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Slc22a1
Gene Detail
Symbol

Name
ID
Slc22a1
solute carrier family 22 (organic cation transporter), member 1
MGI:108111
Synonyms
Lx1, MGC:14019, Oct1, Oct1, Orct, Orct1
Feature Type
protein coding gene
Genetic Map
Chromosome 17
8.63 cM
Detailed Genetic Map ± 1 cM


Mapping data(10)
Sequence Map
Chr17:12648874-12675838 bp, - strand
From NCBI annotation of GRCm38

  26965 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20665  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: SLC22A1
Gene Tree: Slc22a1

Human
homologs
SLC22A1, solute carrier family 22 (organic cation transporter), member 1
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 6580
neXtProt AC: NX_O15245

Human Synonyms: HOCT1, OCT1, oct1_cds

Human Chr (Location): 6q25.3; chr6:160121789-160159198 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a targeted mutation are viable, healthy, and fertile but exhibit an impaired liver uptake and direct intestinal excretion of substrate organic cations.
 
Interactions
Slc22a1 interacts with 32 markers (Mir92-1, Mir103-1, Mir124a-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (9 records)
Data Summary: Results (38)    Tissues (27)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 9
Northern blot 17
RT-PCR 12
cDNA source data(86)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(96) Genomic(4) cDNA(87) Primer pair(4) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000023829 (Evidence)
Entrez Gene 20517 (Evidence)
UniGene 594
DFCI TC1577730
DoTS DT.534274
NIA Mouse Gene Index U037425
Consensus CDS Project CCDS28393.1
International Mouse Phenotyping Consortium Status Slc22a1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 20517 NCBI Gene Model | MGI Sequence Detail 26965 C57BL/6J ±  kb
transcript NM_009202 RefSeq | MGI Sequence Detail 1994 C57BL/6 
polypeptide O08966 UniProt | EBI | MGI Sequence Detail 556 Not Applicable 

For the selected sequences
All sequences(14) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(281 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005828 General substrate transporter
InterPro IPR020846 Major facilitator superfamily domain
InterPro IPR004749 Organic cation transport protein
InterPro IPR005829 Sugar transporter, conserved site
Protein Ontology PR:000014981 solute carrier family 22 member 1
Graphical View of Protein Domain Structure
References
(Earliest) J:35906 Schweifer N, et al., The Lx1 gene maps to mouse chromosome 17 and codes for a protein that is homologous to glucose and polyspecific transmembrane transporters. Mamm Genome. 1996 Oct;7(10):735-40
(Latest) J:220967 Pabla N, et al., Mitigation of acute kidney injury by cell-cycle inhibitors that suppress both CDK4/6 and OCT2 functions. Proc Natl Acad Sci U S A. 2015 Apr 21;112(16):5231-6
All references(49)
Other
accession IDs
MGD-MRK-37054, MGD-MRK-37148

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory