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Prkg2 Gene Detail
Summary
  • Symbol
    Prkg2
  • Name
    protein kinase, cGMP-dependent, type II
  • Synonyms
    cGK-II, Prkgr2
  • Feature Type
    protein coding gene
  • IDs
    MGI:108173
    NCBI Gene: 19092
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr5:98929773-99037351 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      107579 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 48.35 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    PRKG2, protein kinase cGMP-dependent 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PRKG2, protein kinase cGMP-dependent 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    cGK2, cGKII, PKG2, PRKGR2
  • Links
    NCBI Gene ID: 5593
    neXtProt AC: NX_Q13237
    UniProt: Q13237

  • Chr Location
    4q21.21; chr4:81086874-81217837 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 1 allele in 1 genetic background
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit dwarfism, with abnormal skull morphology and short limbs and vertebrae. Defects in axial organization of the growth plates was evident as mice aged. Digestive secretion in response to enterotoxin was reduced.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000033394 VEGA Gene Model | MGI Sequence Detail 107579 C57BL/6J ±  kb
    transcript OTTMUST00000083837 VEGA | MGI Sequence Detail 4968 Not Applicable  
    polypeptide OTTMUSP00000045109 VEGA | MGI Sequence Detail 762 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      871 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 22
      Genomic 1
      cDNA 18
      Primer pair 3

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-19671, MGD-MRK-37212, MGI:2141175
    References
    more
    • Summaries
      All 58
      Developmental Gene Expression 4
      Gene Ontology 7
      Phenotypes 22
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:240186 Wang R, et al., cGMP Signaling Increases Antioxidant Gene Expression by Activating Forkhead Box O3A in the Colon Epithelium. Am J Pathol. 2017 Feb;187(2):377-389

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    09/11/2018
    MGI 6.12
    The Jackson Laboratory