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Rgs4 Gene Detail
Summary
  • Symbol
    Rgs4
  • Name
    regulator of G-protein signaling 4
  • Synonyms
    ESTM48, ESTM50
  • Feature Type
    protein coding gene
  • IDs
    MGI:108409
    NCBI Gene: 19736
  • Gene Overview
    MyGene.info: RGS4
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:169741477-169747642 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 76.84 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    99 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108409
protein coding gene Chr1:169741477-169747642 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016721
protein coding gene Chr1:175396995-175403181 (-)
A/J MGP_AJ_G0016701
protein coding gene Chr1:168226720-168233231 (-)
AKR/J MGP_AKRJ_G0016667
protein coding gene Chr1:173322282-173328444 (-)
BALB/cJ MGP_BALBcJ_G0016662
protein coding gene Chr1:168734514-168740688 (-)
C3H/HeJ MGP_C3HHeJ_G0016486
protein coding gene Chr1:173557445-173563991 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017123
protein coding gene Chr1:181221884-181228034 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014832
protein coding gene Chr1:160011470-160017618 (-)
CAST/EiJ MGP_CASTEiJ_G0016066
protein coding gene Chr1:173173040-173179265 (-)
CBA/J MGP_CBAJ_G0016461
protein coding gene Chr1:187663869-187670043 (-)
DBA/2J MGP_DBA2J_G0016567
protein coding gene Chr1:167113683-167119904 (-)
FVB/NJ MGP_FVBNJ_G0016565
protein coding gene Chr1:165497945-165504130 (-)
LP/J MGP_LPJ_G0016638
protein coding gene Chr1:176458392-176464573 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016590
protein coding gene Chr1:194983714-194989928 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017160
protein coding gene Chr1:173194911-173201097 (-)
PWK/PhJ MGP_PWKPhJ_G0015852
protein coding gene Chr1:166325919-166335752 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015638
protein coding gene Chr1:171965170-171971343 (-)
WSB/EiJ MGP_WSBEiJ_G0016128
protein coding gene Chr1:173310279-173316461 (-)



Homology
more
  • Human Ortholog
    RGS4, regulator of G protein signaling 4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RGS4, regulator of G protein signaling 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    RGP4, SCZD9
  • Links
    NCBI Gene ID: 5999
    neXtProt AC: NX_P49798
    UniProt: P49798

  • Chr Location
    1q23.3; chr1:163068606-163076802 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    22 phenotypes from 5 alleles in 6 genetic backgrounds
    17 phenotypes from multigenic genotypes
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for one null allele display background dependent partially penetrant embryonic lethality, decreased body weight, and mildly impaired coordination. Another allele displays increased cholesterol levels in males. Mice homozygous for a different null allele exhibit no normal phenotype.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 19736 NCBI Gene Model | MGI Sequence Detail 6166 C57BL/6J ±  kb
    transcript NM_009062 RefSeq | MGI Sequence Detail 2952 C57BL/6  
    polypeptide O08899 UniProt | EBI | MGI Sequence Detail 205 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 57
      cDNA 53
      Primer pair 4

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-37452, MGI:1334420, MGI:1334426
    References
    more
    • Summaries
      All 76
      Developmental Gene Expression 21
      Gene Ontology 4
      Phenotypes 19
    • Earliest
      J:36569 Chen CK, et al., RGS-r, a retinal specific RGS protein, binds an intermediate conformation of transducin and enhances recycling. Proc Natl Acad Sci U S A. 1996 Nov 12;93(23):12885-9
    • Latest
      J:259070 Tischfield DJ, et al., Loss of the neurodevelopmental gene Zswim6 alters striatal morphology and motor regulation. Neurobiol Dis. 2017 Jul;103:174-183

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory