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Sparcl1
Gene Detail
 Symbol
Name
ID
Sparcl1
SPARC-like 1
MGI:108110
Synonyms Ecm2, hevin, mast9, Sc1
Feature Type protein coding gene
Genetic Map
Chromosome 5
50.55 cM, cytoband E4
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr5:104079111-104114088 bp, - strand
From Ensembl annotation of GRCm38

  34978 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3438  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: SPARC-like protein 1
Gene Tree: Sparcl1

Human
homologs
Human Homolog SPARCL1, SPARC-like 1 (hevin)
NCBI Gene ID 8404
neXtProt AC  NX_Q14515
Human Synonyms  MAST9, MAST 9, PIG33, SC1
Human Chr (Location)  4q22.1; chr4:87473335-87529503 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(4) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted null mutation exhibit no discernable phenotype; mice are viable and fertile with normal histology and survival.
 
Phenotype Images(1)
Interactions
Sparcl1 interacts with 100 markers (Mir1a-1, Mir1a-2, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process signal transduction
Component extracellular region, extracellular space, ...
Function calcium ion binding, metal ion binding
External Resources: FuncBase
Expression
Literature Summary: (13 records)
Data Summary: Results (57)    Tissues (39)    Images (19)
Theiler Stages: 19, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
Immunohistochemistry 4
RNA in situ 46
RT-PCR 7
cDNA source data(189)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(197) Genomic(4) cDNA(190) Primer pair(3)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000029309 (Evidence)
Entrez Gene13602 (Evidence)
UniGene29027
DFCITC1573824, TC1654602
DoTSDT.101405747, DT.110704867, DT.87073046, DT.94404276, DT.97414309
NIA Mouse Gene IndexU026483
Consensus CDS ProjectCCDS19483.1
International Mouse Knockout Project StatusSparcl1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000029309 Ensembl Gene Model | MGI Sequence Detail 34978 C57BL/6J ±  kb
transcript ENSMUST00000031249 Ensembl | MGI Sequence Detail 3114 Not Applicable 
polypeptide ENSMUSP00000031249 Ensembl | MGI Sequence Detail 650 Not Applicable 

For the selected sequences
All sequences(41) RefSeq(6) UniProt(3)
Polymorphisms RFLP(1) : SNPs within 2kb(331 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR018247 EF-Hand 1, calcium-binding site
InterPro IPR002048 EF-hand domain
InterPro IPR011992 EF-hand-like domain
InterPro IPR003645 Follistatin-like, N-terminal
InterPro IPR015369 Follistatin/Osteonectin EGF domain
InterPro IPR002350 Kazal domain
InterPro IPR001999 Osteonectin-like, conserved site
InterPro IPR016359 SPARC-like protein 1
InterPro IPR019577 SPARC/Testican, calcium-binding domain
Protein Ontology PR:000015476 SPARC-like protein 1
References (Earliest) J:34568 Oritani K, et al., Identification of stromal cell products that interact with pre-B cells. J Cell Biol. 1996 Aug;134(3):771-82
(Latest) J:210410 Chatterjee A, et al., Central corneal thickness does not correlate with TonoLab-measured IOP in several mouse strains with single transgenic mutations of matricellular proteins. Exp Eye Res. 2013 Oct;115:106-12
All references(54)
Other
accession IDs
MGD-MRK-37147

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory