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Rgs8 Gene Detail
Summary
  • Symbol
    Rgs8
  • Name
    regulator of G-protein signaling 8
  • Synonyms
    6530413N01Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:108408
    NCBI Gene: 67792
  • Gene Overview
    MyGene.info: RGS8
  • Alliance
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:153652953-153697669 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 65.41 cM, cytoband G2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    393 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108408
protein coding gene Chr1:153652953-153700323 (.)
129S1/SvImJ MGP_129S1SvImJ_G0016599
protein coding gene Chr1:158496348-158544426 (+)
A/J MGP_AJ_G0016581
protein coding gene Chr1:152101538-152152729 (+)
AKR/J MGP_AKRJ_G0016546
protein coding gene Chr1:156815463-156862364 (+)
BALB/cJ MGP_BALBcJ_G0016541
protein coding gene Chr1:152652821-152700025 (+)
C3H/HeJ MGP_C3HHeJ_G0016366
protein coding gene Chr1:156911235-156962478 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017002
protein coding gene Chr1:163971381-164019721 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014711
protein coding gene Chr1:144390897-144438220 (+)
CAST/EiJ MGP_CASTEiJ_G0015945
protein coding gene Chr1:156429443-156481215 (+)
CBA/J MGP_CBAJ_G0016340
protein coding gene Chr1:169730636-169786834 (+)
DBA/2J MGP_DBA2J_G0016446
protein coding gene Chr1:151127003-151175955 (+)
FVB/NJ MGP_FVBNJ_G0016444
protein coding gene Chr1:149585536-149633071 (+)
LP/J MGP_LPJ_G0016517
protein coding gene Chr1:159611893-159666246 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016470
protein coding gene Chr1:177360396-177412451 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017038
protein coding gene Chr1:156588822-156640719 (+)
PWK/PhJ MGP_PWKPhJ_G0015731
protein coding gene Chr1:150165212-150214970 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015518
protein coding gene Chr1:155383497-155438230 (+)
WSB/EiJ MGP_WSBEiJ_G0016008
protein coding gene Chr1:156671109-156722567 (+)



Homology
more
  • Human Ortholog
    RGS8, regulator of G protein signaling 8
  • Vertebrate Orthologs
    9
  • Human Ortholog
    RGS8, regulator of G protein signaling 8
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 85397
    neXtProt AC: NX_P57771
    UniProt: P57771

  • Chr Location
    1q25.3; chr1:182641814-182753291 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    5 phenotype references
Mice homozygous for a knock-out allele exhibit normal fertility and Purkinje cell morphology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 67792 NCBI Gene Model | MGI Sequence Detail 44717 C57BL/6J ±  kb
transcript NM_026380 RefSeq | MGI Sequence Detail 5827 C57BL/6  
polypeptide Q8BXT1 UniProt | EBI | MGI Sequence Detail 180 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 78
    cDNA 78

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-37451, MGI:1915042
References
more
  • Summaries
    All 38
    Developmental Gene Expression 4
    Gene Ontology 4
    Phenotypes 5
  • Earliest
    J:36569 Chen CK, et al., RGS-r, a retinal specific RGS protein, binds an intermediate conformation of transducin and enhances recycling. Proc Natl Acad Sci U S A. 1996 Nov 12;93(23):12885-9
  • Latest
    J:224692 Dansithong W, et al., Ataxin-2 regulates RGS8 translation in a new BAC-SCA2 transgenic mouse model. PLoS Genet. 2015 Apr;11(4):e1005182

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory