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Pafah1b3 Gene Detail
Summary
  • Symbol
    Pafah1b3
  • Name
    platelet-activating factor acetylhydrolase, isoform 1b, subunit 3
  • Synonyms
    mus[g], PAF-AH alpha1, Pafahg
  • Feature Type
    protein coding gene
  • IDs
    MGI:108414
    NCBI Gene: 18476
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:24994473-24997377 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 13.73 cM, cytoband A3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    16 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108414
 protein coding gene Chr7:24994473-24997411 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031860
 protein coding gene Chr7:23749937-23752861 (-)
A/J MGP_AJ_G0031839
 protein coding gene Chr7:23141300-23144233 (-)
AKR/J MGP_AKRJ_G0031768
 protein coding gene Chr7:23682740-23685636 (-)
BALB/cJ MGP_BALBcJ_G0031846
 protein coding gene Chr7:23354933-23357861 (-)
C3H/HeJ MGP_C3HHeJ_G0031565
 protein coding gene Chr7:24118179-24121075 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032308
 protein coding gene Chr7:24545596-24548492 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029363
 protein coding gene Chr7:24562884-24565735 (-)
CAST/EiJ MGP_CASTEiJ_G0030905
 protein coding gene Chr7:17583921-17590040 (-)
CBA/J MGP_CBAJ_G0031530
 protein coding gene Chr7:25461983-25464879 (-)
DBA/2J MGP_DBA2J_G0031684
 protein coding gene Chr7:23042627-23045552 (-)
FVB/NJ MGP_FVBNJ_G0031637
 protein coding gene Chr7:23044666-23047562 (-)
LP/J MGP_LPJ_G0031763
 protein coding gene Chr7:24056194-24059090 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031674
 protein coding gene Chr7:25165355-25168251 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032340
 protein coding gene Chr7:23390205-23393156 (-)
PWK/PhJ MGP_PWKPhJ_G0030629
 protein coding gene Chr7:17981590-17984941 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030460
 protein coding gene Chr7:14702048-14706825 (-)
WSB/EiJ MGP_WSBEiJ_G0031008
 protein coding gene Chr7:23567583-23570479 (-)



Homology
more
  • Human Ortholog
    PAFAH1B3, platelet activating factor acetylhydrolase 1b catalytic subunit 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PAFAH1B3, platelet activating factor acetylhydrolase 1b catalytic subunit 3
  • Synonyms
    PAFAHG
  • Links
    NCBI Gene ID: 5050
    neXtProt AC: NX_Q15102
    UniProt: Q15102

  • Chr Location
    19q13.2; chr19:42297033-42303546 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    16 phenotypes from multigenic genotypes
    2 images
    10 phenotype references
Homozygous null mice of both sexes are viable and fertile. However, in combination with homozygous disruptions in Pafah1b2, males become infertile.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    21
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    994
  • Tissues
    217
  • cDNA Data
    115
  • Literature Summary
    11
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 18476 NCBI Gene Model | MGI Sequence Detail 2905 C57BL/6J ±  kb
transcript NM_001357350 RefSeq | MGI Sequence Detail 1239 C57BL/6  
polypeptide Q61205 UniProt | EBI | MGI Sequence Detail 232 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 118
    cDNA 115
    Primer pair 3

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-37457
References
more
  • Summaries
    All 48
    Developmental Gene Expression 11
    Gene Ontology 8
    Phenotypes 10
  • Earliest
    J:37333 Albrecht U, et al., Platelet-activating factor acetylhydrolase expression and activity suggest a link between neuronal migration and platelet-activating factor. Dev Biol. 1996 Dec 15;180(2):579-93
  • Latest
    J:197131 Lanctot AA, et al., Spatially dependent dynamic MAPK modulation by the nde1-lis1-brap complex patterns Mammalian CNS. Dev Cell. 2013 May 13;25(3):241-55
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory