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Mlana
Gene Detail
 Symbol
Name
ID
Mlana
melan-A
MGI:108454
Synonyms A930034P04Rik, Mart1
Feature Type protein coding gene
Genetic Map
Chromosome 19
24.28 cM, cytoband C2
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr19:29697941-29708306 bp, + strand
From NCBI annotation of GRCm38

  10366 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4026  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: human melanoma antigen, mart-1 type
Gene Tree: Mlana

Human
homologs
Human Homolog MLANA, melan-A
NCBI Gene ID 2315
neXtProt AC  NX_Q16655
Human Synonyms  MART1, MART-1
Human Chr (Location)  9p24.1; chr9:5890909-5909825 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(2) Targeted(2)
 
Mice homozygous for a knock-out allele exhibit dilute coat color, reduced hair number, reduced melanin and eumelanin and abnormal melanosome morphology in the hair follicle.
 
Interactions
Mlana interacts with 60 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (4 annotations)
Component endoplasmic reticulum membrane, Golgi apparatus, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (21)    Tissues (4)    Images (6)
Theiler Stages: 19
Assay TypeResults
RNA in situ 21
cDNA source data(10)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(11) cDNA(11)
Microarray probesets(2)
Other database
links
Ensembl Gene ModelENSMUSG00000024806 (Evidence)
Entrez Gene77836 (Evidence)
UniGene138437
DFCITC1587408
DoTSDT.101167319, DT.525700
NIA Mouse Gene IndexU019355
Consensus CDS ProjectCCDS29739.1
International Mouse Knockout Project StatusMlana
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 77836 NCBI Gene Model | MGI Sequence Detail 10366 C57BL/6J ±  kb
transcript NM_029993 RefSeq | MGI Sequence Detail 461 Not Specified 
polypeptide NP_084269 RefSeq | MGI Sequence Detail 113 Not Specified 

For the selected sequences
All sequences(15) RefSeq(2) UniProt(2)
Polymorphisms RFLP(1) : SNPs within 2kb(62 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
Protein Ontology PR:000010436 melanoma antigen recognized by T-cells 1
References (Earliest) J:38811 Zhai Y, et al., Cloning and characterization of the genes encoding the murine homologues of the human melanoma antigens MART1 and gp100. J Immunother. 1997 Jan;20(1):15-25
(Latest) J:194886 Aydin IT, et al., Coat color dilution in mice because of inactivation of the melanoma antigen MART-1. Pigment Cell Melanoma Res. 2012 Jan;25(1):37-46
All references(32)
Other
accession IDs
MGD-MRK-37498, MGI:1925086

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory