About   Help   FAQ
Mlx Gene Detail
Summary
  • Symbol
    Mlx
  • Name
    MAX-like protein X
  • Synonyms
    bHLHd13, BigMax alpha, Tcfl4
  • Feature Type
    protein coding gene
  • IDs
    MGI:108398
    NCBI Gene: 21428
  • Gene Overview
    MyGene.info: MLX
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:101087277-101092207 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 64.18 cM, cytoband D
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    32 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108398
protein coding gene Chr11:101086711-101092207 (.)
129S1/SvImJ MGP_129S1SvImJ_G0019179
protein coding gene Chr11:103898099-103903029 (+)
A/J MGP_AJ_G0019147
protein coding gene Chr11:99544555-99549485 (+)
AKR/J MGP_AKRJ_G0019116
protein coding gene Chr11:102641588-102646518 (+)
BALB/cJ MGP_BALBcJ_G0019121
protein coding gene Chr11:100039063-100043993 (+)
C3H/HeJ MGP_C3HHeJ_G0018930
protein coding gene Chr11:102811510-102816440 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019570
protein coding gene Chr11:107113218-107118148 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017196
protein coding gene Chr11:96962694-96967618 (+)
CAST/EiJ MGP_CASTEiJ_G0018484
protein coding gene Chr11:103799777-103804753 (+)
CBA/J MGP_CBAJ_G0018899
protein coding gene Chr11:111577055-111581985 (+)
DBA/2J MGP_DBA2J_G0019011
protein coding gene Chr11:99079568-99084498 (+)
FVB/NJ MGP_FVBNJ_G0019001
protein coding gene Chr11:98622913-98627843 (+)
LP/J MGP_LPJ_G0019080
protein coding gene Chr11:104447958-104452888 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019032
protein coding gene Chr11:111145595-111150525 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019608
protein coding gene Chr11:102961130-102966060 (+)
PWK/PhJ MGP_PWKPhJ_G0018247
protein coding gene Chr11:100130251-100135269 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018039
protein coding gene Chr11:102696242-102701177 (+)
WSB/EiJ MGP_WSBEiJ_G0018533
protein coding gene Chr11:102959498-102964428 (+)



Homology
more
  • Human Ortholog
    MLX, MLX, MAX dimerization protein
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MLX, MLX, MAX dimerization protein
    Orthology source: HomoloGene, HGNC
  • Synonyms
    bHLHd13, MAD7, MXD7, TCFL4, TF4
  • Links
    NCBI Gene ID: 6945
    neXtProt AC: NX_Q9UH92
    UniProt: Q9UH92

  • Chr Location
    17q21.2; chr17:42567060-42573203 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 7969
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: MLX
  • Gene Tree
    Mlx
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000017801 Ensembl Gene Model | MGI Sequence Detail 4931 C57BL/6J ±  kb
transcript ENSMUST00000017945 Ensembl | MGI Sequence Detail 1965 Not Applicable  
polypeptide ENSMUSP00000017945 Ensembl | MGI Sequence Detail 298 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    7 Sequences
  • InterPro Domains
    IPR036638 Helix-loop-helix DNA-binding domain superfamily
    IPR032647 Max-like protein X
    IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
Molecular
Reagents
less
  • All nucleic 21
    cDNA 20
    Primer pair 1

    Microarray probesets 6
Other
Accession IDs
less
MGD-MRK-37440, MGI:1861754
References
more
  • Summaries
    All 45
    Developmental Gene Expression 7
    Gene Ontology 5
    Phenotypes 12
  • Earliest
    J:37128 Bjerknes M, et al., TCFL4: a gene at 17q21.1 encoding a putative basic helix-loop-helix leucine-zipper transcription factor. Gene. 1996 Nov 28;181(1-2):7-11
  • Latest
    J:227117 Hunt LC, et al., The glucose-sensing transcription factor MLX promotes myogenesis via myokine signaling. Genes Dev. 2015 Dec 1;29(23):2475-89

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/06/2018
MGI 6.13
The Jackson Laboratory