Mlana Gene Detail

Summary

• Symbol
  Mlana
• Name
  melan-A
• Synonyms
  A930034P04Rik, Mart1

• Feature Type
  protein coding gene
• IDs
  MGI:108454
  NCBI Gene: 77836
• Alliance
  genome feature page
• Transcription Start Sites
  3 TSS

Location &
Maps

• Sequence Map
  Chr19:29675224-29686034 bp, + strand

  From Ensembl annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 19, 24.28 cM, cytoband C2
• Mapping Data
  3 experiments

Strain
Comparison

• SNPs within 2kb
  481 from dbSNP Build 142
• Strain Annotations
  18
• RFLP
  1

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_108454	protein coding gene	Chr19:29674956-29686034 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025026	protein coding gene	Chr19:28172994-28183501 (+)
A/J	MGP_AJ_G0025003	protein coding gene	Chr19:26766322-26776945 (+)
AKR/J	MGP_AKRJ_G0024971	protein coding gene	Chr19:27712233-27723484 (+)
BALB/cJ	MGP_BALBcJ_G0025002	protein coding gene	Chr19:26801903-26812293 (+)
C3H/HeJ	MGP_C3HHeJ_G0024758	protein coding gene	Chr19:27691292-27701689 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025443	protein coding gene	Chr19:28938330-28950634 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022862	protein coding gene	Chr19:26713918-26724110 (+)
CAST/EiJ	MGP_CASTEiJ_G0024228	protein coding gene	Chr19:27527534-27538090 (+)
CBA/J	MGP_CBAJ_G0024736	protein coding gene	Chr19:30298675-30309171 (+)
DBA/2J	MGP_DBA2J_G0024868	protein coding gene	Chr19:26710908-26721675 (+)
FVB/NJ	MGP_FVBNJ_G0024830	protein coding gene	Chr19:26554719-26565110 (+)
LP/J	MGP_LPJ_G0024953	protein coding gene	Chr19:28163961-28174372 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024857	protein coding gene	Chr19:30230869-30241440 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025498	protein coding gene	Chr19:27737896-27748423 (+)
PWK/PhJ	MGP_PWKPhJ_G0023976	protein coding gene	Chr19:26375754-26386543 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023780	protein coding gene	Chr19:27017222-27029996 (+)
WSB/EiJ	MGP_WSBEiJ_G0024295	protein coding gene	Chr19:27777299-27792690 (+)

Homology

• Human Ortholog
  MLANA, melan-A

• Vertebrate Orthologs
  3

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  MLANA, melan-A
  
• Synonyms
  MART-1, MART1
• Links
  HGNC:7124

  NCBI Gene ID: 2315

  UniProt: Q16655

  
  
• Chr Location
  9p24.1; chr9:5890889-5910606 (+)  GRCh38

---

• MGI Vertebrate Homology
  Mlana stringent orthology
  1 human;1 mouse;1 rat;1 zebrafish
  
• HCOP
  vertebrate homology predictions: MLANA
• Gene Tree
  Mlana
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  4 phenotypes from 1 allele in 1 genetic background
  2 phenotypes from multigenic genotypes
  7 phenotype references
  

• All Mutations and Alleles
  11
• Endonuclease-mediated
  3
• Gene trapped
  2
• Targeted
  6
• Genomic Mutations
  4 involving Mlana
• Find Mice (IMSR)
  8 strains or lines available
• Comparison Matrix
  Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit dilute coat color, reduced hair number, reduced melanin and eumelanin and abnormal melanosome morphology in the hair follicle.

Expression

• Assay Results
  730
• Tissues
  6
• cDNA Data
  11
• Literature Summary
  6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  Xenbase mlana
  ZFIN mlana

Sequences &
Gene Models

• All Sequences
  35
• RefSeq
  4
• UniProt
  4
• CCDS
  CCDS29739.1

• Ensembl
  ENSMUSG00000024806 (Evidence)
• NCBI Gene
  77836

Representative Sequences			Length	Strain/Species
genomic	ENSMUSG00000024806	Ensembl Gene Model | MGI Sequence Detail	10811	C57BL/6J
transcript	ENSMUST00000025719	Ensembl | MGI Sequence Detail	906	Not Applicable
polypeptide	ENSMUSP00000025719	Ensembl | MGI Sequence Detail	113	Not Applicable

Protein
Information

• UniProt
  4 Sequences
• InterPro Domains
  IPR029242 Protein melan-A

Molecular
Reagents

• All nucleic 12

  cDNA 12

  Antibodies 1

  
  

  Microarray probesets 2

Other
Accession IDs

MGD-MRK-37498, MGI:1925086

References

• Summaries
  All 38

  Developmental Gene Expression 6

  Phenotypes 7
• Earliest
  J:38811 Zhai Y, et al., Cloning and characterization of the genes encoding the murine homologues of the human melanoma antigens MART1 and gp100. J Immunother. 1997 Jan;20(1):15-25
• Latest
  J:360836 Kambali M, et al., An increased copy number of glycine decarboxylase (GLDC) associated with psychosis reduces extracellular glycine and impairs NMDA receptor function. Mol Psychiatry. 2024 Aug 30;

TSS for Mlana:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr155907	Chr19:29675305-29675327 (+)	92 bp
Tssr155908	Chr19:29681192-29681206 (+)	5,975 bp
Tssr155909	Chr19:29681223-29681243 (+)	6,009 bp