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Amot Gene Detail
Summary
  • Symbol
    Amot
  • Name
    angiomotin
  • Synonyms
    D0Kist1, E230009N18Rik, mKIAA1071, Sii6
  • Feature Type
    protein coding gene
  • IDs
    MGI:108440
    NCBI Gene: 27494
  • Gene Overview
    MyGene.info: AMOT
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:145446425-145505181 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 66.72 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    341 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108440
 protein coding gene ChrX:145446424-145505533 (-)
129S1/SvImJ MGP_129S1SvImJ_G0036162
 protein coding gene ChrX:143003355-143062571 (-)
A/J MGP_AJ_G0036139
 protein coding gene ChrX:142332603-142392664 (-)
AKR/J MGP_AKRJ_G0036065
 protein coding gene ChrX:146970129-147035637 (-)
BALB/cJ MGP_BALBcJ_G0036130
 protein coding gene ChrX:140542701-140601359 (-)
C3H/HeJ MGP_C3HHeJ_G0035838
 protein coding gene ChrX:143129274-143189875 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036654
 protein coding gene ChrX:147044752-147105345 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033477
 protein coding gene ChrX:133820225-133878612 (-)
CAST/EiJ MGP_CASTEiJ_G0035129
 protein coding gene ChrX:123709067-123771028 (-)
CBA/J MGP_CBAJ_G0035815
 protein coding gene ChrX:151571528-151633760 (-)
DBA/2J MGP_DBA2J_G0035973
 protein coding gene ChrX:141391665-141450273 (-)
FVB/NJ MGP_FVBNJ_G0035907
 protein coding gene ChrX:140604361-140664063 (-)
LP/J MGP_LPJ_G0036064
 protein coding gene ChrX:143953345-144013106 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035943
 protein coding gene ChrX:159451339-159513573 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036690
 protein coding gene ChrX:142299242-142358185 (-)
PWK/PhJ MGP_PWKPhJ_G0034823
 protein coding gene ChrX:120459391-120518937 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034649
 protein coding gene ChrX:124265707-124326016 (-)
WSB/EiJ MGP_WSBEiJ_G0035264
 protein coding gene ChrX:140646991-140705690 (-)



Homology
more
  • Human Ortholog
    AMOT, angiomotin
  • Vertebrate Orthologs
    10
  • Human Ortholog
    AMOT, angiomotin
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 154796
    neXtProt AC: NX_Q4VCS5
    UniProt: Q4VCS5

  • Chr Location
    Xq23; chrX:112774877-112840946 (-)  GRCh38.p7
  • HomoloGene
    Vertebrate Homology Class 15778
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: AMOT
  • Gene Tree
    Amot
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 1 allele in 2 genetic backgrounds
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for a null mutation exhibit impaired migration into proximal extraembryonic regions resulting in furrows of visceral endoderm at the junction of embryonic and extraembryonic regions, vascular insufficiency in the intersomitic region, dilated vessels in the brain and embryonic lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    50
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    16
  • Tissues
    9
  • cDNA Data
    77
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000041688 Ensembl Gene Model | MGI Sequence Detail 58757 C57BL/6J ±  kb
    transcript ENSMUST00000112836 Ensembl | MGI Sequence Detail 6957 Not Applicable  
    polypeptide ENSMUSP00000108455 Ensembl | MGI Sequence Detail 1126 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 79
      cDNA 77
      Primer pair 1
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-37484, MGI:2148071, MGI:2180948, MGI:2442022
    References
    more
    • Summaries
      All 48
      Developmental Gene Expression 7
      Gene Ontology 9
      Phenotypes 5
    • Earliest
      J:44212 Kim SJ, et al., Cloning of novel trinucleotide-repeat (CAG) containing genes in mouse brain. Biochem Biophys Res Commun. 1997 Nov 7;240(1):239-43
    • Latest
      J:271884 Liu Y, et al., AMOT is required for YAP function in high glucose induced liver malignancy. Biochem Biophys Res Commun. 2018 Jan 1;495(1):1555-1561
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/15/2019
    MGI 6.14     		The Jackson Laboratory