About   Help   FAQ
Nrtn
Gene Detail
 Symbol
Name
ID
Nrtn
neurturin
MGI:108417
Feature Type protein coding gene
Genetic Map
Chromosome 17
29.49 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr17:56751325-56757530 bp, - strand
From NCBI annotation of GRCm38

  6206 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7450  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Nrtn

Human
homologs
Human Homolog NRTN, neurturin
NCBI Gene ID 4902
neXtProt AC  NX_Q99748
Human Synonyms  NTN
Human Chr (Location)  19p13.3; chr19:5823807-5828324 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(4) Targeted(3)
Incidental mutations (data from APF )
 
Mice homozygous for disruptions of this gene have drooping, thickened eyelids which are a manifestation of abnormalities in the parasympathetic system.
 
Interactions
Nrtn interacts with 17 markers (Mir98, Mir188, Mir202, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process nerve development, neural crest cell migration, ...
Component axon, extracellular region
Function growth factor activity
External Resources: FuncBase
Expression
Literature Summary: (17 records)
Data Summary: Results (141)    Tissues (126)    Images (28)
Theiler Stages: 18, 19, 22, 23, 28
Assay TypeResults
RNA in situ 138
Western blot 1
RT-PCR 2
cDNA source data(18)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(23) Genomic(2) cDNA(18) Primer pair(2) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000039481 (Evidence)
Entrez Gene18188 (Evidence)
UniGene8074
DFCITC1584575
DoTSDT.60117390
NIA Mouse Gene IndexU037957
Consensus CDS ProjectCCDS28913.1
International Mouse Knockout Project StatusNrtn
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 18188 NCBI Gene Model | MGI Sequence Detail 6206 C57BL/6J ±  kb
transcript NM_008738 RefSeq | MGI Sequence Detail 1023 C57BL/6 
polypeptide P97463 UniProt | EBI | MGI Sequence Detail 195 Not Applicable 

For the selected sequences
All sequences(15) RefSeq(4) UniProt(1)
Polymorphisms RFLP(1) : SNPs within 2kb(3 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001839 Transforming growth factor-beta, C-terminal
Protein Ontology PR:000011439 neurturin
Graphical View of Protein Domain Structure
References (Earliest) J:40677 Kotzbauer PT, et al., Neurturin, a relative of glial-cell-line-derived neurotrophic factor. Nature. 1996 Dec 5;384(6608):467-70
(Latest) J:202753 Uesaka T, et al., GDNF signaling levels control migration and neuronal differentiation of enteric ganglion precursors. J Neurosci. 2013 Oct 9;33(41):16372-82
All references(63)
Other
accession IDs
MGD-MRK-37460

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/19/2014
MGI 5.19
The Jackson Laboratory