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Fzd8 Gene Detail
Summary
  • Symbol
    Fzd8
  • Name
    frizzled class receptor 8
  • Synonyms
    Fz8, mFZ8
  • Feature Type
    protein coding gene
  • IDs
    MGI:108460
    NCBI Gene: 14370
  • Gene Overview
    MyGene.info: FZD8
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr18:9212856-9216201 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 4.91 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    9 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108460
protein coding gene Chr18:9212856-9216201 (.)
129S1/SvImJ MGP_129S1SvImJ_G0024138
protein coding gene Chr18:6174385-6177730 (+)
A/J MGP_AJ_G0024100
protein coding gene Chr18:6123663-6127010 (+)
AKR/J MGP_AKRJ_G0024067
protein coding gene Chr18:6244873-6248220 (+)
BALB/cJ MGP_BALBcJ_G0024099
protein coding gene Chr18:6069721-6073067 (+)
C3H/HeJ MGP_C3HHeJ_G0023866
protein coding gene Chr18:6140813-6144159 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024544
protein coding gene Chr18:6510879-6514224 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021983
protein coding gene Chr18:5679968-5683312 (+)
CAST/EiJ MGP_CASTEiJ_G0023343
protein coding gene Chr18:6126405-6129748 (+)
CBA/J MGP_CBAJ_G0023838
protein coding gene Chr18:6478408-6481754 (+)
DBA/2J MGP_DBA2J_G0023967
protein coding gene Chr18:5949055-5952400 (+)
FVB/NJ MGP_FVBNJ_G0023932
protein coding gene Chr18:5939491-5942836 (+)
LP/J MGP_LPJ_G0024050
protein coding gene Chr18:6195352-6198697 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023961
protein coding gene Chr18:6677478-6680823 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024590
protein coding gene Chr18:6125547-6128892 (+)
PWK/PhJ MGP_PWKPhJ_G0023088
protein coding gene Chr18:6004289-6007632 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022899
protein coding gene Chr18:6384167-6387510 (+)
WSB/EiJ MGP_WSBEiJ_G0023409
protein coding gene Chr18:6083201-6086546 (+)



Homology
more
  • Human Ortholog
    FZD8, frizzled class receptor 8
  • Vertebrate Orthologs
    10
  • Human Ortholog
    FZD8, frizzled class receptor 8
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FZ-8, hFZ8
  • Links
    NCBI Gene ID: 8325
    neXtProt AC: NX_Q9H461
    UniProt: Q9H461

  • Chr Location
    10p11.21; chr10:35638249-35641434 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 2 alleles in 2 genetic backgrounds
    4 phenotypes from multigenic genotypes
    8 phenotype references
Homozygous mutation of this gene does not appear to result in a phenotype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 14370 NCBI Gene Model | MGI Sequence Detail 3346 C57BL/6J ±  kb
transcript NM_008058 RefSeq | MGI Sequence Detail 3346 Not Specified  
polypeptide Q61091 UniProt | EBI | MGI Sequence Detail 685 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 38
    Genomic 1
    cDNA 26
    Primer pair 10
    Other 1

    Microarray probesets 2
Other
Accession IDs
less
MGD-MRK-37504
References
more
  • Summaries
    All 107
    Developmental Gene Expression 61
    Gene Ontology 25
    Phenotypes 8
  • Earliest
    J:37068 Wang Y, et al., A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled. J Biol Chem. 1996 Feb 23;271(8):4468-76
  • Latest
    J:253067 Sigal M, et al., Stromal R-spondin orchestrates gastric epithelial stem cells and gland homeostasis. Nature. 2017 Aug 24;548(7668):451-455

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory