Npy5r
Gene Detail

Symbol Name ID

Npy5r neuropeptide Y receptor Y5 MGI:108082

Synonyms

Y5R

Feature Type

protein coding gene

Genetic Map

Chromosome 8

33.15 cM, cytoband B3-C2
Detailed Genetic Map ± 1 cM


Mapping data(6)

Sequence Map

Chr8:66679965-66688094 bp, - strand From NCBI annotation of GRCm38   8130 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:21241  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: neuropeptide Y receptor 5
Gene Tree: Npy5r

Human homologs

Human Homolog		NPY5R, neuropeptide Y receptor Y5
NCBI Gene ID		4889
neXtProt AC		NX_Q15761
Human Synonyms		NPY5-R, NPYR5, NPYY5-R
Human Chr (Location)		4q31-q32; chr4:164265091-164273086 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Homozygotes for a null allele show increased susceptibility to diet-induced obesity and a reduced orexigenic response to select agonists. Homozygotes for a reporter allele show mild late-onset obesity, increased adiposity, polyphagia, and exacerbated obesity parameters after chronic NPY infusion.

 

Gene Ontology (GO) classifications

All GO classifications: (29 annotations)

Process	cardiac left ventricle morphogenesis, eating behavior, ...
Component	cytoplasm, integral to membrane, ...
Function	G-protein coupled receptor activity, neuropeptide Y receptor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (67)    Tissues (43)    Images (16)
Theiler Stages: 19, 21, 23, 28

Assay Type	Results
RNA in situ	65
RT-PCR	2

cDNA source data(7)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(12) Genomic(4) cDNA(7) Primer pair(1)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000044014 (Evidence)
Entrez Gene	18168 (Evidence)
UniGene	10685
DFCI	TC1585663
DoTS	DT.87051430
NIA Mouse Gene Index	U029884
Consensus CDS Project	CCDS22335.1
International Mouse Knockout Project Status	Npy5r

Sequences

Length	Strain/Species
genomic	18168	NCBI Gene Model | MGI Sequence Detail	8130	C57BL/6J
transcript	NM_016708	RefSeq | MGI Sequence Detail	2314	C57BL/6
polypeptide	O70342	UniProt | EBI | MGI Sequence Detail	466	Not Applicable

All sequences(21) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(1) : SNPs(63 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000276	GPCR, rhodopsin-like
InterPro	IPR017452	GPCR, rhodopsin-like, 7TM
InterPro	IPR000393	Neuropeptide Y5 receptor
InterPro	IPR000611	Neuropeptide Y receptor
Protein Ontology	PR:000001494	neuropeptide Y receptor 5

Graphical View of Protein Domain Structure

References

(Earliest) J:43186 Matsumoto M, et al., Inactivation of a novel neuropeptide Y/peptide YY receptor gene in primate species. J Biol Chem. 1996 Nov 1;271(44):27217-20
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(48)

Other accession IDs

MGD-MRK-37119