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Pxn Gene Detail
Summary
  • Symbol
    Pxn
  • Name
    paxillin
  • Synonyms
    Pax
  • Feature Type
    protein coding gene
  • IDs
    MGI:108295
    NCBI Gene: 19303
Location & Maps
more
  • Sequence Map
    Chr5:115506676-115555987 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      49312 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    PXN, paxillin
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PXN, paxillin
    Orthology source: HomoloGene
  • Links
    NCBI Gene ID: 5829
    neXtProt AC: NX_P49023

  • Chr Location
    12q24.31; chr12:120210439-120265771 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 37697
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: PXN
  • Protein SuperFamily
  • Gene Tree
    Pxn
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 1 allele in 1 genetic background
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    53
  • Chemically induced (other)
    1
  • Gene trapped
    46
  • Radiation induced
    1
  • Targeted
    4
  • Transgenic
    1
  • Genomic Mutations
    2 involving Pxn
  • Incidental Mutations
Homozygous mutant mice die at E9.5 with defects in the amnion, allantois, and headfold structures, as well as impaired growth, and abnormal heart and somite development; mutant fibroblasts show aberrant fibronectin-regulated focal adhesion dynamics, and disorganized membrane cytoskeletal structures.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014676 VEGA Gene Model | MGI Sequence Detail 49312 C57BL/6J ±  kb
transcript OTTMUST00000034818 VEGA | MGI Sequence Detail 2667 Not Applicable  
polypeptide OTTMUSP00000015575 VEGA | MGI Sequence Detail 591 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    569 from dbSNP Build 137
Protein
Information
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  • UniProt
    10 Sequences
  • Protein Ontology
    PR:000013512 paxillin
  • InterPro Domains
    IPR001904 Paxillin
    IPR017305 Transforming growth factor beta-1-induced transcript 1 protein/Leupaxin
    IPR001781 Zinc finger, LIM-type
Molecular
Reagents
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  • All nucleic 98
    Genomic 8
    cDNA 85
    Primer pair 4
    Other 1

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-37334, MGI:2141153, MGI:2141158
References
more
  • Summaries
    All 102
    Developmental Gene Expression 18
    Gene Ontology 22
    Phenotypes 17
  • Earliest
    J:49586 Mazaki Y, et al., Paxillin isoforms in mouse. Lack of the gamma isoform and developmentally specific beta isoform expression. J Biol Chem. 1998 Aug 28;273(35):22435-41
  • Latest
    J:225910 Ellison TS, et al., Suppression of beta3-integrin in mice triggers a neuropilin-1-dependent change in focal adhesion remodelling that can be targeted to block pathological angiogenesis. Dis Model Mech. 2015 Sep 1;8(9):1105-19

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory