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Amot
Gene Detail
Symbol

Name
ID
Amot
angiomotin
MGI:108440
Synonyms
D0Kist1, E230009N18Rik, mKIAA1071, Sii6
Feature Type
protein coding gene
Genetic Map
Chromosome X
66.72 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
ChrX:145446425-145505181 bp, - strand
From VEGA annotation of GRCm38

  58757 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:15778  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Amot

Human
homologs
Human Homolog AMOT, angiomotin
NCBI Gene ID 154796
neXtProt AC  NX_Q4VCS5
Human Chr (Location)  Xq23; chrX:112774877-112840908 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
 
Homozygotes for a null mutation exhibit impaired migration into proximal extraembryonic regions resulting in furrows of visceral endoderm at the junction of embryonic and extraembryonic regions, vascular insufficiency in the intersomitic region, dilated vessels in the brain and embryonic lethality.
 
Interactions
Amot interacts with 444 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (40 annotations)
Process actin cytoskeleton organization, blood vessel endothelial cell migration, ...
Component actin filament, cell junction, ...
Function angiostatin binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (16)    Tissues (9)    Images (10)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 16
cDNA source data(76)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(78) cDNA(76) Primer pair(1) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000018901 (Evidence)
Ensembl Gene ModelENSMUSG00000041688 (Evidence)
Entrez Gene27494 (Evidence)
UniGene100068
DFCITC1589947, TC1593880, TC1598293, TC1617179
DoTSDT.101367985, DT.101715481
NIA Mouse Gene IndexU039763
Consensus CDS ProjectCCDS72443.1
International Mouse Knockout Project StatusAmot
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018901 VEGA Gene Model | MGI Sequence Detail 58757 C57BL/6J ±  kb
transcript OTTMUST00000045440 VEGA | MGI Sequence Detail 6364 Not Applicable 
polypeptide OTTMUSP00000020433 VEGA | MGI Sequence Detail 929 Not Applicable 

For the selected sequences
All sequences(56) RefSeq(10) UniProt(4)
Polymorphisms
SNPs within 2kb(340 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR009114 Angiomotin
InterPro IPR024646 Angiomotin, C-terminal
Protein Ontology PR:000003998 angiomotin
References
(Earliest) J:44212 Kim SJ, et al., Cloning of novel trinucleotide-repeat (CAG) containing genes in mouse brain. Biochem Biophys Res Commun. 1997 Nov 7;240(1):239-43
(Latest) J:199829 Hirate Y, et al., Polarity-dependent distribution of angiomotin localizes Hippo signaling in preimplantation embryos. Curr Biol. 2013 Jul 8;23(13):1181-94
All references(45)
Other
accession IDs
MGD-MRK-37484, MGI:2148071, MGI:2180948, MGI:2442022

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory