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Adcyap1r1
Gene Detail
Symbol

Name
ID
Adcyap1r1
adenylate cyclase activating polypeptide 1 receptor 1
MGI:108449
Synonyms
2900024I10Rik, PAC1, PAC1R, PACAP1-R
Feature Type
protein coding gene
Genetic Map
Chromosome 6
27.38 cM, cytoband B3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr6:55451978-55501451 bp, + strand
From VEGA annotation of GRCm38

  49474 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:870  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ADCYAP1R1
Protein SuperFamily: G protein-coupled receptor, peptide hormone receptor type
Gene Tree: Adcyap1r1

Human
homologs
ADCYAP1R1, adenylate cyclase activating polypeptide 1 (pituitary) receptor type I
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 117
neXtProt AC: NX_P41586

Human Synonyms: PAC1, PAC1R, PACAPR, PACAPRI

Human Chr (Location): 7p14; chr7:31052341-31111479 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Gene trapped(1) Targeted(8)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygotes for targeted mutations affect contextual fear conditioning, elevated locomotor activity, anxiety-like behavior, susceptibility to endotoxic shock, circadian responses to a photic stimulus, and glucose tolerance. Some alleles affect female fertility.
 
Interactions
Adcyap1r1 interacts with 339 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (33 annotations)
Process activation of phospholipase C activity, cAMP-mediated signaling, ...
Component bicellular tight junction, caveola, ...
Function adenylate cyclase binding, ADP-ribosylation factor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (12 records)
Data Summary: Results (213)    Tissues (33)    Images (25)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 201
RT-PCR 1
RNase protection 11
cDNA source data(77)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase adcyap1r1 ; ZFIN adcyap1r1a, adcyap1r1b    NEW 
Molecular
reagents
All nucleic(87) Genomic(7) cDNA(79) Primer pair(1)
Microarray probesets(7)
Other database
links
VEGA Gene Model OTTMUSG00000035961 (Evidence)
Ensembl Gene Model ENSMUSG00000029778 (Evidence)
Entrez Gene 11517 (Evidence)
UniGene 44245
DFCI TC1578542, TC1604303
DoTS DT.101736351, DT.486727
Consensus CDS Project CCDS20166.1, CCDS20167.1
International Mouse Phenotyping Consortium Status Adcyap1r1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035961 VEGA Gene Model | MGI Sequence Detail 49474 C57BL/6J ±  kb
transcript OTTMUST00000092259 VEGA | MGI Sequence Detail 1575 Not Applicable 
polypeptide OTTMUSP00000050944 VEGA | MGI Sequence Detail 524 Not Applicable 

For the selected sequences
All sequences(82) RefSeq(14) UniProt(9)
Polymorphisms
SNPs within 2kb(450 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001879 GPCR, family 2, extracellular hormone receptor domain
InterPro IPR017981 GPCR, family 2-like
InterPro IPR002285 GPCR, family 2, pituitary adenylate cyclase activating polypeptide type 1 receptor
InterPro IPR000832 GPCR, family 2, secretin-like
InterPro IPR017983 GPCR, family 2, secretin-like, conserved site
Protein Ontology PR:000003762 pituitary adenylate cyclase-activating polypeptide type I receptor
References
(Earliest) J:35894 Spengler D, et al., Differential signal transduction by five splice variants of the PACAP receptor. Nature. 1993 Sep 9;365(6442):170-5
(Latest) J:204899 Miura A, et al., Pituitary adenylate cyclase-activating polypeptide type 1 receptor (PAC1) gene is suppressed by transglutaminase 2 activation. J Biol Chem. 2013 Nov 8;288(45):32720-30
All references(73)
Other
accession IDs
MGD-MRK-37493, MGI:1920204, MGI:2141492

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory