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Rgs16 Gene Detail
Summary
  • Symbol
    Rgs16
  • Name
    regulator of G-protein signaling 16
  • Synonyms
    Rgsr
  • Feature Type
    protein coding gene
  • IDs
    MGI:108407
    NCBI Gene: 19734
  • Gene Overview
    MyGene.info: RGS16
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr1:153740349-153745468 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      5120 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 65.43 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    RGS16, regulator of G protein signaling 16
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RGS16, regulator of G protein signaling 16
    Orthology source: HGNC, HomoloGene
  • Synonyms
    A28-RGS14, A28-RGS14P, RGS-R
  • Links
    NCBI Gene ID: 6004
    neXtProt AC: NX_O15492
    UniProt: O15492

  • Chr Location
    1q25.3; chr1:182598623-182604413 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    18 phenotypes from 4 alleles in 4 genetic backgrounds
    1 images
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased fatty acid oxidation and circulating ketone levels when fed a high-fat diet. Mice homozygous for a different knock-out allele exhibit impaired Th1 and Th2 chemotaxis and increased susceptibility toparasitic infection.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000020889 VEGA Gene Model | MGI Sequence Detail 5120 C57BL/6J ±  kb
    transcript OTTMUST00000049392 VEGA | MGI Sequence Detail 2339 Not Applicable  
    polypeptide OTTMUSP00000022875 VEGA | MGI Sequence Detail 201 Not Applicable  
    For the selected sequence
    Polymorphisms
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    • SNPs within 2kb
      97 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 33
      cDNA 32
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
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    MGD-MRK-37450, MGI:1098207
    References
    more
    • Summaries
      All 53
      Developmental Gene Expression 7
      Gene Ontology 6
      Phenotypes 10
    • Earliest
      J:36569 Chen CK, et al., RGS-r, a retinal specific RGS protein, binds an intermediate conformation of transducin and enhances recycling. Proc Natl Acad Sci U S A. 1996 Nov 12;93(23):12885-9
    • Latest
      J:247663 Hwang IY, et al., Normal Thymocyte Egress, T Cell Trafficking, and CD4+ T Cell Homeostasis Require Interactions between RGS Proteins and Galphai2. J Immunol. 2017 Apr 01;198(7):2721-2734

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    09/11/2018
    MGI 6.12
    The Jackson Laboratory