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Vnn1
Gene Detail
 Symbol
Name
ID
Vnn1
vanin 1
MGI:108395
Synonyms pantetheinase, V-1
Feature Type protein coding gene
Genetic Map
Chromosome 10
11.33 cM, cytoband A1-B2
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr10:23894688-23905343 bp, + strand
From VEGA annotation of GRCm38

  10656 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:32130  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 western clawed frog

Protein SuperFamily: biotinidase, eukaryotic type
Gene Tree: Vnn1

Human
homologs
Human Homolog VNN1, vanin 1
NCBI Gene ID 8876
neXtProt AC  NX_O95497
Human Synonyms  HDLCQ8, Tiff66
Human Chr (Location)  6q23-q24; chr6:132680858-132714055 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human VNN1
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions of this gene develop normally and so no abnormalities in the maturation of lymphoid organs. However, membrane bound pantetheinase is absent in livers and kidneys resuulting in an absence of cysteamine in these organs.
 
Interactions
Vnn1 interacts with 105 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process acute inflammatory response, chronic inflammatory response, ...
Component anchored component of membrane, extracellular vesicular exosome, ...
Function GPI anchor binding, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (14 records)
Data Summary: Results (173)    Tissues (120)    Images (34)
Theiler Stages: 18, 20, 21, 22, 23, 24
Assay TypeResults
Immunohistochemistry 12
RNA in situ 115
RT-PCR 46
cDNA source data(25)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(29) Genomic(1) cDNA(25) Primer pair(2) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000044612 (Evidence)
Ensembl Gene ModelENSMUSG00000037440 (Evidence)
Entrez Gene22361 (Evidence)
UniGene27154
DFCITC1581156
DoTSDT.489238
NIA Mouse Gene IndexU011343
EC3.5.1.92
Consensus CDS ProjectCCDS35868.1
International Mouse Knockout Project StatusVnn1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000044612 VEGA Gene Model | MGI Sequence Detail 10656 C57BL/6J ±  kb
transcript OTTMUST00000117358 VEGA | MGI Sequence Detail 2416 Not Applicable 
polypeptide OTTMUSP00000065632 VEGA | MGI Sequence Detail 512 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(4) UniProt(2)
Polymorphisms SNPs within 2kb(101 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR012101 Biotinidase, eukaryotic
InterPro IPR003010 Carbon-nitrogen hydrolase
Protein Ontology PR:000017313 pantetheinase
References (Earliest) J:37066 Aurrand-Lions M, et al., Vanin-1, a novel GPI-linked perivascular molecule involved in thymus homing. Immunity. 1996 Nov;5(5):391-405
(Latest) J:190524 Shalom-Barak T, et al., Placental PPARgamma regulates spatiotemporally diverse genes and a unique metabolic network. Dev Biol. 2012 Dec 1;372(1):143-55
All references(54)
Other
accession IDs
MGD-MRK-37437

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory