Apbb2
Gene Detail

Symbol Name ID

Apbb2 amyloid beta (A4) precursor protein-binding, family B, member 2 MGI:108405

Synonyms

2310007D03Rik, FE65L1, Rirl1, TR2L, Zfra

Feature Type

protein coding gene

Genetic Map

Chromosome 5

34.43 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr5:66298861-66618828 bp, - strand From VEGA annotation of GRCm38   319968 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:32079  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Apbb2

Human homologs

Human Homolog		APBB2, amyloid beta (A4) precursor protein-binding, family B, member 2
NCBI Gene ID		323
neXtProt AC		NX_Q92870
Human Synonyms		FE65L, FE65L1
Human Chr (Location)		4p13; chr4:40812044-41216635 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human APBB2

Alleles and phenotypes

All alleles(158) : Targeted(2) Gene trapped(156)
 

Mice homozygous for a knock-out allele are viable and fertile and display normal brain morphology.

 

Gene Ontology (GO) classifications

All GO classifications: (16 annotations)

Process	actin filament-based movement, axon guidance, ...
Component	cytoplasm, nucleus
Function	histone acetyltransferase binding, protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (70)    Tissues (21)    Images (24)
Theiler Stages: 1, 2, 3, 5, 21, 22, 23, 24, 26, 28

Assay Type	Results
RNA in situ	56
RT-PCR	14

cDNA source data(73)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(75) cDNA(74) Primer pair(1)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000033024 (Evidence)
Ensembl Gene Model	ENSMUSG00000029207 (Evidence)
Entrez Gene	11787 (Evidence)
UniGene	5159
DFCI	TC1574652, TC1588552, TC1590796, TC1664706, TC1687543, TC1767848
DoTS	DT.101204615, DT.101362199, DT.489441, DT.87072424, DT.99850017, DT.99862369
NIA Mouse Gene Index	U026260
PDB	1WGU, 2ROZ, 2YSZ, 2YT0, 2YT1
Consensus CDS Project	CCDS51510.1, CCDS57344.1, CCDS57345.1, CCDS57346.1
International Mouse Knockout Project Status	Apbb2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000033024	VEGA Gene Model | MGI Sequence Detail	319968	C57BL/6J
transcript	OTTMUST00000082403	VEGA | MGI Sequence Detail	6546	Not Applicable
polypeptide	OTTMUSP00000044164	VEGA | MGI Sequence Detail	760	Not Applicable

All sequences(144) RefSeq(10) UniProt(19)

Polymorphisms

SNPs(1523 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR006020	Phosphotyrosine interaction domain
InterPro	IPR011993	Pleckstrin homology-like domain
InterPro	IPR001202	WW/Rsp5/WWP
Protein Ontology	PR:000004120	amyloid beta A4 precursor protein-binding family B member 2

References

(Earliest) J:8500 Van der Bliek AM, et al., Overexpression and amplification of five genes in a multidrug-resistant Chinese hamster ovary cell line. Mol Cell Biol. 1986 May;6(5):1671-8
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(45)

Other accession IDs

MGD-MRK-37448, MGI:1916734, MGI:3526137