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Prkg2 Gene Detail
Summary
  • Symbol
    Prkg2
  • Name
    protein kinase, cGMP-dependent, type II
  • Synonyms
    cGK-II, Prkgr2
  • Feature Type
    protein coding gene
  • IDs
    MGI:108173
    NCBI Gene: 19092
Location & Maps
more
  • Sequence Map
    Chr5:98929773-99037351 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      107579 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 48.35 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    PRKG2, protein kinase, cGMP-dependent, type II
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PRKG2, protein kinase, cGMP-dependent, type II
    Orthology source: HomoloGene, HGNC
  • Synonyms
    cGK2, cGKII, PRKGR2
  • Links
    NCBI Gene ID: 5593
    neXtProt AC: NX_Q13237

  • Chr Location
    4q13.1-q21.1; chr4:81087370-81216743 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 1 allele in 1 genetic background
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Spontaneous
    1
  • Targeted
    3
  • Genomic Mutations
    3 involving Prkg2
  • Incidental Mutations
Homozygous null mice exhibit dwarfism, with abnormal skull morphology and short limbs and vertebrae. Defects in axial organization of the growth plates was evident as mice aged. Digestive secretion in response to enterotoxin was reduced.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033394 VEGA Gene Model | MGI Sequence Detail 107579 C57BL/6J ±  kb
transcript OTTMUST00000083837 VEGA | MGI Sequence Detail 4968 Not Applicable  
polypeptide OTTMUSP00000045109 VEGA | MGI Sequence Detail 762 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    871 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 21
    Genomic 1
    cDNA 17
    Primer pair 3

    Microarray probesets 7
Other
Accession IDs
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MGD-MRK-19671, MGD-MRK-37212, MGI:2141175
References
more
  • Summaries
    All 45
    Developmental Gene Expression 4
    Gene Ontology 5
    Phenotypes 20
  • Earliest
    J:12810 Uhler MD, Cloning and expression of a novel cyclic GMP-dependent protein kinase from mouse brain. J Biol Chem. 1993 Jun 25;268(18):13586-91
  • Latest
    J:220245 Kim S, et al., Network compensation of cyclic GMP-dependent protein kinase II knockout in the hippocampus by Ca2+-permeable AMPA receptors. Proc Natl Acad Sci U S A. 2015 Mar 10;112(10):3122-7

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory