Prkg1 MGI Mouse Gene Detail - MGI:108174 - protein kinase, cGMP-dependent, type I

Symbol

Prkg1
Name

protein kinase, cGMP-dependent, type I
Synonyms

Prkg1b, Prkgr1b

Feature Type

protein coding gene
IDs

MGI:108174
NCBI Gene: 19091
Alliance

gene page
Transcription Start Sites

22 TSS

Sequence Map

Chr19:30541889-31742433 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 25.17 cM, cytoband C2
Mapping Data

3 experiments

SNPs within 2kb

5684 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_108174	protein coding gene	Chr19:30541887-31742675 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0025035	protein coding gene	Chr19:29119361-30372511 (-)
A/J	MGP_AJ_G0025012	protein coding gene	Chr19:27657479-28861829 (-)
AKR/J	MGP_AKRJ_G0024980	protein coding gene	Chr19:28644479-29876012 (-)
BALB/cJ	MGP_BALBcJ_G0025011	protein coding gene	Chr19:27697576-28897781 (-)
C3H/HeJ	MGP_C3HHeJ_G0024767	protein coding gene	Chr19:28614537-29853152 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0025452	protein coding gene	Chr19:29910859-31189263 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022871	protein coding gene	Chr19:27615491-28789231 (-)
CAST/EiJ	MGP_CASTEiJ_G0024237	protein coding gene	Chr19:28502128-29742987 (-)
CBA/J	MGP_CBAJ_G0024745	protein coding gene	Chr19:31340215-32662780 (-)
DBA/2J	MGP_DBA2J_G0024877	protein coding gene	Chr19:27593071-28785593 (-)
FVB/NJ	MGP_FVBNJ_G0024839	protein coding gene	Chr19:27416653-28607561 (-)
LP/J	MGP_LPJ_G0024962	protein coding gene	Chr19:29128613-30378682 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024866	protein coding gene	Chr19:31234297-32543741 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025507	protein coding gene	Chr19:28655717-29906137 (-)
PWK/PhJ	MGP_PWKPhJ_G0023985	protein coding gene	Chr19:27268399-28482022 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0023789	protein coding gene	Chr19:27976721-29241106 (-)
WSB/EiJ	MGP_WSBEiJ_G0024304	protein coding gene	Chr19:28721631-29954865 (-)

Human Ortholog

PRKG1, protein kinase cGMP-dependent 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PRKG1, protein kinase cGMP-dependent 1
Synonyms

AAT8, cGK, cGK1, cGK 1, cGKI, cGKI-alpha, cGKI-BETA, PKG, PKG1, PRKG1B, PRKGR1B
Links

HGNC:9414

NCBI Gene ID: 5592

neXtProt AC: NX_Q13976

UniProt: Q13976
Chr Location

10q11.23-q21.1; chr10:50990888-52298423 (+) GRCh38

MGI Vertebrate Homology

Prkg1 stringent orthology
1 human;1 mouse;3 zebrafish
HCOP

vertebrate homology predictions: PRKG1
Protein SuperFamily

cGMP-dep_kinase
Gene Tree

Prkg1

Diseases

1 with human PRKG1 associations

				Human Disease	Mouse Models
				thoracic aortic aneurysm IDs thoracic aortic aneurysm DOID:14004 EFO:0004282 MESH:D017545 NCI:C27001 OMIM:132900 OMIM:607086 OMIM:607087 OMIM:611788 OMIM:613780 OMIM:615436 ORDO:91387 UMLS_CUI:C0162872

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

55 phenotypes from 7 alleles in 9 genetic backgrounds
10 phenotypes from multigenic genotypes
90 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

20
Endonuclease-mediated

1
Gene trapped

7
Targeted

11
Transposon induced

1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

58 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mutant mice exhibit abnormal smooth muscle function and penile erectile deficiency. Conditional disruption in the hippocampus results in impaired LTP. Mice homozygous for a transposon induced allele exhibit postnatal lethality.

