Btg2
Gene Detail

Symbol Name ID

Btg2 B cell translocation gene 2, anti-proliferative MGI:108384

Synonyms

APRO1, Pc3, TIS21

Feature Type

protein coding gene

Genetic Map

Chromosome 1

58.10 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr1:134075170-134079120 bp, - strand From VEGA annotation of GRCm38   3951 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:31406  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: B-cell translocation protein BTG1/BTG2
Gene Tree: Btg2

Human homologs

Human Homolog		BTG2, BTG family, member 2
NCBI Gene ID		7832
neXtProt AC		NX_P78543
Human Synonyms		PC3, TIS21
Human Chr (Location)		1q32; chr1:203274664-203278730 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(6) : Targeted(6)
 

Homozygous null Btg2^tm1Wbh mice do not exhibit an overt phenotype. Homozygous null Btg2^tm1Spo mice exhibit posterior homeotic transformations of the axial vertebrae.

 

Gene Ontology (GO) classifications

All GO classifications: (21 annotations)

Process	anterior/posterior pattern specification, associative learning, ...
Function	protein binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription

External Resources: FuncBase

Expression

Literature Summary: (31 records)
Data Summary: Results (293)    Tissues (102)    Images (38)
Theiler Stages: 10, 14, 15, 16, 17, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
RNA in situ	247
Northern blot	46

cDNA source data(128)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(131) Genomic(1) cDNA(128) Primer pair(1) Other(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000034725 (Evidence)
Ensembl Gene Model	ENSMUSG00000020423 (Evidence)
Entrez Gene	12227 (Evidence)
UniGene	392646
DFCI	TC1572527, TC1621250
DoTS	DT.535002
NIA Mouse Gene Index	U021782
PDB	3DJN
Consensus CDS Project	CCDS15302.1
International Mouse Knockout Project Status	Btg2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000034725	VEGA Gene Model | MGI Sequence Detail	3951	C57BL/6J
transcript	OTTMUST00000088224	VEGA | MGI Sequence Detail	2743	Not Applicable
polypeptide	OTTMUSP00000048068	VEGA | MGI Sequence Detail	158	Not Applicable

All sequences(32) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(7 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002087	Anti-proliferative protein
Protein Ontology	PR:000004845	protein BTG2

References

(Earliest) J:9454 Tippetts MT, et al., Tumor promoter-inducible genes are differentially expressed in the developing mouse. Mol Cell Biol. 1988 Oct;8(10):4570-2
(Latest) J:192289 Farioli-Vecchioli S, et al., Tis21 knock-out enhances the frequency of medulloblastoma in Patched1 heterozygous mice by inhibiting the Cxcl3-dependent migration of cerebellar neurons. J Neurosci. 2012 Oct 31;32(44):15547-64
All references(74)

Other accession IDs

MGD-MRK-37424, MGI:2138132