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Rgs8 Gene Detail
Summary
  • Symbol
    Rgs8
  • Name
    regulator of G-protein signaling 8
  • Synonyms
    6530413N01Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:108408
    NCBI Gene: 67792
  • Gene Overview
    MyGene.info: RGS8
Location & Maps
more
  • Sequence Map
    Chr1:153653025-153700323 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      47299 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 65.41 cM, cytoband G2
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    RGS8, regulator of G-protein signaling 8
  • Vertebrate Orthologs
    9
  • Human Ortholog
    RGS8, regulator of G-protein signaling 8
    Orthology source: HGNC, HomoloGene
  • Links
    NCBI Gene ID: 85397
    neXtProt AC: NX_P57771

  • Chr Location
    1q25; chr1:182643341-182753307 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    5 phenotype references
  • All Mutations and Alleles
    5
  • Chemically induced (other)
    2
  • Gene trapped
    2
  • Targeted
    1
  • Genomic Mutations
    2 involving Rgs8
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit normal fertility and Purkinje cell morphology.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021608 VEGA Gene Model | MGI Sequence Detail 47299 C57BL/6J ±  kb
transcript OTTMUST00000051304 VEGA | MGI Sequence Detail 8474 Not Applicable  
polypeptide OTTMUSP00000024111 VEGA | MGI Sequence Detail 180 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    441 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 77
    cDNA 77

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-37451, MGI:1915042
References
more
  • Summaries
    All 35
    Developmental Gene Expression 4
    Gene Ontology 5
    Phenotypes 5
  • Earliest
    J:36569 Chen CK, et al., RGS-r, a retinal specific RGS protein, binds an intermediate conformation of transducin and enhances recycling. Proc Natl Acad Sci U S A. 1996 Nov 12;93(23):12885-9
  • Latest
    J:214959 Lodato S, et al., Gene co-regulation by Fezf2 selects neurotransmitter identity and connectivity of corticospinal neurons. Nat Neurosci. 2014 Aug;17(8):1046-54

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory