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Prkag1 Gene Detail
Summary
  • Symbol
    Prkag1
  • Name
    protein kinase, AMP-activated, gamma 1 non-catalytic subunit
  • Synonyms
    Prkaac
  • Feature Type
    protein coding gene
  • IDs
    MGI:108411
    NCBI Gene: 19082
  • Gene Overview
    MyGene.info: PRKAG1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr15:98812797-98831508 bp, - strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      18712 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 54.73 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    PRKAG1, protein kinase AMP-activated non-catalytic subunit gamma 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PRKAG1, protein kinase AMP-activated non-catalytic subunit gamma 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AMPKG
  • Links
    NCBI Gene ID: 5571
    neXtProt AC: NX_P54619
    UniProt: P54619

  • Chr Location
    12q13.12; chr12:49002272-49018975 (-)  GRCh38.p7

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    26 phenotypes from 1 allele in 1 genetic background
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit hemolytic anemia, extramedullary hematopoiesis, and iron accumulation in the spleen, liver, and Kupffer cells.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 19082 NCBI Gene Model | MGI Sequence Detail 18712 C57BL/6J ±  kb
    transcript NM_016781 RefSeq | MGI Sequence Detail 1680 C57BL/6  
    polypeptide O54950 UniProt | EBI | MGI Sequence Detail 330 Not Applicable  
    For the selected sequence
    Polymorphisms
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    • SNPs within 2kb
      87 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 117
      cDNA 114
      Primer pair 1
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-37454, MGI:2145917, MGI:2146255
    References
    more
    • Summaries
      All 64
      Developmental Gene Expression 4
      Diseases 1
      Gene Ontology 6
      Phenotypes 30
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:252248 Laker RC, et al., Ampk phosphorylation of Ulk1 is required for targeting of mitochondria to lysosomes in exercise-induced mitophagy. Nat Commun. 2017 Sep 15;8(1):548

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    10/09/2018
    MGI 6.12
    The Jackson Laboratory