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Prkg1
Gene Detail
Symbol

Name
ID
Prkg1
protein kinase, cGMP-dependent, type I
MGI:108174
Synonyms
Prkg1b, Prkgr1b
Feature Type
protein coding gene
Genetic Map
Chromosome 19
25.17 cM, cytoband C2
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr19:30567551-31765033 bp, - strand
From VEGA annotation of GRCm38

  1197483 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55964  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PRKG1
Protein SuperFamily: cGMP-dependent protein kinase
Gene Tree: Prkg1

Human
homologs
PRKG1, protein kinase, cGMP-dependent, type I
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 5592
neXtProt AC: NX_Q13976

Human Synonyms: 1, AAT8, cGK, cGK1, cGK 1, cGKI, cGKI-alpha, cGKI-BETA, PKG, PRKG1B, PRKGR1B

Human Chr (Location): 10q11.2; chr10:50991151-52298350 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human PRKG1

Mutations,
alleles, and
phenotypes
All mutations/alleles(21) : Gene trapped(10) Targeted(10) Transposon induced(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mutant mice exhibit abnormal smooth muscle function and penile erectile deficiency. Conditional disruption in the hippocampus results in impaired LTP. Mice homozygous for a transposon induced allele exhibit postnatal lethality.
 
Interactions
Prkg1 interacts with 97 markers (Mir7-1, Mir15a, Mir15b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (10 records)
Data Summary: Results (112)    Tissues (20)    Images (24)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 2
RNA in situ 101
Western blot 7
RT-PCR 2
cDNA source data(17)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase prkg1 ; ZFIN prkg1b    NEW 
Molecular
reagents
All nucleic(20) cDNA(18) Primer pair(1) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000043089 (Evidence)
Ensembl Gene Model ENSMUSG00000052920 (Evidence)
Entrez Gene 19091 (Evidence)
UniGene 381170
DFCI TC1586770, TC1590717, TC1616310, TC1613623, TC1612598
DoTS DT.94170780, DT.91575919, DT.91327255, DT.50316102, DT.97391296
NIA Mouse Gene Index U038967
EC 2.7.11.12
Consensus CDS Project CCDS29745.1, CCDS29746.1
International Mouse Phenotyping Consortium Status Prkg1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000043089 VEGA Gene Model | MGI Sequence Detail 1197483 C57BL/6J ±  kb
transcript OTTMUST00000113064 VEGA | MGI Sequence Detail 2841 Not Applicable 
polypeptide OTTMUSP00000063305 VEGA | MGI Sequence Detail 686 Not Applicable 

For the selected sequences
All sequences(54) RefSeq(6) UniProt(3)
Polymorphisms
SNPs within 2kb(5685 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000961 AGC-kinase, C-terminal
InterPro IPR002374 cGMP-dependent kinase
InterPro IPR018488 Cyclic nucleotide-binding, conserved site
InterPro IPR000595 Cyclic nucleotide-binding domain
InterPro IPR018490 Cyclic nucleotide-binding-like
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR014710 RmlC-like jelly roll fold
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000029120 cGMP-dependent protein kinase 1
References
(Earliest) J:12810 Uhler MD, Cloning and expression of a novel cyclic GMP-dependent protein kinase from mouse brain. J Biol Chem. 1993 Jun 25;268(18):13586-91
(Latest) J:220101 Leiss V, et al., Expression of cGMP-dependent protein kinase type I in mature white adipocytes. Biochem Biophys Res Commun. 2014 Sep 12;452(1):151-6
All references(109)
Other
accession IDs
MGD-MRK-19672, MGD-MRK-37213, MGI:2147712

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory