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Plpp1 Gene Detail
Summary
  • Symbol
    Plpp1
  • Name
    phospholipid phosphatase 1
  • Synonyms
    Hpic53, Lipid phosphate phosphatase 1, LPP1, LPP-1, mPAP, Ppap2a
  • Feature Type
    protein coding gene
  • IDs
    MGI:108412
    NCBI Gene: 19012
  • Alliance
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:112937326-113004428 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 13, 63.93 cM, cytoband D2.2
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    763 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108412
protein coding gene Chr13:112937311-113004428 (+)
129S1/SvImJ MGP_129S1SvImJ_G0020940
protein coding gene Chr13:115377447-115455601 (+)
A/J MGP_AJ_G0020890
protein coding gene Chr13:110776809-110845681 (+)
AKR/J MGP_AKRJ_G0020865
protein coding gene Chr13:114118331-114192029 (+)
BALB/cJ MGP_BALBcJ_G0020890
protein coding gene Chr13:111473597-111541177 (+)
C3H/HeJ MGP_C3HHeJ_G0020679
protein coding gene Chr13:113916654-113987591 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021326
protein coding gene Chr13:118809831-118880630 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018895
protein coding gene Chr13:106073564-106139572 (+)
CAST/EiJ MGP_CASTEiJ_G0020199
protein coding gene Chr13:113540337-113616641 (+)
CBA/J MGP_CBAJ_G0020641
protein coding gene Chr13:123405703-123483090 (+)
DBA/2J MGP_DBA2J_G0020764
protein coding gene Chr13:110489973-110557403 (+)
FVB/NJ MGP_FVBNJ_G0020748
protein coding gene Chr13:109184342-109253366 (+)
LP/J MGP_LPJ_G0020840
protein coding gene Chr13:115429037-115498636 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020776
protein coding gene Chr13:123668924-123736098 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021362
protein coding gene Chr13:113579946-113654174 (+)
PWK/PhJ MGP_PWKPhJ_G0019952
protein coding gene Chr13:109230745-109305974 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019774
protein coding gene Chr13:109898753-109969658 (+)
WSB/EiJ MGP_WSBEiJ_G0020256
protein coding gene Chr13:114175974-114252354 (+)



Homology
more
  • Human Ortholog
    PLPP1, phospholipid phosphatase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PLPP1, phospholipid phosphatase 1
  • Synonyms
    LLP1a, LPP1, PAP2, PAP-2a, PPAP2A
  • Links
    NCBI Gene ID: 8611
    neXtProt AC: NX_O14494
    UniProt: O14494

  • Chr Location
    5q11.2; chr5:55424854-55534969 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a hypomorphic allele are viable and fertile with elevated plasma levels of lysophosphatidic acid.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000021759 Ensembl Gene Model | MGI Sequence Detail 67103 C57BL/6J ±  kb
    transcript ENSMUST00000016144 Ensembl | MGI Sequence Detail 1598 Not Applicable  
    polypeptide ENSMUSP00000016144 Ensembl | MGI Sequence Detail 284 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 47
      cDNA 46
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-26084, MGD-MRK-37455, MGI:104646
    References
    more
    • Summaries
      All 47
      Developmental Gene Expression 5
      Gene Ontology 12
      Phenotypes 10
    • Earliest
      J:28807 Egawa K, et al., Isolation of a novel ras-recision gene that is induced by hydrogen peroxide from a mouse osteoblastic cell line, MC3T3-E1. FEBS Lett. 1995 Sep 18;372(1):74-7
    • Latest
      J:325730 Ahuja N, et al., Endothelial Cyp26b1 restrains murine heart valve growth during development. Dev Biol. 2022 Jun;486:81-95

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory