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Irag2 Gene Detail
Summary
  • Symbol
    Irag2
  • Name
    inositol 1,4,5-triphosphate receptor associated 2
  • Synonyms
    D6Int3, D6Int4, D6Int5, D6Int7, D6Int8, Jaw1, Lrmp
  • Feature Type
    protein coding gene
  • IDs
    MGI:108424
    NCBI Gene: 16970
  • Alliance
  • Transcription Start Sites
    16 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:145061379-145120660 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 77.34 cM
  • Mapping Data
    11 experiments
Strain
Comparison
more
  • SNPs within 2kb
    182 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108424
protein coding gene Chr6:145061357-145120660 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031476
protein coding gene Chr6:150089181-150158047 (+)
A/J MGP_AJ_G0031451
protein coding gene Chr6:144152427-144213366 (+)
AKR/J MGP_AKRJ_G0031379
protein coding gene Chr6:148451910-148510675 (+)
BALB/cJ MGP_BALBcJ_G0031458
protein coding gene Chr6:143910919-143970131 (+)
C3H/HeJ MGP_C3HHeJ_G0031180
protein coding gene Chr6:148481789-148543895 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031920
protein coding gene Chr6:154143988-154208703 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029044
protein coding gene Chr6:142902979-142963615 (+)
CAST/EiJ MGP_CASTEiJ_G0030548
protein coding gene Chr6:148097950-148166653 (+)
CBA/J MGP_CBAJ_G0031140
protein coding gene Chr6:159995262-160067761 (+)
DBA/2J MGP_DBA2J_G0031297
protein coding gene Chr6:142958393-143018317 (+)
FVB/NJ MGP_FVBNJ_G0031248
protein coding gene Chr6:141687969-141748780 (+)
LP/J MGP_LPJ_G0031381
protein coding gene Chr6:150191350-150256302 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031288
protein coding gene Chr6:163790721-163857557 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031952
protein coding gene Chr6:148281221-148343234 (+)
PWK/PhJ MGP_PWKPhJ_G0030275
protein coding gene Chr6:141408097-141520290 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030099
protein coding gene Chr6:146438999-146500038 (+)
WSB/EiJ MGP_WSBEiJ_G0030641
protein coding gene Chr6:148874366-148939464 (+)



Homology
more
  • Human Ortholog
    IRAG2, inositol 1,4,5-triphosphate receptor associated 2
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IRAG2, inositol 1,4,5-triphosphate receptor associated 2
  • Synonyms
    JAW1, LRMP
  • Links
    NCBI Gene ID: 4033
    neXtProt AC: NX_Q12912
    UniProt: Q12912

  • Chr Location
    12p12.1; chr12:25052101-25108335 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotype references
Variations (SNPs) in the coding region of the gene, observed between different strains, modify the sensitivity or resistance to induced lung adenomas.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000030263 Ensembl Gene Model | MGI Sequence Detail 59282 C57BL/6J ±  kb
transcript ENSMUST00000032396 Ensembl | MGI Sequence Detail 2319 Not Applicable  
polypeptide ENSMUSP00000032396 Ensembl | MGI Sequence Detail 539 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    14 Sequences
  • InterPro Domains
    IPR008677 MRVI1
Molecular
Reagents
less
  • All nucleic 31
    cDNA 31

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-37467, MGI:2141446
References
more
  • Summaries
    All 41
    Developmental Gene Expression 2
    Gene Ontology 6
    Phenotypes 8
  • Earliest
    J:35633 Behrens TW, et al., Jaw1, A lymphoid-restricted membrane protein localized to the endoplasmic reticulum. J Immunol. 1994 Jul 15;153(2):682-90
  • Latest
    J:287130 Kozono T, et al., Jaw1/LRMP has a role in maintaining nuclear shape via interaction with SUN proteins. J Biochem. 2018 Oct 1;164(4):303-311

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
07/27/2021
MGI 6.17
The Jackson Laboratory