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Bid
Gene Detail
 Symbol
Name
ID
Bid
BH3 interacting domain death agonist
MGI:108093
Synonyms 2700049M22Rik
Feature Type protein coding gene
Genetic Map
Chromosome 6
57.02 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr6:120891930-120916853 bp, - strand
From VEGA annotation of GRCm38

  24924 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:923  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: BH3-interacting domain death agonist
Gene Tree: Bid

Human
homologs
Human Homolog BID, BH3 interacting domain death agonist
NCBI Gene ID 637
neXtProt AC  NX_P55957
Human Synonyms  FP497
Human Chr (Location)  22q11.1; chr22:17734140-17774665 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(65) : Gene trapped(59) Targeted(6)
 
Homozygous null mutants survive with little or no liver damage after injection with antibody against Fas, whereas mice normally die from hepatocellular apoptosis and hemorragic necrosis.
 
Interactions
Bid interacts with 218 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (44 annotations)
Process activation of cysteine-type endopeptidase activity involved in apoptotic process, apoptotic mitochondrial changes, ...
Component cell, cytoplasm, ...
Function protein binding, ubiquitin protein ligase binding
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (12 records)
Data Summary: Results (157)    Tissues (64)    Images (23)
Theiler Stages: 10, 20, 23, 26, 28
Assay TypeResults
RNA in situ 70
Northern blot 14
Western blot 27
RT-PCR 46
cDNA source data(47)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(53) Genomic(2) cDNA(49) Primer pair(2)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000024186 (Evidence)
Ensembl Gene ModelENSMUSG00000004446 (Evidence)
Entrez Gene12122 (Evidence)
UniGene235081
DoTSDT.101364674, DT.532380
NIA Mouse Gene IndexU027813
PDB1DDB, 2VOI
Consensus CDS ProjectCCDS20486.1
International Mouse Knockout Project StatusBid
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024186 VEGA Gene Model | MGI Sequence Detail 24924 C57BL/6J ±  kb
transcript OTTMUST00000086681 VEGA | MGI Sequence Detail 2415 Not Applicable 
polypeptide OTTMUSP00000046939 VEGA | MGI Sequence Detail 195 Not Applicable 

For the selected sequences
All sequences(52) RefSeq(16) UniProt(2)
Polymorphisms All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(147 from dbSNP Build 137)    SNPs within 2kb including multiple locations(159)
Protein-related
information
ResourceIDDescription
InterPro IPR020728 Apoptosis regulator, Bcl-2, BH3 motif, conserved site
InterPro IPR010479 BH3 interacting
Protein Ontology PR:000002183 BH3-interacting domain death agonist
References (Earliest) J:36730 Wang K, et al., BID: a novel BH3 domain-only death agonist. Genes Dev. 1996 Nov 15;10(22):2859-69
(Latest) J:207241 Bleicken S, et al., Proapoptotic Bax and Bak proteins form stable protein-permeable pores of tunable size. J Biol Chem. 2013 Nov 15;288(46):33241-52
All references(158)
Other
accession IDs
MGD-MRK-37130, MGI:1919829, MGI:2141512, MGI:2141571

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory