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Prx
Gene Detail
Symbol

Name
ID
Prx
periaxin
MGI:108176
STS
Synonyms
L-Periaxin
Feature Type
protein coding gene
Genetic Map
Chromosome 7
15.91 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr7:27499324-27520214 bp, + strand
From VEGA annotation of GRCm38

  20891 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:76542  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: PRX
Gene Tree: Prx

Human
homologs
PRX, periaxin
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 57716
neXtProt AC: NX_Q9BXM0

Human Synonyms: CMT4F

Human Chr (Location): 19q13.2; chr19:40393764-40414718 (-)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human PRX

Mutations,
alleles, and
phenotypes
All mutations/alleles(29) : Gene trapped(26) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene display locomotor problems as well as difficulty eating and breathing. Demyelination of peripheral nerves develops with age.
 
Interactions
Prx interacts with 328 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Process regulation of RNA splicing
Component cytoplasm, membrane, ...
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (6)    Tissues (2)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 6
cDNA source data(20)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase prx    NEW 
Molecular
reagents
All nucleic(23) cDNA(22) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000023418 (Evidence)
Ensembl Gene Model ENSMUSG00000053198 (Evidence)
Entrez Gene 19153 (Evidence)
UniGene 10119
DFCI TC1708984, TC1583469
DoTS DT.97412106, DT.526567, DT.101354836, DT.99844296
NIA Mouse Gene Index U007854
Consensus CDS Project CCDS21023.1, CCDS39849.1
International Mouse Phenotyping Consortium Status Prx
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023418 VEGA Gene Model | MGI Sequence Detail 20891 C57BL/6J ±  kb
transcript OTTMUST00000056899 VEGA | MGI Sequence Detail 4841 Not Applicable 
polypeptide OTTMUSP00000027396 VEGA | MGI Sequence Detail 1391 Not Applicable 

For the selected sequences
All sequences(44) RefSeq(6) UniProt(4)
Polymorphisms
All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(131 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001478 PDZ domain
Protein Ontology PR:000013336 periaxin
References
(Earliest) J:31213 Scherer SS, et al., Periaxin expression in myelinating Schwann cells: modulation by axon-glial interactions and polarized localization during development. Development. 1995 Dec;121(12):4265-73
(Latest) J:205645 de Morree A, et al., Self-regulated alternative splicing at the AHNAK locus. FASEB J. 2012 Jan;26(1):93-103
All references(44)
Other
accession IDs
MGD-MRK-37215

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory