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Mlx Gene Detail
Summary
  • Symbol
    Mlx
  • Name
    MAX-like protein X
  • Synonyms
    bHLHd13, BigMax alpha, Tcfl4
  • Feature Type
    protein coding gene
  • IDs
    MGI:108398
    NCBI Gene: 21428
  • Gene Overview
    MyGene.info: MLX
Location & Maps
more
  • Sequence Map
    Chr11:101087277-101092207 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      4931 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 64.18 cM, cytoband D
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    MLX, MLX, MAX dimerization protein
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MLX, MLX, MAX dimerization protein
    Orthology source: HGNC, HomoloGene
  • Synonyms
    bHLHd13, MAD7, MXD7, TCFL4
  • Links
    NCBI Gene ID: 6945
    neXtProt AC: NX_Q9UH92

  • Chr Location
    17q21.1; chr17:42567060-42573203 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 7969
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: MLX
  • Gene Tree
    Mlx
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotype references
  • All Mutations and Alleles
    6
  • Targeted
    6
  • Genomic Mutations
    1 involving Mlx
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000002688 VEGA Gene Model | MGI Sequence Detail 4931 C57BL/6J ±  kb
transcript OTTMUST00000005288 VEGA | MGI Sequence Detail 1965 Not Applicable  
polypeptide OTTMUSP00000002511 VEGA | MGI Sequence Detail 298 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    32 from dbSNP Build 142
Protein
Information
less
  • UniProt
    7 Sequences
  • Protein Ontology
    PR:000010458 max-like protein X
  • InterPro Domains
    IPR032647 Max-like protein X
    IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
Molecular
Reagents
less
  • All nucleic 19
    cDNA 18
    Primer pair 1

    Microarray probesets 6
Other
Accession IDs
less
MGD-MRK-37440, MGI:1861754
References
more
  • Summaries
    All 38
    Developmental Gene Expression 6
    Gene Ontology 5
    Phenotypes 10
  • Earliest
    J:37128 Bjerknes M, et al., TCFL4: a gene at 17q21.1 encoding a putative basic helix-loop-helix leucine-zipper transcription factor. Gene. 1996 Nov 28;181(1-2):7-11
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory