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Hdac1
Gene Detail
 Symbol
Name
ID
Hdac1
histone deacetylase 1
MGI:108086
Synonyms HD1, MommeD5, RPD3
Feature Type protein coding gene
Genetic Map
Chromosome 4
63.26 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr4:129516104-129542713 bp, - strand
From VEGA annotation of GRCm38

  26610 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68426  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 2 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: histone deacetylase class I, eukaryotic type
Gene Tree: Hdac1

Human
homologs
Human Homolog HDAC1, histone deacetylase 1
NCBI Gene ID 3065
neXtProt AC  NX_Q13547
Human Synonyms  GON-10, HD1, RPD3, RPD3L1
Human Chr (Location)  1p34; chr1:32292107-32333623 (+)  GRCh38
Alleles
and
phenotypes
All alleles(28) : Chemically induced (ENU)(1) Gene trapped(16) Targeted(11)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene die as embryos between E9.5 and E10.5.
 
Gene Ontology
(GO)
classifications
All GO classifications: (135 annotations)
Process ATP-dependent chromatin remodeling, cellular response to oxidative stress, ...
Component chromatin, cytoplasm, ...
Function activating transcription factor binding, chromatin binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (26 records)
Data Summary: Results (189)    Tissues (80)    Images (65)
Theiler Stages: 2, 3, 4, 5, 19, 20, 21, 23, 25, 26, 28
Assay TypeResults
Immunohistochemistry 79
RNA in situ 49
Western blot 9
RT-PCR 52
cDNA source data(6)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(12) cDNA(6) Primer pair(5) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000009661 (Evidence)
Ensembl Gene ModelENSMUSG00000028800 (Evidence)
Entrez Gene433759 (Evidence)
NIA Mouse Gene IndexU025556, U038650, U081466
EC3.5.1.98
Consensus CDS ProjectCCDS18696.1
International Mouse Knockout Project StatusHdac1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000009661 VEGA Gene Model | MGI Sequence Detail 26610 C57BL/6J ±  kb
transcript OTTMUST00000022290 VEGA | MGI Sequence Detail 2038 Not Applicable 
polypeptide OTTMUSP00000010171 VEGA | MGI Sequence Detail 482 Not Applicable 

For the selected sequences
All sequences(38) RefSeq(4) UniProt(2)
Polymorphisms SNPs within 2kb(255 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003084 Histone deacetylase
InterPro IPR023801 Histone deacetylase domain
InterPro IPR000286 Histone deacetylase superfamily
Protein Ontology PR:000008478 histone deacetylase 1
References (Earliest) J:36570 Yang WM, et al., Transcriptional repression by YY1 is mediated by interaction with a mammalian homolog of the yeast global regulator RPD3. Proc Natl Acad Sci U S A. 1996 Nov 12;93(23):12845-50
(Latest) J:210274 Turgeon N, et al., The acetylome regulators Hdac1 and Hdac2 differently modulate intestinal epithelial cell dependent homeostatic responses in experimental colitis. Am J Physiol Gastrointest Liver Physiol. 2014 Apr 1;306(7):G594-605
All references(165)
Other
accession IDs
MGD-MRK-37123, MGI:3586542

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory