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Hdac1
Gene Detail
Symbol

Name
ID
Hdac1
histone deacetylase 1
MGI:108086
Synonyms
HD1, MommeD5, RPD3
Feature Type
protein coding gene
Genetic Map
Chromosome 4
63.26 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr4:129516104-129542713 bp, - strand
From VEGA annotation of GRCm38

  26610 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68426  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 2 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: HDAC1
Protein SuperFamily: histone deacetylase class I, eukaryotic type
Gene Tree: Hdac1

Human
homologs
HDAC1, histone deacetylase 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 3065
neXtProt AC: NX_Q13547

Human Synonyms: GON-10, HD1, RPD3, RPD3L1

Human Chr (Location): 1p34; chr1:32292107-32333628 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(30) : Chemically induced (ENU)(1) Gene trapped(16) Targeted(13)
Genomic Mutations involving Hdac1 (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for disruptions in this gene die as embryos between E9.5 and E10.5.
 
Interactions
Hdac1 interacts with 102 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (29 records)
Data Summary: Results (184)    Tissues (76)    Images (65)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 79
RNA in situ 49
Western blot 9
RT-PCR 47
cDNA source data(6)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA HDAC1 ; Xenbase hdac1 ; ZFIN hdac1    NEW 
Molecular
reagents
All nucleic(12) cDNA(6) Primer pair(5) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000009661 (Evidence)
Ensembl Gene Model ENSMUSG00000028800 (Evidence)
Entrez Gene 433759 (Evidence)
NIA Mouse Gene Index U025556, U038650, U081466
EC 3.5.1.98
Consensus CDS Project CCDS18696.1
International Mouse Phenotyping Consortium Status Hdac1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000009661 VEGA Gene Model | MGI Sequence Detail 26610 C57BL/6J ±  kb
transcript OTTMUST00000022290 VEGA | MGI Sequence Detail 2038 Not Applicable 
polypeptide OTTMUSP00000010171 VEGA | MGI Sequence Detail 482 Not Applicable 

For the selected sequences
All sequences(41) RefSeq(6) UniProt(2)
Polymorphisms
SNPs within 2kb(255 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003084 Histone deacetylase
InterPro IPR023801 Histone deacetylase domain
InterPro IPR000286 Histone deacetylase superfamily
Protein Ontology PR:000008478 histone deacetylase 1
References
(Earliest) J:36570 Yang WM, et al., Transcriptional repression by YY1 is mediated by interaction with a mammalian homolog of the yeast global regulator RPD3. Proc Natl Acad Sci U S A. 1996 Nov 12;93(23):12845-50
(Latest) J:220991 Zimberlin CD, et al., HDAC1 and HDAC2 collectively regulate intestinal stem cell homeostasis. FASEB J. 2015 May;29(5):2070-80
All references(178)
Other
accession IDs
MGD-MRK-37123, MGI:3586542

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory