Acaca
Gene Detail

Symbol Name ID

Acaca acetyl-Coenzyme A carboxylase alpha MGI:108451

Synonyms

A530025K05Rik, Acac, Acc1, acetyl-CoA carboxylase, LOC327983

Feature Type

protein coding gene

Genetic Map

Chromosome 11

51.29 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr11:84129672-84401651 bp, + strand From VEGA annotation of GRCm38   271980 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Acaca ± 2 cM)

Gene Tree: Acaca

Human ortholog

ACACA acetyl-CoA carboxylase alpha NCBI Gene ID 31
Human Synonyms: ACAC, ACACAD, ACC, ACC1, ACCA
Human Chr17:35441927-35766902 bp, - strand Reference GRCh37.p2 Primary Assembly
Human Diseases Associated with Human ACACA (1)

Alleles and phenotypes

All alleles(30) : Targeted(5) Gene trapped(25)
 

Homozygous null mice display embryonic lethality before embryo turning with growth arrest at the egg cylinder stage.

 

Gene Ontology (GO) classifications

All GO classifications: (32 annotations)

Process	acetyl-CoA metabolic process, fatty acid biosynthetic process, ...
Component	cytoplasm, cytosol, ...
Function	acetyl-CoA carboxylase activity, ATP binding, ...

External Resources: FuncBase

Expression

Literature Summary: (8 records)
Data Summary: Results (311)    Tissues (135)    Images (42)
Theiler Stages: 11, 22, 23, 28

Assay Type	Results
RNA in situ	278
Western blot	9
RT-PCR	24

cDNA source data(118)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(124) cDNA(121) Primer pair(3)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000000985 (Evidence)
Ensembl Gene Model	ENSMUSG00000020532 (Evidence)
Entrez Gene	107476 (Evidence)
UniGene	31374
DFCI	TC1602014, TC1623328, TC1732092
DoTS	DT.101150898, DT.101237873, DT.101739526, DT.102540907, DT.110938626, DT.491554, DT.91585846, DT.94273723
NIA Mouse Gene Index	U013109, U013752, U368134
EC	6.3.4.14, 6.4.1.2
Consensus CDS Project	CCDS25185.1
International Mouse Knockout Project Status	Acaca

Sequences

Length	Strain/Species
genomic	OTTMUSG00000000985	VEGA Gene Model | MGI Sequence Detail	271980	C57BL/6J
transcript	OTTMUST00000001932	VEGA | MGI Sequence Detail	9513	Not Applicable
polypeptide	OTTMUSP00000000931	VEGA | MGI Sequence Detail	2345	Not Applicable

All sequences(68) RefSeq(3) UniProt(2)

Polymorphisms

SNPs(808 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR013537	Acetyl-CoA carboxylase, central domain
InterPro	IPR011763	Acetyl-coenzyme A carboxyltransferase, C-terminal
InterPro	IPR011762	Acetyl-coenzyme A carboxyltransferase, N-terminal
InterPro	IPR011761	ATP-grasp fold
InterPro	IPR013815	ATP-grasp fold, subdomain 1
InterPro	IPR013816	ATP-grasp fold, subdomain 2
InterPro	IPR001882	Biotin-binding site
InterPro	IPR005482	Biotin carboxylase, C-terminal
InterPro	IPR011764	Biotin carboxylation domain
InterPro	IPR000089	Biotin/lipoyl attachment
InterPro	IPR005481	Carbamoyl-phosphate synthase, large subunit, N-terminal
InterPro	IPR005479	Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain
InterPro	IPR000022	Carboxyl transferase
InterPro	IPR016185	Pre-ATP-grasp fold
InterPro	IPR011054	Rudiment single hybrid motif
InterPro	IPR011053	Single hybrid motif
Protein Ontology	PR:000003596	acetyl-CoA carboxylase 1

References

(Earliest) J:20913 Myohanen S, et al., Nucleotide sequence of mouse spermidine synthase cDNA. DNA Seq. 1994;4(5):343-6
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(58)

Other accession IDs

MGD-MRK-37495, MGI:2443466, MGI:2685584