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Prkg2
Gene Detail
Symbol

Name
ID
Prkg2
protein kinase, cGMP-dependent, type II
MGI:108173
Synonyms
cGK-II, Prkgr2
Feature Type
protein coding gene
Genetic Map
Chromosome 5
48.35 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr5:98929773-99037351 bp, - strand
From VEGA annotation of GRCm38

  107579 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4556  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: cGMP-dependent protein kinase
Gene Tree: Prkg2

Human
homologs
Human Homolog PRKG2, Protein kinase, cGMP-dependent, type II
NCBI Gene ID 5593
neXtProt AC  NX_Q13237
Human Synonyms  cGK2, cGKII, PRKGR2
Human Chr (Location)  4q13.1-q21.1; chr4:81087370-81215117 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice exhibit dwarfism, with abnormal skull morphology and short limbs and vertebrae. Defects in axial organization of the growth plates was evident as mice aged. Digestive secretion in response to enterotoxin was reduced.
 
Interactions
Prkg2 interacts with 308 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process circadian regulation of gene expression, circadian rhythm, ...
Component membrane, nuclear membrane, ...
Function ATP binding, cGMP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (19)    Tissues (10)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 2
RNA in situ 1
Northern blot 3
Western blot 7
RT-PCR 6
cDNA source data(17)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(21) Genomic(1) cDNA(17) Primer pair(3)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000033394 (Evidence)
Ensembl Gene ModelENSMUSG00000029334 (Evidence)
Entrez Gene19092 (Evidence)
DFCITC1590245, TC1619575, TC1659490
DoTSDT.40156544, DT.60102988, DT.94171799
NIA Mouse Gene IndexU026435
EC2.7.11.12
Consensus CDS ProjectCCDS19459.1
International Mouse Knockout Project StatusPrkg2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033394 VEGA Gene Model | MGI Sequence Detail 107579 C57BL/6J ±  kb
transcript OTTMUST00000083837 VEGA | MGI Sequence Detail 4968 Not Applicable 
polypeptide OTTMUSP00000045109 VEGA | MGI Sequence Detail 762 Not Applicable 

For the selected sequences
All sequences(47) RefSeq(6) UniProt(5)
Polymorphisms
SNPs within 2kb(868 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000961 AGC-kinase, C-terminal
InterPro IPR002374 cGMP-dependent kinase
InterPro IPR016232 cGMP-dependent protein kinase
InterPro IPR018488 Cyclic nucleotide-binding, conserved site
InterPro IPR000595 Cyclic nucleotide-binding domain
InterPro IPR018490 Cyclic nucleotide-binding-like
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR014710 RmlC-like jelly roll fold
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000013240 cGMP-dependent protein kinase 2
References
(Earliest) J:12810 Uhler MD, Cloning and expression of a novel cyclic GMP-dependent protein kinase from mouse brain. J Biol Chem. 1993 Jun 25;268(18):13586-91
(Latest) J:202411 Incontro S, et al., The type II cGMP dependent protein kinase regulates GluA1 levels at the plasma membrane of developing cerebellar granule cells. Biochim Biophys Acta. 2013 Aug;1833(8):1820-31
All references(48)
Other
accession IDs
MGD-MRK-19671, MGD-MRK-37212, MGI:2141175

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory