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Gab1
Gene Detail
Symbol

Name
ID
Gab1
growth factor receptor bound protein 2-associated protein 1
MGI:108088
Feature Type
protein coding gene
Genetic Map
Chromosome 8
38.47 cM, cytoband C3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr8:80764434-80880479 bp, - strand
From Ensembl annotation of GRCm38

  116046 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1542  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Gab1

Human
homologs
Human Homolog GAB1, GRB2-associated binding protein 1
NCBI Gene ID 2549
neXtProt AC  NX_Q13480
Human Chr (Location)  4q31.21; chr4:143336527-143474565 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(57) : Gene trapped(46) Targeted(11)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit developmental defects in the placenta, heart, eye, muscle, and skin, and die between embryonic day 13.5 and 18.5.
 
Phenotype Images(4)
Interactions
Gab1 interacts with 312 markers (Mir7-1, Mir7b, Mir10a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process activation of JUN kinase activity, activation of MAPK activity, ...
Component cytoplasm
Function protein binding, signal transducer activity
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (14)    Tissues (14)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 6
Northern blot 8
cDNA source data(177)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(181) cDNA(180) Other(1)
Microarray probesets(6)
Other database
links
Ensembl Gene ModelENSMUSG00000031714 (Evidence)
Entrez Gene14388 (Evidence)
UniGene277409
DFCITC1574444
DoTSDT.492656, DT.103567330
NIA Mouse Gene IndexU030006
Consensus CDS ProjectCCDS22443.1
International Mouse Knockout Project StatusGab1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000031714 Ensembl Gene Model | MGI Sequence Detail 116046 C57BL/6J ±  kb
transcript ENSMUST00000034150 Ensembl | MGI Sequence Detail 4859 Not Applicable 
polypeptide ENSMUSP00000034150 Ensembl | MGI Sequence Detail 695 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(10) UniProt(3)
Polymorphisms
SNPs within 2kb(661 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001849 Pleckstrin homology domain
InterPro IPR011993 Pleckstrin homology-like domain
Protein Ontology PR:000007753 GRB2-associated-binding protein 1
References
(Earliest) J:36572 Weidner KM, et al., Interaction between Gab1 and the c-Met receptor tyrosine kinase is responsible for epithelial morphogenesis. Nature. 1996 Nov 14;384(6605):173-6
(Latest) J:211333 Shin YK, et al., Grb2-associated binder-1 is required for neuregulin-1-induced peripheral nerve myelination. J Neurosci. 2014 May 28;34(22):7657-62
All references(55)
Other
accession IDs
MGD-MRK-37125, MGI:2142409, MGI:2142758

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory