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Pxn
Gene Detail
Symbol

Name
ID
Pxn
paxillin
MGI:108295
Synonyms
Pax
Feature Type
protein coding gene
Genetic Map
Chromosome 5
56.10 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr5:115506676-115555987 bp, + strand
From VEGA annotation of GRCm38

  49312 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37697  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PXN
Protein SuperFamily: leupaxin
Gene Tree: Pxn

Human
homologs
PXN, paxillin
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 5829
neXtProt AC: NX_P49023

Human Chr (Location): 12q24.31; chr12:120210439-120265771 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(50) : Gene trapped(46) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutant mice die at E9.5 with defects in the amnion, allantois, and headfold structures, as well as impaired growth, and abnormal heart and somite development; mutant fibroblasts show aberrant fibronectin-regulated focal adhesion dynamics, and disorganized membrane cytoskeletal structures.
 
Interactions
Pxn interacts with 244 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (47 annotations)
Process activation of MAPK activity, branching morphogenesis of an epithelial tube, ...
Component cell junction, cell leading edge, ...
Function beta-catenin binding, BH4 domain binding, ...
External Resources: FuncBase
Expression
Literature Summary: (18 records)
Data Summary: Results (162)    Tissues (77)    Images (50)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 30
RNA in situ 63
Western blot 33
RT-PCR 36
cDNA source data(84)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase pxn    NEW 
Molecular
reagents
All nucleic(98) Genomic(8) cDNA(85) Primer pair(4) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000014676 (Evidence)
Ensembl Gene Model ENSMUSG00000029528 (Evidence)
Entrez Gene 19303 (Evidence)
UniGene 18714
DFCI TC1691533, TC1613677, TC1573532
DoTS DT.87025699, DT.531981, DT.94212287, DT.99865806, DT.97335386
NIA Mouse Gene Index U006051
Consensus CDS Project CCDS19593.1, CCDS39229.1
International Mouse Phenotyping Consortium Status Pxn
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014676 VEGA Gene Model | MGI Sequence Detail 49312 C57BL/6J ±  kb
transcript OTTMUST00000034818 VEGA | MGI Sequence Detail 2667 Not Applicable 
polypeptide OTTMUSP00000015575 VEGA | MGI Sequence Detail 591 Not Applicable 

For the selected sequences
All sequences(101) RefSeq(16) UniProt(4)
Polymorphisms
SNPs within 2kb(569 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017305 Leupaxin
InterPro IPR001904 Paxillin
InterPro IPR001781 Zinc finger, LIM-type
Protein Ontology PR:000013512 paxillin
References
(Earliest) J:49586 Mazaki Y, et al., Paxillin isoforms in mouse. Lack of the gamma isoform and developmentally specific beta isoform expression. J Biol Chem. 1998 Aug 28;273(35):22435-41
(Latest) J:217881 Mlih M, et al., The Src Homology and Collagen A (ShcA) Adaptor Protein Is Required for the Spatial Organization of the Costamere/Z-disk Network during Heart Development. J Biol Chem. 2015 Jan 23;290(4):2419-30
All references(103)
Other
accession IDs
MGD-MRK-37334, MGI:2141153, MGI:2141158

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory