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Pxn
Gene Detail
 Symbol
Name
ID
Pxn
paxillin
MGI:108295
Synonyms Pax
Feature Type protein coding gene
Genetic Map
Chromosome 5
56.10 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr5:115506676-115555987 bp, + strand
From VEGA annotation of GRCm38

  49312 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37697  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: leupaxin
Gene Tree: Pxn

Human
homologs
Human Homolog PXN, paxillin
NCBI Gene ID 5829
neXtProt AC  NX_P49023
Human Chr (Location)  12q24.31; chr12:120210439-120265771 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(50) : Gene trapped(46) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutant mice die at E9.5 with defects in the amnion, allantois, and headfold structures, as well as impaired growth, and abnormal heart and somite development; mutant fibroblasts show aberrant fibronectin-regulated focal adhesion dynamics, and disorganized membrane cytoskeletal structures.
 
Interactions
Pxn interacts with 245 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (44 annotations)
Process activation of MAPK activity, branching morphogenesis of an epithelial tube, ...
Component cell junction, cell leading edge, ...
Function beta-catenin binding, BH4 domain binding, ...
External Resources: FuncBase
Expression
Literature Summary: (14 records)
Data Summary: Results (162)    Tissues (73)    Images (46)
Theiler Stages: 2, 3, 4, 5, 12, 14, 15, 17, 19, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 30
RNA in situ 63
Western blot 33
RT-PCR 36
cDNA source data(84)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(98) Genomic(8) cDNA(85) Primer pair(4) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000014676 (Evidence)
Ensembl Gene ModelENSMUSG00000029528 (Evidence)
Entrez Gene19303 (Evidence)
UniGene18714
DFCITC1573532, TC1613677, TC1691533
DoTSDT.531981, DT.87025699, DT.94212287, DT.97335386, DT.99865806
NIA Mouse Gene IndexU006051
Consensus CDS ProjectCCDS19593.1, CCDS39229.1
International Mouse Knockout Project StatusPxn
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014676 VEGA Gene Model | MGI Sequence Detail 49312 C57BL/6J ±  kb
transcript OTTMUST00000034818 VEGA | MGI Sequence Detail 2667 Not Applicable 
polypeptide OTTMUSP00000015575 VEGA | MGI Sequence Detail 591 Not Applicable 

For the selected sequences
All sequences(99) RefSeq(16) UniProt(4)
Polymorphisms SNPs within 2kb(569 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017305 Leupaxin
InterPro IPR001904 Paxillin
InterPro IPR001781 Zinc finger, LIM-type
Protein Ontology PR:000013512 paxillin
References (Earliest) J:49586 Mazaki Y, et al., Paxillin isoforms in mouse. Lack of the gamma isoform and developmentally specific beta isoform expression. J Biol Chem. 1998 Aug 28;273(35):22435-41
(Latest) J:199658 Moik D, et al., Mutations in the paxillin-binding site of integrin-linked kinase (ILK) destabilize the pseudokinase domain and cause embryonic lethality in mice. J Biol Chem. 2013 Jun 28;288(26):18863-71
All references(97)
Other
accession IDs
MGD-MRK-37334, MGI:2141153, MGI:2141158

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory