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Prkag1 Gene Detail
Summary
  • Symbol
    Prkag1
  • Name
    protein kinase, AMP-activated, gamma 1 non-catalytic subunit
  • Synonyms
    Prkaac
  • Feature Type
    protein coding gene
  • IDs
    MGI:108411
    NCBI Gene: 19082
  • Gene Overview
    MyGene.info: PRKAG1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr15:98812798-98831508 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      18711 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 54.73 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    PRKAG1, protein kinase AMP-activated non-catalytic subunit gamma 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PRKAG1, protein kinase AMP-activated non-catalytic subunit gamma 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AMPKG
  • Links
    NCBI Gene ID: 5571
    neXtProt AC: NX_P54619
    UniProt: P54619

  • Chr Location
    12q13.12; chr12:49002272-49018975 (-)  GRCh38.p7

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    26 phenotypes from 1 allele in 1 genetic background
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit hemolytic anemia, extramedullary hematopoiesis, and iron accumulation in the spleen, liver, and Kupffer cells.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000067713 Ensembl Gene Model | MGI Sequence Detail 18711 C57BL/6J ±  kb
transcript ENSMUST00000168846 Ensembl | MGI Sequence Detail 1638 Not Applicable  
polypeptide ENSMUSP00000132499 Ensembl | MGI Sequence Detail 330 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    87 from dbSNP Build 142
Protein
Information
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Molecular
Reagents
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  • All nucleic 116
    cDNA 113
    Primer pair 1
    Other 2

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-37454, MGI:2145917, MGI:2146255
References
more
  • Summaries
    All 57
    Developmental Gene Expression 4
    Diseases 1
    Gene Ontology 5
    Phenotypes 29
  • Earliest
    J:13437 Bangham JW, Hairy ears, Eh. Mouse News Lett. 1965;33:68
  • Latest
    J:241401 Bultot L, et al., Benzimidazole derivative small-molecule 991 enhances AMPK activity and glucose uptake induced by AICAR or contraction in skeletal muscle. Am J Physiol Endocrinol Metab. 2016 Oct 01;311(4):E706-E719

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/07/2017
MGI 6.11
The Jackson Laboratory