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Kif2a Gene Detail
Summary
  • Symbol
    Kif2a
  • Name
    kinesin family member 2A
  • Synonyms
    Kif2, Kns2, M-kinesin
  • Feature Type
    protein coding gene
  • IDs
    MGI:108390
    NCBI Gene: 16563
  • Gene Overview
    MyGene.info: KIF2A
Location & Maps
more
  • Sequence Map
    Chr13:106958996-107022126 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      63131 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 58.06 cM, cytoband F
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    KIF2A, kinesin family member 2A
  • Vertebrate Orthologs
    10
  • Human Ortholog
    KIF2A, kinesin family member 2A
    Orthology source: HomoloGene
  • Synonyms
    CDCBM3, HK2, KIF2
  • Links
    NCBI Gene ID: 3796
    neXtProt AC: NX_O00139

  • Chr Location
    5q12-q13; chr5:62306162-62387184 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human KIF2A associations

Human Disease Mouse Models
       Cortical Dysplasia, Complex, with Other Brain Malformations 3; CDCBM3   OMIM: 615411
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    17 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display neonatal lethality, abnormal lamination of the cerebral cortex, hippocampus and cerebellum, impaired neuronal migration, and abnormal axon outgrowth.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029368 VEGA Gene Model | MGI Sequence Detail 63131 C57BL/6J ±  kb
transcript OTTMUST00000087626 VEGA | MGI Sequence Detail 2570 Not Applicable  
polypeptide OTTMUSP00000047690 VEGA | MGI Sequence Detail 743 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    247 from dbSNP Build 142
Protein
Information
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  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000009308 kinesin-like protein KIF2A
  • InterPro Domains
    IPR027640 Kinesin-like protein
    IPR001752 Kinesin motor domain
    IPR019821 Kinesin motor domain, conserved site
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
Molecular
Reagents
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  • All nucleic 105
    cDNA 105

    Microarray probesets 7
Other
Accession IDs
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MGD-MRK-11591, MGD-MRK-37430
References
more
  • Summaries
    All 37
    Developmental Gene Expression 1
    Gene Ontology 5
    Phenotypes 10
  • Earliest
    J:3448 Aizawa H, et al., Kinesin family in murine central nervous system. J Cell Biol. 1992 Dec;119(5):1287-96
  • Latest
    J:207897 Krahling AM, et al., CRIS-a novel cAMP-binding protein controlling spermiogenesis and the development of flagellar bending. PLoS Genet. 2013 Dec;9(12):e1003960

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory