Aldh7a1
Gene Detail

Symbol Name ID

Aldh7a1 aldehyde dehydrogenase family 7, member A1 MGI:108186

Synonyms

Atq1, D18Wsu181e

Feature Type

protein coding gene

Genetic Map

Chromosome 18

30.55 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)

Sequence Map

Chr18:56509687-56572951 bp, - strand From VEGA annotation of GRCm38   63265 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Aldh7a1 ± 2 cM)

Protein SuperFamily: NAD-dependent aldehyde dehydrogenase
Gene Tree: Aldh7a1

Human ortholog

ALDH7A1 aldehyde dehydrogenase 7 family, member A1 NCBI Gene ID 501
Human Synonyms: ATQ1, EPD, PDE
Human Chr5:125878918-125931082 bp, - strand Reference GRCh37.p2 Primary Assembly
Human Diseases Associated with Human ALDH7A1 (1)

Alleles and phenotypes

All alleles(17) : Targeted(2) Gene trapped(15)
 

Mice homozygous for disruptions in this gene display a normal phenotype.

 

Gene Ontology (GO) classifications

All GO classifications: (12 annotations)

Process	metabolic process, oxidation-reduction process
Component	cytoplasm, mitochondrion, ...
Function	aldehyde dehydrogenase (NAD) activity, betaine-aldehyde dehydrogenase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (234)    Tissues (124)    Images (43)
Theiler Stages: 11, 19, 22, 23, 28

Assay Type	Results
RNA in situ	228
RT-PCR	6

cDNA source data(206)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(210) cDNA(207) Primer pair(3)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000035214 (Evidence)
Ensembl Gene Model	ENSMUSG00000053644 (Evidence)
Entrez Gene	110695 (Evidence)
UniGene	30250
DFCI	TC1572084, TC1583648, TC1707961, TC1777657
NIA Mouse Gene Index	U058287
EC	1.2.1.3, 1.2.1.31, 1.2.1.8
Consensus CDS Project	CCDS29258.2, CCDS50291.1
International Mouse Knockout Project Status	Aldh7a1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000035214	VEGA Gene Model | MGI Sequence Detail	63265	C57BL/6J
transcript	OTTMUST00000089709	VEGA | MGI Sequence Detail	1914	Not Applicable
polypeptide	OTTMUSP00000049051	VEGA | MGI Sequence Detail	539	Not Applicable

All sequences(65) RefSeq(4) UniProt(5)

Polymorphisms

All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs(210 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR016160	Aldehyde dehydrogenase, conserved site
InterPro	IPR016163	Aldehyde dehydrogenase, C-terminal
InterPro	IPR015590	Aldehyde dehydrogenase domain
InterPro	IPR016162	Aldehyde dehydrogenase, N-terminal
InterPro	IPR016161	Aldehyde/histidinol dehydrogenase
Protein Ontology	PR:000003931	alpha-aminoadipic semialdehyde dehydrogenase

References

(Earliest) J:4717 Gill RK, et al., Identification of sequence elements in mouse calbindin-D28k gene that confer 1,25-dihydroxyvitamin D3- and butyrate-inducible responses. Proc Natl Acad Sci U S A. 1993 Apr 1;90(7):2984-8
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(42)

Other accession IDs

MGD-MRK-36424, MGD-MRK-37225, MGI:107847