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Mlana Gene Detail
Summary
  • Symbol
    Mlana
  • Name
    melan-A
  • Synonyms
    A930034P04Rik, Mart1
  • Feature Type
    protein coding gene
  • IDs
    MGI:108454
    NCBI Gene: 77836
Location & Maps
more
  • Sequence Map
    Chr19:29697921-29708448 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      10528 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    MLANA, melan-A
  • Vertebrate Orthologs
    8
  • Human Ortholog
    MLANA, melan-A
    Orthology source: HomoloGene
  • Synonyms
    MART1, MART-1
  • Links
    NCBI Gene ID: 2315
    neXtProt AC: NX_Q16655

  • Chr Location
    9p24.1; chr9:5890909-5909822 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    2 phenotypes from multigenic genotypes
    3 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    4
  • Gene trapped
    2
  • Targeted
    2
Mice homozygous for a knock-out allele exhibit dilute coat color, reduced hair number, reduced melanin and eumelanin and abnormal melanosome morphology in the hair follicle.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024806 Ensembl Gene Model | MGI Sequence Detail 10528 C57BL/6J ±  kb
transcript ENSMUST00000025719 Ensembl | MGI Sequence Detail 623 Not Applicable  
polypeptide ENSMUSP00000025719 Ensembl | MGI Sequence Detail 113 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    62 from dbSNP Build 137
  • RFLP
Protein
Information
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  • UniProt
    2 Sequences
  • InterPro Domains
    IPR029242 Protein melan-A
Molecular
Reagents
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  • All nucleic 11
    cDNA 11

    Microarray probesets 2
Other
Accession IDs
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MGD-MRK-37498, MGI:1925086
References
more
  • Summaries
    All 28
    Developmental Gene Expression 2
    Gene Ontology 1
    Phenotypes 3
  • Earliest
    J:38811 Zhai Y, et al., Cloning and characterization of the genes encoding the murine homologues of the human melanoma antigens MART1 and gp100. J Immunother. 1997 Jan;20(1):15-25
  • Latest
    J:226887 Raviv S, et al., PAX6 regulates melanogenesis in the retinal pigmented epithelium through feed-forward regulatory interactions with MITF. PLoS Genet. 2014;10(5):e1004360

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory