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Mlana
Gene Detail
Symbol

Name
ID
Mlana
melan-A
MGI:108454
Synonyms
A930034P04Rik, Mart1
Feature Type
protein coding gene
Genetic Map
Chromosome 19
24.28 cM, cytoband C2
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr19:29697921-29708448 bp, + strand
From Ensembl annotation of GRCm38

  10528 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4026  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

HCOP human homology predictions: MLANA
Protein SuperFamily: human melanoma antigen, mart-1 type
Gene Tree: Mlana

Human
homologs
MLANA, melan-A
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 2315
neXtProt AC: NX_Q16655

Human Synonyms: MART1, MART-1

Human Chr (Location): 9p24.1; chr9:5890909-5909822 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(2) Targeted(2)
 
Mice homozygous for a knock-out allele exhibit dilute coat color, reduced hair number, reduced melanin and eumelanin and abnormal melanosome morphology in the hair follicle.
 
Interactions
Mlana interacts with 60 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (4 annotations)
Component endoplasmic reticulum membrane, Golgi apparatus, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (21)    Tissues (4)    Images (6)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 21
cDNA source data(10)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase mlana    NEW 
Molecular
reagents
All nucleic(11) cDNA(11)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000024806 (Evidence)
Entrez Gene 77836 (Evidence)
UniGene 138437
DFCI TC1587408
DoTS DT.525700, DT.101167319
NIA Mouse Gene Index U019355
Consensus CDS Project CCDS29739.1
International Mouse Phenotyping Consortium Status Mlana
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024806 Ensembl Gene Model | MGI Sequence Detail 10528 C57BL/6J ±  kb
transcript ENSMUST00000025719 Ensembl | MGI Sequence Detail 623 Not Applicable 
polypeptide ENSMUSP00000025719 Ensembl | MGI Sequence Detail 113 Not Applicable 

For the selected sequences
All sequences(17) RefSeq(4) UniProt(2)
Polymorphisms
RFLP(1) : SNPs within 2kb(62 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
Protein Ontology PR:000010436 melanoma antigen recognized by T-cells 1
References
(Earliest) J:38811 Zhai Y, et al., Cloning and characterization of the genes encoding the murine homologues of the human melanoma antigens MART1 and gp100. J Immunother. 1997 Jan;20(1):15-25
(Latest) J:194886 Aydin IT, et al., Coat color dilution in mice because of inactivation of the melanoma antigen MART-1. Pigment Cell Melanoma Res. 2012 Jan;25(1):37-46
All references(31)
Other
accession IDs
MGD-MRK-37498, MGI:1925086

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory