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Adcyap1r1
Gene Detail
 Symbol
Name
ID
Adcyap1r1
adenylate cyclase activating polypeptide 1 receptor 1
MGI:108449
Synonyms 2900024I10Rik, PAC1, PAC1R, PACAP1-R
Feature Type protein coding gene
Genetic Map
Chromosome 6
27.38 cM, cytoband B3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr6:55451978-55501451 bp, + strand
From VEGA annotation of GRCm38

  49474 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:870  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: G protein-coupled receptor, peptide hormone receptor type
Gene Tree: Adcyap1r1

Human
homologs
Human Homolog ADCYAP1R1, adenylate cyclase activating polypeptide 1 (pituitary) receptor type I
NCBI Gene ID 117
neXtProt AC  NX_P41586
Human Synonyms  PAC1, PAC1R, PACAPR, PACAPRI
Human Chr (Location)  7p14; chr7:31052461-31111479 (+)  GRCh38
Alleles
and
phenotypes
All alleles(9) : Gene trapped(1) Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted mutations affect contextual fear conditioning, elevated locomotor activity, anxiety-like behavior, susceptibility to endotoxic shock, circadian responses to a photic stimulus, and glucose tolerance. Some alleles affect female fertility.
 
Gene Ontology
(GO)
classifications
All GO classifications: (33 annotations)
Process activation of phospholipase C activity, cAMP-mediated signaling, ...
Component caveola, cell surface, ...
Function adenylate cyclase binding, ADP-ribosylation factor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (12 records)
Data Summary: Results (213)    Tissues (32)    Images (25)
Theiler Stages: 15, 20, 21, 22, 23, 26, 28
Assay TypeResults
RNA in situ 201
RT-PCR 1
RNase protection 11
cDNA source data(77)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(87) Genomic(7) cDNA(79) Primer pair(1)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000035961 (Evidence)
Ensembl Gene ModelENSMUSG00000029778 (Evidence)
Entrez Gene11517 (Evidence)
UniGene44245
DFCITC1578542, TC1604303
DoTSDT.101736351, DT.486727
Consensus CDS ProjectCCDS20166.1, CCDS20167.1
International Mouse Knockout Project StatusAdcyap1r1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035961 VEGA Gene Model | MGI Sequence Detail 49474 C57BL/6J ±  kb
transcript OTTMUST00000092259 VEGA | MGI Sequence Detail 1575 Not Applicable 
polypeptide OTTMUSP00000050944 VEGA | MGI Sequence Detail 524 Not Applicable 

For the selected sequences
All sequences(80) RefSeq(12) UniProt(9)
Polymorphisms SNPs within 2kb(450 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001879 GPCR, family 2, extracellular hormone receptor domain
InterPro IPR017981 GPCR, family 2-like
InterPro IPR002285 GPCR, family 2, pituitary adenylate cyclase activating polypeptide type 1 receptor
InterPro IPR000832 GPCR, family 2, secretin-like
InterPro IPR017983 GPCR, family 2, secretin-like, conserved site
Protein Ontology PR:000003762 pituitary adenylate cyclase-activating polypeptide type I receptor
References (Earliest) J:35894 Spengler D, et al., Differential signal transduction by five splice variants of the PACAP receptor. Nature. 1993 Sep 9;365(6442):170-5
(Latest) J:194542 Ghai R, et al., Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins. Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):E643-52
All references(72)
Other
accession IDs
MGD-MRK-37493, MGI:1920204, MGI:2141492

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory