Bcar1
Gene Detail

Symbol Name ID

Bcar1 breast cancer anti-estrogen resistance 1 MGI:108091

Synonyms

Cas, Crkas, p130Cas

Feature Type

protein coding gene

Genetic Map

Chromosome 8

57.98 cM, cytoband D3
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr8:111710485-111743849 bp, - strand From Ensembl annotation of GRCm38   33365 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:7674  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Bcar1

Human homologs

Human Homolog		BCAR1, breast cancer anti-estrogen resistance 1
NCBI Gene ID		9564
neXtProt AC		NX_P56945
Human Synonyms		CAS, CAS1, CASS1, CRKAS, P130Cas
Human Chr (Location)		16q23.1; chr16:75262928-75301951 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(22) : Targeted(2) Gene trapped(20)
 

Homozygous null embryos exhibit growth retardation and embryonic lethality, following disruption of cardiac myofibrils, increased vasodilation, and systemic congestion.

 

Gene Ontology (GO) classifications

All GO classifications: (35 annotations)

Process	actin cytoskeleton organization, actin filament organization, ...
Component	cell junction, cytoplasm, ...
Function	protein binding, protein domain specific binding, ...

External Resources: FuncBase

Expression

Literature Summary: (13 records)
Data Summary: Results (165)    Tissues (60)    Images (16)
Theiler Stages: 10, 18, 23, 25, 26, 28

Assay Type	Results
Immunohistochemistry	24
RNA in situ	35
Northern blot	4
Western blot	24
RT-PCR	78

cDNA source data(106)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(112) cDNA(108) Primer pair(3) Other(1)
Microarray probesets(5)

Other database links

Ensembl Gene Model	ENSMUSG00000031955 (Evidence)
Entrez Gene	12927 (Evidence)
UniGene	3758
DFCI	TC1572474, TC1707840
DoTS	DT.101404174, DT.101737098, DT.103570475, DT.490819, DT.91413624, DT.94173865
NIA Mouse Gene Index	U030269
Consensus CDS Project	CCDS52675.1
International Mouse Knockout Project Status	Bcar1

Sequences

Length	Strain/Species
genomic	ENSMUSG00000031955	Ensembl Gene Model | MGI Sequence Detail	33365	C57BL/6J
transcript	ENSMUST00000166232	Ensembl | MGI Sequence Detail	3171	Not Applicable
polypeptide	ENSMUSP00000129584	Ensembl | MGI Sequence Detail	874	Not Applicable

All sequences(59) RefSeq(4) UniProt(6)

Polymorphisms

SNPs(133 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR021901	CAS family, DUF3513
InterPro	IPR014928	Serine rich protein interaction
InterPro	IPR013315	Spectrin alpha chain, SH3 domain
InterPro	IPR001452	Src homology-3 domain
Protein Ontology	PR:000004676	breast cancer anti-estrogen resistance protein 1

References

(Earliest) J:20302 Shaffer JB, et al., Isolation of a cDNA clone for murine catalase and analysis of an acatalasemic mutant. J Biol Chem. 1987 Sep 25;262(27):12908-11
(Latest) J:188792 Sun G, et al., Protein tyrosine phosphatase alpha phosphotyrosyl-789 binds BCAR3 to position Cas for activation at integrin-mediated focal adhesions. Mol Cell Biol. 2012 Sep;32(18):3776-89
All references(63)

Other accession IDs

MGD-MRK-37128, MGI:2142520