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All GO Annotations

53
GO References

16

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

863
Tissues

51
cDNA Data

18
Literature Summary

16

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase prkg1

ZFIN prkg1b

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All Sequences

53
RefSeq

6
UniProt

4
CCDS

CCDS29745.1, CCDS29746.1

Ensembl

ENSMUSG00000052920 (Evidence)
NCBI Gene

19091

			Length	Strain/Species	Flank
genomic	ENSMUSG00000052920	Ensembl Gene Model \| MGI Sequence Detail	1200545	C57BL/6J	± kb
transcript	ENSMUST00000073581	Ensembl \| MGI Sequence Detail	2841	Not Applicable
polypeptide	ENSMUSP00000073268	Ensembl \| MGI Sequence Detail	686	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000029120 cGMP-dependent protein kinase 1

(term hierarchy)
EC

2.7.11.12
InterPro Domains

IPR000961 AGC-kinase, C-terminal

IPR002374 cGMP-dependent kinase

IPR035014 cGMP-dependent protein kinase, catalytic domain

IPR031831 cGMP-dependent protein kinase, N-terminal coiled-coil domain

IPR018488 Cyclic nucleotide-binding, conserved site

IPR000595 Cyclic nucleotide-binding domain

IPR018490 Cyclic nucleotide-binding domain superfamily

IPR017441 Protein kinase, ATP binding site

IPR017892 Protein kinase, C-terminal

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR014710 RmlC-like jelly roll fold

IPR008271 Serine/threonine-protein kinase, active site

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All nucleic 22

cDNA 19

Primer pair 1

Other 2

Microarray probesets 3

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MGD-MRK-19672, MGD-MRK-37213, MGI:2147712

Summaries

All 154

Developmental Gene Expression 16

Gene Ontology 16

Phenotypes 90
Earliest

J:12810 Uhler MD, Cloning and expression of a novel cyclic GMP-dependent protein kinase from mouse brain. J Biol Chem. 1993 Jun 25;268(18):13586-91
Latest

J:312511 Langst N, et al., Cyclic GMP-Dependent Regulation of Vascular Tone and Blood Pressure Involves Cysteine-Rich LIM-Only Protein 4 (CRP4). Int J Mol Sci. 2021 Sep 14;22(18)

TSS for Prkg1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr158827	Chr19:31742638-31742683 (-)	-228 bp
Tssr158826	Chr19:31742427-31742479 (-)	-20 bp
Tssr158825	Chr19:31742400-31742415 (-)	25 bp
Tssr158824	Chr19:31742363-31742390 (-)	56 bp
Tssr158823	Chr19:31642054-31642090 (-)	100,361 bp
Tssr158822	Chr19:31642006-31642018 (-)	100,421 bp
Tssr158821	Chr19:31641775-31641843 (-)	100,624 bp
Tssr158820	Chr19:31641756-31641772 (-)	100,669 bp
Tssr158819	Chr19:31601902-31601903 (-)	140,530 bp
Tssr158818	Chr19:31488410-31488415 (-)	254,020 bp
Tssr158817	Chr19:31428961-31428962 (-)	313,471 bp
Tssr158816	Chr19:31328860-31328870 (-)	413,568 bp
Tssr158815	Chr19:31103497-31103506 (-)	638,931 bp
Tssr158814	Chr19:31097333-31097342 (-)	645,095 bp
Tssr158813	Chr19:31057096-31057097 (-)	685,336 bp
Tssr158812	Chr19:30659261-30659265 (-)	1,083,170 bp
Tssr158811	Chr19:30651991-30651995 (-)	1,090,440 bp
Tssr158810	Chr19:30602915-30602937 (-)	1,139,507 bp
Tssr158809	Chr19:30602885-30602896 (-)	1,139,542 bp
Tssr158808	Chr19:30602849-30602862 (-)	1,139,577 bp
Tssr158807	Chr19:30551570-30551579 (-)	1,190,858 bp
Tssr158806	Chr19:30551546-30551557 (-)	1,190,881 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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