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Prx
Gene Detail
 Symbol
Name
ID
Prx
periaxin
MGI:108176
STS D7Tem23
Synonyms L-Periaxin
Feature Type protein coding gene
Genetic Map
Chromosome 7
15.91 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr7:27499324-27520214 bp, + strand
From VEGA annotation of GRCm38

  20891 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:76542  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Prx

Human
homologs
Human Homolog PRX, periaxin
NCBI Gene ID 57716
neXtProt AC  NX_Q9BXM0
Human Synonyms  CMT4F
Human Chr (Location)  19q13.2; chr19:40393764-40413372 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human PRX
Mutations,
alleles, and
phenotypes
All mutations/alleles(29) : Gene trapped(26) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene display locomotor problems as well as difficulty eating and breathing. Demyelination of peripheral nerves develops with age.
 
Interactions
Prx interacts with 328 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Process regulation of RNA splicing
Component cytoplasm, membrane, ...
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (6)    Tissues (2)   
Theiler Stages: 27, 28
Assay TypeResults
Immunohistochemistry 6
cDNA source data(20)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(23) cDNA(22) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000023418 (Evidence)
Ensembl Gene ModelENSMUSG00000053198 (Evidence)
Entrez Gene19153 (Evidence)
UniGene10119
DFCITC1583469, TC1708984
DoTSDT.101354836, DT.526567, DT.97412106, DT.99844296
NIA Mouse Gene IndexU007854
Consensus CDS ProjectCCDS21023.1, CCDS39849.1
International Mouse Knockout Project StatusPrx
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023418 VEGA Gene Model | MGI Sequence Detail 20891 C57BL/6J ±  kb
transcript OTTMUST00000056899 VEGA | MGI Sequence Detail 4841 Not Applicable 
polypeptide OTTMUSP00000027396 VEGA | MGI Sequence Detail 1391 Not Applicable 

For the selected sequences
All sequences(46) RefSeq(8) UniProt(4)
Polymorphisms All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(131 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001478 PDZ domain
Protein Ontology PR:000013336 periaxin
References (Earliest) J:31213 Scherer SS, et al., Periaxin expression in myelinating Schwann cells: modulation by axon-glial interactions and polarized localization during development. Development. 1995 Dec;121(12):4265-73
(Latest) J:205645 de Morree A, et al., Self-regulated alternative splicing at the AHNAK locus. FASEB J. 2012 Jan;26(1):93-103
All references(45)
Other
accession IDs
MGD-MRK-37215

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory