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Slc22a1
Gene Detail
 Symbol
Name
ID
Slc22a1
solute carrier family 22 (organic cation transporter), member 1
MGI:108111
Synonyms Lx1, MGC:14019, Oct1, Oct1, Orct, Orct1
Feature Type protein coding gene
Genetic Map
Chromosome 17
8.63 cM
Detailed Genetic Map ± 1 cM


Mapping data(10)
Sequence Map
Chr17:12648874-12675838 bp, - strand
From NCBI annotation of GRCm38

  26965 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20665  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Slc22a1

Human
homologs
Human Homolog SLC22A1, solute carrier family 22 (organic cation transporter), member 1
NCBI Gene ID 6580
neXtProt AC  NX_O15245
Human Synonyms  HOCT1, OCT1, oct1_cds
Human Chr (Location)  6q25.3; chr6:160121789-160159111 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted mutation are viable, healthy, and fertile but exhibit an impaired liver uptake and direct intestinal excretion of substrate organic cations.
 
Interactions
Slc22a1 interacts with 32 markers (Mir92-1, Mir103-1, Mir124a-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (38 annotations)
Process acetate ester transport, cation transmembrane transport, ...
Component basolateral plasma membrane, integral component of membrane, ...
Function acetylcholine transmembrane transporter activity, dopamine transmembrane transporter activity, ...
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (38)    Tissues (27)    Images (2)
Theiler Stages: 11, 18, 20, 22, 23, 26, 28
Assay TypeResults
RNA in situ 9
Northern blot 17
RT-PCR 12
cDNA source data(86)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(96) Genomic(4) cDNA(87) Primer pair(4) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000023829 (Evidence)
Entrez Gene20517 (Evidence)
UniGene594
DFCITC1577730
DoTSDT.534274
NIA Mouse Gene IndexU037425
Consensus CDS ProjectCCDS28393.1
International Mouse Knockout Project StatusSlc22a1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 20517 NCBI Gene Model | MGI Sequence Detail 26965 C57BL/6J ±  kb
transcript NM_009202 RefSeq | MGI Sequence Detail 1994 C57BL/6 
polypeptide O08966 UniProt | EBI | MGI Sequence Detail 556 Not Applicable 

For the selected sequences
All sequences(14) RefSeq(2) UniProt(1)
Polymorphisms SNPs within 2kb(281 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005828 General substrate transporter
InterPro IPR020846 Major facilitator superfamily domain
InterPro IPR016196 Major facilitator superfamily domain, general substrate transporter
InterPro IPR004749 Organic cation transport protein
InterPro IPR005829 Sugar transporter, conserved site
Protein Ontology PR:000014981 solute carrier family 22 member 1
Graphical View of Protein Domain Structure
References (Earliest) J:35906 Schweifer N, et al., The Lx1 gene maps to mouse chromosome 17 and codes for a protein that is homologous to glucose and polyspecific transmembrane transporters. Mamm Genome. 1996 Oct;7(10):735-40
(Latest) J:212164 Chen L, et al., OCT1 is a high-capacity thiamine transporter that regulates hepatic steatosis and is a target of metformin. Proc Natl Acad Sci U S A. 2014 Jul 8;111(27):9983-8
All references(48)
Other
accession IDs
MGD-MRK-37054, MGD-MRK-37148

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory