About   Help   FAQ
Slc22a1 Gene Detail
Summary
  • Symbol
    Slc22a1
  • Name
    solute carrier family 22 (organic cation transporter), member 1
  • Synonyms
    Lx1, MGC:14019, Oct1, Oct1, Orct, Orct1
  • Feature Type
    protein coding gene
  • IDs
    MGI:108111
    NCBI Gene: 20517
  • Gene Overview
    MyGene.info: SLC22A1
Location & Maps
more
  • Sequence Map
    Chr17:12648874-12675838 bp, - strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      26965 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 8.63 cM
  • Detailed Genetic Map ± 1 cM
  • Mapping Data
    10 experiments
Homology
more
  • Human Ortholog
    SLC22A1, solute carrier family 22 member 1
  • Vertebrate Orthologs
    7
  • Human Ortholog
    SLC22A1, solute carrier family 22 member 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    HOCT1, OCT1, oct1_cds
  • Links
    NCBI Gene ID: 6580
    neXtProt AC: NX_O15245

  • Chr Location
    6q25.3; chr6:160121789-160159198 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted mutation are viable, healthy, and fertile but exhibit an impaired liver uptake and direct intestinal excretion of substrate organic cations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 20517 NCBI Gene Model | MGI Sequence Detail 26965 C57BL/6J ±  kb
transcript NM_009202 RefSeq | MGI Sequence Detail 1994 C57BL/6  
polypeptide O08966 UniProt | EBI | MGI Sequence Detail 556 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    240 from dbSNP Build 142
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000014981 solute carrier family 22 member 1
  • InterPro Domains
    IPR005828 Major facilitator, sugar transporter-like
    IPR020846 Major facilitator superfamily domain
    IPR004749 Organic cation transport protein/SVOP
    IPR005829 Sugar transporter, conserved site
Molecular
Reagents
less
  • All nucleic 96
    Genomic 4
    cDNA 87
    Primer pair 4
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-37054, MGD-MRK-37148
References
more
  • Summaries
    All 47
    Developmental Gene Expression 9
    Gene Ontology 6
    Phenotypes 8
  • Earliest
    J:35906 Schweifer N, et al., The Lx1 gene maps to mouse chromosome 17 and codes for a protein that is homologous to glucose and polyspecific transmembrane transporters. Mamm Genome. 1996 Oct;7(10):735-40
  • Latest
    J:220967 Pabla N, et al., Mitigation of acute kidney injury by cell-cycle inhibitors that suppress both CDK4/6 and OCT2 functions. Proc Natl Acad Sci U S A. 2015 Apr 21;112(16):5231-6

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
05/24/2016
MGI 6.04
The Jackson Laboratory