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Arhgdig Gene Detail
Summary
  • Symbol
    Arhgdig
  • Name
    Rho GDP dissociation inhibitor (GDI) gamma
  • Synonyms
    Gdi5, Rho-GDI2, Rho-GDI-3, RIP2
  • Feature Type
    protein coding gene
  • IDs
    MGI:108430
    NCBI Gene: 14570
  • Gene Overview
    MyGene.info: ARHGDIG
Location & Maps
more
  • Sequence Map
    Chr17:26196226-26207786 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      11561 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 13.07 cM
Homology
more
  • Human Ortholog
    ARHGDIG, Rho GDP dissociation inhibitor gamma
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ARHGDIG, Rho GDP dissociation inhibitor gamma
    Orthology source: HomoloGene
  • Synonyms
    RHOGDI-3
  • Links
    NCBI Gene ID: 398
    neXtProt AC: NX_Q99819

  • Chr Location
    16p13.3; chr16:280606-283003 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    9 phenotype references
  • All Mutations and Alleles
    8
  • Gene trapped
    3
  • Radiation induced
    2
  • Targeted
    3
  • Genomic Mutations
    2 involving Arhgdig
  • Incidental Mutations
Homozygous null mice are fertile and exhibit no physical, behavioral, learning, or sleep abnormalities.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026505 VEGA Gene Model | MGI Sequence Detail 11561 C57BL/6J ±  kb
transcript OTTMUST00000103625 VEGA | MGI Sequence Detail 2511 Not Applicable  
polypeptide OTTMUSP00000057916 VEGA | MGI Sequence Detail 225 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    99 from dbSNP Build 142
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000004244 rho GDP-dissociation inhibitor 3
  • InterPro Domains
    IPR014756 Immunoglobulin E-set
    IPR024792 Rho GDP-dissociation inhibitor domain
    IPR000406 Rho protein GDP-dissociation inhibitor
Molecular
Reagents
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  • All nucleic 29
    cDNA 28
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-37474
References
more
  • Summaries
    All 29
    Developmental Gene Expression 4
    Gene Ontology 3
    Phenotypes 9
  • Earliest
    J:36812 Zalcman G, et al., RhoGDI-3 is a new GDP dissociation inhibitor (GDI). Identification of a non-cytosolic GDI protein interacting with the small GTP-binding proteins RhoB and RhoG. J Biol Chem. 1996 29;271(48):30366-74
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory