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Hdac1 Gene Detail
Summary
  • Symbol
    Hdac1
  • Name
    histone deacetylase 1
  • Synonyms
    HD1, MommeD5, RPD3
  • Feature Type
    protein coding gene
  • IDs
    MGI:108086
    NCBI Gene: 433759
  • Gene Overview
    MyGene.info: HDAC1
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:129516104-129542646 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 63.26 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    250 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108086
protein coding gene Chr4:129516104-129542713 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028827
protein coding gene Chr4:131439431-131474828 (-)
A/J MGP_AJ_G0028786
protein coding gene Chr4:126194872-126220328 (-)
AKR/J MGP_AKRJ_G0028739
protein coding gene Chr4:129700388-129740421 (-)
BALB/cJ MGP_BALBcJ_G0028809
protein coding gene Chr4:126791443-126824190 (-)
C3H/HeJ MGP_C3HHeJ_G0028523
protein coding gene Chr4:129765282-129790468 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029251
protein coding gene Chr4:136386965-136418540 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026523
protein coding gene Chr4:119326652-119350771 (-)
CAST/EiJ MGP_CASTEiJ_G0027955
protein coding gene Chr4:127945696-127975149 (-)
CBA/J MGP_CBAJ_G0028489
protein coding gene Chr4:139761553-139796240 (-)
DBA/2J MGP_DBA2J_G0028638
protein coding gene Chr4:126627162-126654335 (-)
FVB/NJ MGP_FVBNJ_G0028605
protein coding gene Chr4:125387760-125412159 (-)
LP/J MGP_LPJ_G0028739
protein coding gene Chr4:131717666-131750815 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028631
protein coding gene Chr4:144597061-144623611 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029289
protein coding gene Chr4:130081050-130108406 (-)
PWK/PhJ MGP_PWKPhJ_G0027677
protein coding gene Chr4:123223636-123256914 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027503
protein coding gene Chr4:125944673-125970038 (-)
WSB/EiJ MGP_WSBEiJ_G0028036
protein coding gene Chr4:130202058-130230178 (-)



Homology
more
  • Human Ortholog
    HDAC1, histone deacetylase 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    HDAC1, histone deacetylase 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    GON-10, HD1, RPD3, RPD3L1
  • Links
    NCBI Gene ID: 3065
    neXtProt AC: NX_Q13547
    UniProt: Q13547

  • Chr Location
    1p35.2-p35.1; chr1:32292103-32333628 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    49 phenotypes from 8 alleles in 9 genetic backgrounds
    60 phenotypes from multigenic genotypes
    67 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene die as embryos between E9.5 and E10.5.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 433759 NCBI Gene Model | MGI Sequence Detail 26543 C57BL/6J ±  kb
    transcript NM_008228 RefSeq | MGI Sequence Detail 1971 C57BL/6  
    polypeptide O09106 UniProt | EBI | MGI Sequence Detail 482 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      cDNA 7
      Primer pair 7
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-37123, MGI:3586542
    References
    more
    • Summaries
      All 267
      Developmental Gene Expression 48
      Gene Ontology 78
      Phenotypes 67
    • Earliest
      J:36570 Yang WM, et al., Transcriptional repression by YY1 is mediated by interaction with a mammalian homolog of the yeast global regulator RPD3. Proc Natl Acad Sci U S A. 1996 Nov 12;93(23):12845-50
    • Latest
      J:266522 Elsen GE, et al., The Epigenetic Factor Landscape of Developing Neocortex Is Regulated by Transcription Factors Pax6--> Tbr2--> Tbr1. Front Neurosci. 2018;12:571

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory