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Vnn1
Gene Detail
Symbol

Name
ID
Vnn1
vanin 1
MGI:108395
Synonyms
pantetheinase, V-1
Feature Type
protein coding gene
Genetic Map
Chromosome 10
11.33 cM, cytoband A1-B2
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr10:23894688-23905343 bp, + strand
From VEGA annotation of GRCm38

  10656 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:32130  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 western clawed frog

HCOP human homology predictions: VNN1
Protein SuperFamily: biotinidase, eukaryotic type
Gene Tree: Vnn1

Human
homologs
VNN1, vanin 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 8876
neXtProt AC: NX_O95497

Human Synonyms: HDLCQ8, Tiff66

Human Chr (Location): 6q23-q24; chr6:132680858-132714055 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human VNN1

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions of this gene develop normally and so no abnormalities in the maturation of lymphoid organs. However, membrane bound pantetheinase is absent in livers and kidneys resuulting in an absence of cysteamine in these organs.
 
Interactions
Vnn1 interacts with 105 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process acute inflammatory response, chronic inflammatory response, ...
Component anchored component of membrane, extracellular exosome, ...
Function GPI anchor binding, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (14 records)
Data Summary: Results (173)    Tissues (126)    Images (34)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 12
RNA in situ 115
RT-PCR 46
cDNA source data(25)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase vnn1    NEW 
Molecular
reagents
All nucleic(29) Genomic(1) cDNA(25) Primer pair(2) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000044612 (Evidence)
Ensembl Gene Model ENSMUSG00000037440 (Evidence)
Entrez Gene 22361 (Evidence)
UniGene 27154
DFCI TC1581156
DoTS DT.489238
NIA Mouse Gene Index U011343
EC 3.5.1.92
Consensus CDS Project CCDS35868.1
International Mouse Phenotyping Consortium Status Vnn1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000044612 VEGA Gene Model | MGI Sequence Detail 10656 C57BL/6J ±  kb
transcript OTTMUST00000117358 VEGA | MGI Sequence Detail 2416 Not Applicable 
polypeptide OTTMUSP00000065632 VEGA | MGI Sequence Detail 512 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(4) UniProt(2)
Polymorphisms
SNPs within 2kb(101 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR012101 Biotinidase, eukaryotic
InterPro IPR003010 Carbon-nitrogen hydrolase
Protein Ontology PR:000017313 pantetheinase
References
(Earliest) J:37066 Aurrand-Lions M, et al., Vanin-1, a novel GPI-linked perivascular molecule involved in thymus homing. Immunity. 1996 Nov;5(5):391-405
(Latest) J:214265 Latre de Late P, et al., Vanin-1 inactivation antagonizes the development of adrenocortical neoplasia in Sf-1 transgenic mice. Endocrinology. 2014 Jul;155(7):2349-54
All references(53)
Other
accession IDs
MGD-MRK-37437

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory