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Plpp1 Gene Detail
Summary
  • Symbol
    Plpp1
  • Name
    phospholipid phosphatase 1
  • Synonyms
    Hpic53, Lipid phosphate phosphatase 1, LPP1, LPP-1, mPAP, Ppap2a
  • Feature Type
    protein coding gene
  • IDs
    MGI:108412
    NCBI Gene: 19012
Location & Maps
more
  • Sequence Map
    Chr13:112800894-112867881 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      66988 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 63.93 cM, cytoband D2.2
  • Mapping Data
    1 experiment
Homology
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Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    36
  • Gene trapped
    34
  • Targeted
    2
  • Incidental Mutations
Mice homozygous for a hypomorphic allele are viable and fertile with elevated plasma levels of lysophosphatidic acid.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000021759 Ensembl Gene Model | MGI Sequence Detail 66988 C57BL/6J ±  kb
transcript ENSMUST00000016144 Ensembl | MGI Sequence Detail 1483 Not Applicable  
polypeptide ENSMUSP00000016144 Ensembl | MGI Sequence Detail 284 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    763 from dbSNP Build 142
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000013051 phospholipid phosphatase 1
  • EC
  • InterPro Domains
    IPR028670 Lipid phosphate phosphohydrolase 1
    IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase
Molecular
Reagents
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  • All nucleic 45
    cDNA 45

    Microarray probesets 6
Other
Accession IDs
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MGD-MRK-26084, MGD-MRK-37455, MGI:104646
References
more
  • Summaries
    All 35
    Developmental Gene Expression 3
    Gene Ontology 6
    Phenotypes 8
  • Earliest
    J:28807 Egawa K, et al., Isolation of a novel ras-recision gene that is induced by hydrogen peroxide from a mouse osteoblastic cell line, MC3T3-E1. FEBS Lett. 1995 Sep 18;372(1):74-7
  • Latest
    J:228403 Nakayama J, et al., Decreased peritoneal ovarian cancer growth in mice lacking expression of lipid phosphate phosphohydrolase 1. PLoS One. 2015;10(3):e0120071

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory