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Acaca
Gene Detail
 Symbol
Name
ID
Acaca
acetyl-Coenzyme A carboxylase alpha
MGI:108451
Synonyms A530025K05Rik, Acac, Acc1, acetyl-CoA carboxylase, LOC327983
Feature Type protein coding gene
Genetic Map
Chromosome 11
51.29 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr11:84129672-84401651 bp, + strand
From VEGA annotation of GRCm38

  271980 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31015  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Acaca

Human
homologs
Human Homolog ACACA, acetyl-CoA carboxylase alpha
NCBI Gene ID 31
neXtProt AC  NX_Q13085
Human Synonyms  ACAC, ACACAD, ACC, ACC1, ACCA
Human Chr (Location)  17q21; chr17:37084992-37406822 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human ACACA
Mutations,
alleles, and
phenotypes
All mutations/alleles(30) : Gene trapped(25) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice display embryonic lethality before embryo turning with growth arrest at the egg cylinder stage.
 
Interactions
Acaca interacts with 279 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (33 annotations)
Process acetyl-CoA metabolic process, fatty acid biosynthetic process, ...
Component cytoplasm, cytosol, ...
Function acetyl-CoA carboxylase activity, ATP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (311)    Tissues (135)    Images (42)
Theiler Stages: 11, 22, 23, 28
Assay TypeResults
RNA in situ 278
Western blot 9
RT-PCR 24
cDNA source data(118)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(124) cDNA(121) Primer pair(3)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000000985 (Evidence)
Ensembl Gene ModelENSMUSG00000020532 (Evidence)
Entrez Gene107476 (Evidence)
UniGene31374
DFCITC1602014, TC1623328, TC1732092
DoTSDT.101150898, DT.101237873, DT.101739526, DT.102540907, DT.110938626, DT.491554, DT.91585846, DT.94273723
NIA Mouse Gene IndexU013109, U013752, U368134
EC6.3.4.14, 6.4.1.2
Consensus CDS ProjectCCDS25185.1
International Mouse Knockout Project StatusAcaca
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000985 VEGA Gene Model | MGI Sequence Detail 271980 C57BL/6J ±  kb
transcript OTTMUST00000001932 VEGA | MGI Sequence Detail 9513 Not Applicable 
polypeptide OTTMUSP00000000931 VEGA | MGI Sequence Detail 2345 Not Applicable 

For the selected sequences
All sequences(96) RefSeq(19) UniProt(6)
Polymorphisms SNPs within 2kb(1526 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013537 Acetyl-CoA carboxylase, central domain
InterPro IPR011763 Acetyl-coenzyme A carboxyltransferase, C-terminal
InterPro IPR011762 Acetyl-coenzyme A carboxyltransferase, N-terminal
InterPro IPR011761 ATP-grasp fold
InterPro IPR013815 ATP-grasp fold, subdomain 1
InterPro IPR013816 ATP-grasp fold, subdomain 2
InterPro IPR001882 Biotin-binding site
InterPro IPR005482 Biotin carboxylase, C-terminal
InterPro IPR011764 Biotin carboxylation domain
InterPro IPR000089 Biotin/lipoyl attachment
InterPro IPR005481 Carbamoyl-phosphate synthase, large subunit, N-terminal
InterPro IPR005479 Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain
InterPro IPR000022 Carboxyl transferase
InterPro IPR016185 Pre-ATP-grasp domain
InterPro IPR011054 Rudiment single hybrid motif
InterPro IPR011053 Single hybrid motif
Protein Ontology PR:000003596 acetyl-CoA carboxylase 1
References (Earliest) J:20913 Myohanen S, et al., Nucleotide sequence of mouse spermidine synthase cDNA. DNA Seq. 1994;4(5):343-6
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(59)
Other
accession IDs
MGD-MRK-37495, MGI:2443466, MGI:2685584

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory