Prkg2
Gene Detail

Symbol Name ID

Prkg2 protein kinase, cGMP-dependent, type II MGI:108173

Synonyms

cGK-II, Prkgr2

Feature Type

protein coding gene

Genetic Map

Chromosome 5

48.35 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr5:98929773-99037351 bp, - strand From VEGA annotation of GRCm38   107579 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:4556  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: cGMP-dependent protein kinase
Gene Tree: Prkg2

Human homologs

Human Homolog		PRKG2, Protein kinase, cGMP-dependent, type II
NCBI Gene ID		5593
neXtProt AC		NX_Q13237
Human Synonyms		cGKII, PRKGR2
Human Chr (Location)		4q13.1-q21.1; chr4:82009837-82126215 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Homozygous null mice exhibit dwarfism, with abnormal skull morphology and short limbs and vertebrae. Defects in axial organization of the growth plates was evident as mice aged. Digestive secretion in response to enterotoxin was reduced.

 

Gene Ontology (GO) classifications

All GO classifications: (21 annotations)

Process	circadian regulation of gene expression, circadian rhythm, ...
Component	membrane, plasma membrane
Function	ATP binding, cGMP binding, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (19)    Tissues (10)    Images (1)
Theiler Stages: 20, 22, 24, 28

Assay Type	Results
Immunohistochemistry	2
RNA in situ	1
Northern blot	3
Western blot	7
RT-PCR	6

cDNA source data(17)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(21) Genomic(1) cDNA(17) Primer pair(3)
Microarray probesets(7)

Other database links

VEGA Gene Model	OTTMUSG00000033394 (Evidence)
Ensembl Gene Model	ENSMUSG00000029334 (Evidence)
Entrez Gene	19092 (Evidence)
DFCI	TC1590245, TC1619575, TC1659490
DoTS	DT.40156544, DT.60102988, DT.94171799
NIA Mouse Gene Index	U026435
EC	2.7.11.12
Consensus CDS Project	CCDS19459.1
International Mouse Knockout Project Status	Prkg2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000033394	VEGA Gene Model | MGI Sequence Detail	107579	C57BL/6J
transcript	OTTMUST00000083837	VEGA | MGI Sequence Detail	4968	Not Applicable
polypeptide	OTTMUSP00000045109	VEGA | MGI Sequence Detail	762	Not Applicable

All sequences(43) RefSeq(2) UniProt(5)

Polymorphisms

SNPs(804 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000961	AGC-kinase, C-terminal
InterPro	IPR002374	cGMP-dependent kinase
InterPro	IPR016232	cGMP-dependent protein kinase
InterPro	IPR018488	Cyclic nucleotide-binding, conserved site
InterPro	IPR000595	Cyclic nucleotide-binding domain
InterPro	IPR018490	Cyclic nucleotide-binding-like
InterPro	IPR017441	Protein kinase, ATP binding site
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR014710	RmlC-like jelly roll fold
InterPro	IPR002290	Serine/threonine- / dual-specificity protein kinase, catalytic domain
InterPro	IPR008271	Serine/threonine-protein kinase, active site
Protein Ontology	PR:000013240	cGMP-dependent protein kinase 2

References

(Earliest) J:12810 Uhler MD, Cloning and expression of a novel cyclic GMP-dependent protein kinase from mouse brain. J Biol Chem. 1993 Jun 25;268(18):13586-91
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(47)

Other accession IDs

MGD-MRK-19671, MGD-MRK-37212, MGI:2141175