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Btg2 Gene Detail
Summary
  • Symbol
    Btg2
  • Name
    B cell translocation gene 2, anti-proliferative
  • Synonyms
    APRO1, Pc3, TIS21
  • Feature Type
    protein coding gene
  • IDs
    MGI:108384
    NCBI Gene: 12227
  • Gene Overview
    MyGene.info: BTG2
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:134075170-134079120 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 58.10 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    8 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108384
protein coding gene Chr1:134074865-134079155 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016497
protein coding gene Chr1:137719780-137723728 (-)
A/J MGP_AJ_G0016480
protein coding gene Chr1:132540209-132544159 (-)
AKR/J MGP_AKRJ_G0016445
protein coding gene Chr1:136496660-136500608 (-)
BALB/cJ MGP_BALBcJ_G0016440
protein coding gene Chr1:132873381-132877330 (-)
C3H/HeJ MGP_C3HHeJ_G0016266
protein coding gene Chr1:136588211-136592162 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016901
protein coding gene Chr1:142745774-142749724 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014612
protein coding gene Chr1:125684480-125688470 (-)
CAST/EiJ MGP_CASTEiJ_G0015846
protein coding gene Chr1:135640067-135644026 (-)
CBA/J MGP_CBAJ_G0016239
protein coding gene Chr1:147660487-147664428 (-)
DBA/2J MGP_DBA2J_G0016345
protein coding gene Chr1:131551729-131555677 (-)
FVB/NJ MGP_FVBNJ_G0016344
protein coding gene Chr1:130178522-130182470 (-)
LP/J MGP_LPJ_G0016416
protein coding gene Chr1:138991706-138995656 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016369
protein coding gene Chr1:153385520-153389484 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016937
protein coding gene Chr1:136214774-136218731 (-)
PWK/PhJ MGP_PWKPhJ_G0015632
protein coding gene Chr1:130567805-130571866 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015419
protein coding gene Chr1:135188283-135192247 (-)
WSB/EiJ MGP_WSBEiJ_G0015909
protein coding gene Chr1:136244847-136248796 (-)



Homology
more
  • Human Ortholog
    BTG2, BTG anti-proliferation factor 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    BTG2, BTG anti-proliferation factor 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    APRO1, PC3, TIS21
  • Links
    NCBI Gene ID: 7832
    neXtProt AC: NX_P78543
    UniProt: P78543

  • Chr Location
    1q32.1; chr1:203305536-203309602 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 3 alleles in 3 genetic backgrounds
    1 phenotype from multigenic genotypes
    33 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    11
  • Chemically induced (other)
    2
  • Radiation induced
    1
  • Targeted
    8
  • Genomic Mutations
    3 involving Btg2
  • Find Mice (IMSR)
  • Recombinase Activity
Homozygous null Btg2tm1Wbh mice do not exhibit an overt phenotype. Homozygous null Btg2tm1Spo mice exhibit posterior homeotic transformations of the axial vertebrae.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000020423 Ensembl Gene Model | MGI Sequence Detail 3951 C57BL/6J ±  kb
transcript ENSMUST00000020692 Ensembl | MGI Sequence Detail 2743 Not Applicable  
polypeptide ENSMUSP00000020692 Ensembl | MGI Sequence Detail 158 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 152
    Genomic 1
    cDNA 149
    Primer pair 1
    Other 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-37424, MGI:2138132
References
more
  • Summaries
    All 105
    Developmental Gene Expression 42
    Gene Ontology 9
    Phenotypes 33
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:266542 Hasenpusch-Theil K, et al., Gli3 controls the onset of cortical neurogenesis by regulating the radial glial cell cycle through Cdk6 expression. Development. 2018 Aug 20;145(17)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory