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Rgs4
Gene Detail
 Symbol
Name
ID
Rgs4
regulator of G-protein signaling 4
MGI:108409
Synonyms ESTM48, ESTM50
Feature Type protein coding gene
Genetic Map
Chromosome 1
76.84 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr1:169741477-169747642 bp, - strand
From VEGA annotation of GRCm38

  6166 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4100  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: regulator of G protein signaling, RGS4 type
Gene Tree: Rgs4

Human
homologs
Human Homolog RGS4, regulator of G-protein signaling 4
NCBI Gene ID 5999
neXtProt AC  NX_P49798
Human Synonyms  RGP4, SCZD9
Human Chr (Location)  1q23.3; chr1:163068606-163076802 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Targeted(7)
Incidental mutations (data from APF )
 
Mice homozygous for one null allele display background dependent partially penetrant embryonic lethality, decreased body weight, and mildly impaired coordination. Another allele displays increased cholesterol levels in males. Mice homozygous for a different null allele exhibit no normal phenotype.
 
Interactions
Rgs4 interacts with 354 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process G-protein coupled receptor signaling pathway, negative regulation of G-protein coupled receptor protein signaling pathway, ...
Component cytoplasm, cytosol, ...
Function G-protein alpha-subunit binding, GTPase activator activity
External Resources: FuncBase
Expression
Literature Summary: (16 records)
Data Summary: Results (380)    Tissues (126)    Images (122)
Theiler Stages: 18, 19, 20, 21, 23, 26, 28
Assay TypeResults
RNA in situ 247
In situ reporter (knock in) 90
Northern blot 5
RT-PCR 38
cDNA source data(50)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(54) cDNA(51) Primer pair(3)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000020909 (Evidence)
Ensembl Gene ModelENSMUSG00000038530 (Evidence)
Entrez Gene19736 (Evidence)
UniGene41642
DFCITC1575659, TC1588279, TC1669298
DoTSDT.101377126, DT.483806, DT.94141342
NIA Mouse Gene IndexU022025
Consensus CDS ProjectCCDS15465.1
International Mouse Knockout Project StatusRgs4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020909 VEGA Gene Model | MGI Sequence Detail 6166 C57BL/6J ±  kb
transcript OTTMUST00000049422 VEGA | MGI Sequence Detail 2941 Not Applicable 
polypeptide OTTMUSP00000022896 VEGA | MGI Sequence Detail 205 Not Applicable 

For the selected sequences
All sequences(41) RefSeq(4) UniProt(3)
Polymorphisms RFLP(1) : SNPs within 2kb(100 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR024066 Regulator of G-protein signaling, domain 1
InterPro IPR000342 Regulator of G protein signalling
InterPro IPR016137 Regulator of G protein signalling superfamily
Protein Ontology PR:000013959 regulator of G-protein signaling 4
References (Earliest) J:36569 Chen CK, et al., RGS-r, a retinal specific RGS protein, binds an intermediate conformation of transducin and enhances recycling. Proc Natl Acad Sci U S A. 1996 Nov 12;93(23):12885-9
(Latest) J:209527 Wydeven N, et al., RGS6, but not RGS4, is the dominant regulator of G protein signaling (RGS) modulator of the parasympathetic regulation of mouse heart rate. J Biol Chem. 2014 Jan 24;289(4):2440-9
All references(68)
Other
accession IDs
MGD-MRK-37452, MGI:1334420, MGI:1334426

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory