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Kif2a
Gene Detail
 Symbol
Name
ID
Kif2a
kinesin family member 2A
MGI:108390
Synonyms Kif2, Kns2, M-kinesin
Feature Type protein coding gene
Genetic Map
Chromosome 13
58.06 cM, cytoband F
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr13:106958996-107022126 bp, - strand
From VEGA annotation of GRCm38

  63131 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3320  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: kinesin-related protein KIF2
Gene Tree: Kif2a

Human
homologs
Human Homolog KIF2A, kinesin heavy chain member 2A
NCBI Gene ID 3796
neXtProt AC  NX_O00139
Human Synonyms  CDCBM3, HK2, KIF2
Human Chr (Location)  5q12-q13; chr5:62306162-62387184 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human KIF2A
Alleles
and
phenotypes
All alleles(20) : Gene trapped(18) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice display neonatal lethality, abnormal lamination of the cerebral cortex, hippocampus and cerebellum, impaired neuronal migration, and abnormal axon outgrowth.
 
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process cell cycle, cell differentiation, ...
Component centrosome, cytoplasm, ...
Function ATP binding, microtubule binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (64)    Tissues (7)    Images (23)
Theiler Stages: 23
Assay TypeResults
RNA in situ 64
cDNA source data(105)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(105) cDNA(105)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000029368 (Evidence)
Ensembl Gene ModelENSMUSG00000021693 (Evidence)
Entrez Gene16563 (Evidence)
UniGene355686
DFCITC1579009, TC1586452, TC1596111, TC1612763, TC1666033, TC1762188
Consensus CDS ProjectCCDS26759.1, CCDS49356.1
International Mouse Knockout Project StatusKif2a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029368 VEGA Gene Model | MGI Sequence Detail 63131 C57BL/6J ±  kb
transcript OTTMUST00000087626 VEGA | MGI Sequence Detail 2570 Not Applicable 
polypeptide OTTMUSP00000047690 VEGA | MGI Sequence Detail 743 Not Applicable 

For the selected sequences
All sequences(73) RefSeq(14) UniProt(6)
Polymorphisms SNPs within 2kb(248 from dbSNP Build 137)    SNPs within 2kb including multiple locations(250)
Protein-related
information
ResourceIDDescription
InterPro IPR001752 Kinesin, motor domain
InterPro IPR019821 Kinesin, motor region, conserved site
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000009308 kinesin-like protein KIF2A
References (Earliest) J:3448 Aizawa H, et al., Kinesin family in murine central nervous system. J Cell Biol. 1992 Dec;119(5):1287-96
(Latest) J:198541 Maor-Nof M, et al., Axonal pruning is actively regulated by the microtubule-destabilizing protein kinesin superfamily protein 2A. Cell Rep. 2013 Apr 25;3(4):971-7
All references(38)
Other
accession IDs
MGD-MRK-11591, MGD-MRK-37430

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory