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Npy5r Gene Detail
Summary
  • Symbol
    Npy5r
  • Name
    neuropeptide Y receptor Y5
  • Synonyms
    Y5R
  • Feature Type
    protein coding gene
  • IDs
    MGI:108082
    NCBI Gene: 18168
  • Gene Overview
    MyGene.info: NPY5R
Location & Maps
more
  • Sequence Map
    Chr8:66679965-66688094 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      8130 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 33.15 cM, cytoband B3-C2
  • Mapping Data
    6 experiments
Homology
more
  • Human Ortholog
    NPY5R, neuropeptide Y receptor Y5
  • Vertebrate Orthologs
    9
  • Human Ortholog
    NPY5R, neuropeptide Y receptor Y5
    Orthology source: HGNC, HomoloGene
  • Synonyms
    NPY5-R, NPYR5, NPYY5-R
  • Links
    NCBI Gene ID: 4889
    neXtProt AC: NX_Q15761

  • Chr Location
    4q32.2; chr4:163343868-163352403 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 3 alleles in 4 genetic backgrounds
    20 phenotypes from multigenic genotypes
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    1
  • Targeted
    5
  • Genomic Mutations
    2 involving Npy5r
  • Incidental Mutations
Homozygotes for a null allele show increased susceptibility to diet-induced obesity and a reduced orexigenic response to select agonists. Homozygotes for a reporter allele show mild late-onset obesity, increased adiposity, polyphagia, and exacerbated obesity parameters after chronic NPY infusion.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000044014 Ensembl Gene Model | MGI Sequence Detail 8130 C57BL/6J ±  kb
transcript ENSMUST00000070810 Ensembl | MGI Sequence Detail 2314 Not Applicable  
polypeptide ENSMUSP00000065157 Ensembl | MGI Sequence Detail 466 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    79 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000001494 neuropeptide Y receptor type 5
  • InterPro Domains
    IPR017452 GPCR, rhodopsin-like, 7TM
    IPR000276 G protein-coupled receptor, rhodopsin-like
    IPR000393 Neuropeptide Y5 receptor
    IPR000611 Neuropeptide Y receptor family
Molecular
Reagents
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  • All nucleic 12
    Genomic 4
    cDNA 7
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-37119
References
more
  • Summaries
    All 46
    Developmental Gene Expression 4
    Gene Ontology 9
    Phenotypes 16
  • Earliest
    J:43186 Matsumoto M, et al., Inactivation of a novel neuropeptide Y/peptide YY receptor gene in primate species. J Biol Chem. 1996 Nov 1;271(44):27217-20
  • Latest
    J:204140 Loktev AV, et al., Neuropeptide Y Family Receptors Traffic via the Bardet-Biedl Syndrome Pathway to Signal in Neuronal Primary Cilia. Cell Rep. 2013 Dec 12;5(5):1316-29

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory