Adcyap1r1
Gene Detail

Symbol Name ID

Adcyap1r1 adenylate cyclase activating polypeptide 1 receptor 1 MGI:108449

Synonyms

2900024I10Rik, PAC1, PAC1R, PACAP1-R

Feature Type

protein coding gene

Genetic Map

Chromosome 6

27.38 cM, cytoband B3
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr6:55451978-55501451 bp, + strand From VEGA annotation of GRCm38   49474 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:870  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: G protein-coupled receptor, peptide hormone receptor type
Gene Tree: Adcyap1r1

Human homologs

Human Homolog		ADCYAP1R1, adenylate cyclase activating polypeptide 1 (pituitary) receptor type I
NCBI Gene ID		117
neXtProt AC		NX_P41586
Human Synonyms		PAC1, PAC1R, PACAPR, PACAPRI
Human Chr (Location)		7p14; chr7:31092076-31151093 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(8) : Targeted(7) Gene trapped(1)
 

Homozygotes for targeted mutations affect contextual fear conditioning, elevated locomotor activity, anxiety-like behavior, susceptibility to endotoxic shock, circadian responses to a photic stimulus, and glucose tolerance. Some alleles affect female fertility.

 

Gene Ontology (GO) classifications

All GO classifications: (32 annotations)

Process	activation of phospholipase C activity, cAMP-mediated signaling, ...
Component	caveola, cell surface, ...
Function	adenylate cyclase binding, ADP-ribosylation factor binding, ...

External Resources: FuncBase

Expression

Literature Summary: (12 records)
Data Summary: Results (213)    Tissues (32)    Images (25)
Theiler Stages: 15, 20, 21, 22, 23, 26, 28

Assay Type	Results
RNA in situ	201
RT-PCR	1
RNase protection	11

cDNA source data(77)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(87) Genomic(7) cDNA(79) Primer pair(1)
Microarray probesets(7)

Other database links

VEGA Gene Model	OTTMUSG00000035961 (Evidence)
Ensembl Gene Model	ENSMUSG00000029778 (Evidence)
Entrez Gene	11517 (Evidence)
UniGene	44245
DFCI	TC1578542, TC1604303
DoTS	DT.101736351, DT.486727
Consensus CDS Project	CCDS20166.1, CCDS20167.1
International Mouse Knockout Project Status	Adcyap1r1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000035961	VEGA Gene Model | MGI Sequence Detail	49474	C57BL/6J
transcript	OTTMUST00000092259	VEGA | MGI Sequence Detail	1575	Not Applicable
polypeptide	OTTMUSP00000050944	VEGA | MGI Sequence Detail	524	Not Applicable

All sequences(71) RefSeq(4) UniProt(9)

Polymorphisms

SNPs(398 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001879	GPCR, family 2, extracellular hormone receptor domain
InterPro	IPR017981	GPCR, family 2-like
InterPro	IPR002285	GPCR, family 2, pituitary adenylate cyclase activating polypeptide type 1 receptor
InterPro	IPR000832	GPCR, family 2, secretin-like
InterPro	IPR017983	GPCR, family 2, secretin-like, conserved site
Protein Ontology	PR:000003762	pituitary adenylate cyclase-activating polypeptide type I receptor

References

(Earliest) J:35894 Spengler D, et al., Differential signal transduction by five splice variants of the PACAP receptor. Nature. 1993 Sep 9;365(6442):170-5
(Latest) J:189680 Metz VV, et al., Induction of RAGE shedding by activation of G protein-coupled receptors. PLoS One. 2012;7(7):e41823
All references(70)

Other accession IDs

MGD-MRK-37493, MGI:1920204, MGI:2141492