Rgs8 MGI Mouse Gene Detail - MGI:108408 - regulator of G-protein signaling 8

Symbol

Rgs8
Name

regulator of G-protein signaling 8
Synonyms

6530413N01Rik

Feature Type

protein coding gene
IDs

MGI:108408
NCBI Gene: 67792
Gene Overview

MyGene.info: RGS8
Alliance

gene page
Transcription Start Sites

15 TSS

Sequence Map

Chr1:153652953-153697669 bp, + strand
From NCBI annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 65.41 cM, cytoband G2
Mapping Data

3 experiments

SNPs within 2kb

393 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_108408	protein coding gene	Chr1:153652953-153700323 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016599	protein coding gene	Chr1:158496348-158544426 (+)
A/J	MGP_AJ_G0016581	protein coding gene	Chr1:152101538-152152729 (+)
AKR/J	MGP_AKRJ_G0016546	protein coding gene	Chr1:156815463-156862364 (+)
BALB/cJ	MGP_BALBcJ_G0016541	protein coding gene	Chr1:152652821-152700025 (+)
C3H/HeJ	MGP_C3HHeJ_G0016366	protein coding gene	Chr1:156911235-156962478 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017002	protein coding gene	Chr1:163971381-164019721 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014711	protein coding gene	Chr1:144390897-144438220 (+)
CAST/EiJ	MGP_CASTEiJ_G0015945	protein coding gene	Chr1:156429443-156481215 (+)
CBA/J	MGP_CBAJ_G0016340	protein coding gene	Chr1:169730636-169786834 (+)
DBA/2J	MGP_DBA2J_G0016446	protein coding gene	Chr1:151127003-151175955 (+)
FVB/NJ	MGP_FVBNJ_G0016444	protein coding gene	Chr1:149585536-149633071 (+)
LP/J	MGP_LPJ_G0016517	protein coding gene	Chr1:159611893-159666246 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016470	protein coding gene	Chr1:177360396-177412451 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017038	protein coding gene	Chr1:156588822-156640719 (+)
PWK/PhJ	MGP_PWKPhJ_G0015731	protein coding gene	Chr1:150165212-150214970 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015518	protein coding gene	Chr1:155383497-155438230 (+)
WSB/EiJ	MGP_WSBEiJ_G0016008	protein coding gene	Chr1:156671109-156722567 (+)

Human Ortholog

RGS8, regulator of G protein signaling 8

Vertebrate Orthologs

9

Human Ortholog

RGS8, regulator of G protein signaling 8
Orthology source: HomoloGene, HGNC
Links

HGNC:16810

NCBI Gene ID: 85397

neXtProt AC: NX_P57771

UniProt: P57771
Chr Location

1q25.3; chr1:182641814-182753291 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 23152
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
HCOP

human homology predictions: RGS8
Protein SuperFamily

regulator of G protein signaling, RGS4 type
Gene Tree

Rgs8

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
5 phenotype references

All Mutations and Alleles

5
Chemically induced (other)

2
Gene trapped

2
Targeted

1
Genomic Mutations

2 involving Rgs8
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

1 strains or lines available
Recombinase Activity

1

Mice homozygous for a knock-out allele exhibit normal fertility and Purkinje cell morphology.

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All GO Annotations

17
GO References

4

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

41
Tissues

27
cDNA Data

77
Literature Summary

4

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rgs8

ZFIN rgs8

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Rgs8 interacts with 404 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

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All Sequences

84
RefSeq

26
UniProt

7
CCDS

CCDS15375.1, CCDS83607.1
UniGene

379143

Ensembl

ENSMUSG00000042671 (Evidence)
NCBI Gene

67792

			Length	Strain/Species	Flank
genomic	67792	NCBI Gene Model \| MGI Sequence Detail	44717	C57BL/6J	± kb
transcript	NM_026380	RefSeq \| MGI Sequence Detail	5827	C57BL/6
polypeptide	Q8BXT1	UniProt \| EBI \| MGI Sequence Detail	180	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000013964 regulator of G-protein signaling 8

(term hierarchy)
InterPro Domains

IPR034948 Regulator of G-protein signalling 8

IPR034949 Regulator of G-protein signalling 8, RGS domain

IPR016137 RGS domain

IPR036305 RGS domain superfamily

IPR024066 RGS, subdomain 1/3

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All nucleic 78

cDNA 78

Microarray probesets 4

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MGD-MRK-37451, MGI:1915042

Summaries

All 38

Developmental Gene Expression 4

Gene Ontology 4

Phenotypes 5
Earliest

J:36569 Chen CK, et al., RGS-r, a retinal specific RGS protein, binds an intermediate conformation of transducin and enhances recycling. Proc Natl Acad Sci U S A. 1996 Nov 12;93(23):12885-9
Latest

J:224692 Dansithong W, et al., Ataxin-2 regulates RGS8 translation in a new BAC-SCA2 transgenic mouse model. PLoS Genet. 2015 Apr;11(4):e1005182

TSS for Rgs8:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr9461	Chr1:153652930-153652931 (+)	-22 bp
Tssr9462	Chr1:153652943-153652954 (+)	-4 bp
Tssr9463	Chr1:153653106-153653176 (+)	188 bp
Tssr9464	Chr1:153665282-153665325 (+)	12,351 bp
Tssr9465	Chr1:153665490-153665504 (+)	12,544 bp
Tssr9466	Chr1:153665587-153665595 (+)	12,638 bp
Tssr9467	Chr1:153665627-153665653 (+)	12,687 bp
Tssr9468	Chr1:153665666-153665679 (+)	12,720 bp
Tssr9469	Chr1:153667503-153667512 (+)	14,555 bp
Tssr9470	Chr1:153667635-153667640 (+)	14,685 bp
Tssr9471	Chr1:153667670-153667676 (+)	14,720 bp
Tssr9472	Chr1:153695333-153695339 (+)	42,383 bp
Tssr9473	Chr1:153695366-153695374 (+)	42,417 bp
Tssr9474	Chr1:153695495-153695523 (+)	42,556 bp
Tssr9475	Chr1:153696483-153696502 (+)	43,540 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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