About   Help   FAQ
Npy5r
Gene Detail
 Symbol
Name
ID
Npy5r
neuropeptide Y receptor Y5
MGI:108082
Synonyms Y5R
Feature Type protein coding gene
Genetic Map
Chromosome 8
33.15 cM, cytoband B3-C2
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr8:66679965-66688094 bp, - strand
From NCBI annotation of GRCm38

  8130 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21241  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Protein SuperFamily: neuropeptide Y receptor 5
Gene Tree: Npy5r

Human
homologs
Human Homolog NPY5R, neuropeptide Y receptor Y5
NCBI Gene ID 4889
neXtProt AC  NX_Q15761
Human Synonyms  NPY5-R, NPYR5, NPYY5-R
Human Chr (Location)  4q31-q32; chr4:163343910-163352388 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a null allele show increased susceptibility to diet-induced obesity and a reduced orexigenic response to select agonists. Homozygotes for a reporter allele show mild late-onset obesity, increased adiposity, polyphagia, and exacerbated obesity parameters after chronic NPY infusion.
 
Interactions
Npy5r interacts with 109 markers (Mir1b, Mir7-1, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (31 annotations)
Process cardiac left ventricle morphogenesis, eating behavior, ...
Component cytoplasm, integral component of membrane, ...
Function G-protein coupled receptor activity, neuropeptide Y receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (67)    Tissues (43)    Images (16)
Theiler Stages: 19, 21, 23, 28
Assay TypeResults
RNA in situ 65
RT-PCR 2
cDNA source data(7)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(12) Genomic(4) cDNA(7) Primer pair(1)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000044014 (Evidence)
Entrez Gene18168 (Evidence)
UniGene10685
DFCITC1585663
DoTSDT.87051430
NIA Mouse Gene IndexU029884
Consensus CDS ProjectCCDS22335.1
International Mouse Knockout Project StatusNpy5r
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 18168 NCBI Gene Model | MGI Sequence Detail 8130 C57BL/6J ±  kb
transcript NM_016708 RefSeq | MGI Sequence Detail 2314 C57BL/6 
polypeptide O70342 UniProt | EBI | MGI Sequence Detail 466 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(6) UniProt(2)
Polymorphisms RFLP(1) : SNPs within 2kb(78 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
InterPro IPR000393 Neuropeptide Y5 receptor
InterPro IPR000611 Neuropeptide Y receptor family
Protein Ontology PR:000001494 neuropeptide Y receptor type 5
Graphical View of Protein Domain Structure
References (Earliest) J:43186 Matsumoto M, et al., Inactivation of a novel neuropeptide Y/peptide YY receptor gene in primate species. J Biol Chem. 1996 Nov 1;271(44):27217-20
(Latest) J:204140 Loktev AV, et al., Neuropeptide Y Family Receptors Traffic via the Bardet-Biedl Syndrome Pathway to Signal in Neuronal Primary Cilia. Cell Rep. 2013 Dec 12;5(5):1316-29
All references(49)
Other
accession IDs
MGD-MRK-37119

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/09/2014
MGI 5.19
The Jackson Laboratory