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Fzd8
Gene Detail
Symbol

Name
ID
Fzd8
frizzled homolog 8 (Drosophila)
MGI:108460
Synonyms
Fz8, mFZ8
Feature Type
protein coding gene
Genetic Map
Chromosome 18
4.91 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr18:9212856-9216201 bp, + strand
From NCBI annotation of GRCm38

  3346 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:40606  Vertebrate Homology Class
1 human; 1 mouse; 2 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: FZD8
Protein SuperFamily: G protein-coupled receptor frizzled
Gene Tree: Fzd8

Human
homologs
FZD8, frizzled class receptor 8
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 8325
neXtProt AC: NX_Q9H461

Human Synonyms: FZ-8, hFZ8

Human Chr (Location): 10p11.21; chr10:35638249-35641434 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous mutation of this gene does not appear to result in a phenotype.
 
Interactions
Fzd8 interacts with 241 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (34 annotations)
Process angiogenesis, canonical Wnt signaling pathway, ...
Component Golgi apparatus, integral component of membrane, ...
Function G-protein coupled receptor activity, PDZ domain binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (55 records)
Data Summary: Results (484)    Tissues (281)    Images (113)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 300
In situ reporter (knock in) 83
RT-PCR 101
cDNA source data(23)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase fzd8 ; ZFIN fzd8a, fzd8b    NEW 
Molecular
reagents
All nucleic(35) Genomic(1) cDNA(25) Primer pair(8) Other(1)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000036904 (Evidence)
Entrez Gene 14370 (Evidence)
UniGene 184289
DFCI TC1608824
DoTS DT.101364531
NIA Mouse Gene Index U018390
PDB 4F0A, 1IJY
Consensus CDS Project CCDS29048.1
International Mouse Phenotyping Consortium Status Fzd8
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 14370 NCBI Gene Model | MGI Sequence Detail 3346 C57BL/6J ±  kb
transcript NM_008058 RefSeq | MGI Sequence Detail 3346 Not Specified 
polypeptide Q61091 UniProt | EBI | MGI Sequence Detail 685 Not Applicable 

For the selected sequences
All sequences(15) RefSeq(2) UniProt(1)
Polymorphisms
RFLP(1) : SNPs within 2kb(9 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR020067 Frizzled domain
InterPro IPR000539 Frizzled protein
InterPro IPR015526 Frizzled/secreted frizzled-related protein
InterPro IPR017981 GPCR, family 2-like
Protein Ontology PR:000007724 frizzled-8
Graphical View of Protein Domain Structure
References
(Earliest) J:37068 Wang Y, et al., A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled. J Biol Chem. 1996 Feb 23;271(8):4468-76
(Latest) J:207050 Zhao X, et al., Dynamic expression of secreted Frizzled-related protein 3 (sFRP3) in the developing mouse spinal cord and dorsal root ganglia. Neuroscience. 2013 Jul 1;248C:594-601
All references(94)
Other
accession IDs
MGD-MRK-37504

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory