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Pde1c Gene Detail
Summary
  • Symbol
    Pde1c
  • Name
    phosphodiesterase 1C
  • Feature Type
    protein coding gene
  • IDs
    MGI:108413
    NCBI Gene: 18575
  • Gene Overview
    MyGene.info: PDE1C
Location & Maps
more
  • Sequence Map
    Chr6:56069804-56569103 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      499300 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 27.65 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    PDE1C, phosphodiesterase 1C
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PDE1C, phosphodiesterase 1C
    Orthology source: HomoloGene, HGNC
  • Synonyms
    cam-PDE 1C, hCam-3, Hcam3
  • Links
    NCBI Gene ID: 5137
    neXtProt AC: NX_Q14123

  • Chr Location
    7p14.3; chr7:31616777-32299404 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    2 phenotypes from multigenic genotypes
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Olfactory sensory nerves from homozygous null mice have significantly reduced action potentials in response to odor with slower onset kinetics and a faster response termination.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023509 VEGA Gene Model | MGI Sequence Detail 499300 C57BL/6J ±  kb
transcript OTTMUST00000141813 VEGA | MGI Sequence Detail 3147 Not Applicable  
polypeptide OTTMUSP00000074040 VEGA | MGI Sequence Detail 766 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    5444 from dbSNP Build 142
Protein
Information
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  • UniProt
    8 Sequences
  • Protein Ontology
    PR:000012468 calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C
  • EC
  • InterPro Domains
    IPR023088 3'5'-cyclic nucleotide phosphodiesterase
    IPR002073 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
    IPR023174 3'5'-cyclic nucleotide phosphodiesterase, conserved site
    IPR013706 3'5'-cyclic nucleotide phosphodiesterase N-terminal
    IPR003607 HD/PDEase domain
Molecular
Reagents
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  • All nucleic 43
    cDNA 40
    Primer pair 2
    Other 1

    Microarray probesets 8
Other
Accession IDs
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MGD-MRK-37456
References
more
  • Summaries
    All 37
    Developmental Gene Expression 7
    Gene Ontology 6
    Phenotypes 4
  • Earliest
    J:37553 Yan C, et al., Molecular cloning and characterization of a calmodulin-dependent phosphodiesterase enriched in olfactory sensory neurons. Proc Natl Acad Sci U S A. 1995 Oct 10;92(21):9677-81
  • Latest
    J:174459 Boyle MP, et al., Cell-type-specific consequences of Reelin deficiency in the mouse neocortex, hippocampus, and amygdala. J Comp Neurol. 2011 Aug 1;519(11):2061-89

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory