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Nrtn Gene Detail
Summary
  • Symbol
    Nrtn
  • Name
    neurturin
  • Feature Type
    protein coding gene
  • IDs
    MGI:108417
    NCBI Gene: 18188
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:56751325-56757530 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 29.49 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108417
protein coding gene Chr17:56751323-56757530 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023937
protein coding gene Chr17:58473496-58479451 (-)
A/J MGP_AJ_G0023895
protein coding gene Chr17:56867705-56873930 (-)
AKR/J MGP_AKRJ_G0023864
protein coding gene Chr17:57583791-57592486 (-)
BALB/cJ MGP_BALBcJ_G0023896
protein coding gene Chr17:56686110-56692101 (-)
C3H/HeJ MGP_C3HHeJ_G0023660
protein coding gene Chr17:58308407-58314621 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024342
protein coding gene Chr17:60735954-60743569 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021788
protein coding gene Chr17:53340767-53347142 (-)
CAST/EiJ MGP_CASTEiJ_G0023142
protein coding gene Chr17:58582606-58588805 (-)
CBA/J MGP_CBAJ_G0023636
protein coding gene Chr17:63120780-63126939 (-)
DBA/2J MGP_DBA2J_G0023764
protein coding gene Chr17:55567152-55573353 (-)
FVB/NJ MGP_FVBNJ_G0023730
protein coding gene Chr17:55122651-55128886 (-)
LP/J MGP_LPJ_G0023846
protein coding gene Chr17:59158181-59164382 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023758
protein coding gene Chr17:62592501-62599840 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024386
protein coding gene Chr17:57941973-57947930 (-)
PWK/PhJ MGP_PWKPhJ_G0022888
protein coding gene Chr17:54929220-54935594 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022699
protein coding gene Chr17:54702573-54708766 (-)
WSB/EiJ MGP_WSBEiJ_G0023208
protein coding gene Chr17:58554128-58564785 (-)



Homology
more
  • Human Ortholog
    NRTN, neurturin
  • Vertebrate Orthologs
    7
  • Human Ortholog
    NRTN, neurturin
    Orthology source: HGNC, HomoloGene
  • Synonyms
    NTN
  • Links
    NCBI Gene ID: 4902
    neXtProt AC: NX_Q99748
    UniProt: Q99748

  • Chr Location
    19p13.3; chr19:5805387-5828324 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    24 phenotypes from 1 allele in 1 genetic background
    4 phenotypes from multigenic genotypes
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions of this gene have drooping, thickened eyelids which are a manifestation of abnormalities in the parasympathetic system.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000039481 Ensembl Gene Model | MGI Sequence Detail 6206 C57BL/6J ±  kb
    transcript ENSMUST00000044752 Ensembl | MGI Sequence Detail 1023 Not Applicable  
    polypeptide ENSMUSP00000046512 Ensembl | MGI Sequence Detail 195 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 27
      Genomic 2
      cDNA 20
      Primer pair 4
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-37460
    References
    more
    • Summaries
      All 73
      Developmental Gene Expression 25
      Gene Ontology 5
      Phenotypes 21
    • Earliest
      J:40677 Kotzbauer PT, et al., Neurturin, a relative of glial-cell-line-derived neurotrophic factor. Nature. 1996 Dec 5;384(6608):467-70
    • Latest
      J:257654 Memic F, et al., Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System. Gastroenterology. 2018 Feb;154(3):624-636

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    Funding Information
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    last database update
    12/11/2018
    MGI 6.13
    The Jackson Laboratory