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Ccna2
Gene Detail
Symbol

Name
ID
Ccna2
cyclin A2
MGI:108069
STS
Synonyms
Ccn1, Ccn-1, Ccna, Cyca, CycA2
Feature Type
protein coding gene
Genetic Map
Chromosome 3
17.67 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr3:36564866-36572150 bp, - strand
From VEGA annotation of GRCm38

  7285 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55562  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CCNA2
Protein SuperFamily: cyclin, A/B/D/E types
Gene Tree: Ccna2

Human
homologs
CCNA2, cyclin A2
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 890
neXtProt AC: NX_P20248

Human Synonyms: CCN1, CCNA

Human Chr (Location): 4q27; chr4:121816444-121823933 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Gene trapped(2) Targeted(7)
Incidental mutations (data from Mutagenetix )
 
Embryos homozygous for a targeted mutation implant in the uterine wall, but fail to develop past 5.5 dpc. Notably, mutant embryos develop normally from the four-cell to the post-implantation stage in the absence of detectable maternally-derived gene products.
 
Interactions
Ccna2 interacts with 233 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process cell cycle, cell division, ...
Component cytoplasm, female pronucleus, ...
Function protein binding, protein kinase binding
External Resources: FuncBase
Expression
Literature Summary: (71 records)
Data Summary: Results (211)    Tissues (152)    Images (43)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 14
RNA in situ 106
Western blot 19
RT-PCR 72
cDNA source data(13)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase ccna2    NEW 
Molecular
reagents
All nucleic(24) Genomic(1) cDNA(14) Primer pair(8) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000006485 (Evidence)
Ensembl Gene Model ENSMUSG00000027715 (Evidence)
Entrez Gene 12428 (Evidence)
DFCI TC1572126, TC1591796, TC1769788
PDB 3QHR, 3QHW, 4I3Z, 4II5
Consensus CDS Project CCDS17313.1
International Mouse Phenotyping Consortium Status Ccna2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006485 VEGA Gene Model | MGI Sequence Detail 7285 C57BL/6J ±  kb
transcript OTTMUST00000014821 VEGA | MGI Sequence Detail 2964 Not Applicable 
polypeptide OTTMUSP00000006886 VEGA | MGI Sequence Detail 422 Not Applicable 

For the selected sequences
All sequences(45) RefSeq(2) UniProt(3)
Polymorphisms
RFLP(2) : SNPs within 2kb(127 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR015453 Cyclin A, G2/mitotic-specific
InterPro IPR004367 Cyclin, C-terminal domain
InterPro IPR013763 Cyclin-like
InterPro IPR006671 Cyclin, N-terminal
Protein Ontology PR:000005115 cyclin-A2
References
(Earliest) J:12540 Sakaguchi AY, et al., Chromosome mapping in mouse of genes that regulate the eukaryotic cell cycle. Cytogenet Cell Genet. 1991;58:2138
(Latest) J:220544 Takeda S, et al., Taspase1-dependent TFIIA cleavage coordinates head morphogenesis by limiting Cdkn2a locus transcription. J Clin Invest. 2015 Mar 2;125(3):1203-14
All references(120)
Other
accession IDs
MGD-MRK-1805, MGD-MRK-1807, MGD-MRK-1809, MGD-MRK-2264, MGD-MRK-37106, MGI:2139562

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory