About   Help   FAQ
Mlana
Gene Detail
Symbol

Name
ID
Mlana
melan-A
MGI:108454
Synonyms
A930034P04Rik, Mart1
Feature Type
protein coding gene
Genetic Map
Chromosome 19
24.28 cM, cytoband C2
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr19:29697921-29708448 bp, + strand
From Ensembl annotation of GRCm38

  10528 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4026  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: human melanoma antigen, mart-1 type
Gene Tree: Mlana

Human
homologs
Human Homolog   MLANA, melan-A
NCBI Gene ID 2315
neXtProt AC  NX_Q16655
Human Synonyms  MART1, MART-1
Human Chr (Location)  9p24.1; chr9:5890909-5909822 (+)  GRCh38.p2
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(2) Targeted(2)
 
Mice homozygous for a knock-out allele exhibit dilute coat color, reduced hair number, reduced melanin and eumelanin and abnormal melanosome morphology in the hair follicle.
 
Interactions
Mlana interacts with 60 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (4 annotations)
Component endoplasmic reticulum membrane, Golgi apparatus, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (21)    Tissues (4)    Images (6)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 21
cDNA source data(10)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(11) cDNA(11)
Microarray probesets(2)
Other database
links
Ensembl Gene ModelENSMUSG00000024806 (Evidence)
Entrez Gene77836 (Evidence)
UniGene138437
DFCITC1587408
DoTSDT.525700, DT.101167319
NIA Mouse Gene IndexU019355
Consensus CDS ProjectCCDS29739.1
International Mouse Knockout Project StatusMlana
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024806 Ensembl Gene Model | MGI Sequence Detail 10528 C57BL/6J ±  kb
transcript ENSMUST00000025719 Ensembl | MGI Sequence Detail 623 Not Applicable 
polypeptide ENSMUSP00000025719 Ensembl | MGI Sequence Detail 113 Not Applicable 

For the selected sequences
All sequences(17) RefSeq(4) UniProt(2)
Polymorphisms
RFLP(1) : SNPs within 2kb(62 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
Protein Ontology PR:000010436 melanoma antigen recognized by T-cells 1
References
(Earliest) J:38811 Zhai Y, et al., Cloning and characterization of the genes encoding the murine homologues of the human melanoma antigens MART1 and gp100. J Immunother. 1997 Jan;20(1):15-25
(Latest) J:194886 Aydin IT, et al., Coat color dilution in mice because of inactivation of the melanoma antigen MART-1. Pigment Cell Melanoma Res. 2012 Jan;25(1):37-46
All references(32)
Other
accession IDs
MGD-MRK-37498, MGI:1925086

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
05/12/2015
MGI 5.21
The Jackson Laboratory