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Apbb2 Gene Detail
Summary
  • Symbol
    Apbb2
  • Name
    amyloid beta (A4) precursor protein-binding, family B, member 2
  • Synonyms
    2310007D03Rik, FE65L1, Rirl1, TR2L, Zfra
  • Feature Type
    protein coding gene
  • IDs
    MGI:108405
    NCBI Gene: 11787
  • Gene Overview
    MyGene.info: APBB2
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr5:66298703-66618784 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      320082 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 34.43 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    APBB2, amyloid beta precursor protein binding family B member 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    APBB2, amyloid beta precursor protein binding family B member 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    FE65L, FE65L1
  • Links
    NCBI Gene ID: 323
    neXtProt AC: NX_Q92870
    UniProt: Q92870

  • Chr Location
    4p14-p13; chr4:40810027-41216714 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 32079
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: APBB2
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human APBB2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    13 phenotypes from multigenic genotypes
    31 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are viable and fertile and display normal brain morphology.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000033024 VEGA Gene Model | MGI Sequence Detail 320082 C57BL/6J ±  kb
    transcript OTTMUST00000137968 VEGA | MGI Sequence Detail 3362 Not Applicable  
    polypeptide OTTMUSP00000072603 VEGA | MGI Sequence Detail 760 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      1949 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 87
      cDNA 86
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-37448, MGI:1916734, MGI:3526137
    References
    more
    • Summaries
      All 62
      Developmental Gene Expression 4
      Gene Ontology 5
      Phenotypes 31
    • Earliest
      J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
    • Latest
      J:263434 Strecker P, et al., FE65 and FE65L1 share common synaptic functions and genetically interact with the APP family in neuromuscular junction formation. Sci Rep. 2016 May 11;6:25652

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    Funding Information
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    last database update
    09/11/2018
    MGI 6.12
    The Jackson Laboratory