Vnn1
Gene Detail

Symbol Name ID

Vnn1 vanin 1 MGI:108395

Synonyms

pantetheinase, V-1

Feature Type

protein coding gene

Genetic Map

Chromosome 10

11.33 cM, cytoband A1-B2
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr10:23894688-23905343 bp, + strand From NCBI annotation of GRCm38   10656 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:32130  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 2 dog; 1 chicken

Protein SuperFamily: biotinidase, eukaryotic type
Gene Tree: Vnn1

Human homologs

Human Homolog		VNN1, vanin 1
NCBI Gene ID		8876
neXtProt AC		NX_O95497
Human Synonyms		HDLCQ8, Tiff66
Human Chr (Location)		6q23-q24; chr6:133001997-133035194 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human VNN1

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Mice homozygous for disruptions of this gene develop normally and so no abnormalities in the maturation of lymphoid organs. However, membrane bound pantetheinase is absent in livers and kidneys resuulting in an absence of cysteamine in these organs.

 

Gene Ontology (GO) classifications

All GO classifications: (19 annotations)

Process	acute inflammatory response, cell-cell adhesion, ...
Component	anchored to membrane, integral to membrane, ...
Function	GPI anchor binding, hydrolase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (14 records)
Data Summary: Results (173)    Tissues (120)    Images (34)
Theiler Stages: 18, 20, 21, 22, 23, 24

Assay Type	Results
Immunohistochemistry	12
RNA in situ	115
RT-PCR	46

cDNA source data(25)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(29) Genomic(1) cDNA(25) Primer pair(2) Other(1)
Microarray probesets(5)

Other database links

Ensembl Gene Model	ENSMUSG00000037440 (Evidence)
Entrez Gene	22361 (Evidence)
UniGene	27154
DFCI	TC1581156
DoTS	DT.489238
NIA Mouse Gene Index	U011343
EC	3.5.1.92
Consensus CDS Project	CCDS35868.1
International Mouse Knockout Project Status	Vnn1

Sequences

Length	Strain/Species
genomic	22361	NCBI Gene Model | MGI Sequence Detail	10656	C57BL/6J
transcript	NM_011704	RefSeq | MGI Sequence Detail	2416	C57BL/6
polypeptide	Q9Z0K8	UniProt | EBI | MGI Sequence Detail	512	Not Applicable

All sequences(22) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(159 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR012101	Biotinidase, eukaryotic
InterPro	IPR003010	Carbon-nitrogen hydrolase
Protein Ontology	PR:000017313	pantetheinase

Graphical View of Protein Domain Structure

References

(Earliest) J:37066 Aurrand-Lions M, et al., Vanin-1, a novel GPI-linked perivascular molecule involved in thymus homing. Immunity. 1996 Nov;5(5):391-405
(Latest) J:190524 Shalom-Barak T, et al., Placental PPARgamma regulates spatiotemporally diverse genes and a unique metabolic network. Dev Biol. 2012 Dec 1;372(1):143-55
All references(53)

Other accession IDs

MGD-MRK-37437