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Prx Gene Detail
Summary
  • Symbol
    Prx
  • Name
    periaxin
  • Synonyms
    L-Periaxin
  • Feature Type
    protein coding gene
  • IDs
    MGI:108176
    NCBI Gene: 19153
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:27198730-27219466 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 15.91 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    128 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108176
 protein coding gene Chr7:27196813-27219639 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031914
 protein coding gene Chr7:26159407-26181744 (+)
A/J MGP_AJ_G0031893
 protein coding gene Chr7:25523419-25548142 (+)
AKR/J MGP_AKRJ_G0031823
 protein coding gene Chr7:26207123-26228751 (+)
BALB/cJ MGP_BALBcJ_G0031898
 protein coding gene Chr7:25741498-25763139 (+)
C3H/HeJ MGP_C3HHeJ_G0031620
 protein coding gene Chr7:26582512-26607040 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032363
 protein coding gene Chr7:27017455-27044671 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029415
 protein coding gene Chr7:26759188-26773434 (+)
CAST/EiJ MGP_CASTEiJ_G0030955
 protein coding gene Chr7:19891965-19913895 (+)
CBA/J MGP_CBAJ_G0031585
 protein coding gene Chr7:28212817-28240184 (+)
DBA/2J MGP_DBA2J_G0031737
 protein coding gene Chr7:25328040-25343054 (+)
FVB/NJ MGP_FVBNJ_G0031693
 protein coding gene Chr7:25425937-25447386 (+)
LP/J MGP_LPJ_G0031817
 protein coding gene Chr7:26489494-26510202 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031728
 protein coding gene Chr7:27785221-27810076 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032394
 protein coding gene Chr7:25742669-25768308 (+)
PWK/PhJ MGP_PWKPhJ_G0030679
 protein coding gene Chr7:20358446-20379573 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030513
 protein coding gene Chr7:16731705-16752661 (+)
WSB/EiJ MGP_WSBEiJ_G0031063
 protein coding gene Chr7:26034443-26052804 (+)



Homology
more
  • Human Ortholog
    PRX, periaxin
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PRX, periaxin
  • Synonyms
    CMT4F
  • Links
    NCBI Gene ID: 57716
    neXtProt AC: NX_Q9BXM0
    UniProt: Q9BXM0

  • Chr Location
    19q13.2; chr19:40393764-40414793 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human PRX associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypes from 3 alleles in 4 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display locomotor problems as well as difficulty eating and breathing. Demyelination of peripheral nerves develops with age.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    715
  • Tissues
    5
  • cDNA Data
    22
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 19153 NCBI Gene Model | MGI Sequence Detail 20737 C57BL/6J ±  kb
    transcript NM_019412 RefSeq | MGI Sequence Detail 5260 ZRU/MplStud  
    polypeptide O55103 UniProt | EBI | MGI Sequence Detail 1391 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 26
      cDNA 24
      Primer pair 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-37215
    References
    more
    • Summaries
      All 49
      Developmental Gene Expression 8
      Gene Ontology 8
      Phenotypes 15
    • Earliest
      J:31213 Scherer SS, et al., Periaxin expression in myelinating Schwann cells: modulation by axon-glial interactions and polarized localization during development. Development. 1995 Dec;121(12):4265-73
    • Latest
      J:332131 Perera SN, et al., Insights into olfactory ensheathing cell development from a laser-microdissection and transcriptome-profiling approach. Glia. 2020 Dec;68(12):2550-2584
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory