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Prkg1 Gene Detail
Summary
  • Symbol
    Prkg1
  • Name
    protein kinase, cGMP-dependent, type I
  • Synonyms
    Prkg1b, Prkgr1b
  • Feature Type
    protein coding gene
  • IDs
    MGI:108174
    NCBI Gene: 19091
  • Gene Overview
    MyGene.info: PRKG1
  • Alliance
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:30567551-31765033 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 25.17 cM, cytoband C2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    5679 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108174
protein coding gene Chr19:30564487-31765309 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025035
protein coding gene Chr19:29119361-30372511 (-)
A/J MGP_AJ_G0025012
protein coding gene Chr19:27657479-28861829 (-)
AKR/J MGP_AKRJ_G0024980
protein coding gene Chr19:28644479-29876012 (-)
BALB/cJ MGP_BALBcJ_G0025011
protein coding gene Chr19:27697576-28897781 (-)
C3H/HeJ MGP_C3HHeJ_G0024767
protein coding gene Chr19:28614537-29853152 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025452
protein coding gene Chr19:29910859-31189263 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022871
protein coding gene Chr19:27615491-28789231 (-)
CAST/EiJ MGP_CASTEiJ_G0024237
protein coding gene Chr19:28502128-29742987 (-)
CBA/J MGP_CBAJ_G0024745
protein coding gene Chr19:31340215-32662780 (-)
DBA/2J MGP_DBA2J_G0024877
protein coding gene Chr19:27593071-28785593 (-)
FVB/NJ MGP_FVBNJ_G0024839
protein coding gene Chr19:27416653-28607561 (-)
LP/J MGP_LPJ_G0024962
protein coding gene Chr19:29128613-30378682 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024866
protein coding gene Chr19:31234297-32543741 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025507
protein coding gene Chr19:28655717-29906137 (-)
PWK/PhJ MGP_PWKPhJ_G0023985
protein coding gene Chr19:27268399-28482022 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023789
protein coding gene Chr19:27976721-29241106 (-)
WSB/EiJ MGP_WSBEiJ_G0024304
protein coding gene Chr19:28721631-29954865 (-)



Homology
more
  • Human Ortholog
    PRKG1, protein kinase cGMP-dependent 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PRKG1, protein kinase cGMP-dependent 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AAT8, cGK, cGK1, cGK 1, cGKI, cGKI-alpha, cGKI-BETA, PKG, PKG1, PRKG1B, PRKGR1B
  • Links
    NCBI Gene ID: 5592
    neXtProt AC: NX_Q13976
    UniProt: Q13976

  • Chr Location
    10q11.23-q21.1; chr10:50991151-52298350 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human PRKG1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    54 phenotypes from 9 alleles in 11 genetic backgrounds
    3 phenotypes from multigenic genotypes
    74 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mutant mice exhibit abnormal smooth muscle function and penile erectile deficiency. Conditional disruption in the hippocampus results in impaired LTP. Mice homozygous for a transposon induced allele exhibit postnatal lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000052920 Ensembl Gene Model | MGI Sequence Detail 1197483 C57BL/6J ±  kb
    transcript ENSMUST00000073581 Ensembl | MGI Sequence Detail 2841 Not Applicable  
    polypeptide ENSMUSP00000073268 Ensembl | MGI Sequence Detail 686 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 21
      cDNA 19
      Primer pair 1
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-19672, MGD-MRK-37213, MGI:2147712
    References
    more
    • Summaries
      All 132
      Developmental Gene Expression 12
      Gene Ontology 13
      Phenotypes 74
    • Earliest
      J:12810 Uhler MD, Cloning and expression of a novel cyclic GMP-dependent protein kinase from mouse brain. J Biol Chem. 1993 Jun 25;268(18):13586-91
    • Latest
      J:263287 Troster P, et al., The Absence of Sensory Axon Bifurcation Affects Nociception and Termination Fields of Afferents in the Spinal Cord. Front Mol Neurosci. 2018;11:19

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory