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Mlana Gene Detail
Summary
  • Symbol
    Mlana
  • Name
    melan-A
  • Synonyms
    A930034P04Rik, Mart1
  • Feature Type
    protein coding gene
  • IDs
    MGI:108454
    NCBI Gene: 77836
  • Gene Overview
    MyGene.info: MLANA
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:29697921-29708448 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 24.28 cM, cytoband C2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    62 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108454
protein coding gene Chr19:29697541-29708448 (.)
129S1/SvImJ MGP_129S1SvImJ_G0025026
protein coding gene Chr19:28172994-28183501 (+)
A/J MGP_AJ_G0025003
protein coding gene Chr19:26766322-26776945 (+)
AKR/J MGP_AKRJ_G0024971
protein coding gene Chr19:27712233-27723484 (+)
BALB/cJ MGP_BALBcJ_G0025002
protein coding gene Chr19:26801903-26812293 (+)
C3H/HeJ MGP_C3HHeJ_G0024758
protein coding gene Chr19:27691292-27701689 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025443
protein coding gene Chr19:28938330-28950634 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022862
protein coding gene Chr19:26713918-26724110 (+)
CAST/EiJ MGP_CASTEiJ_G0024228
protein coding gene Chr19:27527534-27538090 (+)
CBA/J MGP_CBAJ_G0024736
protein coding gene Chr19:30298675-30309171 (+)
DBA/2J MGP_DBA2J_G0024868
protein coding gene Chr19:26710908-26721675 (+)
FVB/NJ MGP_FVBNJ_G0024830
protein coding gene Chr19:26554719-26565110 (+)
LP/J MGP_LPJ_G0024953
protein coding gene Chr19:28163961-28174372 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024857
protein coding gene Chr19:30230869-30241440 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025498
protein coding gene Chr19:27737896-27748423 (+)
PWK/PhJ MGP_PWKPhJ_G0023976
protein coding gene Chr19:26375754-26386543 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023780
protein coding gene Chr19:27017222-27029996 (+)
WSB/EiJ MGP_WSBEiJ_G0024295
protein coding gene Chr19:27777299-27792690 (+)



Homology
more
  • Human Ortholog
    MLANA, melan-A
  • Vertebrate Orthologs
    8
  • Human Ortholog
    MLANA, melan-A
    Orthology source: HGNC, HomoloGene
  • Synonyms
    MART1, MART-1
  • Links
    NCBI Gene ID: 2315
    neXtProt AC: NX_Q16655
    UniProt: Q16655

  • Chr Location
    9p24.1; chr9:5890909-5909822 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    2 phenotypes from multigenic genotypes
    3 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit dilute coat color, reduced hair number, reduced melanin and eumelanin and abnormal melanosome morphology in the hair follicle.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024806 Ensembl Gene Model | MGI Sequence Detail 10528 C57BL/6J ±  kb
    transcript ENSMUST00000025719 Ensembl | MGI Sequence Detail 623 Not Applicable  
    polypeptide ENSMUSP00000025719 Ensembl | MGI Sequence Detail 113 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • InterPro Domains
      IPR029242 Protein melan-A
    Molecular
    Reagents
    less
    • All nucleic 12
      cDNA 12

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-37498, MGI:1925086
    References
    more
    • Summaries
      All 34
      Developmental Gene Expression 3
      Gene Ontology 3
      Phenotypes 3
    • Earliest
      J:38811 Zhai Y, et al., Cloning and characterization of the genes encoding the murine homologues of the human melanoma antigens MART1 and gp100. J Immunother. 1997 Jan;20(1):15-25
    • Latest
      J:254646 Mouriaux F, et al., Effects of Long-term Serial Passaging on the Characteristics and Properties of Cell Lines Derived From Uveal Melanoma Primary Tumors. Invest Ophthalmol Vis Sci. 2016 Oct 1;57(13):5288-5301

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory