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Adcyap1r1 Gene Detail
Summary
  • Symbol
    Adcyap1r1
  • Name
    adenylate cyclase activating polypeptide 1 receptor 1
  • Synonyms
    2900024I10Rik, PAC1, PAC1R, PACAP1-R
  • Feature Type
    protein coding gene
  • IDs
    MGI:108449
    NCBI Gene: 11517
  • Gene Overview
    MyGene.info: ADCYAP1R1
Location & Maps
more
  • Sequence Map
    Chr6:55451978-55501451 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      49474 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    ADCYAP1R1, ADCYAP receptor type I
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ADCYAP1R1, ADCYAP receptor type I
    Orthology source: HomoloGene
  • Synonyms
    PAC1, PAC1R, PACAPR, PACAPRI
  • Links
    NCBI Gene ID: 117
    neXtProt AC: NX_P41586

  • Chr Location
    7p14; chr7:31052341-31111479 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 4 alleles in 4 genetic backgrounds
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    13
  • Gene trapped
    1
  • Targeted
    8
  • Transgenic
    4
  • Incidental Mutations
Homozygotes for targeted mutations affect contextual fear conditioning, elevated locomotor activity, anxiety-like behavior, susceptibility to endotoxic shock, circadian responses to a photic stimulus, and glucose tolerance. Some alleles affect female fertility.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035961 VEGA Gene Model | MGI Sequence Detail 49474 C57BL/6J ±  kb
transcript OTTMUST00000092259 VEGA | MGI Sequence Detail 1575 Not Applicable  
polypeptide OTTMUSP00000050944 VEGA | MGI Sequence Detail 524 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    450 from dbSNP Build 142
Protein
Information
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  • UniProt
    9 Sequences
  • Protein Ontology
    PR:000003762 pituitary adenylate cyclase-activating polypeptide type I receptor
  • InterPro Domains
    IPR001879 GPCR, family 2, extracellular hormone receptor domain
    IPR017981 GPCR, family 2-like
    IPR002285 GPCR, family 2, pituitary adenylate cyclase activating polypeptide type 1 receptor
    IPR000832 GPCR, family 2, secretin-like
    IPR017983 GPCR, family 2, secretin-like, conserved site
Molecular
Reagents
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  • All nucleic 87
    Genomic 7
    cDNA 79
    Primer pair 1

    Microarray probesets 7
Other
Accession IDs
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MGD-MRK-37493, MGI:1920204, MGI:2141492
References
more
  • Summaries
    All 71
    Developmental Gene Expression 12
    Gene Ontology 6
    Phenotypes 28
  • Earliest
    J:35894 Spengler D, et al., Differential signal transduction by five splice variants of the PACAP receptor. Nature. 1993 Sep 9;365(6442):170-5
  • Latest
    J:204899 Miura A, et al., Pituitary adenylate cyclase-activating polypeptide type 1 receptor (PAC1) gene is suppressed by transglutaminase 2 activation. J Biol Chem. 2013 Nov 8;288(45):32720-30

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory