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Bid Gene Detail
Summary
  • Symbol
    Bid
  • Name
    BH3 interacting domain death agonist
  • Synonyms
    2700049M22Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:108093
    NCBI Gene: 12122
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr6:120891930-120916853 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      24924 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 57.02 cM
  • Mapping Data
    9 experiments
Homology
more
  • Human Ortholog
    BID, BH3 interacting domain death agonist
  • Vertebrate Orthologs
    8
  • Human Ortholog
    BID, BH3 interacting domain death agonist
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FP497
  • Links
    NCBI Gene ID: 637
    neXtProt AC: NX_P55957
    UniProt: P55957

  • Chr Location
    22q11.21; chr22:17734140-17774665 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    17 phenotypes from 3 alleles in 6 genetic backgrounds
    12 phenotypes from multigenic genotypes
    89 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mutants survive with little or no liver damage after injection with antibody against Fas, whereas mice normally die from hepatocellular apoptosis and hemorragic necrosis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000024186 VEGA Gene Model | MGI Sequence Detail 24924 C57BL/6J ±  kb
    transcript OTTMUST00000086681 VEGA | MGI Sequence Detail 2415 Not Applicable  
    polypeptide OTTMUSP00000046939 VEGA | MGI Sequence Detail 195 Not Applicable  
    For the selected sequence
    Polymorphisms
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    • SNPs within 2kb
      135 from dbSNP Build 142
    • PCR
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 54
      Genomic 2
      cDNA 50
      Primer pair 2

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-37130, MGI:1919829, MGI:2141512, MGI:2141571
    References
    more
    • Summaries
      All 189
      Developmental Gene Expression 16
      Gene Ontology 26
      Phenotypes 89
    • Earliest
      J:36730 Wang K, et al., BID: a novel BH3 domain-only death agonist. Genes Dev. 1996 Nov 15;10(22):2859-69
    • Latest
      J:252459 Hai Q, et al., Quantitative Trait Locus Mapping of Macrophage Cholesterol Metabolism and CRISPR/Cas9 Editing Implicate an ACAT1 Truncation as a Causal Modifier Variant. Arterioscler Thromb Vasc Biol. 2018 Jan;38(1):83-91

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    10/16/2018
    MGI 6.12
    The Jackson Laboratory