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Pafah1b3 Gene Detail
Summary
  • Symbol
    Pafah1b3
  • Name
    platelet-activating factor acetylhydrolase, isoform 1b, subunit 3
  • Synonyms
    mus[g], Pafahg
  • Feature Type
    protein coding gene
  • IDs
    MGI:108414
    NCBI Gene: 18476
  • Gene Overview
    MyGene.info: PAFAH1B3
Location & Maps
more
  • Sequence Map
    Chr7:25295049-25297986 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      2938 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 13.73 cM, cytoband A3
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    PAFAH1B3, platelet activating factor acetylhydrolase 1b catalytic subunit 3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PAFAH1B3, platelet activating factor acetylhydrolase 1b catalytic subunit 3
    Orthology source: HGNC, HomoloGene
  • Synonyms
    PAFAHG
  • Links
    NCBI Gene ID: 5050
    neXtProt AC: NX_Q15102

  • Chr Location
    19q13.1; chr19:42297033-42302800 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    15 phenotypes from multigenic genotypes
    2 images
    9 phenotype references
Homozygous null mice of both sexes are viable and fertile. However, in combination with homozygous disruptions in Pafah1b2, males become infertile.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023231 VEGA Gene Model | MGI Sequence Detail 2938 C57BL/6J ±  kb
transcript OTTMUST00000056245 VEGA | MGI Sequence Detail 901 Not Applicable  
polypeptide OTTMUSP00000027005 VEGA | MGI Sequence Detail 232 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    16 from dbSNP Build 142
Protein
Information
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  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000012229 platelet-activating factor acetylhydrolase IB subunit gamma
  • EC
  • InterPro Domains
    IPR013830 SGNH hydrolase-type esterase domain
Molecular
Reagents
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  • All nucleic 116
    cDNA 113
    Primer pair 3

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-37457
References
more
  • Summaries
    All 46
    Developmental Gene Expression 10
    Gene Ontology 7
    Phenotypes 9
  • Earliest
    J:37333 Albrecht U, et al., Platelet-activating factor acetylhydrolase expression and activity suggest a link between neuronal migration and platelet-activating factor. Dev Biol. 1996 Dec 15;180(2):579-93
  • Latest
    J:197131 Lanctot AA, et al., Spatially dependent dynamic MAPK modulation by the nde1-lis1-brap complex patterns Mammalian CNS. Dev Cell. 2013 May 13;25(3):241-55

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory