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Btg2 Gene Detail
Summary
  • Symbol
    Btg2
  • Name
    B cell translocation gene 2, anti-proliferative
  • Synonyms
    APRO1, Pc3, TIS21
  • Feature Type
    protein coding gene
  • IDs
    MGI:108384
    NCBI Gene: 12227
  • Gene Overview
    MyGene.info: BTG2
Location & Maps
more
  • Sequence Map
    Chr1:134075170-134079120 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3951 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 58.10 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    BTG2, BTG anti-proliferation factor 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    BTG2, BTG anti-proliferation factor 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    APRO1, PC3, TIS21
  • Links
    NCBI Gene ID: 7832
    neXtProt AC: NX_P78543

  • Chr Location
    1q32; chr1:203305536-203309602 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 3 alleles in 3 genetic backgrounds
    1 phenotype from multigenic genotypes
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    11
  • Chemically induced (other)
    2
  • Radiation induced
    1
  • Targeted
    8
  • Genomic Mutations
    3 involving Btg2
Homozygous null Btg2tm1Wbh mice do not exhibit an overt phenotype. Homozygous null Btg2tm1Spo mice exhibit posterior homeotic transformations of the axial vertebrae.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034725 VEGA Gene Model | MGI Sequence Detail 3951 C57BL/6J ±  kb
transcript OTTMUST00000088224 VEGA | MGI Sequence Detail 2743 Not Applicable  
polypeptide OTTMUSP00000048068 VEGA | MGI Sequence Detail 158 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    8 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 151
    Genomic 1
    cDNA 148
    Primer pair 1
    Other 1

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-37424, MGI:2138132
References
more
  • Summaries
    All 86
    Developmental Gene Expression 40
    Gene Ontology 8
    Phenotypes 26
  • Earliest
    J:9454 Tippetts MT, et al., Tumor promoter-inducible genes are differentially expressed in the developing mouse. Mol Cell Biol. 1988 Oct;8(10):4570-2
  • Latest
    J:231532 Lange C, et al., Relief of hypoxia by angiogenesis promotes neural stem cell differentiation by targeting glycolysis. EMBO J. 2016 May 2;35(9):924-41

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory