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Ddn Gene Detail
Summary
  • Symbol
    Ddn
  • Name
    dendrin
  • Synonyms
    LOC328602
  • Feature Type
    protein coding gene
  • IDs
    MGI:108101
    NCBI Gene: 13199
Location & Maps
more
  • Sequence Map
    Chr15:98803782-98807925 bp, - strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      4144 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 54.69 cM
  • Mapping Data
    4 experiments
Homology
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  • Human Ortholog
    DDN, dendrin
  • Vertebrate Orthologs
    7
  • Human Ortholog
    DDN, dendrin
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 23109
    neXtProt AC: NX_O94850

  • Chr Location
    12q13.12; chr12:48995149-49001091 (-)  GRCh38.p2

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    24 phenotype references
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    1
  • Radiation induced
    2
  • Targeted
    3
  • Genomic Mutations
    3 involving Ddn
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit normal proteinuria in resposne to LPS treatment.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 13199 NCBI Gene Model | MGI Sequence Detail 4144 C57BL/6J ±  kb
transcript NM_001013741 RefSeq | MGI Sequence Detail 3740 C57BL/6  
polypeptide Q80TS7 UniProt | EBI | MGI Sequence Detail 710 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    8 from dbSNP Build 142
Protein
Information
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Molecular
Reagents
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  • All nucleic 7
    cDNA 6
    Primer pair 1

    Microarray probesets 1
Other
Accession IDs
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MGD-MRK-37138, MGI:2685594
References
more
  • Summaries
    All 27
    Developmental Gene Expression 1
    Diseases 1
    Gene Ontology 5
    Phenotypes 24
  • Earliest
    J:44483 Brady KP, et al., Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Genome Res. 1997 Nov;7(11):1085-93
  • Latest
    J:225647 Weins A, et al., Dendrin ablation prolongs life span by delaying kidney failure. Am J Pathol. 2015 Aug;185(8):2143-57

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory