Hdac1
Gene Detail

Symbol Name ID

Hdac1 histone deacetylase 1 MGI:108086

Synonyms

HD1, MommeD5, RPD3

Feature Type

protein coding gene

Genetic Map

Chromosome 4

63.26 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr4:129516104-129542713 bp, - strand From VEGA annotation of GRCm38   26610 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:68426  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 2 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: histone deacetylase class I, eukaryotic type
Gene Tree: Hdac1

Human homologs

Human Homolog		HDAC1, histone deacetylase 1
NCBI Gene ID		3065
neXtProt AC		NX_Q13547
Human Synonyms		GON-10, HD1, RPD3, RPD3L1
Human Chr (Location)		1p34; chr1:32757708-32799224 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(25) : Targeted(8) Gene trapped(16) Chemically induced(1)
 

Mice homozygous for disruptions in this gene die as embryos between E9.5 and E10.5.

 

Gene Ontology (GO) classifications

All GO classifications: (114 annotations)

Process	cellular response to oxidative stress, chromatin modification, ...
Component	chromatin, cytoplasm, ...
Function	activating transcription factor binding, chromatin binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (24 records)
Data Summary: Results (113)    Tissues (57)    Images (13)
Theiler Stages: 2, 3, 4, 5, 19, 20, 21, 23, 25, 26, 28

Assay Type	Results
Immunohistochemistry	6
RNA in situ	49
Western blot	6
RT-PCR	52

cDNA source data(6)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(12) cDNA(6) Primer pair(5) Other(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000009661 (Evidence)
Ensembl Gene Model	ENSMUSG00000028800 (Evidence)
Entrez Gene	433759 (Evidence)
NIA Mouse Gene Index	U025556, U038650, U081466
EC	3.5.1.98
Consensus CDS Project	CCDS18696.1
International Mouse Knockout Project Status	Hdac1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000009661	VEGA Gene Model | MGI Sequence Detail	26610	C57BL/6J
transcript	OTTMUST00000022290	VEGA | MGI Sequence Detail	2038	Not Applicable
polypeptide	OTTMUSP00000010171	VEGA | MGI Sequence Detail	482	Not Applicable

All sequences(36) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(123 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003084	Histone deacetylase
InterPro	IPR023801	Histone deacetylase domain
InterPro	IPR000286	Histone deacetylase superfamily
Protein Ontology	PR:000008478	histone deacetylase 1

References

(Earliest) J:36570 Yang WM, et al., Transcriptional repression by YY1 is mediated by interaction with a mammalian homolog of the yeast global regulator RPD3. Proc Natl Acad Sci U S A. 1996 Nov 12;93(23):12845-50
(Latest) J:195044 Wang Y, et al., Development and regeneration of Sox2+ endoderm progenitors are regulated by a Hdac1/2-Bmp4/Rb1 regulatory pathway. Dev Cell. 2013 Feb 25;24(4):345-58
All references(137)

Other accession IDs

MGD-MRK-37123, MGI:3586542