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Rgs16
Gene Detail
Symbol

Name
ID
Rgs16
regulator of G-protein signaling 16
MGI:108407
Synonyms
Rgsr
Feature Type
protein coding gene
Genetic Map
Chromosome 1
65.43 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr1:153740349-153745468 bp, + strand
From VEGA annotation of GRCm38

  5120 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2196  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: RGS16
Protein SuperFamily: regulator of G protein signaling, RGS4 type
Gene Tree: Rgs16

Human
homologs
RGS16, regulator of G-protein signaling 16
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 6004
neXtProt AC: NX_O15492

Human Synonyms: A28-RGS14, A28-RGS14P, RGS-R

Human Chr (Location): 1q25-q31; chr1:182598623-182604413 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(4) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele exhibit increased fatty acid oxidation and circulating ketone levels when fed a high-fat diet. Mice homozygous for a different knock-out allele exhibit impaired Th1 and Th2 chemotaxis and increased susceptibility to parasitic infection.
 
Interactions
Rgs16 interacts with 206 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process G-protein coupled receptor signaling pathway, negative regulation of signal transduction, ...
Component cytoplasm, membrane raft, ...
Function GTPase activator activity
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (170)    Tissues (24)    Images (22)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 164
Northern blot 6
cDNA source data(30)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase rgs16    NEW 
Molecular
reagents
All nucleic(32) cDNA(31) Primer pair(1)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000020889 (Evidence)
Ensembl Gene Model ENSMUSG00000026475 (Evidence)
Entrez Gene 19734 (Evidence)
UniGene 181709
DFCI TC1577749
DoTS DT.529353, DT.97338705
PDB 3C7K, 3C7L
Consensus CDS Project CCDS15376.1
International Mouse Phenotyping Consortium Status Rgs16
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020889 VEGA Gene Model | MGI Sequence Detail 5120 C57BL/6J ±  kb
transcript OTTMUST00000049392 VEGA | MGI Sequence Detail 2339 Not Applicable 
polypeptide OTTMUSP00000022875 VEGA | MGI Sequence Detail 201 Not Applicable 

For the selected sequences
All sequences(28) RefSeq(2) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(99 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016137 RGS domain
InterPro IPR024066 RGS, subdomain 1
Protein Ontology PR:000013950 regulator of G-protein signaling 16
References
(Earliest) J:36569 Chen CK, et al., RGS-r, a retinal specific RGS protein, binds an intermediate conformation of transducin and enhances recycling. Proc Natl Acad Sci U S A. 1996 Nov 12;93(23):12885-9
(Latest) J:220524 Pehrson JG, et al., Mice without MacroH2A Histone Variants. Mol Cell Biol. 2014;34(24):4523-33
All references(43)
Other
accession IDs
MGD-MRK-37450, MGI:1098207

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory