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Ube2m Gene Detail
Summary
  • Symbol
    Ube2m
  • Name
    ubiquitin-conjugating enzyme E2M
  • Synonyms
    2510040H03Rik, MGC:25453, MGC:37197, UBC12, Ubc-rs2
  • Feature Type
    protein coding gene
  • IDs
    MGI:108278
    NCBI Gene: 22192
  • Gene Overview
    MyGene.info: UBE2M
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:12769047-12772202 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 7.73 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    24 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108278
 protein coding gene Chr7:12769047-12772202 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031664
 protein coding gene Chr7:10443869-10446882 (-)
A/J MGP_AJ_G0031637
 protein coding gene Chr7:10283565-10286581 (-)
AKR/J MGP_AKRJ_G0031560
 protein coding gene Chr7:10512604-10515647 (-)
BALB/cJ MGP_BALBcJ_G0031642
 protein coding gene Chr7:10398041-10401082 (-)
C3H/HeJ MGP_C3HHeJ_G0031364
 protein coding gene Chr7:10617562-10620576 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032106
 protein coding gene Chr7:10973625-10976664 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029200
 protein coding gene Chr7:11881328-11884470 (-)
CAST/EiJ MGP_CASTEiJ_G0030722
 protein coding gene Chr7:8174305-8177430 (-)
CBA/J MGP_CBAJ_G0031321
 protein coding gene Chr7:11193364-11196411 (-)
DBA/2J MGP_DBA2J_G0031479
 protein coding gene Chr7:10166060-10169073 (-)
FVB/NJ MGP_FVBNJ_G0031435
 protein coding gene Chr7:10163753-10166793 (-)
LP/J MGP_LPJ_G0031566
 protein coding gene Chr7:10528442-10532825 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031470
 protein coding gene Chr7:11278957-11281997 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032136
 protein coding gene Chr7:10301147-10304159 (-)
PWK/PhJ MGP_PWKPhJ_G0030450
 protein coding gene Chr7:8650011-8652998 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030276
 protein coding gene Chr7:6410735-6413855 (-)
WSB/EiJ MGP_WSBEiJ_G0030817
 protein coding gene Chr7:10329664-10332676 (-)



Homology
more
  • Human Ortholog
    UBE2M, ubiquitin conjugating enzyme E2 M
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    UBE2M, ubiquitin conjugating enzyme E2 M
  • Synonyms
    hUbc12, UBC12, UBC-RS2
  • Links
    NCBI Gene ID: 9040
    neXtProt AC: NX_P61081
    UniProt: P61081

  • Chr Location
    19q13.43; chr19:58555712-58558976 (-)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 2 alleles in 3 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased embryo size, abnormal embryonic epiblast morphology, absent primitive node and head folds, failure to gastrulate, and complete lethality prior to organogenesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    762
  • Tissues
    52
  • cDNA Data
    134
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 22192 NCBI Gene Model | MGI Sequence Detail 3156 C57BL/6J ±  kb
    transcript NM_145578 RefSeq | MGI Sequence Detail 1295 C57BL/6  
    polypeptide P61082 UniProt | EBI | MGI Sequence Detail 183 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 136
      cDNA 134
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-37317, MGI:1917500
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 6
      Gene Ontology 4
      Phenotypes 13
    • Earliest
      J:44483 Brady KP, et al., Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Genome Res. 1997 Nov;7(11):1085-93
    • Latest
      J:261328 Zou J, et al., Neddylation mediates ventricular chamber maturation through repression of Hippo signaling. Proc Natl Acad Sci U S A. 2018 Apr 24;115(17):E4101-E4110
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/19/2021
    MGI 6.17     		The Jackson Laboratory