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Ei24 Gene Detail
Summary
  • Symbol
    Ei24
  • Name
    etoposide induced 2.4 mRNA
  • Synonyms
    PIG8
  • Feature Type
    protein coding gene
  • IDs
    MGI:108090
    NCBI Gene: 13663
  • Gene Overview
    MyGene.info: EI24
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:36779159-36797393 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 20.68 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    178 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108090
protein coding gene Chr9:36779153-36797393 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034556
protein coding gene Chr9:34696628-34715119 (-)
A/J MGP_AJ_G0034535
protein coding gene Chr9:33798116-33816766 (-)
AKR/J MGP_AKRJ_G0034462
protein coding gene Chr9:34542669-34562828 (-)
BALB/cJ MGP_BALBcJ_G0034526
protein coding gene Chr9:33640883-33659362 (-)
C3H/HeJ MGP_C3HHeJ_G0034239
protein coding gene Chr9:34955008-34975297 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035048
protein coding gene Chr9:35833544-35851752 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031974
protein coding gene Chr9:32930240-32949203 (-)
CAST/EiJ MGP_CASTEiJ_G0033560
protein coding gene Chr9:34653676-34671617 (-)
CBA/J MGP_CBAJ_G0034212
protein coding gene Chr9:37065596-37083817 (-)
DBA/2J MGP_DBA2J_G0034370
protein coding gene Chr9:33850568-33868799 (-)
FVB/NJ MGP_FVBNJ_G0034311
protein coding gene Chr9:33109111-33127532 (-)
LP/J MGP_LPJ_G0034455
protein coding gene Chr9:34935490-34955227 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034357
protein coding gene Chr9:38718292-38736592 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035067
protein coding gene Chr9:34473484-34492596 (-)
PWK/PhJ MGP_PWKPhJ_G0033266
protein coding gene Chr9:33751856-33770646 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033100
protein coding gene Chr9:34687485-34707473 (-)
WSB/EiJ MGP_WSBEiJ_G0033676
protein coding gene Chr9:34279185-34297581 (-)



Homology
more
  • Human Ortholog
    EI24, EI24, autophagy associated transmembrane protein
  • Vertebrate Orthologs
    9
  • Human Ortholog
    EI24, EI24, autophagy associated transmembrane protein
    Orthology source: HomoloGene, HGNC
  • Synonyms
    EPG4, PIG8, TP53I8
  • Links
    NCBI Gene ID: 9538
    neXtProt AC: NX_O14681
    UniProt: O14681

  • Chr Location
    11q24.2; chr11:125569216-125584689 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    41 phenotypes from 2 alleles in 3 genetic backgrounds
    8 images
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted allele do not survive to the neonatal stage.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000062762 Ensembl Gene Model | MGI Sequence Detail 18235 C57BL/6J ±  kb
    transcript ENSMUST00000163192 Ensembl | MGI Sequence Detail 2309 Not Applicable  
    polypeptide ENSMUSP00000132270 Ensembl | MGI Sequence Detail 358 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • InterPro Domains
      IPR009890 Etoposide-induced 2.4
    Molecular
    Reagents
    less
    • All nucleic 132
      cDNA 129
      Primer pair 1
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-37127, MGI:2142953, MGI:2142976
    References
    more
    • Summaries
      All 44
      Developmental Gene Expression 6
      Gene Ontology 10
      Phenotypes 8
    • Earliest
      J:36240 Lehar SM, et al., Identification and cloning of EI24, a gene induced by p53 in etoposide-treated cells. Oncogene. 1996 Mar 21;12(6):1181-7
    • Latest
      J:215801 Lieu KG, et al., The p53-induced factor Ei24 inhibits nuclear import through an importin beta-binding-like domain. J Cell Biol. 2014 May 12;205(3):301-12

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory