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Amot Gene Detail
Summary
  • Symbol
    Amot
  • Name
    angiomotin
  • Synonyms
    D0Kist1, E230009N18Rik, mKIAA1071, Sii6
  • Feature Type
    protein coding gene
  • IDs
    MGI:108440
    NCBI Gene: 27494
  • Gene Overview
    MyGene.info: AMOT
Location & Maps
more
  • Sequence Map
    ChrX:145446425-145505181 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      58757 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 66.72 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    AMOT, angiomotin
  • Vertebrate Orthologs
    10
  • Human Ortholog
    AMOT, angiomotin
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 154796
    neXtProt AC: NX_Q4VCS5
    UniProt: Q4VCS5

  • Chr Location
    Xq23; chrX:112774877-112840946 (-)  GRCh38.p7
  • HomoloGene
    Vertebrate Homology Class 15778
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: AMOT
  • Gene Tree
    Amot
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from 1 allele in 2 genetic backgrounds
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a null mutation exhibit impaired migration into proximal extraembryonic regions resulting in furrows of visceral endoderm at the junction of embryonic and extraembryonic regions, vascular insufficiency in the intersomitic region, dilated vessels in the brain and embryonic lethality.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    40
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    16
  • Tissues
    9
  • cDNA Data
    76
  • Literature Summary
    6
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018901 VEGA Gene Model | MGI Sequence Detail 58757 C57BL/6J ±  kb
transcript OTTMUST00000045440 VEGA | MGI Sequence Detail 6364 Not Applicable  
polypeptide OTTMUSP00000020433 VEGA | MGI Sequence Detail 929 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    341 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 78
    cDNA 76
    Primer pair 1
    Other 1

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-37484, MGI:2148071, MGI:2180948, MGI:2442022
References
more
  • Summaries
    All 43
    Developmental Gene Expression 6
    Gene Ontology 9
    Phenotypes 4
  • Earliest
    J:44212 Kim SJ, et al., Cloning of novel trinucleotide-repeat (CAG) containing genes in mouse brain. Biochem Biophys Res Commun. 1997 Nov 7;240(1):239-43
  • Latest
    J:236978 Santos R, et al., Conditional Creation and Rescue of Nipbl-Deficiency in Mice Reveals Multiple Determinants of Risk for Congenital Heart Defects. PLoS Biol. 2016 Sep;14(9):e2000197
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/12/2017
MGI 6.10 		The Jackson Laboratory