About   Help   FAQ
Frrs1 Gene Detail
Summary
  • Symbol
    Frrs1
  • Name
    ferric-chelate reductase 1
  • Synonyms
    Sdfr2
  • Feature Type
    protein coding gene
  • IDs
    MGI:108076
    NCBI Gene: 20321
Location & Maps
more
  • Sequence Map
    Chr3:116859464-116908177 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      48714 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    FRRS1, ferric chelate reductase 1
  • Vertebrate Orthologs
    11
  • Human Ortholog
    FRRS1, ferric chelate reductase 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    SDFR2, SDR2
  • Links
    NCBI Gene ID: 391059
    neXtProt AC: NX_Q6ZNA5

  • Chr Location
    1p21.2; chr1:99708632-99766630 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 40653
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;2 zebrafish
  • HCOP
    human homology predictions: FRRS1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    74
  • Chemically induced (other)
    1
  • Gene trapped
    70
  • Radiation induced
    1
  • Targeted
    2
  • Genomic Mutations
    2 involving Frrs1
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000054477 VEGA Gene Model | MGI Sequence Detail 48714 C57BL/6J ±  kb
transcript OTTMUST00000135306 VEGA | MGI Sequence Detail 2377 Not Applicable  
polypeptide OTTMUSP00000071627 VEGA | MGI Sequence Detail 592 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    500 from dbSNP Build 137
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 81
    cDNA 81

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-37113, MGI:2139633
References
more
  • Summaries
    All 32
    Developmental Gene Expression 1
    Gene Ontology 4
    Phenotypes 12
  • Earliest
    J:36732 Shirozu M, et al., Characterization of novel secreted and membrane proteins isolated by the signal sequence trap method. Genomics. 1996 Nov 1;37(3):273-80
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
01/26/2016
MGI 6.02
The Jackson Laboratory