Rgs4
Gene Detail

Symbol Name ID

Rgs4 regulator of G-protein signaling 4 MGI:108409

Synonyms

ESTM48, ESTM50

Feature Type

protein coding gene

Genetic Map

Chromosome 1

76.84 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr1:169741477-169747642 bp, - strand From VEGA annotation of GRCm38   6166 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Rgs4 ± 2 cM)

Protein SuperFamily: regulator of G protein signaling, RGS4 type
Gene Tree: Rgs4

Human ortholog

RGS4 regulator of G-protein signaling 4 NCBI Gene ID 5999
Human Synonyms: RGP4, SCZD9
Human Chr1:163038396-163046592 bp, + strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(6) : Targeted(6)
 

Mice homozygous for one null allele display background dependent partially penetrant embryonic lethality, decreased body weight, and mildly impaired coordination. Another allele displays increased cholesterol levels in males. Mice homozygous for a different null allele exhibit no normal phenotype.

 

Gene Ontology (GO) classifications

All GO classifications: (17 annotations)

Process	G-protein coupled receptor signaling pathway, negative regulation of G-protein coupled receptor protein signaling pathway, ...
Component	cytoplasm, cytosol, ...
Function	G-protein alpha-subunit binding, GTPase activator activity

External Resources: FuncBase

Expression

Literature Summary: (15 records)
Data Summary: Results (380)    Tissues (126)    Images (122)
Theiler Stages: 18, 19, 20, 21, 23, 26, 28

Assay Type	Results
RNA in situ	247
In situ reporter (knock in)	90
Northern blot	5
RT-PCR	38

cDNA source data(49)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(53) cDNA(50) Primer pair(3)
Microarray probesets(7)

Other database links

VEGA Gene Model	OTTMUSG00000020909 (Evidence)
Ensembl Gene Model	ENSMUSG00000038530 (Evidence)
Entrez Gene	19736 (Evidence)
UniGene	41642
DFCI	TC1575659, TC1588279, TC1669298
DoTS	DT.101377126, DT.483806, DT.94141342
NIA Mouse Gene Index	U022025
Consensus CDS Project	CCDS15465.1
International Mouse Knockout Project Status	Rgs4

Sequences

Length	Strain/Species
genomic	OTTMUSG00000020909	VEGA Gene Model | MGI Sequence Detail	6166	C57BL/6J
transcript	OTTMUST00000049422	VEGA | MGI Sequence Detail	2941	Not Applicable
polypeptide	OTTMUSP00000022896	VEGA | MGI Sequence Detail	205	Not Applicable

All sequences(39) RefSeq(2) UniProt(3)

Polymorphisms

RFLP(1) : SNPs(52 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR024066	Regulator of G-protein signaling, domain 1
InterPro	IPR000342	Regulator of G protein signalling
InterPro	IPR016137	Regulator of G protein signalling superfamily
Protein Ontology	PR:000013959	regulator of G-protein signaling 4

References

(Earliest) J:36569 Chen CK, et al., RGS-r, a retinal specific RGS protein, binds an intermediate conformation of transducin and enhances recycling. Proc Natl Acad Sci U S A. 1996 Nov 12;93(23):12885-9
(Latest) J:184660 Kvajo M, et al., Avoiding mouse traps in schizophrenia genetics: lessons and promises from current and emerging mouse models. Neuroscience. 2012 Jun 1;211:136-64
All references(62)

Other accession IDs

MGD-MRK-37452, MGI:1334420, MGI:1334426