Prx
Gene Detail

Symbol Name ID

Prx periaxin MGI:108176

STS

D7Tem23

Synonyms

L-Periaxin

Feature Type

protein coding gene

Genetic Map

Chromosome 7

15.91 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr7:27499324-27520214 bp, + strand From VEGA annotation of GRCm38   20891 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:76542  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque

Gene Tree: Prx

Human homologs

Human Homolog		PRX, periaxin
NCBI Gene ID		57716
neXtProt AC		NX_Q9BXM0
Human Synonyms		CMT4F
Human Chr (Location)		19q13.2; chr19:40899671-40919271 (-)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human PRX

Alleles and phenotypes

All alleles(28) : Targeted(2) Gene trapped(26)
 

Mice homozygous for disruptions in this gene display locomotor problems as well as difficulty eating and breathing. Demyelination of peripheral nerves develops with age.

 

Gene Ontology (GO) classifications

All GO classifications: (6 annotations)

Component	cytoplasm, membrane, ...
Function	protein binding

External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (6)    Tissues (1)   
Theiler Stages: 28

Assay Type	Results
Immunohistochemistry	6

cDNA source data(20)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(23) cDNA(22) Primer pair(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000023418 (Evidence)
Ensembl Gene Model	ENSMUSG00000053198 (Evidence)
Entrez Gene	19153 (Evidence)
UniGene	10119
DFCI	TC1583469, TC1708984
DoTS	DT.101354836, DT.526567, DT.97412106, DT.99844296
NIA Mouse Gene Index	U007854
Consensus CDS Project	CCDS21023.1, CCDS39849.1
International Mouse Knockout Project Status	Prx

Sequences

Length	Strain/Species
genomic	OTTMUSG00000023418	VEGA Gene Model | MGI Sequence Detail	20891	C57BL/6J
transcript	OTTMUST00000056899	VEGA | MGI Sequence Detail	4841	Not Applicable
polypeptide	OTTMUSP00000027396	VEGA | MGI Sequence Detail	1391	Not Applicable

All sequences(42) RefSeq(4) UniProt(4)

Polymorphisms

All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs(85 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001478	PDZ domain
Protein Ontology	PR:000013336	periaxin

References

(Earliest) J:31213 Scherer SS, et al., Periaxin expression in myelinating Schwann cells: modulation by axon-glial interactions and polarized localization during development. Development. 1995 Dec;121(12):4265-73
(Latest) J:185953 Sherman DL, et al., Drp2 and periaxin form cajal bands with dystroglycan but have distinct roles in schwann cell growth. J Neurosci. 2012 Jul 4;32(27):9419-28
All references(43)

Other accession IDs

MGD-MRK-37215