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Prkg1 Gene Detail
Summary
  • Symbol
    Prkg1
  • Name
    protein kinase, cGMP-dependent, type I
  • Synonyms
    Prkg1b, Prkgr1b
  • Feature Type
    protein coding gene
  • IDs
    MGI:108174
    NCBI Gene: 19091
  • Gene Overview
    MyGene.info: PRKG1
Location & Maps
more
  • Sequence Map
    Chr19:30567551-31765033 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      1197483 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 25.17 cM, cytoband C2
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    PRKG1, protein kinase, cGMP-dependent, type I
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PRKG1, protein kinase, cGMP-dependent, type I
    Orthology source: HomoloGene
  • Synonyms
    AAT8, cGK, cGK1, cGK 1, cGKI, cGKI-alpha, cGKI-BETA, PKG, PRKG1B, PRKGR1B
  • Links
    NCBI Gene ID: 5592
    neXtProt AC: NX_Q13976

  • Chr Location
    10q11.2; chr10:50991151-52298350 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human PRKG1 associations

Human Disease Mouse Models
       Aortic Aneurysm, Familial Thoracic 8; AAT8   OMIM: 615436
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    53 phenotypes from 8 alleles in 10 genetic backgrounds
    3 phenotypes from multigenic genotypes
    66 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    22
  • Gene trapped
    10
  • Targeted
    11
  • Transposon induced
    1
  • Incidental Mutations
Mutant mice exhibit abnormal smooth muscle function and penile erectile deficiency. Conditional disruption in the hippocampus results in impaired LTP. Mice homozygous for a transposon induced allele exhibit postnatal lethality.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000043089 VEGA Gene Model | MGI Sequence Detail 1197483 C57BL/6J ±  kb
transcript OTTMUST00000113064 VEGA | MGI Sequence Detail 2841 Not Applicable  
polypeptide OTTMUSP00000063305 VEGA | MGI Sequence Detail 686 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    5679 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 20
    cDNA 18
    Primer pair 1
    Other 1

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-19672, MGD-MRK-37213, MGI:2147712
References
more
  • Summaries
    All 110
    Developmental Gene Expression 10
    Gene Ontology 11
    Phenotypes 66
  • Earliest
    J:12810 Uhler MD, Cloning and expression of a novel cyclic GMP-dependent protein kinase from mouse brain. J Biol Chem. 1993 Jun 25;268(18):13586-91
  • Latest
    J:222967 Nakamura T, et al., Prevention of PKG1alpha oxidation augments cardioprotection in the stressed heart. J Clin Invest. 2015 Jun;125(6):2468-72

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory