Rgs16 MGI Mouse Gene Detail - MGI:108407 - regulator of G-protein signaling 16

Symbol

Rgs16
Name

regulator of G-protein signaling 16
Synonyms

Rgsr

Feature Type

protein coding gene
IDs

MGI:108407
NCBI Gene: 19734
Alliance

genome feature page
Transcription Start Sites

2 TSS

Sequence Map

Chr1:153616099-153621212 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 65.43 cM
Mapping Data

2 experiments

SNPs within 2kb

278 from dbSNP Build 142
Strain Annotations

19
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_108407	protein coding gene	Chr1:153616095-153621214 (+)
129S1/SvImJ	ENSMUSG00200001942	protein coding gene	Chr1:151057038-151062159 (+)
A/J	ENSMUSG00195013640	protein coding gene	Chr1:150434618-150439740 (+)
AKR/J	ENSMUSG00220005524	protein coding gene	Chr1:150243388-150248509 (+)
BALB/cJ	ENSMUSG00180032228	protein coding gene	Chr1:150664253-150669374 (+)
C3H/HeJ	ENSMUSG00175002613	protein coding gene	Chr1:150701114-150706233 (+)
C57BL/6NJ	ENSMUSG00215003263	protein coding gene	Chr1:150599281-150604401 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014712	protein coding gene	Chr1:144478323-144483460 (+)
CAST/EiJ	ENSTCUG00005005655	protein coding gene	Chr1:149250300-149255441 (+)
CBA/J	ENSMUSG00210030095	protein coding gene	Chr1:150604889-150610008 (+)
DBA/2J	ENSMUSG00185041679	protein coding gene	Chr1:154896547-154901666 (+)
FVB/NJ	ENSMUSG00205016864	protein coding gene	Chr1:149736770-149741889 (+)
JF1/MsJ	ENSUMUG00000015012	protein coding gene	Chr1:154045217-154050338 (+)
LP/J	ENSMUSG00230012483	protein coding gene	Chr1:154458663-154463778 (+)
NOD/ShiLtJ	ENSMUSG00190012385	protein coding gene	Chr1:150453002-150458123 (+)
NZO/HlLtJ	ENSMUSG00225005098	protein coding gene	Chr1:158117913-158123033 (+)
PWK/PhJ	ENSLUMG00010029111	protein coding gene	Chr1:149403142-149408268 (+)
SPRET/EiJ	ENSMSPG00010005065	protein coding gene	Chr1:152717053-152721418 (+)
WSB/EiJ	ENSIUOG00005022896	protein coding gene	Chr1:150024858-150029988 (+)

Human Ortholog

RGS16, regulator of G protein signaling 16

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RGS16, regulator of G protein signaling 16
Synonyms

A28-RGS14, A28-RGS14P, RGS-R
Links

HGNC:9997

NCBI Gene ID: 6004

UniProt: O15492
Chr Location

1q25.3; chr1:182598623-182604394 (-) GRCh38

MGI Vertebrate Homology

Rgs16 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: RGS16
Gene Tree

Rgs16

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Phenotype Summary

21 phenotypes from 4 alleles in 4 genetic backgrounds
1 images
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

16
Chemically induced (other)

2
Endonuclease-mediated

7
Targeted

5
Transgenic

2
Genomic Mutations

3 involving Rgs16
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

20 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Mice homozygous for a knock-out allele exhibit increased fatty acid oxidation and circulating ketone levels when fed a high-fat diet. Mice homozygous for a different knock-out allele exhibit impaired Th1 and Th2 chemotaxis and increased susceptibility toparasitic infection.

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All GO Annotations

20
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

768
Tissues

25
cDNA Data

31
Literature Summary

8

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rgs16

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All Sequences

41
RefSeq

2
UniProt

3
CCDS

CCDS15376.1

Ensembl

ENSMUSG00000026475 (Evidence)
NCBI Gene

19734

			Length	Strain/Species	Flank
genomic	19734	NCBI Gene Model \| MGI Sequence Detail	5114	C57BL/6J	± kb
transcript	NM_011267	RefSeq \| MGI Sequence Detail	2333	C57BL/6
polypeptide	P97428	UniProt \| EBI \| MGI Sequence Detail	201	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000013950 regulator of G-protein signaling 16

(term hierarchy)
PDB

3C7K, 3C7L
InterPro Domains

IPR016137 RGS domain

IPR036305 RGS domain superfamily

IPR024066 RGS, subdomain 1/3

IPR044926 RGS, subdomain 2

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All nucleic 34

cDNA 32

Primer pair 2

Microarray probesets 5

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MGD-MRK-37450, MGI:1098207

Summaries

All 63

Developmental Gene Expression 8

Gene Ontology 9

Phenotypes 16
Earliest

J:36569 Chen CK, et al., RGS-r, a retinal specific RGS protein, binds an intermediate conformation of transducin and enhances recycling. Proc Natl Acad Sci U S A. 1996 Nov 12;93(23):12885-9
Latest

J:365026 Weisshaar N, et al., Rgs16 promotes antitumor CD8(+) T cell exhaustion. Sci Immunol. 2022 May 27;7(71):eabh1873

TSS for Rgs16:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr9477	Chr1:153616090-153616106 (+)	-1 bp
Tssr9478	Chr1:153616281-153616286 (+)	185 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24