Amot
Gene Detail

Symbol Name ID

Amot angiomotin MGI:108440

Synonyms

D0Kist1, E230009N18Rik, mKIAA1071, Sii6

Feature Type

protein coding gene

Genetic Map

Chromosome X

66.72 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

ChrX:145446425-145505181 bp, - strand From VEGA annotation of GRCm38   58757 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:15778  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Amot

Human homologs

Human Homolog		AMOT, angiomotin
NCBI Gene ID		154796
neXtProt AC		NX_Q4VCS5
Human Chr (Location)		Xq23; chrX:112774877-112840908 (-)  GRCh38

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Homozygotes for a null mutation exhibit impaired migration into proximal extraembryonic regions resulting in furrows of visceral endoderm at the junction of embryonic and extraembryonic regions, vascular insufficiency in the intersomitic region, dilated vessels in the brain and embryonic lethality.

 

Gene Ontology (GO) classifications

All GO classifications: (40 annotations)

Process	actin cytoskeleton organization, blood vessel endothelial cell migration, ...
Component	actin filament, cell junction, ...
Function	angiostatin binding, protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (5 records)

Data Summary: Results (16)    Tissues (9)    Images (10)
Theiler Stages: 9, 10, 11, 13

Assay Type	Results
RNA in situ	16

cDNA source data(76)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(78) cDNA(76) Primer pair(1) Other(1)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000018901 (Evidence)
Ensembl Gene Model	ENSMUSG00000041688 (Evidence)
Entrez Gene	27494 (Evidence)
UniGene	100068
DFCI	TC1589947, TC1593880, TC1598293, TC1617179
DoTS	DT.101367985, DT.101715481
NIA Mouse Gene Index	U039763
Consensus CDS Project	CCDS72443.1
International Mouse Knockout Project Status	Amot

Sequences

Length	Strain/Species
genomic	OTTMUSG00000018901	VEGA Gene Model | MGI Sequence Detail	58757	C57BL/6J
transcript	OTTMUST00000045440	VEGA | MGI Sequence Detail	6364	Not Applicable
polypeptide	OTTMUSP00000020433	VEGA | MGI Sequence Detail	929	Not Applicable

All sequences(56) RefSeq(10) UniProt(4)

Polymorphisms

SNPs within 2kb(340 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR009114	Angiomotin
InterPro	IPR024646	Angiomotin, C-terminal
Protein Ontology	PR:000003998	angiomotin

References

(Earliest) J:44212 Kim SJ, et al., Cloning of novel trinucleotide-repeat (CAG) containing genes in mouse brain. Biochem Biophys Res Commun. 1997 Nov 7;240(1):239-43
(Latest) J:199829 Hirate Y, et al., Polarity-dependent distribution of angiomotin localizes Hippo signaling in preimplantation embryos. Curr Biol. 2013 Jul 8;23(13):1181-94
All references(45)

Other accession IDs

MGD-MRK-37484, MGI:2148071, MGI:2180948, MGI:2442022