Rgs8 MGI Mouse Gene Detail - MGI:108408 - regulator of G-protein signaling 8

Rgs8 Gene Detail

Symbol

Rgs8
Name

regulator of G-protein signaling 8
Synonyms

6530413N01Rik

Feature Type

protein coding gene
IDs

MGI:108408
NCBI Gene: 67792
Gene Overview

MyGene.info: RGS8
Alliance

gene page

Sequence Map

Chr1:153653025-153700323 bp, + strand
From VEGA annotation of GRCm38

Mouse Genome Browser
Download
Sequence

47299 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 65.41 cM, cytoband G2
Mapping Data

3 experiments

Human Ortholog

RGS8, regulator of G protein signaling 8

Vertebrate Orthologs

9

Human Ortholog

RGS8, regulator of G protein signaling 8
Orthology source: HGNC, HomoloGene
Links

HGNC:16810

NCBI Gene ID: 85397

neXtProt AC: NX_P57771

UniProt: P57771
Chr Location

1q25.3; chr1:182641814-182753291 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 23152
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
HCOP

human homology predictions: RGS8
Protein SuperFamily

regulator of G protein signaling, RGS4 type
Gene Tree

Rgs8

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
5 phenotype references

All Mutations and Alleles

5
Chemically induced (other)

2
Gene trapped

2
Targeted

1
Genomic Mutations

2 involving Rgs8
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

11 strains or lines available
Recombinase Activity

1

Mice homozygous for a knock-out allele exhibit normal fertility and Purkinje cell morphology.

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All GO Annotations

17
GO References

4

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

41
Tissues

27
cDNA Data

77
Literature Summary

4

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rgs8

ZFIN rgs8

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Rgs8 interacts with 404 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

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All Sequences

86
RefSeq

26
UniProt

7
CCDS

CCDS15375.1, CCDS83607.1
UniGene

379143

			Length	Strain/Species	Flank
genomic	OTTMUSG00000021608	VEGA Gene Model \| MGI Sequence Detail	47299	C57BL/6J	± kb
transcript	OTTMUST00000051304	VEGA \| MGI Sequence Detail	8474	Not Applicable
polypeptide	OTTMUSP00000024111	VEGA \| MGI Sequence Detail	180	Not Applicable

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SNPs within 2kb

441 from dbSNP Build 142

RFLP

1

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UniProt

7 Sequences
Protein Ontology

PR:000013964 regulator of G-protein signaling 8

(term hierarchy)
InterPro Domains

IPR034948 Regulator of G-protein signalling 8

IPR034949 Regulator of G-protein signalling 8, RGS domain

IPR016137 RGS domain

IPR036305 RGS domain superfamily

IPR024066 RGS, subdomain 1/3

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All nucleic 78

cDNA 78

Microarray probesets 4

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MGD-MRK-37451, MGI:1915042

Summaries

All 39

Developmental Gene Expression 4

Gene Ontology 4

Phenotypes 5
Earliest

J:36569 Chen CK, et al., RGS-r, a retinal specific RGS protein, binds an intermediate conformation of transducin and enhances recycling. Proc Natl Acad Sci U S A. 1996 Nov 12;93(23):12885-9
Latest

J:224692 Dansithong W, et al., Ataxin-2 regulates RGS8 translation in a new BAC-SCA2 transgenic mouse model. PLoS Genet. 2015 Apr;11(4):e1005182

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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