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Hdac1 Gene Detail
Summary
  • Symbol
    Hdac1
  • Name
    histone deacetylase 1
  • Synonyms
    HD1, MommeD5, RPD3
  • Feature Type
    protein coding gene
  • IDs
    MGI:108086
    NCBI Gene: 433759
  • Gene Overview
    MyGene.info: HDAC1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr4:129516104-129542713 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      26610 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 63.26 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    HDAC1, histone deacetylase 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    HDAC1, histone deacetylase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GON-10, HD1, RPD3, RPD3L1
  • Links
    NCBI Gene ID: 3065
    neXtProt AC: NX_Q13547
    UniProt: Q13547

  • Chr Location
    1p35.2-p35.1; chr1:32292103-32333628 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    49 phenotypes from 8 alleles in 9 genetic backgrounds
    60 phenotypes from multigenic genotypes
    66 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene die as embryos between E9.5 and E10.5.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000009661 VEGA Gene Model | MGI Sequence Detail 26610 C57BL/6J ±  kb
    transcript OTTMUST00000022290 VEGA | MGI Sequence Detail 2038 Not Applicable  
    polypeptide OTTMUSP00000010171 VEGA | MGI Sequence Detail 482 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      250 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 14
      cDNA 7
      Primer pair 6
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-37123, MGI:3586542
    References
    more
    • Summaries
      All 263
      Developmental Gene Expression 45
      Gene Ontology 76
      Phenotypes 66
    • Earliest
      J:36570 Yang WM, et al., Transcriptional repression by YY1 is mediated by interaction with a mammalian homolog of the yeast global regulator RPD3. Proc Natl Acad Sci U S A. 1996 Nov 12;93(23):12845-50
    • Latest
      J:262229 Vecera J, et al., HDAC1 and HDAC3 underlie dynamic H3K9 acetylation during embryonic neurogenesis and in schizophrenia-like animals. J Cell Physiol. 2018 Jan;233(1):530-548

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    07/10/2018
    MGI 6.12
    The Jackson Laboratory