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Gab1
Gene Detail
 Symbol
Name
ID
Gab1
growth factor receptor bound protein 2-associated protein 1
MGI:108088
Feature Type protein coding gene
Genetic Map
Chromosome 8
38.47 cM, cytoband C3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr8:80764434-80880479 bp, - strand
From NCBI annotation of GRCm38

  116046 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1542  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Gab1

Human
homologs
Human Homolog GAB1, GRB2-associated binding protein 1
NCBI Gene ID 2549
neXtProt AC  NX_Q13480
Human Chr (Location)  4q31.21; chr4:143336527-143474565 (+)  GRCh38
Alleles
and
phenotypes
All alleles(57) : Gene trapped(46) Targeted(11)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit developmental defects in the placenta, heart, eye, muscle, and skin, and die between embryonic day 13.5 and 18.5.
 
Phenotype Images(4)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process activation of JUN kinase activity, activation of MAPK activity, ...
Component cytoplasm
Function protein binding, signal transducer activity
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (14)    Tissues (14)    Images (2)
Theiler Stages: 22, 28
Assay TypeResults
RNA in situ 6
Northern blot 8
cDNA source data(177)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(181) cDNA(180) Other(1)
Microarray probesets(6)
Other database
links
Ensembl Gene ModelENSMUSG00000031714 (Evidence)
Entrez Gene14388 (Evidence)
UniGene277409
DFCITC1574444
DoTSDT.103567330, DT.492656
NIA Mouse Gene IndexU030006
Consensus CDS ProjectCCDS22443.1
International Mouse Knockout Project StatusGab1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 14388 NCBI Gene Model | MGI Sequence Detail 116046 C57BL/6J ±  kb
transcript NM_021356 RefSeq | MGI Sequence Detail 4877 C57BL/6 
polypeptide Q9QYY0 UniProt | EBI | MGI Sequence Detail 695 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(10) UniProt(2)
Polymorphisms SNPs within 2kb(661 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001849 Pleckstrin homology domain
InterPro IPR011993 Pleckstrin homology-like domain
Protein Ontology PR:000007753 GRB2-associated-binding protein 1
Graphical View of Protein Domain Structure
References (Earliest) J:36572 Weidner KM, et al., Interaction between Gab1 and the c-Met receptor tyrosine kinase is responsible for epithelial morphogenesis. Nature. 1996 Nov 14;384(6605):173-6
(Latest) J:206901 Findlay GM, et al., Interaction domains of Sos1/Grb2 are finely tuned for cooperative control of embryonic stem cell fate. Cell. 2013 Feb 28;152(5):1008-20
All references(54)
Other
accession IDs
MGD-MRK-37125, MGI:2142409, MGI:2142758

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory