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Ptpn18 Gene Detail
Summary
  • Symbol
    Ptpn18
  • Name
    protein tyrosine phosphatase, non-receptor type 18
  • Synonyms
    FLP1, HSCF, PTP-HSCF, Ptpk1, PTP-K1
  • Feature Type
    protein coding gene
  • IDs
    MGI:108410
    NCBI Gene: 19253
  • Gene Overview
    MyGene.info: PTPN18
  • Alliance
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:34498843-34514814 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 13.25 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    26 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108410
protein coding gene Chr1:34498810-34514814 (+)
129S1/SvImJ MGP_129S1SvImJ_G0015909
protein coding gene Chr1:32847094-32866294 (+)
A/J MGP_AJ_G0015893
protein coding gene Chr1:32062679-32079062 (+)
AKR/J MGP_AKRJ_G0015849
protein coding gene Chr1:32450248-32466031 (+)
BALB/cJ MGP_BALBcJ_G0015847
protein coding gene Chr1:31711520-31727659 (+)
C3H/HeJ MGP_C3HHeJ_G0015681
protein coding gene Chr1:32647965-32664658 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016300
protein coding gene Chr1:34340196-34362142 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014022
protein coding gene Chr1:29223386-29239456 (+)
CAST/EiJ MGP_CASTEiJ_G0015261
protein coding gene Chr1:32504321-32522528 (+)
CBA/J MGP_CBAJ_G0015652
protein coding gene Chr1:35295943-35313813 (+)
DBA/2J MGP_DBA2J_G0015753
protein coding gene Chr1:31386686-31402737 (+)
FVB/NJ MGP_FVBNJ_G0015755
protein coding gene Chr1:30937447-30955849 (+)
LP/J MGP_LPJ_G0015823
protein coding gene Chr1:33186056-33206630 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0015775
protein coding gene Chr1:37546176-37570110 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016347
protein coding gene Chr1:32438000-32457322 (+)
PWK/PhJ MGP_PWKPhJ_G0015044
protein coding gene Chr1:31117220-31133500 (+)
SPRET/EiJ MGP_SPRETEiJ_G0014827
protein coding gene Chr1:32417110-32434019 (+)
WSB/EiJ MGP_WSBEiJ_G0015323
protein coding gene Chr1:32422797-32438666 (+)



Homology
more
  • Human Ortholog
    PTPN18, protein tyrosine phosphatase non-receptor type 18
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PTPN18, protein tyrosine phosphatase non-receptor type 18
  • Synonyms
    BDP1, PTP-HSCF
  • Links
    NCBI Gene ID: 26469
    neXtProt AC: NX_Q99952
    UniProt: Q99952

  • Chr Location
    2q21.1; chr2:130356007-130375409 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000026126 Ensembl Gene Model | MGI Sequence Detail 15972 C57BL/6J ±  kb
transcript ENSMUST00000027302 Ensembl | MGI Sequence Detail 1559 Not Applicable  
polypeptide ENSMUSP00000027302 Ensembl | MGI Sequence Detail 453 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000013453 tyrosine-protein phosphatase non-receptor type 18
  • EC
  • InterPro Domains
    IPR016130 Protein-tyrosine phosphatase, active site
    IPR003595 Protein-tyrosine phosphatase, catalytic
    IPR029021 Protein-tyrosine phosphatase-like
    IPR000242 Tyrosine-specific protein phosphatase, PTPase domain
    IPR000387 Tyrosine-specific protein phosphatases domain
Molecular
Reagents
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  • All nucleic 19
    Genomic 1
    cDNA 15
    Primer pair 3

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-37453
References
more
  • Summaries
    All 37
    Developmental Gene Expression 6
    Gene Ontology 8
    Phenotypes 7
  • Earliest
    J:36011 Huang K, et al., Cloning and characterization of PTP-K1, a novel nonreceptor protein tyrosine phosphatase highly expressed in bone marrow. Oncogene. 1996 Oct 3;13(7):1567-73
  • Latest
    J:244597 Cui W, et al., Towards Functional Annotation of the Preimplantation Transcriptome: An RNAi Screen in Mammalian Embryos. Sci Rep. 2016 Nov 21;6:37396

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
01/18/2022
MGI 6.17
The Jackson Laboratory