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Rgs16
Gene Detail
 Symbol
Name
ID
Rgs16
regulator of G-protein signaling 16
MGI:108407
Synonyms Rgsr
Feature Type protein coding gene
Genetic Map
Chromosome 1
65.43 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr1:153740349-153745468 bp, + strand
From VEGA annotation of GRCm38

  5120 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2196  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: regulator of G protein signaling, RGS4 type
Gene Tree: Rgs16

Human
homologs
Human Homolog RGS16, regulator of G-protein signaling 16
NCBI Gene ID 6004
neXtProt AC  NX_O15492
Human Synonyms  A28-RGS14, A28-RGS14P, RGS-R
Human Chr (Location)  1q25-q31; chr1:182598623-182604413 (-)  GRCh38
Alleles
and
phenotypes
All alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit increased fatty acid oxidation and circulating ketone levels when fed a high-fat diet. Mice homozygous for a different knock-out allele exhibit impaired Th1 and Th2 chemotaxis and increased susceptibility to parasitic infection.
 
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process G-protein coupled receptor signaling pathway, negative regulation of signal transduction, ...
Component cytoplasm, membrane raft, ...
Function GTPase activator activity
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (170)    Tissues (23)    Images (22)
Theiler Stages: 22, 23, 24, 26, 28
Assay TypeResults
RNA in situ 164
Northern blot 6
cDNA source data(30)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents
All nucleic(32) cDNA(31) Primer pair(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000020889 (Evidence)
Ensembl Gene ModelENSMUSG00000026475 (Evidence)
Entrez Gene19734 (Evidence)
UniGene181709
DFCITC1577749
DoTSDT.529353, DT.97338705
PDB3C7K, 3C7L
Consensus CDS ProjectCCDS15376.1
International Mouse Knockout Project StatusRgs16
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020889 VEGA Gene Model | MGI Sequence Detail 5120 C57BL/6J ±  kb
transcript OTTMUST00000049392 VEGA | MGI Sequence Detail 2339 Not Applicable 
polypeptide OTTMUSP00000022875 VEGA | MGI Sequence Detail 201 Not Applicable 

For the selected sequences
All sequences(28) RefSeq(2) UniProt(3)
Polymorphisms RFLP(1) : SNPs within 2kb(99 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR024066 Regulator of G-protein signaling, domain 1
InterPro IPR000342 Regulator of G protein signalling
InterPro IPR016137 Regulator of G protein signalling superfamily
Protein Ontology PR:000013950 regulator of G-protein signaling 16
References (Earliest) J:36569 Chen CK, et al., RGS-r, a retinal specific RGS protein, binds an intermediate conformation of transducin and enhances recycling. Proc Natl Acad Sci U S A. 1996 Nov 12;93(23):12885-9
(Latest) J:205685 Ding Y, et al., IL-17RA is essential for optimal localization of follicular Th cells in the germinal center light zone to promote autoantibody-producing B cells. J Immunol. 2013 Aug 15;191(4):1614-24
All references(42)
Other
accession IDs
MGD-MRK-37450, MGI:1098207

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory