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Bcar1
Gene Detail
Symbol

Name
ID
Bcar1
breast cancer anti-estrogen resistance 1
MGI:108091
Synonyms
Cas, Crkas, p130Cas
Feature Type
protein coding gene
Genetic Map
Chromosome 8
57.98 cM, cytoband D3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr8:111710485-111743849 bp, - strand
From Ensembl annotation of GRCm38

  33365 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7674  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: BCAR1
Gene Tree: Bcar1

Human
homologs
BCAR1, breast cancer anti-estrogen resistance 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 9564
neXtProt AC: NX_P56945

Human Synonyms: CAS, CAS1, CASS1, CRKAS, P130Cas

Human Chr (Location): 16q23.1; chr16:75229030-75268053 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(25) : Gene trapped(20) Targeted(5)
 
Homozygous null embryos exhibit growth retardation and embryonic lethality, following disruption of cardiac myofibrils, increased vasodilation, and systemic congestion.
 
Interactions
Bcar1 interacts with 68 markers (Mir1b, Mir22, Mir28b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (40 annotations)
Process actin cytoskeleton organization, actin filament organization, ...
Component actin cytoskeleton, cell junction, ...
Function protein binding, protein domain specific binding, ...
External Resources: FuncBase
Expression
Literature Summary: (15 records)
Data Summary: Results (165)    Tissues (63)    Images (16)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 24
RNA in situ 35
Northern blot 4
Western blot 24
RT-PCR 78
cDNA source data(106)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase bcar1    NEW 
Molecular
reagents
All nucleic(112) cDNA(108) Primer pair(3) Other(1)
Microarray probesets(5)
Other database
links
Ensembl Gene Model ENSMUSG00000031955 (Evidence)
Entrez Gene 12927 (Evidence)
UniGene 3758
DFCI TC1572474, TC1707840
DoTS DT.94173865, DT.91413624, DT.490819, DT.103570475, DT.101404174, DT.101737098
NIA Mouse Gene Index U030269
Consensus CDS Project CCDS52675.1
International Mouse Phenotyping Consortium Status Bcar1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000031955 Ensembl Gene Model | MGI Sequence Detail 33365 C57BL/6J ±  kb
transcript ENSMUST00000166232 Ensembl | MGI Sequence Detail 3171 Not Applicable 
polypeptide ENSMUSP00000129584 Ensembl | MGI Sequence Detail 874 Not Applicable 

For the selected sequences
All sequences(63) RefSeq(6) UniProt(6)
Polymorphisms
SNPs within 2kb(175 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR021901 CAS family, DUF3513
InterPro IPR014928 Serine rich protein interaction
InterPro IPR013315 Spectrin alpha chain, SH3 domain
InterPro IPR001452 Src homology-3 domain
Protein Ontology PR:000004676 breast cancer anti-estrogen resistance protein 1
References
(Earliest) J:20302 Shaffer JB, et al., Isolation of a cDNA clone for murine catalase and analysis of an acatalasemic mutant. J Biol Chem. 1987 Sep 25;262(27):12908-11
(Latest) J:213067 Riccomagno MM, et al., Cas adaptor proteins organize the retinal ganglion cell layer downstream of integrin signaling. Neuron. 2014 Feb 19;81(4):779-86
All references(71)
Other
accession IDs
MGD-MRK-37128, MGI:2142520

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory