Nrtn
Gene Detail

Symbol Name ID

Nrtn neurturin MGI:108417

Feature Type

protein coding gene

Genetic Map

Chromosome 17

29.49 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr17:56751325-56757530 bp, - strand From NCBI annotation of GRCm38   6206 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:7450  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 2 dog; 1 chicken

Gene Tree: Nrtn

Human homologs

Human Homolog		NRTN, neurturin
NCBI Gene ID		4902
neXtProt AC		NX_Q99748
Human Synonyms		NTN
Human Chr (Location)		19p13.3; chr19:5823818-5828335 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(7) : Targeted(3) Gene trapped(4)
 

Mice homozygous for disruptions of this gene have drooping, thickened eyelids which are a manifestation of abnormalities in the parasympathetic system.

 

Gene Ontology (GO) classifications

All GO classifications: (8 annotations)

Process	nerve development, neural crest cell migration, ...
Component	axon, extracellular region
Function	growth factor activity

External Resources: FuncBase

Expression

Literature Summary: (17 records)
Data Summary: Results (141)    Tissues (126)    Images (28)
Theiler Stages: 18, 19, 22, 23, 28

Assay Type	Results
RNA in situ	138
Western blot	1
RT-PCR	2

cDNA source data(18)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(23) Genomic(2) cDNA(18) Primer pair(2) Other(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000039481 (Evidence)
Entrez Gene	18188 (Evidence)
UniGene	8074
DFCI	TC1584575
DoTS	DT.60117390
NIA Mouse Gene Index	U037957
Consensus CDS Project	CCDS28913.1
International Mouse Knockout Project Status	Nrtn

Sequences

Length	Strain/Species
genomic	18188	NCBI Gene Model | MGI Sequence Detail	6206	C57BL/6J
transcript	NM_008738	RefSeq | MGI Sequence Detail	1023	C57BL/6
polypeptide	P97463	UniProt | EBI | MGI Sequence Detail	195	Not Applicable

All sequences(13) RefSeq(2) UniProt(1)

Polymorphisms

RFLP(1) : SNPs(3 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001839	Transforming growth factor-beta, C-terminal
Protein Ontology	PR:000011439	neurturin

Graphical View of Protein Domain Structure

References

(Earliest) J:40677 Kotzbauer PT, et al., Neurturin, a relative of glial-cell-line-derived neurotrophic factor. Nature. 1996 Dec 5;384(6608):467-70
(Latest) J:183370 Langsdorf A, et al., Neural crest cell origin and signals for intrinsic neurogenesis in the mammalian respiratory tract. Am J Respir Cell Mol Biol. 2011 Mar;44(3):293-301
All references(61)

Other accession IDs

MGD-MRK-37460