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Bcar1 Gene Detail
Summary
  • Symbol
    Bcar1
  • Name
    breast cancer anti-estrogen resistance 1
  • Synonyms
    Cas, Crkas, p130Cas
  • Feature Type
    protein coding gene
  • IDs
    MGI:108091
    NCBI Gene: 12927
  • Gene Overview
    MyGene.info: BCAR1
Location & Maps
more
  • Sequence Map
    Chr8:111710485-111743849 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      33365 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 57.98 cM, cytoband D3
  • Detailed Genetic Map ± 1 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    BCAR1, BCAR1, Cas family scaffolding protein
  • Vertebrate Orthologs
    9
  • Human Ortholog
    BCAR1, BCAR1, Cas family scaffolding protein
    Orthology source: HomoloGene
  • Synonyms
    CAS, CAS1, CASS1, CRKAS, P130Cas
  • Links
    NCBI Gene ID: 9564
    neXtProt AC: NX_P56945

  • Chr Location
    16q23.1; chr16:75229030-75268053 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 2 alleles in 2 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    25
  • Gene trapped
    20
  • Targeted
    5
Homozygous null embryos exhibit growth retardation and embryonic lethality, following disruption of cardiac myofibrils, increased vasodilation, and systemic congestion.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000031955 Ensembl Gene Model | MGI Sequence Detail 33365 C57BL/6J ±  kb
transcript ENSMUST00000166232 Ensembl | MGI Sequence Detail 3171 Not Applicable  
polypeptide ENSMUSP00000129584 Ensembl | MGI Sequence Detail 874 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    174 from dbSNP Build 142
Protein
Information
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  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000004676 breast cancer anti-estrogen resistance protein 1
  • InterPro Domains
    IPR028848 Breast cancer anti-estrogen resistance protein 1
    IPR021901 CAS family, DUF3513
    IPR014928 Serine rich protein interaction
    IPR001452 SH3 domain
    IPR013315 Spectrin alpha chain, SH3 domain
Molecular
Reagents
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  • All nucleic 112
    cDNA 108
    Primer pair 3
    Other 1

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-37128, MGI:2142520
References
more
  • Summaries
    All 69
    Developmental Gene Expression 15
    Gene Ontology 14
    Phenotypes 9
  • Earliest
    J:20302 Shaffer JB, et al., Isolation of a cDNA clone for murine catalase and analysis of an acatalasemic mutant. J Biol Chem. 1987 Sep 25;262(27):12908-11
  • Latest
    J:219153 Jeong da E, et al., The 31-kDa caspase-generated cleavage product of p130Cas antagonizes the action of MyoD during myogenesis. Biochem Biophys Res Commun. 2014 Feb 21;444(4):509-13

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory