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Ccna2
Gene Detail
 Symbol
Name
ID
Ccna2
cyclin A2
MGI:108069
STS D3Nds36
Synonyms Ccn1, Ccn-1, Ccna, Cyca, CycA2
Feature Type protein coding gene
Genetic Map
Chromosome 3
17.67 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr3:36564866-36572150 bp, - strand
From VEGA annotation of GRCm38

  7285 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55562  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: cyclin, A/B/D/E types
Gene Tree: Ccna2

Human
homologs
Human Homolog CCNA2, cyclin A2
NCBI Gene ID 890
neXtProt AC  NX_P20248
Human Synonyms  CCN1, CCNA
Human Chr (Location)  4q27; chr4:121816444-121823933 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(2) Targeted(5)
Incidental mutations (data from Mutagenetix )
 
Embryos homozygous for a targeted mutation implant in the uterine wall, but fail to develop past 5.5 dpc. Notably, mutant embryos develop normally from the four-cell to the post-implantation stage in the absence of detectable maternally-derived gene products.
 
Interactions
Ccna2 interacts with 234 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process cell cycle, cell division, ...
Component cytoplasm, female pronucleus, ...
Function protein binding, protein kinase binding
External Resources: FuncBase
Expression
Literature Summary: (65 records)
Data Summary: Results (205)    Tissues (149)    Images (40)
Theiler Stages: 3, 4, 11, 15, 19, 20, 21, 22, 23, 24, 26, 28
Assay TypeResults
Immunohistochemistry 12
RNA in situ 106
Western blot 19
RT-PCR 68
cDNA source data(13)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(23) Genomic(1) cDNA(14) Primer pair(7) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000006485 (Evidence)
Ensembl Gene ModelENSMUSG00000027715 (Evidence)
Entrez Gene12428 (Evidence)
DFCITC1572126, TC1591796, TC1769788
PDB3QHR, 3QHW, 4I3Z, 4II5
Consensus CDS ProjectCCDS17313.1
International Mouse Knockout Project StatusCcna2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006485 VEGA Gene Model | MGI Sequence Detail 7285 C57BL/6J ±  kb
transcript OTTMUST00000014821 VEGA | MGI Sequence Detail 2964 Not Applicable 
polypeptide OTTMUSP00000006886 VEGA | MGI Sequence Detail 422 Not Applicable 

For the selected sequences
All sequences(44) RefSeq(2) UniProt(2)
Polymorphisms RFLP(2) : SNPs within 2kb(127 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR014400 Cyclin A/B/D/E
InterPro IPR015453 Cyclin A, G2/mitotic-specific
InterPro IPR004367 Cyclin, C-terminal domain
InterPro IPR013763 Cyclin-like
InterPro IPR006671 Cyclin, N-terminal
Protein Ontology PR:000005115 cyclin-A2
References (Earliest) J:12540 Sakaguchi AY, et al., Chromosome mapping in mouse of genes that regulate the eukaryotic cell cycle. Cytogenet Cell Genet. 1991;58:2138
(Latest) J:210466 Liu P, et al., Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus. Nature. 2014 Apr 24;508(7497):541-5
All references(115)
Other
accession IDs
MGD-MRK-1805, MGD-MRK-1807, MGD-MRK-1809, MGD-MRK-2264, MGD-MRK-37106, MGI:2139562

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory