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Rgs8
Gene Detail
 Symbol
Name
ID
Rgs8
regulator of G-protein signaling 8
MGI:108408
Synonyms 6530413N01Rik
Feature Type protein coding gene
Genetic Map
Chromosome 1
65.41 cM, cytoband G2
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr1:153653025-153700323 bp, + strand
From VEGA annotation of GRCm38

  47299 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:23152  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: regulator of G protein signaling, RGS4 type
Gene Tree: Rgs8

Human
homologs
Human Homolog RGS8, regulator of G-protein signaling 8
NCBI Gene ID 85397
neXtProt AC  NX_P57771
Human Chr (Location)  1q25; chr1:182643901-182674743 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Gene trapped(2) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit normal fertility and Purkinje cell morphology.
 
Interactions
Rgs8 interacts with 405 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process G-protein coupled receptor signaling pathway, negative regulation of signal transduction, ...
Component cytoplasm, plasma membrane
Function GTPase activator activity
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (41)    Tissues (27)    Images (13)
Theiler Stages: 19, 23, 28
Assay TypeResults
RNA in situ 41
cDNA source data(76)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(77) cDNA(77)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000021608 (Evidence)
Ensembl Gene ModelENSMUSG00000042671 (Evidence)
Entrez Gene67792 (Evidence)
UniGene379143
DFCITC1583416, TC1588920, TC1652654, TC1732458
DoTSDT.87069420
NIA Mouse Gene IndexU000928
Consensus CDS ProjectCCDS15375.1
International Mouse Knockout Project StatusRgs8
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021608 VEGA Gene Model | MGI Sequence Detail 47299 C57BL/6J ±  kb
transcript OTTMUST00000051304 VEGA | MGI Sequence Detail 8474 Not Applicable 
polypeptide OTTMUSP00000024111 VEGA | MGI Sequence Detail 180 Not Applicable 

For the selected sequences
All sequences(91) RefSeq(26) UniProt(7)
Polymorphisms RFLP(1) : SNPs within 2kb(440 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR024066 Regulator of G-protein signaling, domain 1
InterPro IPR000342 Regulator of G protein signalling
InterPro IPR016137 Regulator of G protein signalling superfamily
Protein Ontology PR:000013964 regulator of G-protein signaling 8
References (Earliest) J:36569 Chen CK, et al., RGS-r, a retinal specific RGS protein, binds an intermediate conformation of transducin and enhances recycling. Proc Natl Acad Sci U S A. 1996 Nov 12;93(23):12885-9
(Latest) J:205051 Miller JA, et al., Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. Development. 2013 Nov;140(22):4633-44
All references(38)
Other
accession IDs
MGD-MRK-37451, MGI:1915042

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory