About   Help   FAQ
Rgs4
Gene Detail
Symbol

Name
ID
Rgs4
regulator of G-protein signaling 4
MGI:108409
Synonyms
ESTM48, ESTM50
Feature Type
protein coding gene
Genetic Map
Chromosome 1
76.84 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr1:169741477-169747642 bp, - strand
From VEGA annotation of GRCm38

  6166 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4100  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: RGS4
Protein SuperFamily: regulator of G protein signaling, RGS4 type
Gene Tree: Rgs4

Human
homologs
RGS4, regulator of G-protein signaling 4
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 5999
neXtProt AC: NX_P49798

Human Synonyms: RGP4, SCZD9

Human Chr (Location): 1q23.3; chr1:163068606-163076802 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Targeted(8)
Incidental mutations (data from APF )
 
Mice homozygous for one null allele display background dependent partially penetrant embryonic lethality, decreased body weight, and mildly impaired coordination. Another allele displays increased cholesterol levels in males. Mice homozygous for a different null allele exhibit no normal phenotype.
 
Interactions
Rgs4 interacts with 354 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (17 records)
Data Summary: Results (388)    Tissues (131)    Images (130)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 251
In situ reporter (knock in) 90
Northern blot 5
Western blot 2
RT-PCR 40
cDNA source data(50)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA RGS4 ; Xenbase rgs4 ; ZFIN rgs4    NEW 
Molecular
reagents
All nucleic(56) cDNA(52) Primer pair(4)
Microarray probesets(7)
Other database
links
VEGA Gene Model OTTMUSG00000020909 (Evidence)
Ensembl Gene Model ENSMUSG00000038530 (Evidence)
Entrez Gene 19736 (Evidence)
UniGene 41642
DFCI TC1669298, TC1588279, TC1575659
DoTS DT.483806, DT.101377126, DT.94141342
NIA Mouse Gene Index U022025
Consensus CDS Project CCDS15465.1
International Mouse Phenotyping Consortium Status Rgs4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020909 VEGA Gene Model | MGI Sequence Detail 6166 C57BL/6J ±  kb
transcript OTTMUST00000049422 VEGA | MGI Sequence Detail 2941 Not Applicable 
polypeptide OTTMUSP00000022896 VEGA | MGI Sequence Detail 205 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(2) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(100 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR024066 Regulator of G-protein signaling, domain 1
InterPro IPR016137 Regulator of G protein signalling superfamily
Protein Ontology PR:000013959 regulator of G-protein signaling 4
References
(Earliest) J:36569 Chen CK, et al., RGS-r, a retinal specific RGS protein, binds an intermediate conformation of transducin and enhances recycling. Proc Natl Acad Sci U S A. 1996 Nov 12;93(23):12885-9
(Latest) J:218509 Kim HJ, et al., Patterns of gene expression associated with Pten deficiency in the developing inner ear. PLoS One. 2014;9(6):e97544
All references(70)
Other
accession IDs
MGD-MRK-37452, MGI:1334420, MGI:1334426

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/23/2015
MGI 5.22
The Jackson Laboratory