 10
      Other 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-37504
    References
    more
    • Summaries
      All 111
      Developmental Gene Expression 63
      Gene Ontology 23
      Phenotypes 10
    • Earliest
      J:37068 Wang Y, et al., A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled. J Biol Chem. 1996 Feb 23;271(8):4468-76
    • Latest
      J:277277 Zieman AG, et al., Altered keratinocyte differentiation is an early driver of keratin mutation-based palmoplantar keratoderma. Hum Mol Genet. 2019 Jul 1;28(13):2255-2270

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    last database update
    10/15/2019
    MGI 6.14
    The Jackson Laboratory