Gab1
Gene Detail

Symbol Name ID

Gab1 growth factor receptor bound protein 2-associated protein 1 MGI:108088

Feature Type

protein coding gene

Genetic Map

Chromosome 8

38.47 cM, cytoband C3
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr8:80764434-80880479 bp, - strand From NCBI annotation of GRCm38   116046 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1542  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Gab1

Human homologs

Human Homolog		GAB1, GRB2-associated binding protein 1
NCBI Gene ID		2549
neXtProt AC		NX_Q13480
Human Chr (Location)		4q31.21; chr4:144257983-144395718 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(57) : Targeted(11) Gene trapped(46)
 

Homozygotes for targeted null mutations exhibit developmental defects in the placenta, heart, eye, muscle, and skin, and die between embryonic day 13.5 and 18.5.

 
Phenotype Images(4)

Gene Ontology (GO) classifications

All GO classifications: (16 annotations)

Process	activation of JUN kinase activity, activation of MAPK activity, ...
Component	cytoplasm
Function	phospholipid binding, protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (8 records)
Data Summary: Results (14)    Tissues (14)    Images (1)
Theiler Stages: 22, 28

Assay Type	Results
RNA in situ	6
Northern blot	8

cDNA source data(179)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(183) cDNA(182) Other(1)
Microarray probesets(6)

Other database links

Ensembl Gene Model	ENSMUSG00000031714 (Evidence)
Entrez Gene	14388 (Evidence)
UniGene	277409
DFCI	TC1574444
DoTS	DT.103567330, DT.492656
NIA Mouse Gene Index	U030006
Consensus CDS Project	CCDS22443.1
International Mouse Knockout Project Status	Gab1

Sequences

Length	Strain/Species
genomic	14388	NCBI Gene Model | MGI Sequence Detail	116046	C57BL/6J
transcript	NM_021356	RefSeq | MGI Sequence Detail	4877	C57BL/6
polypeptide	Q9QYY0	UniProt | EBI | MGI Sequence Detail	695	Not Applicable

All sequences(22) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(593 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001849	Pleckstrin homology domain
InterPro	IPR011993	Pleckstrin homology-like domain
Protein Ontology	PR:000007753	GRB2-associated-binding protein 1

Graphical View of Protein Domain Structure

References

(Earliest) J:36572 Weidner KM, et al., Interaction between Gab1 and the c-Met receptor tyrosine kinase is responsible for epithelial morphogenesis. Nature. 1996 Nov 14;384(6605):173-6
(Latest) J:191481 Zhao J, et al., Endothelial Grb2-associated binder 1 is crucial for postnatal angiogenesis. Arterioscler Thromb Vasc Biol. 2011 May;31(5):1016-23
All references(53)

Other accession IDs

MGD-MRK-37125, MGI:2142409, MGI:2142758