Rgs16
Gene Detail

Symbol Name ID

Rgs16 regulator of G-protein signaling 16 MGI:108407

Synonyms

Rgsr

Feature Type

protein coding gene

Genetic Map

Chromosome 1

65.43 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr1:153740349-153745468 bp, + strand From VEGA annotation of GRCm38   5120 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:2196  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: regulator of G protein signaling, RGS4 type
Gene Tree: Rgs16

Human homologs

Human Homolog		RGS16, regulator of G-protein signaling 16
NCBI Gene ID		6004
neXtProt AC		NX_O15492
Human Synonyms		A28-RGS14, A28-RGS14P, RGS-R
Human Chr (Location)		1q25-q31; chr1:182567758-182573548 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Mice homozygous for a knock-out allele exhibit increased fatty acid oxidation and circulating ketone levels when fed a high-fat diet. Mice homozygous for a different knock-out allele exhibit impaired Th1 and Th2 chemotaxis and increased susceptibility to parasitic infection.

 

Gene Ontology (GO) classifications

All GO classifications: (9 annotations)

Process	G-protein coupled receptor signaling pathway, negative regulation of signal transduction, ...
Component	cytoplasm, membrane raft, ...
Function	GTPase activator activity

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (170)    Tissues (23)    Images (22)
Theiler Stages: 22, 23, 24, 26, 28

Assay Type	Results
RNA in situ	164
Northern blot	6

cDNA source data(30)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(32) cDNA(31) Primer pair(1)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000020889 (Evidence)
Ensembl Gene Model	ENSMUSG00000026475 (Evidence)
Entrez Gene	19734 (Evidence)
UniGene	181709
DFCI	TC1577749
DoTS	DT.529353, DT.97338705
PDB	3C7K, 3C7L
Consensus CDS Project	CCDS15376.1
International Mouse Knockout Project Status	Rgs16

Sequences

Length	Strain/Species
genomic	OTTMUSG00000020889	VEGA Gene Model | MGI Sequence Detail	5120	C57BL/6J
transcript	OTTMUST00000049392	VEGA | MGI Sequence Detail	2339	Not Applicable
polypeptide	OTTMUSP00000022875	VEGA | MGI Sequence Detail	201	Not Applicable

All sequences(28) RefSeq(2) UniProt(3)

Polymorphisms

RFLP(1) : SNPs(58 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR024066	Regulator of G-protein signaling, domain 1
InterPro	IPR000342	Regulator of G protein signalling
InterPro	IPR016137	Regulator of G protein signalling superfamily
Protein Ontology	PR:000013950	regulator of G-protein signaling 16

References

(Earliest) J:36569 Chen CK, et al., RGS-r, a retinal specific RGS protein, binds an intermediate conformation of transducin and enhances recycling. Proc Natl Acad Sci U S A. 1996 Nov 12;93(23):12885-9
(Latest) J:188966 Shankar SP, et al., RGS16 attenuates pulmonary Th2/Th17 inflammatory responses. J Immunol. 2012 Jun 15;188(12):6347-56
All references(39)

Other accession IDs

MGD-MRK-37450, MGI:1098207