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Adcyap1r1 Gene Detail
Summary
  • Symbol
    Adcyap1r1
  • Name
    adenylate cyclase activating polypeptide 1 receptor 1
  • Synonyms
    2900024I10Rik, PAC1, PAC1R, PACAP1-R
  • Feature Type
    protein coding gene
  • IDs
    MGI:108449
    NCBI Gene: 11517
  • Gene Overview
    MyGene.info: ADCYAP1R1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr6:55451978-55501451 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      49474 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 27.38 cM, cytoband B3
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    ADCYAP1R1, ADCYAP receptor type I
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ADCYAP1R1, ADCYAP receptor type I
    Orthology source: HGNC, HomoloGene
  • Synonyms
    PAC1, PAC1R, PACAPR, PACAPRI
  • Links
    NCBI Gene ID: 117
    neXtProt AC: NX_P41586
    UniProt: P41586

  • Chr Location
    7p14.3; chr7:31052341-31114005 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    17 phenotypes from 5 alleles in 5 genetic backgrounds
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for targeted mutations affect contextual fear conditioning, elevated locomotor activity, anxiety-like behavior, susceptibility to endotoxic shock, circadian responses to a photic stimulus, and glucose tolerance. Some alleles affect female fertility.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000035961 VEGA Gene Model | MGI Sequence Detail 49474 C57BL/6J ±  kb
    transcript OTTMUST00000092259 VEGA | MGI Sequence Detail 1575 Not Applicable  
    polypeptide OTTMUSP00000050944 VEGA | MGI Sequence Detail 524 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      450 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      9 Sequences
    • InterPro Domains
      IPR001879 GPCR, family 2, extracellular hormone receptor domain
      IPR036445 GPCR family 2, extracellular hormone receptor domain superfamily
      IPR017981 GPCR, family 2-like
      IPR002285 GPCR, family 2, pituitary adenylate cyclase activating polypeptide type 1 receptor
      IPR000832 GPCR, family 2, secretin-like
      IPR017983 GPCR, family 2, secretin-like, conserved site
    Molecular
    Reagents
    less
    • All nucleic 88
      Genomic 7
      cDNA 80
      Primer pair 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-37493, MGI:1920204, MGI:2141492
    References
    more
    • Summaries
      All 83
      Developmental Gene Expression 14
      Gene Ontology 8
      Phenotypes 32
    • Earliest
      J:35894 Spengler D, et al., Differential signal transduction by five splice variants of the PACAP receptor. Nature. 1993 Sep 9;365(6442):170-5
    • Latest
      J:251951 Hannibal J, et al., PAC1- and VPAC2 receptors in light regulated behavior and physiology: Studies in single and double mutant mice. PLoS One. 2017;12(11):e0188166

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    09/11/2018
    MGI 6.12
    The Jackson Laboratory