Rgs8
Gene Detail

Symbol

Name
ID

Rgs8
regulator of G-protein signaling 8
MGI:108408

Synonyms

6530413N01Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 1
65.41 cM, cytoband G2
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr1:153653025-153700323 bp, + strand From VEGA annotation of GRCm38   47299 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:23152  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: regulator of G protein signaling, RGS4 type
Gene Tree: Rgs8

Human
homologs

Human Homolog		RGS8, regulator of G-protein signaling 8
NCBI Gene ID		85397
neXtProt AC		NX_P57771
Human Chr (Location)		1q25; chr1:182643901-182674743 (-)  GRCh38

Mutations,
alleles, and
phenotypes

All mutations/alleles(3) : Gene trapped(2) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 

Mice homozygous for a knock-out allele exhibit normal fertility and Purkinje cell morphology.

 

Interactions

Rgs8 interacts with 405 markers (Mir1a-1, Mir1a-2, Mir1b, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (8 annotations)

Process	G-protein coupled receptor signaling pathway, negative regulation of signal transduction, ...
Component	cytoplasm, plasma membrane
Function	GTPase activator activity

External Resources: FuncBase

Expression

Literature Summary: (4 records)

Data Summary: Results (41)    Tissues (27)    Images (13)    Tissue x Stage Matrix (view)

Assay Type	Results
RNA in situ	41

cDNA source data(76)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas

Molecular
reagents

All nucleic(77) cDNA(77)
Microarray probesets(4)

Other database
links

VEGA Gene Model	OTTMUSG00000021608 (Evidence)
Ensembl Gene Model	ENSMUSG00000042671 (Evidence)
Entrez Gene	67792 (Evidence)
UniGene	379143
DFCI	TC1652654, TC1588920, TC1583416, TC1732458
DoTS	DT.87069420
NIA Mouse Gene Index	U000928
Consensus CDS Project	CCDS15375.1
International Mouse Knockout Project Status	Rgs8

Sequences

Length	Strain/Species
genomic	OTTMUSG00000021608	VEGA Gene Model | MGI Sequence Detail	47299	C57BL/6J
transcript	OTTMUST00000051304	VEGA | MGI Sequence Detail	8474	Not Applicable
polypeptide	OTTMUSP00000024111	VEGA | MGI Sequence Detail	180	Not Applicable

All sequences(97) RefSeq(26) UniProt(13)

Polymorphisms

RFLP(1) : SNPs within 2kb(440 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR024066	Regulator of G-protein signaling, domain 1
InterPro	IPR000342	Regulator of G protein signalling
InterPro	IPR016137	Regulator of G protein signalling superfamily
Protein Ontology	PR:000013964	regulator of G-protein signaling 8

References

(Earliest) J:36569 Chen CK, et al., RGS-r, a retinal specific RGS protein, binds an intermediate conformation of transducin and enhances recycling. Proc Natl Acad Sci U S A. 1996 Nov 12;93(23):12885-9
(Latest) J:214959 Lodato S, et al., Gene co-regulation by Fezf2 selects neurotransmitter identity and connectivity of corticospinal neurons. Nat Neurosci. 2014 Aug;17(8):1046-54
All references(39)

Other
accession IDs

MGD-MRK-37451, MGI:1915042