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Kif4 Gene Detail
Summary
  • Symbol
    Kif4
  • Name
    kinesin family member 4
  • Synonyms
    D330050K22Rik, Kns4, N-5 kinesin
  • Feature Type
    protein coding gene
  • IDs
    MGI:108389
    NCBI Gene: 16571
  • Gene Overview
    MyGene.info: KIF4A
Location & Maps
more
  • Sequence Map
    ChrX:100625737-100727214 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      101478 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome X, 43.72 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    KIF4A, kinesin family member 4A
  • Vertebrate Orthologs
    9
  • Human Ortholog
    KIF4A, kinesin family member 4A
    Orthology source: HomoloGene, HGNC
  • Synonyms
    KIF4, KIF4G1, MRX100
  • Links
    NCBI Gene ID: 24137
    neXtProt AC: NX_O95239

  • Chr Location
    Xq13.1; chrX:70290029-70420924 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human KIF4A associations

Human Disease Mouse Models
       Mental Retardation, X-Linked 100; MRX100   OMIM: 300923
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    10 images
    5 phenotype references
  • All Mutations and Alleles
    12
  • Gene trapped
    10
  • Targeted
    2
  • Incidental Mutations
Male chimeras hemizygous for a gene trapped allele appear normal at E9.5.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018285 VEGA Gene Model | MGI Sequence Detail 101478 C57BL/6J ±  kb
transcript OTTMUST00000044183 VEGA | MGI Sequence Detail 4983 Not Applicable  
polypeptide OTTMUSP00000019864 VEGA | MGI Sequence Detail 1231 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    657 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 104
    cDNA 103
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-11593, MGD-MRK-37429, MGI:2147873
References
more
  • Summaries
    All 40
    Developmental Gene Expression 4
    Gene Ontology 4
    Phenotypes 5
  • Earliest
    J:3448 Aizawa H, et al., Kinesin family in murine central nervous system. J Cell Biol. 1992 Dec;119(5):1287-96
  • Latest
    J:194052 Corbel C, et al., Unusual chromatin status and organization of the inactive X chromosome in murine trophoblast giant cells. Development. 2013 Feb;140(4):861-72

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory