About   Help   FAQ
Prkg2 Gene Detail
Summary
  • Symbol
    Prkg2
  • Name
    protein kinase, cGMP-dependent, type II
  • Synonyms
    cGK-II, Prkgr2
  • Feature Type
    protein coding gene
  • IDs
    MGI:108173
    NCBI Gene: 19092
  • Alliance
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:98929773-99037351 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 48.35 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    871 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108173
protein coding gene Chr5:98929773-99038699 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029777
protein coding gene Chr5:100306931-100416820 (-)
A/J MGP_AJ_G0029743
protein coding gene Chr5:96599524-96707231 (-)
AKR/J MGP_AKRJ_G0029689
protein coding gene Chr5:99796859-99906247 (-)
BALB/cJ MGP_BALBcJ_G0029753
protein coding gene Chr5:97613849-97722583 (-)
C3H/HeJ MGP_C3HHeJ_G0029476
protein coding gene Chr5:100126508-100235258 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030208
protein coding gene Chr5:104526568-104641897 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027443
protein coding gene Chr5:91884344-91993650 (-)
CAST/EiJ MGP_CASTEiJ_G0028887
protein coding gene Chr5:98756455-98871142 (-)
CBA/J MGP_CBAJ_G0029446
protein coding gene Chr5:108118427-108229773 (-)
DBA/2J MGP_DBA2J_G0029590
protein coding gene Chr5:96786713-96899225 (-)
FVB/NJ MGP_FVBNJ_G0029549
protein coding gene Chr5:95604335-95712501 (-)
LP/J MGP_LPJ_G0029678
protein coding gene Chr5:100917170-101029253 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029578
protein coding gene Chr5:113241090-113360260 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030241
protein coding gene Chr5:99237312-99357531 (-)
PWK/PhJ MGP_PWKPhJ_G0028605
protein coding gene Chr5:95220440-95329848 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028440
protein coding gene Chr5:96935471-97057795 (-)
WSB/EiJ MGP_WSBEiJ_G0028965
protein coding gene Chr5:99576430-99688598 (-)



Homology
more
  • Human Ortholog
    PRKG2, protein kinase cGMP-dependent 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PRKG2, protein kinase cGMP-dependent 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    cGK2, cGKII, PKG2, PRKGR2
  • Links
    NCBI Gene ID: 5593
    neXtProt AC: NX_Q13237
    UniProt: Q13237

  • Chr Location
    4q21.21; chr4:81086874-81217837 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 1 allele in 1 genetic background
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit dwarfism, with abnormal skull morphology and short limbs and vertebrae. Defects in axial organization of the growth plates was evident as mice aged. Digestive secretion in response to enterotoxin was reduced.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000029334 Ensembl Gene Model | MGI Sequence Detail 107579 C57BL/6J ±  kb
    transcript ENSMUST00000161490 Ensembl | MGI Sequence Detail 4968 Not Applicable  
    polypeptide ENSMUSP00000124963 Ensembl | MGI Sequence Detail 762 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 22
      Genomic 1
      cDNA 18
      Primer pair 3

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-19671, MGD-MRK-37212, MGI:2141175
    References
    more
    • Summaries
      All 57
      Developmental Gene Expression 4
      Gene Ontology 7
      Phenotypes 22
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:240186 Wang R, et al., cGMP Signaling Increases Antioxidant Gene Expression by Activating Forkhead Box O3A in the Colon Epithelium. Am J Pathol. 2017 Feb;187(2):377-389

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    12/11/2018
    MGI 6.13
    The Jackson Laboratory