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Nrtn
Gene Detail
Symbol

Name
ID
Nrtn
neurturin
MGI:108417
Feature Type
protein coding gene
Genetic Map
Chromosome 17
29.49 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr17:56751325-56757530 bp, - strand
From Ensembl annotation of GRCm38

  6206 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7450  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: NRTN
Gene Tree: Nrtn

Human
homologs
NRTN, neurturin
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 4902
neXtProt AC: NX_Q99748

Human Synonyms: NTN

Human Chr (Location): 19p13.3; chr19:5805359-5828324 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(4) Targeted(3)
Incidental mutations (data from APF )
 
Mice homozygous for disruptions of this gene have drooping, thickened eyelids which are a manifestation of abnormalities in the parasympathetic system.
 
Interactions
Nrtn interacts with 17 markers (Mir98, Mir188, Mir202, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process nerve development, neural crest cell migration, ...
Component axon, extracellular region
Function growth factor activity
External Resources: FuncBase
Expression
Literature Summary: (18 records)
Data Summary: Results (141)    Tissues (126)    Images (28)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 138
Western blot 1
RT-PCR 2
cDNA source data(18)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(23) Genomic(2) cDNA(18) Primer pair(2) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000039481 (Evidence)
Entrez Gene 18188 (Evidence)
UniGene 8074
DFCI TC1584575
DoTS DT.60117390
NIA Mouse Gene Index U037957
Consensus CDS Project CCDS28913.1
International Mouse Phenotyping Consortium Status Nrtn
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000039481 Ensembl Gene Model | MGI Sequence Detail 6206 C57BL/6J ±  kb
transcript ENSMUST00000044752 Ensembl | MGI Sequence Detail 1023 Not Applicable 
polypeptide ENSMUSP00000046512 Ensembl | MGI Sequence Detail 195 Not Applicable 

For the selected sequences
All sequences(15) RefSeq(4) UniProt(1)
Polymorphisms
RFLP(1) : SNPs within 2kb(3 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001839 Transforming growth factor-beta, C-terminal
Protein Ontology PR:000011439 neurturin
References
(Earliest) J:40677 Kotzbauer PT, et al., Neurturin, a relative of glial-cell-line-derived neurotrophic factor. Nature. 1996 Dec 5;384(6608):467-70
(Latest) J:217097 Fonseca-Pereira D, et al., The neurotrophic factor receptor RET drives haematopoietic stem cell survival and function. Nature. 2014 Oct 2;514(7520):98-101
All references(63)
Other
accession IDs
MGD-MRK-37460

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory