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Pcbp2 Gene Detail
Summary
  • Symbol
    Pcbp2
  • Name
    poly(rC) binding protein 2
  • Synonyms
    alphaCP-2, Hnrpx
  • Feature Type
    protein coding gene
  • IDs
    MGI:108202
    NCBI Gene: 18521
  • Gene Overview
    MyGene.info: PCBP2
Location & Maps
more
  • Sequence Map
    Chr15:102470632-102500059 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      29428 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 57.61 cM, cytoband F1
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    PCBP2, poly(rC) binding protein 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PCBP2, poly(rC) binding protein 2
    Orthology source: HomoloGene
  • Synonyms
    hnRNP-E2, HNRNPE2, HNRPE2
  • Links
    NCBI Gene ID: 5094
    neXtProt AC: NX_Q15366

  • Chr Location
    12q13.13; chr12:53452102-53481162 (+)  GRCh38.p2

Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    29 phenotype references
  • All Mutations and Alleles
    101
  • Chemically induced (other)
    1
  • Gene trapped
    94
  • Radiation induced
    2
  • Targeted
    4
  • Genomic Mutations
    3 involving Pcbp2
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000056851 Ensembl Gene Model | MGI Sequence Detail 29428 C57BL/6J ±  kb
transcript ENSMUST00000077037 Ensembl | MGI Sequence Detail 2868 Not Applicable  
polypeptide ENSMUSP00000076294 Ensembl | MGI Sequence Detail 362 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    82 from dbSNP Build 142
  • PCR
Protein
Information
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  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000012336 poly(rC)-binding protein 2
  • InterPro Domains
    IPR004087 K Homology domain
    IPR004088 K Homology domain, type 1
Molecular
Reagents
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  • All nucleic 23
    Genomic 2
    cDNA 19
    Primer pair 2

    Microarray probesets 2
Other
Accession IDs
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MGD-MRK-10809, MGD-MRK-37241, MGI:2146212, MGI:96165
References
more
  • Summaries
    All 38
    Developmental Gene Expression 2
    Diseases 1
    Gene Ontology 6
    Phenotypes 29
  • Earliest
    J:14357 Hahm K, et al., Isolation of a murine gene encoding a nucleic acid-binding protein with homology to hnRNP K. Nucleic Acids Res. 1993 Aug 11;21(16):3894
  • Latest
    J:228665 Zhang Y, et al., The RNA-binding protein PCBP2 inhibits Ang II-induced hypertrophy of cardiomyocytes though promoting GPR56 mRNA degeneration. Biochem Biophys Res Commun. 2015 Aug 28;464(3):679-84

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory