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Apbb2
Gene Detail
Symbol

Name
ID
Apbb2
amyloid beta (A4) precursor protein-binding, family B, member 2
MGI:108405
Synonyms
2310007D03Rik, FE65L1, Rirl1, TR2L, Zfra
Feature Type
protein coding gene
Genetic Map
Chromosome 5
34.43 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr5:66298861-66618828 bp, - strand
From VEGA annotation of GRCm38

  319968 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:32079  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Apbb2

Human
homologs
Human Homolog APBB2, amyloid beta (A4) precursor protein-binding, family B, member 2
NCBI Gene ID 323
neXtProt AC  NX_Q92870
Human Synonyms  FE65L, FE65L1
Human Chr (Location)  4p13; chr4:40810027-41216714 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human APBB2
Mutations,
alleles, and
phenotypes
All mutations/alleles(159) : Gene trapped(156) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele are viable and fertile and display normal brain morphology.
 
Interactions
Apbb2 interacts with 386 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process actin filament-based movement, axon guidance, ...
Component cytoplasm, nucleus
Function beta-amyloid binding, histone acetyltransferase binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (66)    Tissues (20)    Images (24)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 56
RT-PCR 10
cDNA source data(83)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(85) cDNA(84) Primer pair(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000033024 (Evidence)
Ensembl Gene ModelENSMUSG00000029207 (Evidence)
Entrez Gene11787 (Evidence)
UniGene5159
DFCITC1590796, TC1588552, TC1574652, TC1664706, TC1767848, TC1687543
DoTSDT.101204615, DT.101362199, DT.99850017, DT.87072424, DT.489441, DT.99862369
NIA Mouse Gene IndexU026260
PDB2YSZ, 2ROZ, 1WGU, 2YT0, 2YT1
Consensus CDS ProjectCCDS51510.1, CCDS57344.1, CCDS57345.1, CCDS57346.1
International Mouse Knockout Project StatusApbb2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033024 VEGA Gene Model | MGI Sequence Detail 319968 C57BL/6J ±  kb
transcript OTTMUST00000082403 VEGA | MGI Sequence Detail 6546 Not Applicable 
polypeptide OTTMUSP00000044164 VEGA | MGI Sequence Detail 760 Not Applicable 

For the selected sequences
All sequences(182) RefSeq(30) UniProt(37)
Polymorphisms
SNPs within 2kb(1968 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006020 Phosphotyrosine interaction domain
InterPro IPR011993 Pleckstrin homology-like domain
InterPro IPR001202 WW domain
Protein Ontology PR:000004120 amyloid beta A4 precursor protein-binding family B member 2
References
(Earliest) J:8500 Van der Bliek AM, et al., Overexpression and amplification of five genes in a multidrug-resistant Chinese hamster ovary cell line. Mol Cell Biol. 1986 May;6(5):1671-8
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(48)
Other
accession IDs
MGD-MRK-37448, MGI:1916734, MGI:3526137

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory